• Title/Summary/Keyword: Experimental Validation

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Toxicity of Organophosphorus Flame Retardants (OPFRs) and Their Mixtures in Aliivibrio fischeri and Human Hepatocyte HepG2 (인체 간세포주 HepG2 및 발광박테리아를 활용한 유기인계 난연제와 그 혼합물의 독성 스크리닝)

  • Sunmi Kim;Kyounghee Kang;Jiyun Kim;Minju Na;Jiwon Choi
    • Journal of Environmental Health Sciences
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    • v.49 no.2
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    • pp.89-98
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    • 2023
  • Background: Organophosphorus flame retardants (OPFRs) are a group of chemical substances used in building materials and plastic products to suppress or mitigate the combustion of materials. Although OPFRs are generally used in mixed form, information on their mixture toxicity is quite scarce. Objectives: This study aims to elucidate the toxicity and determine the types of interaction (e.g., synergistic, additive, and antagonistic effect) of OPFRs mixtures. Methods: Nine organophosphorus flame retardants, including TEHP (tris(2-ethylhexyl) phosphate) and TDCPP (tris(1,3-dichloro-2-propyl) phosphate), were selected based on indoor dust measurement data in South Korea. Nine OPFRs were exposed to the luminescent bacteria Aliivibrio fischeri for 30 minutes and the human hepatocyte cell line HepG2 for 48 hours. Chemicals with significant toxicity were only used for mixture toxicity tests in HepG2. In addition, the observed ECx values were compared with the predicted toxicity values in the CA (concentration addition) prediction model, and the MDR (model deviation ratio) was calculated to determine the type of interaction. Results: Only four chemicals showed significant toxicity in the luminescent bacteria assays. However, EC50 values were derived for seven out of nine OPFRs in the HepG2 assays. In the HepG2 assays, the highest to lowest EC50 were in the order of the molecular weight of the target chemicals. In the further mixture tests, most binary mixtures show additive interactions except for the two combinations that have TPhP (triphenyl phosphate), i.e., TPhP and TDCPP, and TPhP and TBOEP (tris(2-butoxyethyl) phosphate). Conclusions: Our data shows OPFR mixtures usually have additivity; however, more research is needed to find out the reason for the synergistic effect of TPhP. Also, the mixture experimental dataset can be used as a training and validation set for developing the mixture toxicity prediction model as a further step.

Proposal of a Fail-Safe Requirement Analysis Procedure to Identify Critical Common Causes an Aircraft System (항공기 시스템의 치명적인 공통 요인을 식별하기 위한 고장-안전 요구분석 절차 제안)

  • Lim, San-Ha;Lee, Seon-ah;Jun, Yong-Kee
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.50 no.4
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    • pp.259-267
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    • 2022
  • The existing method of deriving the fail-safe design requirements for the domestic developed rotary-wing aircraft system may miss the factors that cause critical system function failures, when being applied to the latest integrated avionics system. It is because the existing method analyzes the severity effect of the failures caused by a single item. To solve the issue, we present a systematic analysis procedure for deriving fail-safe design requirements of system architecture by utilizing functional hazard assessment and development assurance level analysis of SAE ARP4754A, international standard for complex system development. To demonstrate that our proposed procedure can be a solution for the aforementioned issue, we set up experimental environments that include common factors that can cause critical function failures of a system, and we conducted a cross-validation with the existing method. As a result, we showed that the proposed procedure can identify the potential critical common factors that the existing method have missed, and that the proposed procedure can derive fail-safe design requirements to control the common factors.

Class Classification and Validation of a Musculoskeletal Risk Factor Dataset for Manufacturing Workers (제조업 노동자 근골격계 부담요인 데이터셋 클래스 분류와 유효성 검증)

  • Young-Jin Kang;;;Jeong, Seok Chan
    • The Journal of Bigdata
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    • v.8 no.1
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    • pp.49-59
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    • 2023
  • There are various items in the safety and health standards of the manufacturing industry, but they can be divided into work-related diseases and musculoskeletal diseases according to the standards for sickness and accident victims. Musculoskeletal diseases occur frequently in manufacturing and can lead to a decrease in labor productivity and a weakening of competitiveness in manufacturing. In this paper, to detect the musculoskeletal harmful factors of manufacturing workers, we defined the musculoskeletal load work factor analysis, harmful load working postures, and key points matching, and constructed data for Artificial Intelligence(AI) learning. To check the effectiveness of the suggested dataset, AI algorithms such as YOLO, Lite-HRNet, and EfficientNet were used to train and verify. Our experimental results the human detection accuracy is 99%, the key points matching accuracy of the detected person is @AP0.5 88%, and the accuracy of working postures evaluation by integrating the inferred matching positions is LEGS 72.2%, NECT 85.7%, TRUNK 81.9%, UPPERARM 79.8%, and LOWERARM 92.7%, and considered the necessity for research that can prevent deep learning-based musculoskeletal diseases.

Generation of calibration standard gases using capillary gas divider: uncertainty measurement and method validation (다중 모세관을 이용한 교정용 표준가스의 제조: 불확도와 유효성 평가)

  • Lee, Sangyun;Hwang, Eun-Jin;Jung, Hye-Ja;Lee, Kwang-Woo;Chun, Ki-Joon
    • Analytical Science and Technology
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    • v.19 no.5
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    • pp.369-375
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    • 2006
  • Calibration gas mixtures were prepared using dynamic volumetric method according to ISO 6145-5 and the uncertainty was evaluated. Ten identical capillaries with 0.25 mm in inner diameter and 50 cm in length were applied in this system. Dilution ratio of parent gas was determined by the number of capillaries that passes parent gas and that passes balance gas through. Capillaries were made of Teflon which had good chemical stability against adsorption of gaseous substances. Mechanical valves were introduced in this system in order to minimize the thermal effect of solenoid valves. Concentration of prepared gases were compared with master grade standard gases in cylinders made by RiGAS Co. and calibration of the instrument were completed using comparison method according to ISO 6143. Experimental results showed that the coefficient of variance of diluted oxygen standard gases showed less then 0.2% in most dilution range, that of diluted hydrogen sulfide standard gases showed less then 1.0%. Therefore, it is proven that the standard gases prepared by this system are appropriate to be used as a calibration standards in ambient monitoring, etc.

A Development of Torsional Analysis Model and Parametric Study for PSC Box Girder Bridge with Corrugated Steel Web (복부 파형강판을 사용한 PSC 복합 교량의 비틀림 해석모델의 제안 및 변수해석)

  • Lee, Han-Koo;Kim, Kwang-Soo
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.28 no.2A
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    • pp.281-288
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    • 2008
  • The Prestressed Concrete (hereinafter PSC) box girder bridges with corrugated steel webs have been drawing an attention as a new structure type of PSC bridge fully utilizing the feature of concrete and steel. However, the previous study focused on the shear buckling of the corrugated steel web and development of connection between concrete flange and steel web. Therefore, it needs to perform a study on the torsional behavior and develop the rational torsional analysis model for PSC box girder with corrugated steel web. In this study, torsional analysis model is developed using Rausch's equation based on space truss model, equilibrium equation considering softening effect of reinforced concrete element and compatibility equation. Validation studies are performed on developed model through the comparison with the experimental results of loading test for PSC box girder with corrugated steel webs. Parametric studies are also performed to investigate the effect of prestressing force and concrete strength in torsional behavior of PSC box girder with corrugated steel web. The modified correction factor is also derived for the torsional coefficient of PSC box girder with corrugated steel web through the parametric study using the proposed anlaytical model.

Numerical Simulations of Cellular Secondary Currents in Open-Channel Flows using Non-linear k-ε Model (비선형 k-ε 모형을 이용한 개수로 흐름에서의 격자형 이차흐름 구조 수치모의)

  • Kang, Hyeongsik;Choi, Sung-Uk;Park, Moonhyeong
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.28 no.6B
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    • pp.643-651
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    • 2008
  • In the present paper, turbulent open-channel flows over longitudinal bedforms are numerically simulated. The Reynolds- averaged Navier-Stokes equations in curvilinear coordinates are solved with the non-linear $k-{\varepsilon}$ model by Speziale( 1987). First, the developed model is applied to rectangular open channel flows for purposes of model validation and parameter sensitivity studies. It is found that the parameters $C_D$ and $C_E$ are important to the intensity of secondary currents and the level of turbulent anisotropy, respectively. It is found that the non-linear $k-{\varepsilon}$ model can hardly reproduce the turbulence anisotropy near the free surface. However, the overall pattern of the secondary currents by the present model is seen to coincide with measured data. Then, numerical simulations of turbulent flows over longitudinal bedforms are performed, and the simulated results are compared with the experimental data in the literature. The simulated secondary currents clearly show upflows and downflows over the ridges and troughs, respectively. The numerical results of secondary currents, streamwise mean velocity, and turbulence structures compare favorably with the measured data. However, it is observed that the secondary currents towards the troughs were significantly weak compared with the measured data.

Three-Dimensional Numerical Simulations of Open-Channel Flows with Alternate Vegetated Zones (교행식생 영역을 갖는 개수로 흐름에서의 3차원 수치모의)

  • Kang, Hyeongsik;Kim, Kyu-Ho;Im, Dongkyun
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.29 no.3B
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    • pp.247-257
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    • 2009
  • In the present paper, turbulent open-channel flows with alternate vegetated zones are numerically simulated using threedimensional model. The Reynolds-averaged Navier-Stokes Equations are solved with the ${\kappa}-{\varepsilon}$ model. The CFD code developed by Olsen(2004) is used for the present study. For model validation, the partly vegetated channel flows are simulated, and the computed depth-averaged mean velocity and Reynolds stress are compared with measured data in the literature. Comparisons reveal that the present model successfully predicts the mean flow and turbulent structures in vegetated open-channel. However, it is found that the ${\kappa}-{\varepsilon}$ model cannot accurately predict the momentum transfer at the interface between the vegetated zone and the non-vegetated zone. It is because the ${\kappa}-{\varepsilon}$ model is the isotropic turbulence model. Next, the open channel flows with alternate vegetated zones are simulated. The computed mean velocities are compared well with the previously reported measured data. Good agreement between the simulated results and the experimental data was found. Also, the turbulent flows are computed for different densities of vegetation. It is found that the vegetation curves the flow and the meandering flow pattern becomes more obvious with increasing vegetation density. When the vegetation density is 9.97%, the recirculation flows occur at the locations opposite to the vegetation zones. The impacts of vegetation on the flow velocity and the water surface elevation are also investigated.

An Experiment for Surface Soil Moisture Mapping Using Sentinel-1 and Sentinel-2 Image on Google Earth Engine (Google Earth Engine 제공 Sentinel-1과 Sentinel-2 영상을 이용한 지표 토양수분도 제작 실험)

  • Jihyun Lee ;Kwangseob Kim;Kiwon Lee
    • Korean Journal of Remote Sensing
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    • v.39 no.5_1
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    • pp.599-608
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    • 2023
  • The increasing interest in soil moisture data using satellite data for applications of hydrology, meteorology, and agriculture has led to the development of methods for generating soil moisture maps of variable resolution. This study demonstrated the capability of generating soil moisture maps using Sentinel-1 and Sentinel-2 data provided by Google Earth Engine (GEE). The soil moisture map was derived using synthetic aperture radar (SAR) image and optical image. SAR data provided by the Sentinel-1 analysis ready data in GEE was applied with normalized difference vegetation index (NDVI) based on Sentinel-2 and Environmental Systems Research Institute (ESRI)-based Land Cover map. This study produced a soil moisture map in the research area of Victoria, Australia and compared it with field measurements obtained from a previous study. As for the validation of the applied method's result accuracy, the comparative experimental results showed a meaningful range of consistency as 4-10%p between the values obtained using the algorithm applied in this study and the field-based ones, and they also showed very high consistency with satellite-based soil moisture data as 0.5-2%p. Therefore, public open data provided by GEE and the algorithm applied in this study can be used for high-resolution soil moisture mapping to represent regional land surface characteristics.

Performance Prediction for Plenoptic Microscopy Under Numerical Aperture Unmatching Conditions (수치 구경 불일치 플렌옵틱 현미경 성능 예측 방안 연구)

  • Ha Neul Yeon;Chan Lee;Seok Gi Han;Jun Ho Lee
    • Korean Journal of Optics and Photonics
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    • v.35 no.1
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    • pp.9-17
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    • 2024
  • A plenoptic optical system for microscopy comprises an objective lens, tube lens, microlens array (MLA), and an image sensor. Numerical aperture (NA) matching between the tube lens and MLA is used for optimal performance. This paper extends performance predictions from NA matching to unmatching cases and introduces a computational technique for plenoptic configurations using optical analysis software. Validation by fabricating and experimenting with two sample systems at 10× and 20× magnifications resulted in predicted spatial resolutions of 12.5 ㎛ and 6.2 ㎛ and depth of field (DOF) values of 530 ㎛ and 88 ㎛, respectively. The simulation showed resolutions of 11.5 ㎛ and 5.8 ㎛, with DOF values of 510 ㎛ and 70 ㎛, while experiments confirmed predictions with resolutions of 11.1 ㎛ and 5.8 ㎛ and DOF values of 470 ㎛ and 70 ㎛. Both formula-based prediction and simulations yielded similar results to experiments that were suitable for system design. However, regarding DOF values, simulations were closer to experimental values in accuracy, recommending reliance on simulation-based predictions before fabrication.

Bearing Capacity Evaluation of Hybrid Suction Bucket Foundations on Clay Under Horizontal Loads Using a Centrifuge (원심모형실험을 활용한 점토지반에 설치된 하이브리드 석션 버켓기초의 수평방향 지지력 평가)

  • Kim, Jae-Hyun;Lee, Cheol-Ju;Shin, Hee Jeong;Kim, Seong Hwan;Goo, Jeong Min;Jung, Chung Yeol;Jeon, Young-Jin
    • Journal of the Korean Geotechnical Society
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    • v.39 no.12
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    • pp.61-73
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    • 2023
  • Suction buckets are feasible options for offshore foundations to support subsea structures in deep water, enabling suction-induced installation by pumps. Recently, hybrid suction bucket foundations that combine single or multiple suction buckets with a mat foundation have been considered. The foundations effectively increase the load capacity while reducing construction costs. However, there is still insufficient experimental validation of hybrid suction bucket foundations regarding their bearing capacity. Furthermore, research on the horizontal load capacity under low vertical and moment loads is inadequate. In this study, we investigate the feasibility of using a hybrid suction bucket foundation for subsea installations in clay. We considered two types of hybrid suction bucket foundations: a circular mat with a single suction bucket and a square mat with multiple buckets. Centrifuge tests were performed to understand the hybrid suction bucket foundation characteristics under horizontal loads and their corresponding bearing capacity. Particularly, we verified the effect of the mat foundation and bucket embedment depth on the horizontal bearing mechanism and capacities. Results confirmed that the hybrid suction bucket foundation outperforms the single suction bucket.