• Journal of Microbiology and Biotechnology
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• 제18권1호
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• pp.171-175
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• 2008

Here, we report that Vibrio parahaemolyticus induces a rapid remodeling of macrophage actin and activates RhoB GTPase. Mutational analysis revealed that the effects depend on type III secretion system 1 regulated translocation of a V. parahaemolyticus effector protein, VP1686, into the macrophages. Remodeling of actin is shown to be necessary for increased bacterial uptake followed by initiation of apoptosis in macrophages. This provides evidence for functional association of the VP1686 in triggering an eat me-and-die signal to the host.

• 대한수학교육학회지:수학교육학연구
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• 제8권2호
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• pp.605-620
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• 1998

This paper suggested a geometry learning model which relates an exploratory learning model with GSP applications, Such a model adopts GSP's capability of visualizing dynamic geometric figures and exploratory learning method's advantages of discovering properties and relations of geometric problem proving and concepts associated with geometric inferencing of students. The research was conducted for 3 middle school students by applying the proposed model for 6times at computer laboratory. The overall procedure was videotaped so that the collected data was later analyzed by qualitative methodology. The analysis indicated that the students with less than van Hiele 4 level took advantages of adoption our proposed model to gain concrete understandings of geometric principles and concepts with GSP. One of the lessons learned from this study suggested that the roles of students and a teacher who want to employ the proposed model need to change their roles respectively.

• The Journal of Asian Finance, Economics and Business
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• 제6권4호
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• pp.171-177
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• 2019

This study aims to investigate the effect of eating-out types on the acceptance intention of artificial seasoning when consumers eat out at restaurants. Eating-out types considered to be typical when customers visit restaurants, such as the food-exploratory type, health-oriented type, and convenience-seeking type, were studied. Based on the research of previous studies, three eating-out types were selected for the study, which were "food-exploratory", "convenience-seeking", "health-oriented". This study was conducted by AMOS 22.0 with 300 questionnaires, and the Structural Equation Model (SEM) was used for examining the hypotheses as statistical method in this study. As a result, eating-out types such as "food-exploratory" and "convenience-seeking" were found to significantly affect the acceptance intention of artificial seasoning. However, consumers' acceptance intention of artificial seasoning differed depending on their consumption value. The path coefficients from food-exploratory type and health-oriented type to acceptance intention were more significant in the hedonic-oriented group than the utilitarian-oriented group. The results of this study suggest eating-out types relate to acceptance intention of artificial seasoning and provide meaningful implications for consumers' psychological consumption value when they consider artificial seasoning.

• International Journal of Internet, Broadcasting and Communication
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• 제16권1호
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• pp.203-214
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• 2024

This study seeks to provide implications for domestic-related policies through exploratory analysis research to support AI-based policy decision-making. The following should be considered when establishing an AI-based decision-making model in Korea. First, we need to understand the impact that the use of AI will have on policy and the service sector. The positive and negative impacts of AI use need to be better understood, guided by a public value perspective, and take into account the existence of different levels of governance and interests across public policy and service sectors. Second, reliability is essential for implementing innovative AI systems. In most organizations today, comprehensive AI model frameworks to enable and operationalize trust, accountability, and transparency are often insufficient or absent, with limited access to effective guidance, key practices, or government regulations. Third, the AI system is accountable. The OECD AI Principles set out five value-based principles for responsible management of trustworthy AI: inclusive growth, sustainable development and wellbeing, human-centered values and fairness values and fairness, transparency and explainability, robustness, security and safety, and accountability. Based on this, we need to build an AI-based decision-making system in Korea, and efforts should be made to build a system that can support policies by reflecting this. The limiting factor of this study is that it is an exploratory study of existing research data, and we would like to suggest future research plans by collecting opinions from experts in related fields. The expected effect of this study is analytical research on artificial intelligence-based decision-making systems, which will contribute to policy establishment and research in related fields.

• Asia Marketing Journal
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• 제15권3호
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• pp.79-95
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• 2013

New product innovation is a process of embodying new knowledge in a product and technology licensing is getting popular as a means to innovations and introduction of new product to the market in today's competitive global market environment. Incumbents often rely on technology licensing to access new product opportunities created by other firms. Prior research has examined various aspects of technology licensing agreements such as specific contract terms of licensing agreements, e.g., distribution of control rights, exclusivity of licensing agreements, cross-licensing, and the scope of licensing agreements. This study aims to provide answers to an important, but under-researched question: why do some incumbents initiate more licensing agreement for exploratory learning while others do it for exploitative learning along the innovation process? We attempt to extend our knowledge of licensing agreements from an organizational learning perspective. Technology licensing as a specific form of interfirm linkages can be initiated with different learning objectives along the process of new product innovation. The exploratory stages of the innovation process such as discovery or research stages involve extensive searches to create new knowledge or capabilities, whereas the exploitative stages of the innovation process such as application or test stages near the commercialization are more focused on developing specific applications or improving their efficiency or reliability. Thus, different stages of the innovation process generate different types of learning and the resulting technological resources. We examine when incumbents as licensees initiate more licensing agreements for exploratory learning objectives and when more for exploitative learning objectives, focusing on two factors that may influence a firm's formation of exploratory and exploitative licensing agreements: 1) its past radical and incremental innovation experience and 2) its internal investments in R&D and marketing. We develop and test our hypotheses regarding the relationship between a firm's radical and incremental new product experience, R&D investment intensity and marketing investment intensity, and the likelihood of engaging in exploratory and exploitive licensing agreements. Using data collected from various secondary sources (Recap database, Compustat database, and FDA website), we analyzed technology licensing agreements initiated in the biotechnology and pharmaceutical industries from 1988 to 2011. The results of this study show that incumbents initiate exploratory rather than exploitative licensing agreements when they have more radical innovation experience and when they invest in R&D activities more intensively; in contrast, they initiate exploitative rather than exploratory licensing agreements when they have more incremental innovation experience and when they invest in marketing activities more intensively. The findings of this study contribute to the licensing and interfirm cooperation studies. First, this study lays a foundation to understand the organizational learning aspect of technology licensing agreements. Second, this study sheds lights on how a firm's internal investments in R&D and marketing are linked to its tendency to initiate licensing agreements along the innovation process. Finally, the findings of this study provide important insight to managers regarding which technologies to gain via licensing agreements. This study suggests that firms need to consider their internal investments in R&D and marketing as well as their past innovation experiences when they initiate licensing agreements along the process of new product innovation.

• 대한간호학회지
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• 제18권2호
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• pp.128-134
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• 1988

This paper argues that nursing theories ideosyncratic to situations should be developed through research, if nursing practice is to be effective in achieving the objective of promoting, maintaining, or restoring health of clients / patients. After reviewing (1) the interactive relationship between the theory and research, (2) the type and sequence of research for theory- building, (3) the hierarchy of theories, and (4) congruence between the type of theory and research approach, it suggests (1) that more exploratory studies (research) should be undertaken as a way to develop descriptive theories that may lead to new hypotheses, (2) that more empirical studies should also be undertaken to test if new hypotheses generated from exploratory studies may be useful in the setting of nuring practice, (3) that more studies should be undertaken to develop useful measures of nursing concepts, and (4) that more replicated studies should be undertaken in order to give rise to the external validity of new theories. It also discusses the ethical considerations of nursing research in the future.

• 기술혁신연구
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• 제4권1호
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• pp.165-183
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• 1996

In acquiring and transferring a superior knowledge assesing the intermediate result value of a competitive R&D project is very important for a firm engaging in R&D. Most existing literatures on R&D evaluation are concerned with project selection and resource allocation. In this paper the stage of an R&D project is classified into research, exploratory development, and development. And a model is suggested which evaluates the intermediate result value before completion of development stage under duopoly and oligopolistic competition. Assessed value of the intermediate result transferred to the next tier company can be used as a minimum acceptable price to the inventor when more advanced knowledge acquired through R&D is transferred to the next tier one. The model suggested is composed of structural variables including research cost, success rates, potential profits, discount rate degree of competition. By using exponential distribution for invertion process time in each stage, we derive a formula that can assess the value of the intermediate result, and we demonstrate how the model can be applied to a competitive R&D situation through an example.

• Journal of Sport and Applied Science
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• 제4권4호
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• pp.7-17
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• 2020

Purpose: This study started with interest in sport culture and is meaningful as an exploratory study to help with the basic understanding of sport culture research. Research design, data, and methodology: The approach of this study is the exploratory approach by literature reviews. This study carried out exploratory research on thinking about diversity of sports culture and the development process of sports culture by human history periods. Results: First, in thinking about cultural diversity, cultural absolutism and cultural relativism were identified. The characteristics of sports culture can identify universality, individuality and diffusion, and the attributes of sports culture included sharing, learning, accumulation, whole systematic relationship and change. Second, the characteristics of sports culture were identified by the approach of each historical era. The historical stages were divided into ancient civilizations, ancient Greece and Rome, middle ages and early modern period, and late modern period. Sports have historically been found to have a British-centered European origin or popularized in the United States. Conclusions: with the characteristics of modern sports culture, the globalization of sports culture, the prominence of sports industry and sports space marketing, and the symbiotic influence relationship of sports and mass media were examined and future directions were discussed.

• 융합경영연구
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• 제5권2호
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• pp.33-39
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• 2017

As the aging population geworsened by the a of the low fertility rate in the wake of the birth of the low birth rate, the rapid increase in the retirement age of the baby boomers in the wake of the birth of the Korean War is a significant indication of the separation of the aged and the role of the economically rich and the role of the role of the economically rich. Therefore, this study aims to address issues and countermeasures. The study aims to provide basic data for the future life of the baby boom generation by examining the problems and responses to the economic activity after the retirement activity of the baby boomers. The research suggests that the limit was limited to the retirement age of the baby boomer generation in order to boost the employment of the elderly. Due to the lack of exploration of the exploratory research, the lack of analysis of exploratory facts is the biggest limitation of the analysis. So, further analysis of this will lead to meaningful studies. Looking at the composition of this study, the introduction of the study included the necessity and purpose of the study. The focus on the point was on the concepts and characteristics of the baby boomer, and analyzed the characteristics of the economic activity and analyses and analyses of domestic and international cases. In conclusion, the issue was drawn up and the alternatives were sought.

• 대한교통학회지
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• 제26권3호
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• pp.53-66
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• 2008

본 연구는 기존의 도로기능 분류체계를 보완하면서 유형화된 도로구간들의 교통특성을 규명하기 위해 새로운 관점에서 도로특성분류 개념을 정립하였다. 도로특성분류는 교통계획, 교통운영관리 등의 교통전반으로 설계 및 정책을 수립하고 지침을 마련하는데 중요한 판단자료로 이용될 것으로 기대된다. 또한, 도로특성분류를 위해 일반국도 상시지점 조사자료를 토대로 12개의 설명변수를 산출하였으며, 이 설명변수들간의 상호상관을 통한 잠재구조 및 다중공선성 검토, 요인점수를 추출하는 탐색적 요인분석을 수행하였다. 연구 방향은 탐색적 요인분석의 각 실행단계별 접하게 되는 의사결정 문제를 세밀하게 검토하였으며, 각 논점별로 올바른 평가기준 방법을 제시하여 최종적인 종합결론을 도출하였다. 적정 설명변수와 요인 수를 결정하기 위해 10개의 시나리오를 비교분석한 결과, 처음 제시한 12개의 설명변수를 모두 포함한 경우가 가장 우수한 것으로 분석되었으며, 4개의 요인이 가장 적정한 것으로 나타났다. 본 연구결과는 추후에 다양한 분석방법(군집분석, 회귀분석, 판별분석 등)에 있어서 객관적인 입력자료로 사용됨에 따라 보다 정확한 연구결과가 도출될 것으로 기대된다.