• Korean Chemical Engineering Research
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• v.53 no.2
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• pp.236-242
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• 2015

We present two data-driven modeling methods, partial least square (PLS) and artificial neural network (ANN), to predict the major operating and performance variables of a polymer electrolyte membrane (PEM) fuel cell stack. PLS and ANN models were constructed using the experimental data obtained from the testing of a 30 kW-class PEM fuel cell stack, and then were compared with each other in terms of their prediction and computational performances. To reduce the complexity of the models, we combined a variables importance on PLS projection (VIP) as a variable selection method into the modeling procedure in which the predictor variables are selected from a set of input operation variables. The modeling results showed that the ANN models outperformed the PLS models in predicting the average cell voltage and cathode outlet temperature of the fuel cell stack. However, the PLS models also offered satisfactory prediction performances although they can only capture linear correlations between the predictor and output variables. Depending on the degree of modeling accuracy and speed, both ANN and PLS models can be employed for performance predictions, offline and online optimizations, controls, and fault diagnoses in the field of PEM fuel cell designs and operations.

• Journal of Pharmaceutical Investigation
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• v.30 no.3
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• pp.191-199
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• 2000

Genomics is providing targets faster than we can validate them and combinatorial chemistry is providing new chemical entities faster than we can screen them. Historically, the drug discovery cascade has been established as a sequential process initiated with a potency screening against a selected biological target. In this sequential process, pharmacokinetics was often regarded as a low-throughput activity. Typically, limited pharmacokinetics studies would be conducted prior to acceptance of a compound for safety evaluation and, as a result, compounds often failed to reach a clinical testing due to unfavorable pharmacokinetic characteristics. A new paradigm in drug discovery has emerged in which the entire sample collection is rapidly screened using robotized high-throughput assays at the outset of the program. Higher-throughput pharmacokinetics (HTPK) is being achieved through introduction of new techniques, including automation for sample preparation and new experimental approaches. A number of in vitro and in vivo methods are being developed for the HTPK. In vitro studies, in which many cell lines are used to screen absorption and metabolism, are generally faster than in vivo screening, and, in this sense, in vitro screening is often considered as a real HTPK. Despite the elegance of the in vitro models, however, in vivo screenings are always essential for the final confirmation. Among these in vivo methods, cassette dosing technique, is believed the methods that is applicable in the screening of pharmacokinetics of many compounds at a time. The widespread use of liquid chromatography (LC) interfaced to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) allowed the feasibility of the cassette dosing technique. Another approach to increase the throughput of in vivo screening of pharmacokinetics is to reduce the number of sample analysis. Two common approaches are used for this purpose. First, samples from identical study designs but that contain different drug candidate can be pooled to produce single set of samples, thus, reducing sample to be analyzed. Second, for a single test compound, serial plasma samples can be pooled to produce a single composite sample for analysis. In this review, we validated the issue whether the second method can be applied to practical screening of in vivo pharmacokinetics using data from seven of our previous bioequivalence studies. For a given drug, equally spaced serial plasma samples were pooled to achieve a 'Pooled Concentration' for the drug. An area under the plasma drug concentration-time curve (AUC) was then calculated theoretically using the pooled concentration and the predicted AUC value was statistically compared with the traditionally calculated AUC value. The comparison revealed that the sample pooling method generated reasonably accurate AUC values when compared with those obtained by the traditional approach. It is especially noteworthy that the accuracy was obtained by the analysis of only one sample instead of analyses of a number of samples that necessitates a significant man-power and time. Thus, we propose the sample pooling method as an alternative to in vivo pharmacokinetic approach in the selection potential lead(s) from combinatorial libraries.

• Journal of Korean Public Health Nursing
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• v.25 no.2
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• pp.153-173
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• 2011

Purpose: This study was conducted to analyze trends in research papers published in the Journal of Korean Public Health Nursing, and to compare and contrast similarities and differences of papers before and after listing in the Korea Citation Index (KCI) in 2007. Methods: A descriptive study was conducted with 266 published studies during the 10-year period. The criteria for analysis included types of research, characteristics of researchers and participants, designs, data collection methods and study instruments, ethical considerations, data analysis, and keywords. Results: Studies conducted with grants constituted 23.7%, and students (32.3%) and general populations (25.2%) comprised the largest proportion of the study participants. The majority of the papers were quantitative research (93.2%), and self-reported methods (63.1%) were most frequently utilized. Seventy percent of the studies obtained verbal consent from the participants. Among the study instruments, psychosocial indicators (41.1%) were most frequently employed. The trends indicated that grant studies, students and general populations as study participants, and experimental studies increased, and use of written consent increased after KCI registration. Conclusions: The results could be used to understand the context of scientific research and to improve the quality of the research papers published in the Journal of Korean Public Health Nursing.

• Journal of the Korean GEO-environmental Society
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• v.18 no.7
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• pp.13-20
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• 2017

Soil nailing is ground reinforcement method using the shear strength of ground and the pullout shear resistance force of nail. It is mainly used for reinforcement of cut slopes, earth retaining structures and retaining walls, etc. It may be designed considering the pullout resistance of nail in the case of earth retaining structure and retaining wall, but it should be designed considering not only pullout resistance but also shear and bending resistance in the case of slope. However, conservative designs considering only pullout resistance are being done and most of the studies are about increasing pullout resistance by improving of material, shape and construction method of nail. Actually, Shear bending deformations occur centering on the active surface in ground reinforced with the nail. The grout with relatively low strength is destroyed and separated from the reinforcing material. As a result, the ground is collapsed while reducing the frictional resistance rapidly. Therefore, it is necessary to develop the method to increase the shear resistance while preventing separation of nail and grout body. In this study, an experimental study was conducted on new soil nailing method which can increase shear resistance by forming protrusions through pressurized grouting after installing a packer on the outside of deformed bar.

• Korean Journal of Social Welfare
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• v.59 no.4
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• pp.5-34
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• 2007

This study explores the effects of philanthropy education for elementary school students by using a mixed method. To examine the effects of philanthropy education, two different approaches in research methods are conducted with different data collected from different target groups on the same phenomenon: a) experimental designs to analyze students' change(prosocial behaviors) by philanthropy education program performed in a summer camp(43 participants) and elementary schools(162 students); and b) qualitative analysis on students' changes in perceptual, attitudinal, and behavioral aspects by students' diary and memorandum(66 participants) and intensive interviews with teachers(5 teachers) and parents(4 mothers). The analysis of both quantitative and qualitative results shows that philanthropy education has effects on students' changes in diverse aspects including prosocial behavior. First, the results of quantitative analysis show that in every component of the prosocial behavior such as helping, being kind, empathizing, sharing, protecting, and cooperating, students have positive changes after philanthropy education. Such changes are statistically significant as well. Second, the results of qualitative analysis show that students after having philanthropy education display positive changes in diverse aspects. Particularly, the quantitative results are converged with the qualitative results from students, parents, and teachers. On the other hand, unique finding from qualitative analysis is that students after having philanthropy education can have fundamental changes in their personality. Such a change is commonly confirmed by students, parents, and teachers. This study makes it possible to compare results or to validate, confirm, or corroborate quantitative results with qualitative findings on the effects of philanthropy education for students.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.2A
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• pp.137-146
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• 2005

IP-based design methodology has been popularly employed for SoC design to reduce design complexity and to cope with time-to-market pressure. Interface modules for communication between system buses and IPs are required, since many IPs employ different protocols. Automatic generation of these interface modules would enhance designer's productivity and IP's reusability. This paper proposes an automatic interface generation system based on FSM generated from the protocol description of IPs. The proposed system provides the library modules for the standard buses to reduce the burdens of describing the protocols for data transfer from/to standard buses. Experimental results show that the area of the interface circuits generated by the proposed system had been increased slightly by 4.5% on the average when compared to manual designs. In the experiment, where bus clock is 100 Mhz and slave module clock is 34 Mhz, the latency of the interface had been increased by 7.1% in burst mode to transfer 16 data words. However, occupation of system bus can be reduce by 64.9%. A chip designer can generate an interface that improves the efficiency of system bus, by using this system.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.10a
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• pp.431-435
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• 2011

This paper presents optimized searching technique to improve the performance of H.264/AVC. The proposed CAVLC encoder uses forward and backward searching algorithm to compute the parameters. By zero-block skipping technique and pipelined scheduling, the proposed CAVLC encoder can obtain better performance. The experimental result shows that the proposed architecture needs only 66.6 cycles on average for each $16{\times}16$ macroblock encoding. The proposed architecture improves the performance by 13.8% than that of previous designs. The proposed CAVLC encoder was implemented using VerilogHDL and synthesized with Megnachip $0.18{\mu}m$ standard cell library. The synthesis result shows that the gate count is about 15.6K with 125Mhz clock frequency.

• Journal of KIISE:Computing Practices and Letters
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• v.13 no.4
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• pp.231-239
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• 2007

This paper presents the trade-off relationship between area and performance in the hardware design space exploration for the Korean national standard 128-bit block cipher algorithm SEED. In this paper, we compare the following four hardware design types of SEED algorithm : (1) Design 1 that is 16 round fully pipelining approach, (2) Design 2 that is a one round looping approach, (3) Design 3 that is a G function sharing and looping approach, and (4) Design 4 that is one round with internal 3 stage pipelining approach. The Design 1, Design 2, and Design 3 are the existing design approaches while the Design 4 is the newly proposed design in this paper. Our new design employs the pipeline between three G-functions and adders consisting of a F function, which results in the less area requirement than Design 2 and achieves the higher performance than Design 2 and Design 3 due to pipelining and module sharing techniques. We design and implement all the comparing four approaches with real hardware targeting FPGA for the purpose of exact performance and area analysis. The experimental results show that Design 4 has the highest performance except Design 1 which pursues very aggressive parallelism at the expanse of area. Our proposed design (Design 4) shows the best throughput/area ratio among all the alternatives by 2.8 times. Therefore, our new design for SEED is the most efficient design comparing with the existing designs.

• Korean Journal of Applied Biomechanics
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• v.24 no.2
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• pp.139-149
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• 2014

The purpose of this study was to evaluate the effect of angle change of forefoot's adhesive outsole on the electromyographic activity (EMG) of the erector spinae and selected lower limbs muscle during downhill walking over $-20^{\circ}$ ramp. Thirteen male university students (age: $25.4{\pm}3.9$ yrs, height: $176.2{\pm}5.1$ cm, weight: $717.4{\pm}105.0$ N) who have no musculoskeletal disorder were recruited as the subjects. To assess the myoelectric activities of selected muscles, six of surface EMG electrodes with on-site pre-amplification circuitry were attached to erector spinae (ES), rectus femoris (RF), biceps femoris (BF), tibialis anterior (TA), lateral gastrocnemius (LG), and medial gastrocnemius (MG). To obtain maximum EMG levels of the selected muscles for normalization, five maximum effort isometric contraction were performed before the experimental trials. Each subject walked over $0^{\circ}$ and $20^{\circ}$ ramp with three different forefeet's EVA outsole (0, 10, $20^{\circ}$) in random order at a speed of $1.2{\pm}0.1$ m/s. For each trial being analyzed, five critical instants and four phases were identified from the recording. The results of this study showed that the average muscle activities of MG and LG decreased in $20^{\circ}$ shoes compared to $0^{\circ}$ and $10^{\circ}$ ones in the initial double limb stance (IDLS). In initial single limb stance (ISLS) phase, the average muscle activities of ES increased with the angle of forefoot's adhesive outsole, indicating that the increment of shoes' angle induce upper body to flex anteriorly in order to maintain balance of trunk. In terminal double limb stance (TDLS) phase, average muscle activities of TA significantly increased in $20^{\circ}$ outsole compared to $0^{\circ}$ and $10^{\circ}$ ones. There was no external forces acting on the right foot other than the gravity during terminal single limb stance (TSLS) phase, all muscles maintained moderate levels of activity.

• Journal of the Korean Society of Hazard Mitigation
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• v.11 no.3
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• pp.209-218
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• 2011

The present study proposes a new estimation relationship for the transmission rate of the steel breakwater which is expected to make up for the weakness points in existing hard solution for shore protection. The steel breakwater consists of the wave dissipator of the dual horizontal plates, the supporting columns and their foundations, and thus its respective designs should also be conducted one by one. Furthermore, the breakwater has to ensure both functions of shore protection and structure stabilization. The study produced experimental data for the stability and safety investigation of the steel breakwater. The forces acting on the steel breakwater were classified into two categories, one is vertical up and down loads for the pile resistance and the other was maximum difference of the vertical load acting on horizontally different position for the torsion. The study applied the stability force produced by the summation of maximum pressure at each point and the safety force acting on each point simultaneously. The regular wave corresponding to the significant wave was utilized for measuring wave pressure and force. The study showed the method for the proper position of submerged upper plate by considering occurrence frequency of tide level. The design process finally determined by trial and error is proposed in the present study.