• 동의생리병리학회지
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• 제25권5호
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• pp.934-944
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• 2011

This study was designed to investigate the effects of Kyungohkgo to improve aerobic capacity and eliminate exercise-induced fatigue in high school soccer players. Twenty four subjects were participated and randomly assigned into two groups [KG, Kyungohkgo group (n=12); PG, Placebo control group (n=12)]. Two groups were completed treadmill exercise protocol using graded exercise test at before and after experimental treatment of 4 weeks. The $VO_2$max and endurance time were measured by gas analysis and heart rate (HR) was measured by polar system at pre, post 0, post 5, post 15, post 30 and post 60 minutes. Blood samples were collected to analyze blood components. 1. The $VO_2$max was significant increased in the group of after intake Kyungohkgo compared to the group of after intake placebo (p<.05). 2. The HR was significant decreased in the group of after intake Kyungohkgo compared to the group of after intake placebo during recovery time at post 5 mins(p<.05), 30 mins(p<.01), 60 mins(p<.01). 3. Weight, body mass index, percent body fat, anaerobic threshold, endurance time, blood lactate concentrate, lactate dyhydrogenase, creatine kinase, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, other energy sources(total-cholesterol, triglyceride, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, creatinine) and electrolyte (Na, K, Cl) were shown no significant differences between groups. These results suggested that Kyungohkgo can be used as ergogenic aids to improve aerobic capacity and eliminate exercise-induced fatigue.

• 생명과학회지
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• 제18권11호
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• pp.1612-1616
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• 2008

심폐지구력은 질병, 장애, 수명 등과 연관된 중요한 건강 지표이다. 지구성 운동이 대개 심폐지구력향상을 위한 방법으로 알려져 있는 반면 대부분의 저항성 운동은 심폐지구력향상을 위한 좋은 방법으로 고려치 않고 있다. 그러나, 짧은 휴식기간을 가진 저 강도 혹은 중간 강도의 저항성운동은 특히 노인들이나 관상동맥질환을 가진 환자들의 심폐지구력향상에 도움을 줄 수 있을 것이다. 본 총설은 지구성운동과 저항성운동 시의 생리학적변화를 이해하고, 저항성운동이 심폐지구력향상에 도움을 줄 수 있다는 사실을 이론적으로 뒷받침하고자 한다.

• 대한한방내과학회지
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• 제36권3호
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• pp.297-307
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• 2015

Objectives: We aimed to evaluate the effect of Cervi Cornu and coenzymeQ10 on exercise and endurance capacity in rats and mice. Methods: The extract of Cervi Cornu was manufactured by the pharmacy department of Kyung Hee Oriental Medical Hospital, and CoQ10 soft cap (Ildong Pharmaceutical) was used. In total, 24 rats and 30 mice were divided into 3 groups: Control (rat=8, mouse=10), CoQ10 alone (rat=8, mouse=10), Cervi Cornu extract, and CoQ10 (rat=8, mouse=10). Ergogenic effect was evaluated by administering the Cervi Cornu extract and coenzymeQ10 to rats and measuring the time to exhaustion during treadmill running; endurance capacity was assessed by measuring cold water swimming time, serum lactate level, and serum corticosterone level in each group. At 1 week from the end of treatment, we recalculated time to exhaustion during treadmill running in rats to investigate the long-term effect of the Cervi Cornu extract and coenzymeQ10. Results: Cervi Cornu extract has long-term benefits in that it preserves the ergogenic effect caused by exercise. Cervi Cornu and coenzymeQ10 have no effect on increasing cold water swimming time in ICR mice. CoenzymeQ10 decreases the serum corticosterone level in ICR mice performing cold water swimming test. Conclusions: Cervi Cornu seems to preserve the ergogenic effect caused by exercise, but a larger study is needed to investigate effect of Cervi Cornu and coenzymeQ10 on improving endurance capacity. CoenzymeQ10 decreases serum corticosterone level and it is related with the anti-psychological fatigue effect.

• 생명과학회지
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• 제21권8호
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• pp.1127-1133
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• 2011

본 연구는 65세 이상 79세 사이의 남자고령자를 대상으로 16주간의 태극권 운동프로그램을 통해 신체적, 생리적 변화를 살펴보았으며, 일상생활을 영위하기 위한 신체적, 생리적 건강의 척도가 될 수 있는 건강체력과 신체조성의 변화에 어떤 영향을 미치는지 그 효과를 분석한 결과 다음과 같은 결론을 얻었다. 건강체력 요인의 심폐지구력, 근지구력, 유연성, 평형성은 유의한(p<0.05) 영향을 미치는 것으로 나타났으며, 신체조성 요인의 이완기 혈압과 체지방, 제지방에서 유의한 영향을 미치는 것으로 나타났다. 태극권 운동프로그램이 고령화 시기에 건강체력과 신체조성 요인에서 긍정적인 변화를 가져옴으로써 건강체력관련 요인이 상당부분 개선된 것으로 나타났는데 이와 같은 긍정적인 변화는 남자고령자에 건강한 신체활동을 위해서는 체력을 증진, 유지시키는 것이 중요하다. 특히, 규칙적인 태극권 운동이 어느 정도 영향을 미치는지에 대한 생리학적 기전을 명확하게 규명하기 위해서는 연령별 및 성별에 따라 다양한 측면에서 검토 되어야 할 필요성이 있으며, 고령화 사회에 대비한 구체적이고도 현실적인 연구가 지속적으로 이루어져야 할 것으로 사료된다.

• The Journal of Korean Physical Therapy
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• 제26권6호
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• pp.411-417
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• 2014

Purpose: This study attempts to find the effects of water-based exercise performed on stroke patients in their physiological cost index and static and dynamic balance. Methods: The subjects were 30 stroke patients, who were randomly divided a water-based exercise group and a land-based exercise group, each with 15 patients. Both exercises ware performed 3 day per week, for 40 minutes a day, for a period of eight weeks. Results: The Water-based exercise group showed a decreased physiological cost index compared to the land-based exercise group, with the physiological cost index of the water-based exercise group decreasing, while the land-based exercise group, showing a significant decrease. Water-based exercise increased static and dynamic balance capacity better than land-based group, showing a significant difference and better efficiency of water-based exercise when compared to land-based exercise. Conclusion: From the result of the study, we found that water-based exercise is more effective in improving PCI and static and dynamic balance capacity. Through this study, training in water-based stroke patients could use cardiovascular endurance and buoyancy and the vortex, as an effective treatment that can enhance the growth and voluntary participation in the range of the patient's own movement the thought is, in consideration of the changes in the physiological cost index due to the difference in the ground and water, and should establish a training program that matches the purpose.

• 운동영양학회지
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• 제24권2호
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• pp.11-21
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• 2020

[Purpose] Doxorubicin (DOX) is a potent anti-cancer drug that appears to have severe myotoxicity due to accumulation. The skeletal muscle has a regeneration capacity through satellite cell activation when exposed to extracellular stimulus or damage. Endurance exercise (EXE) is a therapeutic strategy that improves pathological features and contributes to muscle homeostasis. Thus, this study investigated the effect of EXE training in mitigating chronic DOX-induced myotoxicity. [Methods] Male C57BL/6J mice were housed and allowed to acclimatize with free access to food and water. All the mice were randomly divided into four groups: sedentary control (CON, n=9), exercise training (EXE, n=9), doxorubicin treatment (DOX, n=9), doxorubicin treatment and exercise training (DOX+EXE, n=9) groups. The animals were intraperitoneally injected with 5 mg/kg/week of DOX treatment for 4 weeks, and EXE training was initiated for treadmill adaptation for 1 week and then performed for 4 weeks. Both sides of the soleus (SOL) muscle tissues were dissected and weighed after 24 hours of the last training sessions. [Results] DOX chemotherapy induced an abnormal myofiber's phenotype and transition of myosin heavy chain (MHC) isoforms. The paired box 7 (PAX7) and myoblast determination protein 1 (MYOD) protein levels were triggered by DOX, while no alterations were shown for the myogenin (MYOG). DOX remarkably impaired the a-actinin (ACTN) protein, but the EXE training seems to repair it. DOX-induced myotoxicity stimulated the expression of the forkhead box O3 (FOXO3a) protein, which was accurately controlled and adjusted by the EXE training. However, the FOXO3a-mediated downstream markers were not associated with DOX and EXE. [Conclusion] EXE postconditioning provides protective effects against chronic DOX-induced myotoxicity, and should be recommended to alleviate cancer chemotherapy-induced late-onset myotoxicity.

• 한국식품영양과학회지
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• 제40권12호
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• pp.1700-1707
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• 2011

본 연구에서는 4주간 혼합곡 식이를 공급하여 treadmill을 통한 운동시간과 glycogen 저장능력 변화를 관찰함으로써 지구력 개선에 대한 평가를 하였다. 7주령 SD rats은 정상군 (Nor, 정상식이, n=6), 대조군(Con, 20% 정상식이+80% milled rice, n=6), GI(혼합곡 식이 I, n=6), GII(혼합곡 식이 II, n=6), GIII(혼합곡 III, n=6)와 GIV(혼합곡 식이 IV, n=6)으로 임의 군배정을 하였다. 지구력 시험은 24일간의 적응훈련과 혼합곡 식이 공급을 한 후 실시하였다. 운동 지속시간과 glycogen 저장능력은 혼합곡 식이 공급에 의해서 증가하였다. 더욱이 25 min 운동 그리고/또는 탈진 시까지의 운동 후에서 혈액 내 무기질 인, CPK와 lactate의 농도는 혼합곡 투여에 의하여 감소하였으나, GOP, GTP, lactate LDH의 농도는 군간 차이는 보이지 않았다. 본 연구에서는 4주간의 혼합곡 식이가 운동 지속 시간과 glycogen 장 능력이 증가되었으며, 피로물질인 무기질 인, CPK와 lactate의 농도가 감소시킴으로써 지구력 개선에 도움을 줄 것으로 생각된다.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2008년도 제49회 학술심포지움 및 국제학술대회
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• pp.28.1-28.1
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• 2008

• 보건교육건강증진학회지
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• 제18권3호
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• pp.177-186
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• 2001

The purpose of this study was to investigate the of regular worksite health exercise program participation on related fitness. Subject for study were 34 middle-aged women in Kwangju-city. To achieve this, body composition, cardiopulmonary function, physical fitness of every subjects were measured before and post regular health exercise program participation during 12 week. The results of this study were as follows: 1. Regular health exercise program participation result from improving the body composition, but there is not significant different statistically(p〈.05). 2. Significant differences were observed in the cardiopulmonary function(vital capacity, VO$_2$ max) after regular exercise program during 12 week(p〈.05). 3. Significant differences were observed in the flexibility(sitting trunk flexion), abdominal endurance(sit-ups), power (standing high jump), agility(trunk reaction time) after regular exercise program during 12 week(p〈.05).

• 한국약용작물학회지
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• 제26권4호
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• pp.271-280
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• 2018

Background: Astragalus membranaceus is a well known oriental medicinal herb. The polysaccharides of the aboveground parts (AMA) and the radix (AMR) of A. membranaceus are the most important functional constituents. Methods and Results: The aim of this study was to determine the effects of AMA and AMR on the oxidative damage induced in the skeletal muscle of rats subjected to exhaustive exercise. Sprague-Dawley rats were randomly divided into exercise and non-exercise groups; in the groups receiving the test compounds, AMA and AMR were administered orally for 30 days. Skeletal muscle samples were collected from each rat after running to exhaustion on a treadmill to determine the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) and the concentation of malondialdehyde (MDA). The antioxidant enzyme activities of SOD and GSH-Px of skeletal muscle of AMA- and AMR-treated groups were significantly higher than those of the control and commercial sports drink (SPD)-treated groups in exhaustive exercise rats. In addition, MDA concentrations in the skeletal muscle of the AMA- and AMR-treated groups were significantly lower than those of the control and SPD-treated groups. In the present study, the effects of AMA and AMR on exercise endurance capacity were also evaluated in mice subjected to a swimming exercise test. AMA and AMR supplementation prolonged the swimming time of mice and enhanced exercise endurance capacity. AMA and AMR possess the ability to retard and lower the production of blood lactate, and prevent the decrease of serum blood glucose. Conclusions: These results showed that, AMR and AMA exerted beneficial effect in mice, increasing the activity of the antioxidant systems and inhibiting oxidative stress induced by exhaustive exercise. The compounds improved exercise performance and showed anti-fatigue effects against exhaustive exercise.