• Journal of Nutrition and Health
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• 제30권10호
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• pp.1180-1187
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• 1997

Cigarette smoking is a major risk factor of atherosclerosis and has been reported to contain an abundance of free radical species which could be expected to deplete antioxidants such as vitamin C . The present study was designed to investigate the relationship between smoking, plasma lipid and lipoprotein concentration, and plasma vitamin C level. Fifty-five healthy male smokers and 32 non-smokers were investigated in the study. Mean age, body weight , BMI and blood pressure made no differences in both smokers and non-smokers. Significantly, smokers has higher plasma total cholesterol and LDL-C , and lower HDL-C /LDL-C ratio compared with non-smokers. Plasma level of thiobartiturin acid reactive substances(TBARS), indicator of lipid peroxidation and increased susceptibility of LDL towards lipid perosidation, were elevated in smokers(p<0.001), while the plasma vitamin C level of smokers was significantly lower than that of non-smokers(p<0.05), indicating that elevated lipid peroxidation are associated with decreased plasma vitamin C content. In non-smokers a significantly positive correlation was observed between dietary vitamin C intake and plasma levels, but no such association observed in smokers. Lack of such a relationship and the decreased plasma vitamin C level in the smokers suggest that smoking may cause increased turnover of the plasma antioxidant. Consuquently, the sustained free radical load derived from smoking causes an imbalance in oxidant/antioxidant status and it could be expected that cigarette smoking renders plasma LDL more susceptible to oxidative modification . In the present study the possible explanations for that cigarette smokers have a higher risk of cardiovascular disease include the changes of blood lipid and lipoprotein concentration, and plasma vitamin C status which might have protective functions against free radicals -medaited lipid peroxidation.

• 한국농공학회논문집
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• 제62권4호
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• pp.13-22
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• 2020

The Doam Lake watershed has a significant impact on the downstream water system due to nutrients and sediment outflow during rainfall caused by steep slopes, soil losses, and fertilization. These non-point sources are unclear in the discharge area and are affected by land use patterns, soil characteristics, and topographical features of the watershed. Therefore, this study conducted rainfall monitoring from July to October 2019 in Songcheon upstream of the Doam Lake watershed, one of the non-point pollution source management areas. Then, after analyzing rainfall runoff, Event Mean Concentration (EMC) and Mass First Flush ratio (MFFn) were calculated to compare and analyze the characteristics of rainfall and the non-point pollutant discharge. As a result of the analysis, it showed various non-point pollutant emission characteristics for each rainfall event. In addition, the concentration of EMC and the MFFn were affected by the average rainfall intensity and the maximum rainfall intensity, and were not significantly affected by the number of antecedent drying days. In the future, it is expected that effective non-point source reduction measures and management measures according to rainfall intensity through continuous monitoring and analysis will be needed.

• 대한핵의학회지
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• 제16권1호
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• pp.23-30
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• 1982

Serum thyroxine binding globulin (TBG) was measured with a radioimmunoassay (RIA) kit (GammaDab TBG). The TBG concentration in 23 adult normals was $23.7{\pm}1.9{\mu}g/ml(mean{\pm}SD)$. The serum TBG levels of $21.6{\pm}3.5{\mu}g/ml$) in hyperthyroidism, $24.7{\pm}4.9{\mu}g/ml$ in subacute thyroiditis, $20.7{\pm}7.0{\mu}g/ml$ in liver cirrhosis and $22.6{\pm}3.7{\mu}g/ml$ in sick patient were not significantly different from normals. The levels of $31.8{\pm}5.9{\mu}g/ml$ in hypothyroidism, $36.2{\pm}5.1{\mu}g/ml$ in pregnancy (p<0.01, p<0.001) and $29.3{\pm}6.1{\mu}g/ml$ in molar pregnancy (p<0.01) were significanty higher that in normals. In various cases without thyroid dieases (euthroid group), the TBG concentration correlated with the value for Amerlex $T_3$ (r=0.816) though there was curvilinear relationship. This relationship was altered in hyperthyroidism, subacute thyroiditis and molar pregnancy in which sera were overloaded with thyroxine $(T_4)$ so that concentration of unoccupied binding sites on TBG (free TBG concentration) were more decreased than expected from normal TBG concentrations. Hypothyroidism was also separated from the curvilinear relationship in euthyroid group indicating that free TBG concentrations were more increased relative to slightly increased TBG concentrations. Measurement of the TBG concentration was considered useful in the diagnosis of TBG defiency, in differentiating molar pregnancy from hyperthyroidism and for correct understanding the hormone binding in liver dieases and other nonthyroidal illness.

• 한국환경과학회지
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• 제28권7호
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• pp.581-594
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• 2019

This research investigated the characteristics of $PM_{10}$ and $PM_{2.5}$ concentrations at the main subway stations in Busan. Annual mean $PM_{10}$ concentrations at the Seomyeon 1- waiting room and platform were $51.3{\mu}g/m^3$ and $47.5{\mu}g/m^3$, respectively, and the annual $PM_{2.5}$ concentration at the Seomyeon 1- platform was $28.8{\mu}g/m^3$. $PM_{2.5}$/$PM_{10}$ ratio at Seomyeon 1-platform and Dongnae station were 0.58 and 0.53, respectively. Diurnal variation of $PM_{10}$ concentration at subway stations in Busan was categorized into four types, depending on the number of peaks and the times at which the peaks occurred. Unlike the areas outside of the subway stations which reported maximum $PM_{10}$ concentration mostly in spring across the entire locations, the interiors of the subway stations reported the maximum $PM_{10}$ concentration in spring, winter, and even summer, depending on their location. $PM_{10}$ concentration was highest on Saturday and lowest on Sunday. The numbers of days when $PM_{10}$ concentration exceeded $100{\mu}g/m^3$ and $80{\mu}g/m^3$ per day over the last three years at the subway stations in Busan were 36 and 239, respectively. The findings of this research are expected to enhace the understanding of the fine particle characteristics at subway stations in Busan and be useful for developing a strategy for controlling urban indoor air quality.

• 한국작물학회지
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• 제36권2호
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• pp.112-126
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• 1991

The atmospheric carbon dioxide concentration is ever-increasing and expected to reach about 600 ppmv some time during next century. Such an increase of $CO_2$ may cause a warming of the earth's surface of 1.5 to 4.5$^{\circ}C$, resulting in great changes in natural and agricultural ecosystems. The climatic scenario under doubled $CO_2$ projected by general circulation model of Goddard Institute for Space Studies(GISS) was adopted to evaluate the potential impact of climate change on agroclimatic resources, net primary productivity and rice productivity in Korea. The annual mean temperature was expected to rise by 3.5 to 4.$0^{\circ}C$ and the annual precipitation to vary by -5 to 20% as compared to current normal climate (1951 to 1980), resulting in the increase of possible duration of crop growth(days above 15$^{\circ}C$ in daily mean temperature) by 30 to 50 days and of effective accumulated temperature(EAT=∑Ti, Ti$\geq$1$0^{\circ}C$) by 1200 to 150$0^{\circ}C$. day which roughly corresponds to the shift of its isopleth northward by 300 to 400 km and by 600 to 700 m in altitude. The hydrological condition evaluated by radiative dryness index (RDI =Rn/ $\ell$P) is presumed to change slightly. The net primary productivity under the 2$\times$$CO_2$ climate was estimated to decrease by 3 to 4% when calculated without considering the photosynthesis stimulation due to $CO_2$ enrichment. Empirical crop-weather model was constructed for national rice yield prediction. The rice yields predicted by this model under 2 $\times$ $CO_2$ climatic scenario at the technological level of 1987 were lower by 34-43% than those under current normal climate. The parameters of MACROS, a dynamic simulation model from IRRI, were modified to simulate the growth and development of Korean rice cultivars under current and doubled $CO_2$ climatic condition. When simulated starting seedling emergence of May 10, the rice yield of Hwaseongbyeo(medium maturity) under 2 $\times$ $CO_2$ climate in Suwon showed 37% reduction compared to that under current normal climate. The yield reduction was ascribable mainly to the shortening of vegetative and ripening period due to accelerated development by higher temperature. Any simulated yields when shifted emergence date from April 10 to July 10 with Hwaseongbyeo (medium maturity) and Palgeum (late maturity) under 2 $\times$ $CO_2$ climate did not exceed the yield of Hwaseongbyeo simulated at seedling emergence on May 10 under current climate. The imaginary variety, having the same characteristics as those of Hwaseongbyeo except growth duration of 100 days from seedling emergence to heading, showed 4% increase in yield when simulated at seedling emergence on May 25 producing the highest yield. The simulation revealed that grain yields of rice increase to a greater extent under 2$\times$ $CO_2$-doubled condition than under current atmospheric $CO_2$ concentration as the plant type becomes more erect.

• Journal of Pharmaceutical Investigation
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• 제9권3호
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• pp.1-8
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• 1979

The main route of metabolism of isonicotinic acid hydrazid (INH) in man is its conjugation with acetyl coenzyme A to form acetyl-INH. The reaction is catalyzed by an N-acetyl transferase in the liver. The acetylated drug can be excreted by the kidney more efficiently than INH, and the biological half-life of the drug in the body depends upon how rapidly the drug can be acetylated. This report measured the concentration of INH in the blood of 147 individuals 6 hours after they received a standard dose (9.8mg/kg) and plotted the data as a frequeney distribution hiotogram. There was bimodality, with a mean for one subpopulation at approximately $0.6{\sim}0.8\;mcg/ml.$, and a mean for the other subpopulation between 2.8 and 4.0mcg/ml. As might be expected slow acetylators of INH are more likely to develop a cumulative toxicity to the drug. The principle ,toxicity to INH is a peripheral neuritis but this adverse effect can be prevented by given extra pyridoxin to the patients, and the vitamin does not alter the antitubercular activity of INH. This report carried out that pyridoxine does not alter the ratio of free INH to the total INH in blood.

• 한국환경과학회지
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• 제31권7호
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• pp.555-567
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• 2022

With the introduction of the tele-monitoring system (TMS) in South Korea, monitoring of the concentration of pollutants discharged from nationwide water quality TMS attachments is possible. In addition, the Ministry of Environment is implementing a smart sewage system program that combines ICT technology with wastewater treatment plants. Thus, many institutions are adopting the automatic operation technique which uses process operation factors and TMS data of sewage treatment plants. As a part of the preliminary study, a multilayer perceptron (MLP) analysis method was applied to TMS data to identify predictability degree. TMS data were designated as independent variables, and each pollutant was considered as an independent variables. To verify the validity of the prediction, root mean square error analysis was conducted. TMS data from two public sewage treatment plants in Chungnam were used. The values of RMSE in SS, T-N, and COD predictions (excluding T-P) in treatment plant A showed an error range of 10%, and in the case of treatment plant B, all items showed an error exceeding 20%. If the total amount of data used MLP analysis increases, the predictability of MLP analysis is expected to increase further.

• 한국대기환경학회지
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• 제28권1호
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• pp.59-67
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• 2012

Platform screen doors (PSD) installed at 289 stations in Seoul metropolitan subway from November 2005 to December 2009, are expected to prevent death from a fall and improve air quality. In this study, we systematically surveyed changes in radon concentrations before and after PSD installation in Seoul metropolitan subway stations. By solid-state nuclear track detectors (SSNTD), the radon concentrations before and after the PSD installation were measured at 54 stations of 6 lines from 2 to 7 reported to have relatively high radon concentrations. Mean radon concentrations at platforms were decreased by approximately 56% from 121.7 Bq/$m^3$ to 54.0 Bq/$m^3$. Before PSD installation, mean radon concentrations were in the decreasing order for subway lines 7, 5, 6, 3, 4 and 2. On the other hand, after PSD installation the order was changed to 5, 6, 7, 3, 4 and 2. According to a radon map of Seoul metropolitan subway, the number of platforms where radon concentration over was 74 Bq/$m^3$ decreased from 38 to 12 after PSD installation.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2004년도 International Conference Global Environmental Problems and their Health Consequences
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• pp.213-216
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• 2004

This work was based on the hypotheses that fingernail clippings can be used as a biomarker for the subchronic exposure to fluoride. This study was conducted to prove the hypotheses and fingernail clippings were collected form 120 preschool children aged $3{\sim}6$ residing in Jumunjin(community water fluoridation area) and Kangnung(non-fluoridation area). The acid-diffusible fluoride in the fingernail clipping was isolated by the acid-diffusion technique and measured with a fluoride electrode. The mean fingernail fluoride as the children's living area were 4.49ug/g(SD 2.43) to Jumunjin and 2.68ug/g(SD 1.13) to Kangnung. As would be expected, the fluoride concentration in fingernail clippings were significantly different between the two geographical groups(p<0.001) determined by t-test.

• 오토저널
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• 제12권3호
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• pp.63-70
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• 1990

In a premixed flame stabilized by a streamlined step, the flame structure and combustion characteristics were investigated to identify the effect of the pressure pulsation in a combustion air. A flame stabilizing limits, visualization, mean temperature, ion current and gas concentration (O$_{2}$, CO$_{2}$, CO, UHC) were measured. With the combustion air of higher pressure pulsation, the development of the mixing layer was fast and wide, the temperature and combustion intensity were higher at arbitrary section. But, the effect was notably decreased with X=150 mm downstream. And a first eddy formation from step edge was earlier. Thus, with the combustion air of higher pressure pulsation, high rate of heat generation was expected.