In order to develop optimal formulation and iontophoresis condition for the transdermal delivery of levodopa, we have evaluated the effect of two permeation enhancers, ethanol and oleic acid in microemulsion, on transdermal delivery of levodopa. In vitro flux studies were performed at $33^{\circ}C$, using side-by-side diffusion cell and full thickness hairless mouse skin. Current density applied was $0.4\;mA/cm^2$ and current was off after 6 hours application. Levodopa was analysed by HPLC at 280 nm. The o/w microemulsions of oleic acid in buffer solution (pH 2.5 & 4.5) were prepared using oleic acid, Tween 80 and ethanol. The existence of microemulsion regions were investigated in pseudo-ternary phase diagrams. Contrary to our expectation, cumulative amount of levodopa transported from microemulsion (pH 2.5) for 10 hours was similar to that from aqueous solution in all delivery methods (passive, anodal and cathodal). When pH of the micro-emulsion was pH 4.5, cumulative amount of levodopa transported for 10 hours increased about 40% (anodal) to 50% (cathodal), when compared to that from aqueous solution. Flux from pH 4.5 microemulsion showed higher value than that from pH 2.5 in all delivery methods. These results seem to indicate that electroosmosis plays more dominant role than electrorepulsion in the flux of levodopa at pH 2.5. The effect of ethanol on iontophoretic flux was studied using pH 2.5 phosphate buffer solution containing 3% or 5% (v/v) ethanol. Flux enhancement was observed in passive and anodal delivery as the concentration of the ethanol increased. Without ethanol, cathodal delivery showed higher flux than anodal delivery. Anodal delivery increased the cumulative amount of levodopa transported 1.6 fold by 5% ethanol after 10 hours. However, in cathodal delivery, no flux enhancement of levodopa was observed during current application and only marginal increase in cumulative amount transported after 10 hours was observed by 5% ethanol. These results seem to be related to the decrease in dielectric constant of the medium and the lipid extraction of the ethanol, which decrease the electroosmotic flow, and thus decrease the flux. Overall, the results provide important insights into the role of electroosmosis and electrorepulsion in the transport of levodopa through skin, and provide some useful informations for optimal formulation for levodopa.
The purpose of this study is to pay attention to the expression of good and evil which has Been significantly developed out of the existing dichotomous good and evil in animation films and to identify for them. Even though 3D animation films provides us with a sense of realistic existence due to surprising technical powers, the stories contained in such films tend to remain in the limit of family films. However, recently, some films have been presented beyond such limit with a scenario that makes people introspect their inner side. Among them, this study considered the expression of good and evil of , which extended the meaning of didactic morality into the dimension of 'Philosophy of Dionysian yes', as significant for research purpose. More specifically, this study looked at and discussed this film in more details in the aspect of focusing on the value of good and evil for eliminating the boundary of the existing perspective and pursuing positive overcoming. The frame of the concept for discussion used the philosophical statements of Kant and Hegel as well as Nietzsche who explained the meaning of good and evil with Dionysian view. As to the method of research, this study attempted to understand the theoretically related concepts and discuss the meaning, along with the presentation of examples, by inputting such meaning into the expression of good and evil presented in the film. This study has the implication in identifying that an animation film, as a virtual world, plays a role of opening a new prospect for conversion of thought in our real world and expecting a future progress.
Ahn, Chang Hyuk;Kwon, Jae Hyeong;Joo, Jin Chul;Song, Ho Myeon;Joh, Gyeongie
Journal of Korean Society of Environmental Engineers
/
v.34
no.6
/
pp.421-429
/
2012
This study was aimed to analyze the water quality characteristics of the Hwapocheon Stream and to be utilized in the further related research. Water in the upper stream became a dammed pool due to the existence of 14 weirs, and pollutants such as both sewage and irrigation water were introduced into the mainstream passing through farming settlements and agricultural land. For these reasons, filamentous cyanobacteria (Oscillatoria sp.) bloomed at the bottom of the dammed pool. Also in the midstream and downstream, tributaries with high pollutant concentrations [e.g., Comocheon (T3) and Yongdeokcheon (T8)] were inflowed, and had a negative impact on water quality of the mainstream, especially nitrogen and phosphorus. In the Hwapocheon Stream, dissolved oxygen (DO) decreased, and suspended solid (SS) increased toward the downstream. The result showed that hydraulic retention time, SS, COD, and concentration of $NH_4{^+}$ were important water quality factors of the Hwapocheon Stream. The high concentration of benthic organic matter and rich in attached algae in the core of Hwapo-wetland were expected to give impact on the water quality of the mainstream. In the spatial manner, water quality showed increasing trend in the weir zone, and it was constant or decreased trend in wetland. In the seasonal manner, the nutrient concentrations were high in the winter dry season, however, the organic matter concentrations were high in spring and summer. Generally, the concentrations of phytoplankton value were $40{\mu}g\;chl-{\alpha}/L$ or less in all reaches except for the high concentrations in the weir and wetland area in June.
Introducing International Style, P. Johnson and H. R. Hitchcock gave three standards to be the Modern, volume and surface, regularity, and exclusion of applied decoration. In spite of the negation of stylistic, formal approach in the Modernist Manifestoes, one usually have understood Modernity in Architecture with its formal character, especially with no ornament and flat, abstract, white surface. Modernism as a new paradigm in architecture have emphasized that there is no representation of anything outside and only present architecture in itself. They said that Modernism only cared about the language of Architecture without figural reference. So apparently there is no way to prove to its Modernity with formal condition. Modernity is in Spirit and contents. But actually we understand well its existence by visual communication This study deals with this difficult situation how Modernity represents itself without visual media and asks the question how simultaneously it presents its thingness and materiality In order to analyse contradictory situation between representation and presentation in Modern Architecture we need to survey the historical process of changing position of ornaments and its meaning in time. With the crisis of representation the role of ornament have seriously changed and divided. It caused the two situation in pre-Modern Architecture. Firstly, Architecture tend to be a high art and formal expression became important much more. The Use of Ornament became a kind of fashion to show the power, class, money. Secondly, Ornament lost its cultural weight and the structure and material aspect became the central in architecture. Rational Structuralism would be the essential character in Modern Architecture. Here the theory of G. Semper and A. Loos on cladding(dressing) and Ornament can help its problems and limits. In the situation without conventional ornament Modernists need to present modernity with new media that only show the thing itself and by that it does not represent any thing else as like the value, idea outside buildings. They believed that only it concerned esthetics and morality in architecture. But in reality it referred to art and machines as like ships, aircraft, and cars. By excluding Ornament and showing the process of clearing, abstract, flat, white surface 'represent' Modernity by the indirect way referring the concept of transparency, reason, sanitation, tectonics, etc. An Ideology and myth intervened architectural discourse to make the doxa about the representation in Architecture. Surface must be a different kind of media and message that can communicate in different way with compared to conventional Ornament. Decorated Shed by R. Venturi and Post-Functionalism by P. Eisenman, that are the most famous post-modern discourse, shows well difficult and contradictory condition in contemporary architecture concerning representation and form, meaning and form.
The informativeness of accounting earnings to investors may be used as a measure of the quality of accounting information. The ownership structure is considered to be related to both of two variables, the reliability of earnings reflecting the economic performance of the enterprise and the existence of alternative information sources. Earnings manipulation may mitigate the correlation between accounting earnings and the economic performance and alternative information sources decrease the value of accounting earnings as an information. Thus ownership structure could influence the informativeness of accounting earnings. This paper classifies ownership into three categories, management or inside ownership, institutional investors and large outside blockholders, and diffuse outside ownership and examines theoretically the difference of information effectiveness under each ownership structure. The earnings manipulation hypothesis supports the assertion that the separation of ownership from control motivates earnings manipulation. And differential information hypothesis suggests that more non-accounting information of firms with institutional or concentrated outside ownership is provided. Outside blockholders have alternative information sources that make accounting manipulation ineffective. While most previous studies have examined the effect of ownership on the informativeness of earnings from earnings manipulation hypothesis, this study is motivated by both earnings manipulation hypothesis and differential information hypothesis.
Objective : The meridian and the acupuncture point of oriental medicine are very important in the department of acupuncture and moxibustion. Recently, we needed to study on the phenomenon of the meridian and acupuncture point with objective data. And then, I made a study of effects on the thermal changes of Five-shu-points(五輸穴) of the Lung meridian with acupuncture on Taeyon($L_9$, 太淵), using Digital infrared thermal imaging(D.I.T.I). Method : This study researched into clinical statistics for 60 men who are in good health. The objective was divided into two groups, one was the control group(CON, N=30) and the other was acupuncture group(ACU, N=30). The first, I took a picture for 60 men with the Digital infrared thermal imaging(D.I.T.I.). After 10 minutes, I took a second picture for each group following experimental methods. Results : I. The Mean temperature of Sasang($L_{11}$), Oje($L_{10}$), Taeyon($L_9$), Kyonggo($L_8$), Choldaek($L_5$) and Taenung($P_7$) area in adult men with good health, made a no significant difference with left and right side points. 2. Acupuncture group with acupuncture stimularion on Taeyon($L_9$) had a effect on much thermal changes of Sasang($L_{11}$), Oje($L_{10}$), Taeyon($L_9$), Kyonggo($L_8$) and Choldaek($L_5$) than control group. The thermal changes of the area which is a meridian point in the Lung Meridian of acupuncture group differed from control group with significant decrease and increase following the decreasing or increasing temperature class. Each class of ascent and descent thermal change was statistically significant value compared with control group. 3. Acupuncture group with acupuncture stimulation on Taeyon($L_9$) had not a effect on thermal changes of Taenung($P_7$) area than control group. And the increasing and decreasing temperature class of the acupuncture group did not significantly differ from control group. Conclusion : I could think that the acupuncture on Taeyon($L_9$) affected the thermal change of the area which is the Five-shu-points in the Lung Meridian. And then I could relate these results with the existence of the meridian and acupuncture point.
This study analyzes the chicken-related prescription shown in the literature summarized by standing tradition deliberate aims to investigate the clinical efficacy of native chickens. Therefore, The old traditional medicine books of native chickens translate and organize the relevant prescriptions. The manuscript old documents is prescribed by the old central documents sourced directly from generation to generation descendants technical publishing contemporary situation sake of the development of this unique formulation not only contemporary who established himself through numerous trials and errors. Browse almost circular in traditional medicine prescription, which is scattered throughout the country is difficult, and because of the loss can not be confirmed even its existence. This study is to establish the analysis and separated by organized to establish a database on the basis of prescription and mixed herbs in a variety of functional foods developed through usability evaluation methods of treatment. Therefore, the management systems of native chickens related to lack of knowledge and information to foster the continued expansion and specialized training and knowledge of the future growth engine industry through the added value of cultural projects of national knowledge resources. Finally, convergence research and evaluate the usefulness of native chickens through interdisciplinary research systems, and practical measures of functional foods and alternative medicine are presented as well.
Dance films, which started together as a combination of dance and video technology, have evolved into a new genre. Overseas, from early 1950s, experimental dance films have been produced and the dance film association is organized along with many dance film festivals are being held. However, it has not been long since the perception and creativity of the genre of dance films in Korea. Under these circumstances, holding of the 'Seoul Dance Film Festival' and experimental approaches by 'Dance Film Project' are important for the development of domestic dance films. Therefore, this paper explores the concept and development of dance films, the status and features of various overseas dance film festivals and the 'Seoul Dance Film Festival'. This paper also explores the roll and function of 'Seoul Dance Film Festival' and 'Dance Film Project', and their expected benefit along with possibilities of prosperity of domestic dance film. 'Dance Film Project' is the educational and experimental venue for producing of dance films, and the 'Seoul Dance Film Festival' is a platform for producing dance film makers, show of works, dialogue with audiences, international exchanges, and distributions. The dance film festival embodies the value of the past and current flow of the dance film and is intrinsic to the existence of a live content that can be predicted the future aspect of its roll. The two groups mutual growth and development are expected to play a positive role in the development of domestic dance films.
In early Josun(朝鮮) era, the scholars, genteels, and high officials in Josun dynasty paid attention to Sijo(時調) who hoped Josun society would share Confucian values. Sijo poems written by them are based upon Confucian ideology, giving an opportunity to its members to make sure their homogeneity and helping Josun dynasty sustain its regime. Gyongichega(景幾體歌) has, however, already failed to be an appropriate genre to do these functions. Nevertheless, in the late Josun dynasty when there were agitation in class hieracy, development of currency economics, maldistribution of wealth, and pursuit of enjoyment, obscene poems turned out. Consequently these songs contributed to encroaching and eventually destroying the Josun dynasty. The question that who are in charge of creating and enjoying Sasulsijo(辭說時調) cannot be answered by approaching it in the social class point of view. The range of the maker or the reader of Sasulsijo in the late Josun dynasty was much more extensive than that in the early times. Not only aristocracy or the middle society but even some of the lower class may have made and enjoyed those songs. In the meantime, it is singer-songwriters whom Park, Hyogwan blamed for their profiteering abuse of obscenity that is supposed to have been mainly reponsible for the creation of those songs. Siga is a double-edged art in its essence--the good and the bad. The lewd songs were, in the early Josun, strictly controlled but in the late Josun dynasty, were thriving due to social changes. In this context, songs based on Confucian ideology as well as the ones focused on sexual love became decayed along with the collapse of the Josun dynasty. Even though, in the light of the history of Siga, those two types of Siga are underestimated in its artistic value, they have very special social historical meaning in doing positive and negative functions for existence and destroy of the Josun dynasty.
We conducted principal component analyses using the quantitative characteristics of the genus Sorbaria to investigate and explore morphological variation and diagnostic characteristics. The genus Sorbaria was divided into two groups based on erect or pendulous inflorescence, the existence of hairs on the ovary and follicle surfaces, the number of stamens, and the shape of the sepal. As a result of our investigation and of a morphometric analysis, these two groups could be also classified using quantitative characteristics, in this case the number of leaflets, the size of the leaflets, the width of the inflorescence, the size of the sepal, the petal, and the follicles and seeds. In the Sorbifolia group (S. grandiflora and S. sorbifolia complex), the size of lateral leaflets, number of veins, gland and stellate density on the abaxial surface of leaflets, and the petal and follicle size were found to be useful identification characteristics. The terminal and lateral leaflet size and the gland and stellate density on the abaxial surface of the leaflets were found to be characters of taxonomic value for the Kirilowii group (S. arborea complex, S. kirilowii, and S. tomentosa complex). The results of the numerical analysis conducted here can provide valuable information to those reconsidering and delimiting a taxonomic revision of the genus Sorbaria.
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