• Journal of Society of Preventive Korean Medicine
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• v.7 no.1
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• pp.29-45
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• 2003

Objectives : Suoyounsoodan(首烏延壽丹) composed of Polygonum multiflorum THUNB. and some medical herbs is known as formula of senescence delay effect The purpose of this study is to investigate the effect of Suoyounsoodan(首烏延壽丹) on antioxidant enzyme activity such as Thiobarbituric acid reactive substance(TBARS), Superoxide dismutase(SOD), Catalase(CAT), Glutathione peroxidase(GSH-px) in rat plasma and liver. Methods: Sprague-Dawley rats divided into 4 groups, Young group(8 weeks old, N-8), Aging group(18 weeks old, N-18), pathologically induced aging group(injected D-galactose 50mg/kg, 1time/day for 6 weeks, CON) and Suoyounsoodan(首烏延壽丹) administered group(D-galactose 50mg/kg and Suoyounsoodan extracts 840.0mg/kg 1time/day for 6 weeks, SOY). Rats were sacrificed and TBARS, SOD, CAT, and GSH-px were mesured in rat plasma and liver. Results: Plasma and liver TBARS concentrations of SOY group was sinificantly lower than that of control. Red blood cell(RBC) SOD activities of SOY group was increased(F=3.405, p=0.034, ANOVA test), and RBC catalase activities of all experimental groups were not significantly different. RBC GSH-px activities of SOY group was increased(F=9.261, p=0.0001, ANOVA test). Liver SOD activities of SOY group was higher than that of control(F=3.806, p=0.023, ANOVA test). Liver catalase activities of all experimental groups were not significantly different, and liver GSH-px activity of SOY group was significantly higher than that of control(F=3.572, p=0.029, ANOVA test). Conclusions: According to the above results, It is considered Suoyounsoodan is effective in inhibiting lipid peroxidation and increasing anti oxidative enzyme activities in D-galactose induced aging rat.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.31 no.6
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• pp.335-343
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• 2019

Overtopping discharge for sea dike having low mound and high wave wall (LMHW sea dike) is investigated with hydraulic experiments in this study. Vertical, Flare and Bullnose type wave walls are selected and Tetrapods (double layer) and Accropode (one layer) are adopted for armour layers of the front slope. The results of the hydraulic experiments are compared to the overtopping formulas for armoured rubble slopes and vertical sea dikes suggested by EurOtop Manual. Predicted overtopping discharges are underestimated as the roughness efficiency factors (γ_f) of armour blocks suggested by EurOtop are adopted when the overtopping formula for armoured rubble slopes sea dike is used. Meanwhile the predicted overtopping discharges agree well with the hydraulic experiments when the modified roughness efficiency factors redefined by multiplying efficiency factor of the heights of armoured crest berm and wave wall (γ_AR) are adopted. Return wall effects on a vertical wall (Kortenhaus et al., 2003; Pearson et al., 2004a) and the effects on a smooth dike slope (Van Doorslaer et al., 2015) in EurOtop Manual are investigated for Flare and Bullnose type wave walls. As a results of the comparison between experimental results and 2 formulas, return wall effect on a smooth dike was more valid for LMHW sea dike.

• Journal of Korean Traditional Oncology
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• v.20 no.2
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• pp.13-21
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• 2015

Objective : The objective of this study was to investigate the experimental efficacy of anti-tumor activity of the complexed herbal formula, Onbaekwon (OBW), which was derived from the literature of Traditional Korean Medicine, Dongeuibogam. Methods : Nine Cancer cell lines, LoVo, MCF-7, HepG2, AGS, A549, NCI-H69, HL-60, Sarcoma 180, LL/2, were prepared and the cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2yl)-2,5-dephenyl tetrazolium bromide (MTT) assay. Four of them, NCI-H69, HL-60, Sarcoma 180, and LL/2, showed strong cytotoxic activities and they were additionally undergone flow cytometry to find out their effects on apoptosis. ICR male mice were implanted with Sarcoma 180 intraperitoneally and divided into 8 species for each group. Control group was treated with normal saline, positive control group was treated with cyclophosphamide 8mg/kg, and experimental group was treated with OBW 1 g/kg. Results : Among 9 cancer cell lines, NCI-H69, HL-60, Sarcoma 180, and LL/2, expressed less than 0.10 mg/ml of $IC_{50}$ under 0.1~1mg/ml of OBW. NCI-H69, HL-60, Sarcoma 180, and LL/2, showed dose-dependent efficacy of apoptosis. When Sarcoma 180 cancer cell was implanted in ICR male mice and treated with the OBW, they prolonged the median overall survival for 0.8 days, from 17.5 to 18.3. Conclusion : OBW showed strong cytotoxicity to some cancer cells, which are NCI-H69, HL-60, Sarcoma 180, and LL/2, and its apoptotic activity was dose-dependent. OBW prolonged the median survival of mice implanted with Sarcoma 180. Further researches would be expected to support the efficacy of OBW.

• Parasites, Hosts and Diseases
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• v.26 no.3
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• pp.179-188
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• 1988

The life cycle of Fibricola seoulensis was studied in the laboratory and in the field, with special interests in the larval developments within the eggs and in the intermediate hosts. The first emergence of miracidia after incubation of eggs in 26C water began on the ninth day. The miracidia, elongate and cylindrical shape, had epidermal plates in the formula of 6, 9, 4 and 3, with two pairs of flame cells and lateral processes. A kind of fresh water snail, Hippeutis (H.) cantori, was found to shed furcocercous cercariae from the 13th day after experimental challenge with miracidia while Physa acute failed to shed. The same kind of snail collected from the field also shed the same cercariae. The cercariae were equipped with 2 pairs of penetration glands and 5 pairs of fame cells. The tadpoles of Rana nigromaculata were found susceptible to experimental infection with the cercariae. The same kind of tadpoles collected from various areas were also found naturally infected. The metacercariae in the tadpoles which were infected experimentally became infective to the definitive host in 21 days. The metacercariae were located free in the body cavity of tadpoles, and attained sexual maturity in rats in 7 days. The present study successfully followed the complete life cycle of F. seoulensis and found that it is possible to maintain the life cycle in the laboratory.

• Journal of Korean Society of Steel Construction
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• v.26 no.4
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• pp.323-334
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• 2014

In this paper, experimental program and associated numerical study were carried out to evaluate the fire resistance of unprotected concrete-filled rectangular steel tubular (CFT) columns subjected to the standard fire. The key testing parameters included the length effect, the load ratio, and the sectional dimensions of the CFT columns. Temperature distribution and axial deformation of the CFT column specimens were measured and analyzed. Rather early local buckling of steel tubes was observed in all the specimens. This caused subsequent load transfer from steel tube to concrete, and eventually triggered concrete crushing, or complete loss of the load bearing capacity of the column. This implies that the limit state of local buckling as well as overall flexural buckling should be incorporated in fire design procedure. As expected, the fire resistance time of specimen with higher load ratio consistently lessened. The prediction of fire resistance time of unprotected CFT columns based on the limiting steel temperature in current design codes or the formula proposed by previous studies is slightly conservative compared to the fire test results available. To establish the finite element analysis model that can be used to predict the thermal and structural behaviour of unprotected CFT columns in fire, the fully coupled thermal-stress analysis was also tried by using the commercial code ABAQUS. The numerical results showed a reasonable global correlation with the experimental results.

• Journal of the Korea institute for structural maintenance and inspection
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• v.22 no.1
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• pp.176-182
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• 2018

The purpose of this study was to investigate the safety and rationality of buckling strength and length coefficient by comparing with the design standards of domestic and foreign compression materials based on the buckling test results of circular steel pipe with ball joints. The types of round steel pipes selected for buckling performance evaluation were ø$48.6{\times}2.8t$, ø$60.5{\times}3.2t$ and ø$76.3{\times}3.2t$. For the design of domestic and foreign compression materials, Korea 's Load Resistance and Factor Design, Japan' s Limit State Design, and British Standard BS5950 standard were applied. In this study, we compared and analyzed the buckling performance between the experimental results of the previous research and the domestic and foreign design standards. The results were summarized as follows. As a result of applying the full length of the member to the buckling length in the compression materials design standards of each country, it was 64-89% of the buckling strength by the experiment. Therefore, it is deemed desirable to perform the member design according to the current design standard formula for safety. Experimental results show that the measured buckling strength was 1.02-1.43 times higher than the buckling strength of pure cylindrical steel tubes in the design standards of Korea, Japan and the United Kingdom compression materials. Consequently, it seemed that the buckling strength of individual member in the design of space frame structure should be considered buckling coefficient as the length of pure round steel pipe rather than the length of inter-node.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.44 no.6
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• pp.577-583
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• 2011

In 2007, pet food contaminated with melamine caused hundreds of dogs and cats to develop renal failure all over the world. In 2008, over 294,000 infants consumed infant formula and developed kidney stones in China. Further investigation revealed that fish feed also contained melamine; this raised concerns about melamine residues in edible fish tissues, which could have caused the urinary tract stone epidemic. In Korea, catfish fed with assorted feed that included cuttlefish organs that contained melamine developed whitening syndrome and fell dead in some populations in 2008. This event raised suspicions about the toxicity of melamine and all feeds containing melamine were immediately recalled. In this study, we investigated the rates of melamine accumulation and depletion in muscle and viscera of catfish to propose proper withdrawal periods. One group of catfish was fed a commercially available diet that contained 30, 100 and 300 mg melamine per kg diet for 14 days. To investigate residual melamine contents in muscle and viscera, other experimental groups were fed a melamine free diet after being fed melamine for 7 days. The residual amount of melamine was analyzed by LC-MS/MS. The melamine concentration in muscle was estimated to be 3.7 mg/kg after 6 days of feeding with a diet containing 300 mg melamine/kg. After 2 days of culture with a melamine free diet, the residual melamine was depleted and the concentration had decreased from 1.15 mg/kg to 0.19 mg/kg in the muscle of catfish fed a diet containing 300 mg melamine/kg for 7 days. The residual amount of melamine was reduced to 0.03 mg/kg in muscle after 7 days of culture with a melamine free diet and was undetectable after a prolonged culture period of 14 days. Catfish tend to excrete melamine rapidly after oral administration and changes in body color were not observed during the short dosing period.

• The korean journal of orthodontics
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• v.31 no.1 s.84
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• pp.15-24
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• 2001

In order to achieve a desirable tooth movement, it is of great importance to control the M/F ratio and to know the location of the center of resistance. The purpose of this study was to locate the center of resistance and the axis of rotation, and to estimate the stress distribution in the periodontal ligament with experimental model. After preparing a model of an upper canine with a simulated periodontal ligament and alveolar bone, the force and moment were applied. The tooth movement was traced using measuring device with LVDTs(Linear variable differential transformers) that can measure three dimensional tooth movement in real time. The results were as follows. 1. The location of center of resistance by transverse force was $29\%$ of root length measured from alveolar crest to apex regardless of force magnitude. The position of the center of resistance is more coronal than that of two-dimensional model($42\%$). 2. The center of resistance and the axis of rotation coincide when couple moment was applied. 3. As the magnitude of moment increases, tooth tends to extrude irrespective of the direction of the moment. 4. The relationship between location of force and axis of rotation (a x b = $49.6\;mm^2$) was obtained. A tooth movement can be predicted through this formula. 5. The centers of rotation by transverse force were plotted linearly.

• Journal of the Korean Home Economics Association
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• v.20 no.4
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• pp.155-168
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• 1982

What is attempted here is to find out an optimum method for the design of physical environments that could save human energy expenditures and safely perform household duties. There are, if any, very little amount of research done in this area. This is particulary so when the work relates to the designing of household storage facilities in the light of the energy metabolism of human body. The first step to this study, therefore, is to find out the ways by which we can determine the energy metabolism of human body accurately. To measure the volume and the concentration of human respiration continuously and automatically, a new apparatus is selected here. This includes the recording system with the Wright Respirometer and the Expired Gas Analyzer as well as the computer system to multiply volume by concentration of human respiration and to integrate them for a given time. Then, the author experimented on the reliability of this apparatus and came to the conclusion that this apparatus satisfied our need to research the energy metabolism of human body. Next, the general plan and procedures to experiment with this apparatus have been determined as follows: 1) subjects are three young and sound females. Their physical characteristics are shown in Table 1 and most approximates the standard characteristics of Japanese females, 2) height of open shelves is selected in such away as to correspond to the respective height of each subject(see Table 2), 3) utensils to be stored are box shaped object, which weight is 0.5kg, 1.0kg, 2.0kg or 3.0kg, 4) working motions are given while one or two hands as to place utensil on each shelf from the standard working board, 85 cm in height and then to place back it on the board from the shelf and repeated in constant velocity as 10 times per a minute, 5) each posture of motion is chosen by each subject in free, 6) procedures of measurement of human energy metabolism ard shown at(6), 1, Section 3 as specific methods for using this apparatus. Findings of this study are as follows: 1. Human energy expenditures for storing utensils on shelves by each subject are shown in quantity more accurately than in any other studies, under varying conditions about height of shelves, load of utensils and working motion with one hand and two hands (see Fig. 8~13 and Table 3). 2. Experimental formulae of human energy expenditure for that work are shown as formula (8), (9) and (10), to generalize results of 1. and to apply those for working motion under given conditions. 3. As results of analysis on gained data, we are able to show the standard model of human energy expenditures for storing untensils on shelves by the standard Japanese female (see Table 7 and Fig. 14).

• Journal of Society of Preventive Korean Medicine
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• v.6 no.2
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• pp.112-127
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• 2002

Objectives: Younnyeniksoobulrodan(延年益壽不老丹) composed of Polygonum multiflorum THUNB. and some medical herbs is known as formula of senescence delay effect. The purpose of this study is to investigate the effect of Younnyeniksoobulrodan(延年益壽不老丹) on antioxidant enzyme activity such as Thiobarbituric acid reactive substance(TBARS), Superoxide dismutase(SOD), Catalase(CAT), Glutathione peroxidase (GSH-px) in rat erythrocytes and liver. Methods: Sprague-Dawley rats divided into 4 gorups, Young group(8 weeks old, N-8), Aging group(18 weeks old, N-18), pathologically induced aging gorup(injected D-galatose 50mg／kg, 1time／day for 6 weeks, CON) and Younnyeniksoobulrodan(延年益壽不老丹) administered group(D-galactose 50mg／kg and Younnyeniksoobulrodan extracts 840.0mg／kg 1time／day for 6 weeks, YIB). Rats were sacrificed and TBARS, SOD, CAT, and GSH-px were measured in rat erythrocytes and liver. Results: Plasma and liver TBARS concentrations of YIB group were significantly lower than those of control. Red blood cell(RBC) SOD activities of YIB group was increased(F=3.445, p=0.033, ANOVA test), and RBC catalase activities of all experimental group were not significantly different. RBC GSH-px activities of YIB group was increased(F=9.365,p=0.0001, ANOVA test). Liver SOD activities of YIB group was higher than those of control(F=4.967, p=0.008, ANOVA test). Liver catalase activities of all experimental group were not significantly different, and liver GSH-px activity of YIB group was significantly higher than that of control(F=3.846, p=0.022,ANOVA test). Conclusions: According to the above results, it is considered that Younnyeniksoobulrodan is effective in inhibiting lipid peroxidation and increasing antioxidative enzyme activities in D-galactose induced aging rat.