• 한국군사과학기술학회지
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• 제15권2호
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• pp.121-129
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• 2012

In this study, in terms of the exercise vehicles of the weapon systems having negative buoyancy, the analysis on the operation concepts was performed and the new methods of floating to surface were proposed. In case of having negative buoyancy, the additional methods for recovering the exercise vehicle have to be considered. As parts of recovering the exercise vehicle, for floating to surface the new methods of weight discharge, weight separation and sea water discharge were proposed. The conceptual design about sea water discharge method was performed. It was confirmed that those methods could be applied to the design of the exercise vehicle having negative buoyancy.

• 한국약용작물학회지
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• 제26권1호
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• pp.72-81
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• 2018

Background: Polysaccharides are the most important functional constituent in Astragalus membranaceus. The purpose of the present study was to evaluate the effect of polysaccharides isolated from the aboveground parts of A. membranaceus (AMA) and polysaccharides isolated from the roots of A. membranaceus (AMR) immune function by modulated cytotoxic T cell and Th1- and Th2-related cytokines kinetics. Methods and Results: Sprague-Dawley rats were randomly divided into exhaustive exercise case groups and non-exercise case, AMA and AMR samples were administered orally for 30 days (500 mg/kg/day and 10 mg/kg/day, respectively) and were compared to those rats in the groups fed commercial sports drink (SPD) and vehicle. Both exhaustive exercise groups and non-exercise groups had a lower ratio of $CD4^+$ and $CD8^+$ cells in the spleens of the rat fed AMA and AMR compared to those in the rats fed SPD and vehicle group. These results suggested that AMA and AMR promote an increase in the proportion of cytotoxic T cells. The IL-4-producing T lymphocytes decreased significantly in the AMR (10 mg/kg/day) group compared to SPD and vehicle, whereas the AMA group increased the IL-4 concentration more than the SPD and vehicle in exhaustive exercise group. However, the populations of IFN-${\gamma}$-producing T lymphocytes of AMR and AMA increased. AMA decreased the concentration of IFN-${\gamma}$ to inhibit the Th1 response and thereby increased the concentration of IL-4 to induce a Th2 response that was related to humoral immunity in the non-exercise group. Conclusions: These results showed that, in addition to Th1/Th2 regulation, AMR and AMA played an important immuno-modulatory role after exhaustive exercise-induced Th1/Th2 lymphocyte imbalance, which might be correlated with cytokine producing immunoregulatory cells.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권12호
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• pp.5878-5904
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• 2017

This paper proposes a novel intelligent wheelchair vehicle system that enables upper limb exercises, lower limb standing exercises and rehabilitation training in a daily life. The proposed system, which can be used to prevent at least the degeneration of body movements and further atrophy of musculoskeletal system functions, considers the characteristics and mobility of the old and the disabled. Its main purpose is to help the old and the disabled perform their daily activities as much as they can, minimizing the extent of secondary disabilities. In other words, the system will provide the old and the disabled with regular and quantitative rehabilitation exercises and diagnosis using the wheelchair-based upper/lower limb rehabilitation vehicle system and then verify their effectiveness. The system comprises an electric wheelchair, a biometric module to identify individual characteristics, and an upper/lower limb rehabilitation vehicle. In this paper the design and configuration of the developed vehicle is described, and its operation method is presented. Moreover, to verify the tracking performance of the proposed system, dangerous situations according to biosignal changes occurring during the rehabilitation exercise of a non-disabled examinee are analyzed and the performance of the upper/lower limb rehabilitation exercise function depending on muscle strength is evaluated through a neural network algorithm.

• 생약학회지
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• 제44권1호
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• pp.83-90
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• 2013

The aim of this study was to evaluate the effect of hot water extract of peduncle obtained from Hovenia dulcis Thunb (HD) which is commercially developed for the protective effect on the alcoholic hepatotoxicity, on the endurance capacity for weight loaded forced swimming mice. The swimming times to exhaustion in mice fed 100 and 200 mg/kg HD for 2 weeks were prolonged 3.6 and 3.7 fold, and for 4 weeks 1.9 and 2.7 fold compared with each vehicle control ($42.8{\pm}20.5$ min and $67.7{\pm}47.8$ min, for 2 and 4 weeks), respectively. Blood biochemical parameters for ALT, AST, creatinine and BUN were not significantly different between from HD fed or control mice. Although HD fed mice swam over 2 fold longer time than vehicle control mice at 4 weeks, blood biomarkers of physical fatigue such as glucose, triglyceride and free fatty acid, lactate were not significant different and even tended to ameliorate. Hepatic lipid peroxidation and SOD activity did not significantly change in HD fed- and vehicle control exhausted swimming mice at 2 or 4 weeks. However, catalase activity in HD-fed mice was significantly increased in a dose-dependent manner compared with vehicle control mice. The present study indicates that HD improved physical fatigue and exercise performance in mice. Therefore, it has a potential for the pharmacological effect of anti-fatigue.

• 생약학회지
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• 제47권3호
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• pp.258-263
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• 2016

In this study, we tested anti-fatigue effect of Kyung-Ok-Ko (KOK). We examined the exercise performance effects of KOK (600 mg/kg) at 2nd, 3rd and 4th week. The exercise performance of KOK treated group was significantly improved than that of vehicle control (VC) group on grip strength (2nd week), exhausted time of treadmill (3rd week) and exhausted time of weight loaded swimming (4th week). We also investigated the effects of KOK on the change of fatigue parameters in blood, skeletal muscle and liver after swimming exercise. KOK significantly reduced lactate level and enhanced glucose level in blood. Equally KOK significantly increased glycogen in skeletal muscle. However, the glycogen level of KOK in the liver was not significantly increased compared to VC group. These results show that supplementation of KOK may improve the anti-fatigue activity and exercise capacity.

• 생명과학회지
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• 제25권11호
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• pp.1214-1222
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• 2015

본 연구는 난소 제거 수술을 시행하여 폐경기를 유도시킨 뒤 고지방 식이를 섭취한 쥐에게서 나타난 신체 변화에 있어 운동과 갈근/지황 섭취에 의한 개선 효과를 관찰하고, 그러한 효과가 골격근에서의 후성 유전적 발현 변화에 의한 것임을 규명하고자 하였다. 8주령의 쥐(rat, n=60)의 난소를 제거한 뒤 고지방 식이를 유도하면서 트레드밀 운동(exercise)을 실시하는 그룹과 비운동(sedentary) 그룹으로 나누었다. 두 그룹을 각각 estradiol, 갈근과 지황의 3:1 복합물(HT051), 그리고 물 섭취 군으로 다시 나누어 총 8주간 경구 투여를 함께 실시하였다. 그 결과 운동 그룹과 갈근/지황 섭취 그룹에서 체중이 유의하게 감소하였고, 가자미근과 족저근의 근질량 또한 운동 그룹과 갈근/지황 섭취 그룹에서 유의하게 증가하였다. 한편, 가자미근에서 물을 섭취하며 운동하지 않은 그룹의 H3K9 아세틸화가 억제 되었고 H3K9의 메틸화에는 변화가 없었다. 족저근의 경우 운동 그룹에서 H3K9 아세틸화가 현저하게 눈에 띄었고, 반대로 메틸화는 줄어든 것이 관찰되었다. 나아가 H3K9의 아세틸화와 메틸화를 조절하는 대표적인 효소 중 HDAC4, HDAC5, G9a 유전자의 mRNA 발현양을 정량한 결과, 가자미근에서는 모두 유의한 차이가 없었고 족저근에서 운동 한 그룹의 HDAC5와 G9a 유전자의 mRNA 발현양이 유의하게 감소하였지만 HDAC4의 mRNA는 차이가 없었다. 또한 운동과 갈근/지황의 상호작용 효과는 나타나지 않았다. 본 연구를 통하여 운동과 갈근/지황 섭취가 체중 감소, 근질량 증가에 영향을 미치고, 이러한 현상은 히스톤 H3K9 부분의 아세틸화와 메틸화에 의한 유전자 발현 조절이 그 기전으로 작용한다는 것을 알 수 있었다.

• Structural Engineering and Mechanics
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• 제18권5호
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• pp.609-626
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• 2004

The Land Transport Authority of Singapore has a continuing program of highway bridge upgrading, to refurbish and strengthen bridges to allow for increasing vehicle traffic and increasing axle loads. One subject of this program has been a short span bridge taking a busy highway across a coastal inlet near a major port facility. Experiment-based structural assessments of the bridge were conducted before and after upgrading works including strengthening. Each assessment exercise comprised two separate components; a strain and acceleration monitoring exercise lasting approximately one month, and a full-scale dynamic test carried out in a single day. This paper reports the application of extreme value statistics to estimate bridge live loads using strain measurements.

• 한국가구학회지
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• 제23권4호
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• pp.467-478
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• 2012

Interurban railway is expanded by transportation that population can be centralism and cope efficiently in traffic jam by augmentation of vehicles in the city. Railroad chair departs in space of an existent simple rest and products that can raise human body standard and size by powerful engineering vicinity, quality of the material, psychological satisfaction etc. of users are developed steadily. Specially, study of space that can use various materials efficiently with bodily size government official because various of man and woman old and the young etc.. are using in occasion of the train is urgently required. Specially, railroad chair is a product that material and standard, structure, human body engineering, a finish etc. is studied variously. In the case of advanced nation, in case of design a chair operating time of railroad, is placed as all standards orderly and harmonious because is considered exercise dynamics etc.. and designs. The other side, in the case of our country, study expert of chair is short real and is depending on technological data of overseas railway vehicle. Chair for railroad must consider removal of short-range, long distance. That have to be consider to a lot of uncomfortable such as psychological satisfaction of user because the domestic Motor Companies are defining in fair development study and many researchers but the railroad chair company are not accumulated professional manpower and technological know-how. Railway vehicle can recognize that overseas visitors as well as native is important element as space that space is exposed internationally by product that Public personality which used cultural value is strong. Therefore, wish to plan valid spec relationship presentation of various design and specification, function etc.. and contribute to railroad chair development design process lists and analyzes van instances of railway vehicle chair of inside and outside of the country through this study.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.816-823
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• 2007

As the South Korean rolling stock industry is developing designs for full compliance with the European Standards, it is fitting to take a look at these two core standards. The paper presents an overview of the load cases and structural requirements developed in Europe for the design of safe and compatible rolling stock vehicles. These load cases and structural requirements have been compiled into two standards namely EN12663 and EN15227. Standard EN12663 was developed as a reference design requirements standard. The work was mandated and sponsored by the European Committee for Standardization and Standard issuing National Institutions. EN12663 specifies a series of proof and fatigue load cases for European rolling stock regulations compliant vehicle designs. As EN12663 does not address the crashworthiness issue, a dedicated crashworthiness standard, EN15227, was therefore developed in a similar manner through industry wide consultations managed by a Trans-European working group of experienced engineers and specialists. In both standards, the vehicle and/or trains are grouped into categories reflecting the vehicle types and/or their indented operational function. EN15227, developed to complement EN12663, addresses the "passive" crashworthiness capability of the vehicles and trains. EN15227 specifies reference crash scenarios similar to those found in the Technical Specification for Interoperability (TSI) of high speed trains operating in Europe. The overview also touches on a general comparison with the corresponding British Group Standard (GM/RT2100) and also the UIC leaflet based load cases. The exercise is extended to pertinent design load cases specified by the Federal Railroad Administration (FRA) in the US.

• Smart Structures and Systems
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• 제15권3호
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• pp.665-682
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• 2015

Structural identification or St-Id is 'the parametric correlation of structural response characteristics predicted by a mathematical model with analogous characteristics derived from experimental measurements'. This paper describes a St-Id exercise on Humber Bridge that adopted a novel two-stage approach to first calibrate and then validate a mathematical model. This model was then used to predict effects of wind and temperature loads on global static deformation that would be practically impossible to observe. The first stage of the process was an ambient vibration survey in 2008 that used operational modal analysis to estimate a set of modes classified as vertical, torsional or lateral. In the more recent second stage a finite element model (FEM) was developed with an appropriate level of refinement to provide a corresponding set of modal properties. A series of manual adjustments to modal parameters such as cable tension and bearing stiffness resulted in a FEM that produced excellent correspondence for vertical and torsional modes, along with correspondence for the lower frequency lateral modes. In the third stage traffic, wind and temperature data along with deformation measurements from a sparse structural health monitoring system installed in 2011 were compared with equivalent predictions from the partially validated FEM. The match of static response between FEM and SHM data proved good enough for the FEM to be used to predict the un-measurable global deformed shape of the bridge due to vehicle and temperature effects but the FEM had limited capability to reproduce static effects of wind. In addition the FEM was used to show internal forces due to a heavy vehicle to to estimate the worst-case bearing movements under extreme combinations of wind, traffic and temperature loads. The paper shows that in this case, but with limitations, such a two-stage FEM calibration/validation process can be an effective tool for performance prognosis.