• 제목/요약/키워드: Experimental

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임상약학 담당교수에 의한 한국 약학전문대학원의 실무실습준비 현황 평가 (Evaluation of Current Preparing Status for Experimental Practice by Faculty of Clinical Pharmacy in Korea)

  • 이옥상;임성실
    • 약학회지
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    • 제57권3호
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    • pp.219-225
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    • 2013
  • The Korean pharmacy education has introduced new curriculum since 2011. In the new curriculum, pharmacy students have been provided strenthen experimental education and clinical pharmacy has been more important than previous curriculum. Thus, faculties in the college of pharmacy should prepare the circumstances correlated with the changed curriculum. To accomplish successful setting, all faculty and practice experts must work together and need financial assisstant from the college. However, there are many different obstacles among 35 colleges of pharmacy in Korea. In order to narrow a gap among students and find the way to overcome it together, we studied the problem of preparation process in Korean colleges of Pharmacy. We studied the process of practical education in college of pharmacy by means of self-reporting questionnaire from November 29th 2012 to December 31th 2012. The questionaire comprised of syllabus related to clinical pharmacy, the number of professor in charge of clinical pharmacy or pharmacotherapeutics, the plan of securing faculties in the field of clinical pharmacy, the budget, site, instrument for preparing experimental education, the lesson time number of experimental education, MOU, education and treatment of preceptor in the practice site and committee of experimental education in the college. Total 21 of 35 colleges participated in this survey. They showed different composition of syllabus, budget, the circumstances of experimental education, the education and treatment of preceptor. Most colleges are unclear the site and preceptor of experimental education and they did not contract the MOU with the sites. 9 of 21 also did not have the committee of experimental education in the colleges. From 2013, some colleges of pharmacy start actual experimental education. Inadequete preparation and different quality of education can make student incomplete pharmacists, so it will be negative effect on public health. To overcome challenge and obtain desirable goal, funding/administrative assistant from the college and networking within 35 colleges of pharmacy are needed.

집단 의사소통 프로그램이 역기능적 의사소통, 자기존중감 및 우울에 미치는 효과-정신질환자 어머니 집단을 중심으로- (The Effects of the Group Communication Program on the Dysfunctional Communication, Self-Esteem and Depression-In the Group of Mothers with Children of Mental Disorders-)

  • 이길자
    • 대한간호학회지
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    • 제28권3호
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    • pp.801-809
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    • 1998
  • This study was carried out the group communication program which I had composed of using the Satir's communication family theory and skills. The purpose of this study was to investigate the effects on the dysfunctional communication self-esteem and depression, executed this program for the mothers group with caring the mental disorders. and then for the test of some hypotheses it was devided two groups ; the experimental group(n=20) and control group(n=25). In the control group they were learned two session family education program in the psychiatric clinics of Pusan National University Hospital and in the experimental group they had experienced during the 10 session by the group communication program. In the methods of the statistics on this datas, it was to statistics X²test for the comparison between the experimental group and control group with general characteristics. The effect of the Group Communication Program was to analyse ANCOVA between pre-post test on the disfunctional communication, self-esteem and depression in the control group and experimental group. The conclusions were derived from the results and test of hypothesis as followings ; 1) The results were tested the differentiation between the experimental and control group, and the pre-post test in the experimental group with dysfunctional communication self-esteem and depression. Some hypothesis were tested and supported as followings : It was supported that the level of dysfunctional communication of the experimental group would be lower than the control group (Hypothesis 1) It was supported that the level of self-esteem of the experimental group would be higher than the control group (Hypothesis 2). It was supported that the level of depression of the experimental group would be lower than the control group (Hypothesis 3). 2) The relation of the dysfunctional communication with the self-esteem was presented negative correlation and with the depression was not correlation. The relation of the self-esteem with the depression was presented significantly negative correlation. The relation of the sacrificuny pattern of dysfuntional communication with the self-esteem was presented negative correlation and with the depression positive correlation.

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Collagenase가 백서 치아이동 후 복귀현상에 미치는 효과에 관한 조직화학적 연구 (AN HISTOCHEMICAL STUDY ON THE EFFECTS OF COLLAGENASE DURING THE RELAPSE PERIOD FOLLOWING RAT'S TOOTH MOVEMENT)

  • 황현수;유영규
    • 대한치과교정학회지
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    • 제14권1호
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    • pp.173-183
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    • 1984
  • The author has observed the effects of collagenase on the relapse phenomenon and the histochemical changes during the relapse period. 50 rats were used. : 3rats as a normal group, 15rats as control groups, and 32rats as experimental groups. Rat's teeth were moved for 10days with helical spring applied, followed by injection of "collagenase in Hank's sol." to the experimental groups and the "Hank's sol." to the control group in the interdental gingiva on the 10th day, and the spring was removed on the 11th day. After injection, the experimental animals were sacrificed on the 11th, 13th, 15th, 17th, 20th, and 24th day and prepared histochemically for the Hematoxylin-Eosin, Van-Gieson, and Methyl Green-pyronin staining. The results are as follows: 1. Group I (11th day): In the control group the supracrestal fibers were stretched and the metabolic rate was high. Experimental group showed that supracrestal fibers were resor, bed, disarrayed, and the metabolic rate was low. 2. Group II (13th day): In the control group, the supracrestal fibers began to change from the vertical direction to tooth-axis to the parallel. Experimental group showed that supracrestal fibers were completely resorbed. 3. Group IV (17th day): The control group showed almost normal structure. Form this group the metabolic rates were low. Experimental group showed the most destructive pattern. 4. Group VI (24th day): Experimental group showed almost normal structure. It follows that experimental groups were relapsed less than the control groups, and collagenase was effective in the prevention of relapse after rat's experimental tooth movement.

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다양한 구강위생기구를 이용하여 임플란트 표면의 Prophylaxis 시행시 표면형태의 변화분석 (Analysis of surface form change after performing prophylaxis procedure on implant surface using various oral hygiene instruments)

  • 이선구;임성빈;정진형;권상호
    • Journal of Periodontal and Implant Science
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    • 제34권1호
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    • pp.1-17
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    • 2004
  • It is improtant that performing prophylaxis procedure on an infected implant surface in order to treat peri-implantitis should not change the surface roughness and composition, so that the surface can be recovered to almost same condition as initial implant surface. This thesis, therefore, studied an effect of various oral hygiene instrument on implant surface. A surface roughness measurement instrument and an infection electron microscope were used to observe a change on surface. The purpose of this study was to obtain a clinical guidelines during implant care and peri-implantitis treatment. The result were as follows 1. Ra values (surface roughness value) at experimental group 1, group 2, and group 5 were increased significantly as compared with comparison group(p<0.05). 2. When compared experimental group 1 with each experimental groups at which prohylaxis procedure was performed, mean values of Ra at experimental group 2, group 3, group 6, and group 7 were decreased significantly(p<0.05). 3. Mean value of Ra was lowest at experimental group 2, and highest at experimental group 2, and highest at experimental group 5. 4. Analysis of SEM showed that was significant surface change at experimental group 2, group 3, group 4, group 5, and group 6 as compared with comparison group(X1000). 5. Analysis fo EDX showed that a quantity of Ti on surface for experimental group 6 was very similar to that for comparison group. In conclusion, air-powder abrasive and citric acid, plastic instrument are safe methods to use for performing prophylaxis procedure on implant care or for cleaning and sterilization process on treatment of peri-implantitis, based on the result that those method did not affect implant surface roughness and Ti composition.

달팽이 점액이 아토피 피부염 환자의 피부장벽 회복에 미치는 영향 (The Effects of Snail Secretion Filtrate on the damaged skin barrier's recovery of the Atopic dermatitis)

  • 오민지;박성민;김희택
    • 한방안이비인후피부과학회지
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    • 제23권3호
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    • pp.138-153
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    • 2010
  • Purposes : The object of present study is to detect the Effects of Snail Secretion Filtrate and Hyaluronic acid on the skin barrier's recovery of the Atopic dermatitis. Methods : A total of 20 patients who visited Semyung Hanny Oriental Medical Center from september 1st, 2009 to August 31th, 2010 were included in this study. In this study, they were treated with Snail Secretion Filtrate(experimental group) and Hyaluronic acid(control group). For 4 weeks gross examination, hematological examination and instrumentation through skin-ANBT equipment were made before and after the experiments to see how well the products for experimental group act against those for control group in recovering the damaged skin barriers by Atopic dermatitis. Results : 1. In the primary endpoint, SCORAD Index showed a statistically significant decline in both the control group and the experimental group. However, the experimental group showed greater statistical significance than the control group. 2. In the secondary endpoint index of skin hydration, both the control group and the experimental group did not show a statistically significant increase. However, the degree of skin hydration in the experimental group is greater than in the control group. 3. In global assessment of efficacy, it was higher in the experimental group than in the control group for both the subjects and the researchers. 4. To evaluate the safety of the products for the human body, hematological examination and hematological biochemical examination were conducted; both the control group and the experimental group showed no abnormal level. Therefore, the safety of the products, if used for so long a time, proved to be safe for the human body. 5. Product satisfaction was higher in the experimental group than in the control group. Conclusions : According to above experiments, Snail Secretion Filtrate was effective on the Atopic dermatitis.

흰쥐에서 아급성 연독성에 대한 감두탕의 예방효과에 관한 연구(II) - 소변 및 혈액에 미치는 영향을 중심으로 - (A Study on the Preventive Effect of Kam Doo Decoction on the Subacute Lead Toxicity in Rats)

  • 이선동;이용욱;방형애
    • 한국환경보건학회지
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    • 제20권1호
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    • pp.83-95
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    • 1994
  • This study was performed to investigate the preventive effect of KDD against lead toxicity. KDD of 133, 266, 532 and 1,064 mg/kg were administered twice to the rats of Sprague-Dawley strain and then 300 mg/kg lead acetate was given to times, respectively. 1. The $\delta$-ALAD concentration in the urine showed 10.6 ~16.4 mg/kg in the control group indicated statistical significance for the experimental group II, III, IV, V (p<0.05). Also, the Coproporphyrin concentration had 0.119 ~ 0.226 $\mu$g/ml in the control group indicated statiscial significance for the experimental group V of 10 weeks (p<0.05). 2. The $\delta$-ALAD concentration in the blood showed 13.28 ~ 16.08 ALAD unit in the control group indicated statistical significance for the experimental group I (Pb 300 mg/kg) of 6 and 8 weeks, for the experimental group III, IV of 8 and 10 weeks, and for the experimental group V of 4 weeks (p<0.05). The $\delta$-ALAD concentration of experimental group I (Pb 300 mg/kg) group was inclined to decrease during the experiment period. The $\delta$-ALAD concentration of experimental group I (Pb 300 mg/kg) showed statistical significance for the experimental group II, III, IV, V of 6, 8 and 10 weeks. But, there was no statistical significance in the concentration change of hemoglobin, RBC, WBC, hematocrit, Ca, protein among the experimental groups. In conclusion, this study revealed the preventive effect of KDD against lead toxicity and its mechnism inferred to facilitate lead excretion in urinary following hinderance of lead absorption in the gastric-intestine and organs.

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안구운동이 성인 편마비 환자의 마비측에 따른 균형증진에 미치는 영향 (The Effect of Eye Movement on Balance Improvement by Plegia Side of Adult Hemiplegic Patient)

  • 구봉오;배성수;김한수;이동호
    • The Journal of Korean Physical Therapy
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    • 제14권4호
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    • pp.1-19
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    • 2002
  • The purpose of this study is to identify influence that eye movement have an effect on postural control and balance performance by plegia side of the impaired patients of central nervous system. Subjects are patients with the impairment of central nervous system and experimental and control groups are forty people and thirty people seperatively, Total subjects were selected to seventy persons, but twelve persons of experimental group quit during the experimental periods and eight persons of control group did not measure after exercise. Therefore, twenty eight persons of experimental group and twenty two persons of control group were selected in this study and experimental group peformed eye movement for eight weeks according to the exercise program of this study. The measurement of dependent variable is right static balance, left static balance, bilateral static balance, and bilateral dynamic balance before exercise and after eighth week of exercise, examiner again measured and analyzed the results. The results were as follows: 1. As the result of comparing balance performance ability after test of the experimental and control group with right hemiplegia and control group, all of static balance performance ability of right side (p < 0.01), static balance performance ability of left side (p < 0.01), static balance performance ability of bilateral side(p < 0.01), dynamic balance performance ability of bilateral side(p < 0.05) of experimental group were statistically greater improved than those of the control group. 2. As the result of comparing balance performance ability after test of the experimental and control group with left hemiplegia and control group, all of static balance performance ability of right side (p < 0.01), static balance performance ability of left side (p < 0.01), static balance performance ability of bilateral side(p < 0.05), dynamic balance performance ability of bilateral side(p < 0.05) of experimental group were statistically greater improved than those of the control group.

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반추수(反芻獸)의 창상성심낭심근염(創傷性心囊心筋炎)에 관(關)한 실험적연구(實驗的硏究) (Experimental Studies on Induced Traumatic Pericarditis and Myocarditis in Ruminants)

  • 정창국;남치주;성재기;옥종화
    • 대한수의학회지
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    • 제20권2호
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    • pp.127-134
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    • 1980
  • This study was performed to obtain an accurate methods of diagnosis in early stage of traumatic pericarditis and myocarditis in ruminants. Korean native goats were used as experimental animal and traumatic pericarditis and myocarditis were induced by surgical intervention. The changes in clinical signs, hematological values, blood enzymes and electrocardigrams were observed for 14 days after operation. The results obtained were as follows: 1. Body temperature in experimental group of induced traumatic pericarditis and myocarditis was slightly increased than control group that was rumenotomized. Heart rate was increased in both groups but the increased rate was noticed remarkably in experimental group. There was no change in respiratory rate in experimental and control group. 2. Total leucocytes counts and neutrophil percentage maintained higher level after operation and lymphocytes percentage noticed reversed proportion to neutrophil in both groups. 3. Serum total protein concentration and alkaline phosphatase activities after operation showed a little lower levels than these values prior to operation. Serum glutamic oxaloacetic transaminase and lactic dehydrogenase activities in control group showed slight increase through all the experimental period, while in experimental group these activities were markedly elevated and an increase in serum lactic dehydrogenase activities was more remarkable comparing to serum glutamic oxaloacetic transaminase. 4. Electrocardiograms in control group did not show any abnormalities except for slight increase in heart rate. In experimental group the amplitude of QRS complex was increased in duration of experimental period. The transference from QRS complex to T wave was uncertain and S-T segment moved upward obliquely through electrical zero line.

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성견 치조골 결손부에 자가골이식과 조직유도재생막을 이용한 치주치료시 치유효과에 관한 비교연구 (COMPARATIVE STUDY OF AUTOGENOUS BONE GRAFT AND GUIDED TISSUE REGENERATION IN THE TREATMENT OF PERIODONTAL DEFECT IN DOGS)

  • 홍기석;김종여;정진형
    • Journal of Periodontal and Implant Science
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    • 제24권1호
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    • pp.205-216
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    • 1994
  • The goal of periodontal therapy is the regeneration of the periodontium lost by periodontal disease. The purpose of this study was to evaluate the regenerative potential of the autogenous bone graft and guided tissue regeneration in the treatment of periodontal bony defect in dogs. Experimental periodontitis were induced in the mandibular left 3rd premolar and right 3rd and 4th premolars of 5 dogs using orthodontic ligature wire. After 6 weeks, the ligature wire removed, surgical procedure were performed as follows. 1) control group : Flap operation(Mn.Lt 3rd premolar) 2) experimental group I : Flap operation + autogenous bone graft (Mn.Rt. 3rd premolar) 3) experimental group II : Flap operation + Gore-Tex membrane (Mn.Rt. 4th premoalr) Thereafter, dogs were sacrificed on the 1,2,4,8,16th week and the specimens were prepared and stained with hematoxyline-eosin stain for the light microscopic examination. The results of this study were as follows. 1. The apical migration of junctional epithelium was most remarkable in the flap operation and the experimental group II was less than the experimental group I. 2. In the formation of new alveolar bone, it was found in experimental group I,II and experimental group I is more than II. In the control group, few bone formation was found. 3. In the formation of new cementum, it was found in experimental group I,II and experimental group II is more than I. So, the periodontal therapy combined with autogenous and guided tissue regeneration will be produce the periodontal regeneration.

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Iridoid 화합물이 치수절단 후 잔존치수 조직에 미치는 영향 (THE EFFECT OF IRIDOID COMPOUND ON THE REMAINING PULP TISSUE AFTER PULPOTOMY)

  • 권혁춘;박동성;손호현
    • Restorative Dentistry and Endodontics
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    • 제22권2호
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    • pp.710-719
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    • 1997
  • Aucubin, an iridoid glucoside, which is isolated from Aucuba japonica, has some biological effects. This study was to investigate the effect of aucubin on the remainig pulp tissues after pulpotomy. Mongrel dog's coronal pulps were mechanically exposed with a sterile round bur and excised with sterile sharp excarvator. After bleeding was controlled, in control group, $Ca(OH)_2$ powder was applied on the remaining pulps and the cavities were sealed with Z.O.E. cement. In experimental group 1, mixed powder with $Ca(OH)_2$ and aucubin(l : 1 by weight) was applied on the pulpotomized pulp surfaces. After the cavities were covered with sterile aluminum foil, they were sealed with Z.O.E. cement. In experimental group 2, only aucubin powder was applied on the remaining pulps and then they were treated the same as experimental group 1. In the all groups, the pulps were histopathologically observed by light microscope at the time intervals of 1, 2 and 4 weeks after experiment. The results were as follows : 1. In control and experimental groups, mild vascular congestion and bleeding were found in most of the specimens. Less inflammatory infiltration was observed in experimental groups than in control group. 2. Dentin bridge formation was found after 1 week at both control and experimental group 1. Dentin birdge had discontinuous osteodentin like appearance or contained some dentin chips. In experimental group 2, dentin bridge was not seen. 3. The coagulation necrosis layer on the remaining pulp tissues was seen in all groups. In experimental group 2, the thickest layer was observed. And in control group, coagulation necrosis layer was similar as in experimental group 1.

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