• Journal of Korea Society of Digital Industry and Information Management
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• v.8 no.4
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• pp.273-288
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• 2012

In recent years, smartphone is the most widely used ubiquitous functionality. People do not want to just call other people any more by using a cellular phone; they want to connect to the Internet and use various applications. Hence, cellular phones need to become smart. A smartphone has an operating system and many applications. Specifically the goals of this research are; (1) to suggest theory framework of acceptance about smartphone based on TAM, (2) to examine relationships between exogenous variables. The research model and hypotheses were developed based on the theories of technology acceptance model. Questionnaire was used to collect data. The analysis of this study is designed as individual level to examine the causal relationship among variables. The the reliability and validity of data was tested by explanatory factor analysis, Cronbach's alpha coefficient, confirmatory factor analysis, and correlation analysis. Also, the structural equation model(SEM) analysis was performed to test the usefulness of the model. The analysis results revealed that social norms and individual innovation are major influential variables on the perceived usefulness of smartphone. Also, social norms are influential variables on the perceived enjoyment of smartphone.

• Journal of Korea Society of Digital Industry and Information Management
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• v.7 no.2
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• pp.185-203
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• 2011

In recent years, blogs have become important resources for information sharing; and tourism blogs are providing a new way of sharing tour experiences. Blogs are becoming very popular amongst web users to share their life experiences with other web users around the world. Specifically the goals of this research are; (1) to suggest theory framework of acceptance and user satisfaction about toruism blogs based on TAM, (2) to examine relationships between exogenous variables and (3) to suggest effectiveness of tourism blogs in a marketing perspective. The research model and hypotheses were developed based on the theories of technology acceptance model. Questionnaire was used to collect data. The analysis of this study is designed as individual level to examine the causal relationship among variables. The the reliability and validity of data was tested by explanatory factor analysis, Cronbach's alpha coefficient, confirmatory factor analysis, and correlation analysis. Also, the structural equation model(SEM) analysis was performed to test the usefulness of the model. The analysis results revealed that interaction, entertainment, system quality and information quality are major influential variables on the perceived usefulness of tourism blog. Also, entertainment and system quality are influential variables on the perceived ease of use of tourism blog.

• Journal of the Korean Institute of Landscape Architecture
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• v.18 no.3 s.39
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• pp.143-154
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• 1990

This study aims at identifying factors and variables which have significant effects on users satisfaction with recreational activities and facilities in Apsan city natural park and therby establishing indicies of planning and / or development of urban forest. To test the causal models of this research, The data were gathered by self-administered questionnaires from 1,147 households in Taegu city which were selected by the multi-stage probabiling sampling method. The analysis of the data primarily consist of two phases : The first analysis dealt with exploratory factor analysis which identified major factors involved in satisfaction with recreational activities and facilities in Apasn city natural park and the second analysis tested the fit of causal models of this research to the data using LISREL methodology. The factor analysis identified that three significant factors are involved in satisfaction with recreational activities and five significant factors are inherent in satisfaction with recreational facilities. The second phase analysis tested the fit of the causal models for satisfaction with recreational activities and facilities to the data and identified statistically significant causal linkage among overall satisfaction with the park, other indogenous factors and exogenous variables. These significant relationships represent important factors and variables that should be considered in planning and/of development of the city natural park. On the basis of there significant causal relationships implications for planning and/or development of the city natural park were suggested.

• Journal of the Korean Institute of Landscape Architecture
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• v.23 no.1
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• pp.39-50
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• 1995

This Study aims at identifying factor and variables which have significant effects on user satisfaction with recreational resources and facilities in Juwang National Park and there-by establishes indicies of planning and / or management of the park. To test the causal models of this research, the data was gathered by self-administered questionnaires from users in Juwang National Park. The analysis of the data was conducted in two phases. The first analysis dealt with exploratory gactor analysis which identified major factors involved in satisfaction with recreational facilities in Juwang National Park. The second analysis tested the fit of causal models of this research to the data using LISREL methodology. The factor analysis identified six significant factors in satisfaction with recreational resources, The six factors are convenient park facilities, natural landacape resources, linear park facilities, mineral springs and Buddhist temples, commercial and sleeping accommodations, rest areas and open space for passive recreational activity. The second phase analysis tested the fit of the causal model for satisfaction with recreation facilities to the data. The phase identified statistically significant causal links among overall satisfaction with the park, and other indigenous factors and exogenous variables. From these causal relationships, implications for future management of Juwang National Park were suggested.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.12 no.1
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• pp.356-368
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• 1999

The gu-chang is oriental medical disease name. This study has been carried out to investigate pathogenic factor, pathogenesis, treatment method and medicine of the gu chang by referring to literatures. The results were obtained as follows; 1. Pathogenic factors are pungent taste, stir frying, rich and fatty diet, alchol, disorder of emotion, exogenous pathogen, excessive fatigue and indulgence in sexual activities. 2. Pathogenesis of the gu chang is that the fire heat go up to the mouse. 3. The symptoms are divided into two syndrome. one is sthenia syndrome(實證) - red color and swelling, unendurable pain, strong pulse(脈實), the other is asthenia syndrome(虛症) - pink color, a slight pain, relapse, loose stool, feeble pulse(脈虛). 4. The treatment method is divided into two parts. one is a sthenic syndrome (實證) - clearing strong heat (淸實熱), the other is a asthenic syndrome(虛症) - nourishing yin(滋陰) and clearing deficient heat (淸虛熱), reinforcing the spleen and strengthening middle - JIAO(健脾 補中). 5. The prescription were liang ge san(凉膈散), Ij jhong tang(理中湯) ,xie xim tang(瀉心湯), bu ja li jhong tang, (附子理中湯),liuwei wan(六味元), ba wei wan(八味元), zhuye shigao tang(竹葉石膏湯), si wu tang(四物湯), bu zhong yi gi tang(補中益氣湯) etc.

• Molecules and Cells
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• v.43 no.2
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• pp.99-106
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• 2020

Cells are constantly exposed to endogenous and exogenous stresses that can result in DNA damage. In response, they have evolved complex pathways to maintain genomic integrity. RUNX family transcription factors (RUNX1, RUNX2, and RUNX3 in mammals) are master regulators of development and differentiation, and are frequently dysregulated in cancer. A growing body of research also implicates RUNX proteins as regulators of the DNA damage response, often acting in conjunction with the p53 and Fanconi anemia pathways. In this review, we discuss the functional role and mechanisms involved in RUNX factor mediated response to DNA damage and other cellular stresses. We highlight the impact of these new findings on our understanding of cancer predisposition associated with RUNX factor dysregulation and their implications for designing novel approaches to prevent cancer formation in affected individuals.

• International journal of advanced smart convergence
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• v.10 no.3
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• pp.172-180
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• 2021

The purpose of this study is to analyze the structural relationship among perfectionism and dance achievement of middle and high school students majoring in dance. Specifically, this study aims to investigate the effects of perfectionism on dance achievement through the medium of dance commitment and career decision-making self-efficacy. For this purpose, a structural equation model based on the previous studies was constructed with perfectionism as an exogenous variable and dance commitment, career decision-making self-efficacy, and dance achievement as endogenous variables. The final subjects of this study were 279 middle and high school students majoring in dance. The data were processed by frequency analysis to find out personal characteristics using SPSS 23 and exploratory factor analysis and reliability analysis were conducted on the research tools. In addition, AMOS 21 was used for confirmatory factor analysis, correlation analysis and structural equation model analysis. As a result of data processing on the research model. First, the sub-dimensions of perfectionism tendency 'worry about mistakes', 'personal standard', and 'doubt about behavior' had a statistically significant effect on dance commitment. Second, the sub-dimensions of perfectionism 'worry about mistakes', 'personal standard', and 'doubt about behavior' had statistically significant effects on career decision-making self-efficacy. Third, dance commitment did not have a statistically significant effect on dance achievement, but career decision-making self-efficacy had a statistically significant effect on dance achievement. These results provide implications.

• Journal of Microbiology and Biotechnology
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• v.30 no.12
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• pp.1810-1818
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• 2020

Inhibitor K562 (IK) protein was first isolated from the culture medium of K562 cells, a leukemia cell line, and is an inhibitory regulator of interferon-γ-induced major histocompatibility complex class II expression. Recently, exogenous truncated IK (tIK) protein showed potential as a therapeutic agent for inflammation-related diseases. In this study, we designed a novel putative anti-inflammatory peptide derived from tIK protein based on homology modeling of the human interleukin-10 (hIL-10) structure, and investigated whether the peptide exerted inhibitory effects against pro-inflammatory cytokines such as IL-17 and tumor necrosis factor-α (TNF-α). The peptide contains key residues involved in binding hIL-10 to the IL-10 receptor, and exerted strong inhibitory effects on IL-17 (43.8%) and TNF-α (50.7%). In addition, we used circular dichroism spectroscopy to confirm that the peptide is usually present in a random coil configuration in aqueous solution. In terms of toxicity, the peptide was found to be biologically safe. The mechanisms by which the short peptide derived from human tIK protein exerts inhibitory effects against IL-17 and TNF-α should be explored further. We also evaluated the feasibility of using this novel peptide in skincare products.

• Journal of Life Science
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• v.19 no.3
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• pp.317-321
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• 2009

Down syndrome (DS) results from overexpressed genes on an extra copy of human chromosome 21. Among various phenotypes seen in DS patients, mental retardation, such as learning and memory deficits, is a major factor that prevents DS individuals from leading fully independent lives. The Dyrk1A gene that plays a critical role in neurodevelopment has been isolated from chromosome 21, and transgenic mice with over-expression of Dyrk1A show severe hippocampal dependent learning and memory defects. In the present study, as an initial step to test the treatment of Dyrk1A dependent mental retardation phenotypes in model animals, we isolated human Dyrk1A specific lentiviral short hairpin RNA (shRNA) that inhibits the exogenous human Dyrk1A expression, but not the endogenous mouse expression in transgenic mice with human Dyrk1A overexpression. This limited and specific repression of exogenous human Dyrk1A will prove to be valuable information, if Dyrk1A dependent learning and memory defects in DS patients could be treated or at least ameliorated in vivo.

• BMB Reports
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• v.38 no.2
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• pp.121-127
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• 2005

Drosophila protects itself from infection by microbial organisms by means of its pivotal defense, the so-called innate immunity system. This is its sole defense as it lacks an adaptive immunity system such as is found in mammals. The strong conservation of innate immunity systems in organisms from Drosophila to mammals, and the ease with which Drosophila can be manipulated genetically, makes this fly a good model system for investigating the mechanisms of virulence of a number of medically important pathogens. Potentially damaging endogenous and/or exogenous challenges sensed by specific receptors initiate signals via the Toll and/or Imd signaling pathways. These in turn activate the transcription factors Dorsal, Dorsal-related immune factor (Dif) and Relish, culminating in transcription of genes involved in the production of antimicrobial peptides, melanization, phagocytosis, and the cytoskeletal rearrangement required for appropriate responses. Clarifying the regulatory interactions between the various pathways involved is very important for understanding the specificity and termination mechanism of the immune response.