Journal of Pharmaceutical Investigation
- Volume 9 Issue 3
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- Pages.1-8
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- 1979
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
The Inactivation of Isonicotinic Acid Hydrazid (INH)
Isonicotinic Acid Hydrazid (INH)의 불활성화(不活性化)에 관한 연구(硏究)
- Kim, Jae-Baek (College of Pharmacology, Wongkwang University)
- 김재백 (원광대학교 약학대학)
- Published : 1979.09.20
Abstract
The main route of metabolism of isonicotinic acid hydrazid (INH) in man is its conjugation with acetyl coenzyme A to form acetyl-INH. The reaction is catalyzed by an N-acetyl transferase in the liver. The acetylated drug can be excreted by the kidney more efficiently than INH, and the biological half-life of the drug in the body depends upon how rapidly the drug can be acetylated. This report measured the concentration of INH in the blood of 147 individuals 6 hours after they received a standard dose (9.8mg/kg) and plotted the data as a frequeney distribution hiotogram. There was bimodality, with a mean for one subpopulation at approximately
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