• Journal of Radiopharmaceuticals and Molecular Probes
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• v.4 no.1
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• pp.26-31
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• 2018

Macrophages play a key role in atherosclerotic plaque formation, but their participation has been discerned largely via ex vivo analyses of atherosclerotic lesions. Therefore, we aimed to identify atherosclerosis on noninvasive in vivo imaging using reporter gene system. This study demonstrated that recruitment of macrophages could be detected in atherosclerotic plaques of Apolipoprotein E knockout (ApoE-/-) mice with a sodium iodide symporter (NIS) gene imaging system using $^{99m}Tc-SPECT$. This novel approach to tracking macrophages to atherosclerotic plaques in vivo could have applications in studies of arteriosclerotic vascular disease.

• Toxicological Research
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• v.29 no.1
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• pp.1-6
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• 2013

The process of drug discovery and development requires substantial resources and time. The drug industry has tried to reduce costs by conducting appropriate animal studies together with molecular biological and genetic analyses. Basic science research has been limited to in vitro studies of cellular processes and ex vivo tissue examination using suitable animal models of disease. However, in the past two decades new technologies have been developed that permit the imaging of live animals using radiotracer emission, X-rays, magnetic resonance signals, fluorescence, and bioluminescence. The main objective of this review is to provide an overview of small animal molecular imaging, with a focus on nuclear imaging (single photon emission computed tomography and positron emission tomography). These technologies permit visualization of toxicodynamics as well as toxicity to specific organs by directly monitoring drug accumulation and assessing physiological and/or molecular alterations. Nuclear imaging technology has great potential for improving the efficiency of the drug development process.

• The Korean Journal of Nuclear Medicine
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• v.28 no.3
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• pp.293-300
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• 1994

It is well known that Tc-99m HMPAO brain SPECT can reflect the functional lesions better than X-ray computerized tomography(CT) and magnetic resonance imaging(MRI) in the cerebral disorders. In order to evaluate the clinical utilities of Tc-99m HMPAO brain SPECT in patients with post-traumatic chronic organic mental disorder(OMD), we included 28 patients diagnosed as OMD in department of psychiatry after traumatic head injury. And we compared the results of Tc-99m HMPAO SPECT with those of MRI, EEG and MINI mental status ex amination(MMSE). The results were as follows 1) All patients diagnosed as OMD showed diffuse or focal decreased cerebral perfusion on Tc-99m HMPAO SPECT. 2) Most frequent lesion on brain Tc-99m HMPAO SPECT was decreased perfusion on both frontal lobe. And most frequent lesion on brain Tc-99m HMPAO SPECT showing normal brain MRI result was also decreased both frontal perfusion. 3) Eight of 28 patients showed focal brain MRI lesions(4 small frontal hygroma, 3 small cerebral infarction and 1 cerebellar encephalomalacia) which were not detected in brain Tc-99m HMPAO SPECT. 4) The patients showing less than 20 points on MMSE disclosed abnormal results of EEG more frequently than those disclosing more than 20 points. In conclusion, we think that Tc-99m HMPAO brain SPECT is sensitive method to detect functional lesions of the brains in patients with chronic post-traumatic organic mental disorder.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.11C
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• pp.1112-1123
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• 2002

Providing a multimedia service requires efficient network bandwidth allocation scheduling. Typically, transmission of information with bursty characteristics, such as a video data stream, utilizes some type of smoothing technique that reduces the transmission rate fluctuation. While capable of a drastic reduction in the peak transmission rate, even the optimum smoothing algorithm proposed to date, however, is rather inadequate for multi-stream applications that share network bandwidth since such an algorithm has been designed and applied toward handling each independent stream. In this paper, we proposed an efficient bandwidth allocation algorithm that addresses these shortcomings. The proposed bandwidth allocation algorithm is divided into two steps, a static bandwidth allocation and a dynamic bandwidth allocation. In the former case, the peak rate reduction is achieved by maintaining the accumulated data in the user buffer at a high level, whereas the concept of real demand factor is employed to meet the needs of multi-stream bandwidth allocation in the latter case, Finally, the proposed algorithm's performance was verified with ExSpect 6.41, a Petri net simulation tool.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.5B
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• pp.448-456
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• 2003

In this parer, an ABR (Available Bit Rate) congestion control algorithm for voice transmission in ATM networks was proposed. To deal with the network congestion problem, not only the buffer level of a switch but also the variation of the buffer level were considered. Also, to resolve the unfairness among sources where the bit transfer rates vary, a loading factor that is used to adjust the bit rate was introduced. To show the superiority of this paper over others, simulation was done with a network of 7 voice sources and 4 switches, which was represented by Petri net model. ExSpect was used for simulation. The simulation results showed that there was improvement in network utilization and that unfairness among sources were resolved a lot.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.61-61
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• 2000

Since FMS(Flexible Manufacturing System) such as semiconductor production systems have the characteristic that each device has to be commonly used in several stages, it is difficult to find an optimal solution. In this paper, we proposed the new algorithm which can get the optimal ratio of sharing resources. We will implement the proposed algorithm to semiconductor production systems. We introduce the optimal algorithm, which is modeled and analyzed by ExSpect, a petri net based simulation tool. When there exist conflicts of sharing resources, the scheduling method is adopted, which gives a priority to the most preceded process. The suggested algorithm can be used not only in semiconductor production systems but also in various FMS.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.66-66
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• 2000

In this parer, we introduce an algorithm to control flows of the traffic in multi-intersections. It is pointed out that the main problem in traffic control is how to resolve the congested situations for the particular time-durations and directions. The heavy load to a certain direction usually leads the intersection to congested situations, and the adjacent intersections are affected. We control and analyze the traffic flow of multi-intersections consisting of five intersections, in which four intersections are linked to the four directions of the central one. The entrance of vehicles of each direction is described using the concept of probability. We compare the performance of the pretimed signal controls to the traffic adaptive signal controller using a Petri Net simulation tool, Exspect.

• The Korean Journal of Nuclear Medicine
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• v.26 no.1
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• pp.49-57
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• 1992

혈관확장제 투여에 의한 약물부하 심근스캔시는 운동부하 심근스캔시와 비교하여 심박출량과 관상 동백 혈류의 증가정도가 달라서 심근내 T1-201의 농도가 달라진다. 그러므로 부하 심근관류스캔의 정량적 판독시에 각각의 부하에 특이적인 Normal file을 사용하지 않으면 이러한 심근내 T1-201 농도의 차이로 인하여 관류 결손의 크기가 다르게 나타날 수 있으리라 추측할 수 있다. 본 연구는 좌전하행지의 유의한 협착이 있는 34명의 단일 혈관 관상동맥 환자에서 이러한 가정이 실제적으로 어떻게 나타나는가를 조사하였다. 환자들은 adenosine 140ug/kg/min을 정맥주사하고 T1-201 SPECT를 실시하였다. 관류결손의 크기는 답차운동부하 T1-201 스캔을 실시한 정상인에서 구한 Normal File (File-ex)과 adenosine T1-201 스캔의 Normal File (File-ad)을 각각 이용하여 만든 극성지도에서 구한 adenosine 심근스캔의 관류결손의 범위지수(extent score)와 중증도지수(severity score)로 표시하였고, 이들의 값을 비교하여 아래의 결과를 얻었다. File-ex로 구한 관류결손의 범위지수는 $19{\pm}13%$였고 File-ad로 구한 범위는 $11{\pm}10%$였다(차이 $8.1{\pm}1.6%$, p=0.0001), 중증도지수는 File-ex를 사용하였을 때 $582{\pm}479$였고 File-ad를 사용하였을때는 $310{\pm}309$였다(차이 $272{\pm}49$, p<0.0001). $50\sim70%$의 중등도의 내경 협착이 있었던 20명의 환자에서는 범위지수는 File-ex와 File-ad에서 각각 $17{\pm}10$과 $7{\pm}7%$(p=0.001)였고, 70% 이상의 내경 협착이 있었던 14명에서의 범위 지수는 각각 $24{\pm}16$과 $18{\pm}10%$ (p=0.03)로 모두에서 File-ex를 사용하였을때의 값이 컸다. 이와 같은 성적으로 보아 T1-201 스핀에서 관류결손의 정도를 정량적으로 첨가할 시에는 부하에 특이적인 Normal File을 사용하여야 관류 결손의 정도를 정확하게 추출할 수 있다는 사실을 알 수가 있다. 즉 dipyridamole이나 adenosine부하경사에서 운동부하의 Normal File을 사용하면 관류결손의 정도가 과대평가 된다는 것이다.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.39 no.6
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• pp.53-67
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• 2002

The multimedia synchronization is one of the key issues to be resolved in order to provide a good quality of multimedia related services, such as Video on Demands(VoD), Lecture on Demands(LoD), and tele-conferences. In this paper, we introduce an adaptive multimedia synchronization algorithm using the level of buffers and load of servers, which are modeled and analyzed by ExSpect, a Petri net based simulation tool. In the proposed algorithm, the audio and video buffers are divided to 5 different levels, and the pre-defined play-out speed controller tries to make the buffer level to be normal in different temporal relations between multimedia streams using buffer levels and server loads. Because each multimedia packet is played by the pre-defined play-out speed, the media data can be reproduced within the permissible limit of errors while preserving the level of buffers to be normal. The proposed algorithm is able to handle and support various communication restrictions between providers and users, and offers little jitter play-out to many users in networks with the limited transmission capability. The performance of the developed algorithm is analyzed in various network conditions using a Petri net simulation tool.

• The Korean Journal of Nuclear Medicine
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• v.37 no.4
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• pp.219-228
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• 2003

Purpose: The amount of salvaged myocardium is an important prognostic factor in patients with acute myocardial infarction (MI). We investigated if early Tl-201 SPECT imaging could be used to predict the salvaged myocardium and functional recovery in acute MI after primary PTCA. Materials and Methods: In 36 patients with first acute MI treated with primary PTCA, serial echocardiography and Tl-201 SPECT imaging ($5.8{\pm}2.1$ days after PTDA) were performed. Regional wall motion and perfusion were quantified with on 16-segment myocardial model with 5-point and 4-point scaling system, respectively. Results: Wall motion was improved in 78 of the 212 dyssynergic segments on 1 month follow-up echocardiography and 97 on 7 months follow-up echocardiography, which were proved to be salvaged myocardium. The areas under receiver operating characteristic curves of Tl-201 perfusion score for detecting salvaged myocardial segments were 0.79 for 1 month follow-up and 0.83 for 7 months follow-up. The sensitivity and specificity of Tl-201 redistribution images with optimum cutoff of 40% of peak thallium activity for detecting salvaged myocardium were 84.6% and 55.2% for 1 month follow-up, and 87.6% and 64.3% for 7 months follow-up, respectively. There was a linear relationship between the percentage of peak thallium activity on early redistribution imaging and the likelihood of segmental functional improvement 7 months after reperfusion. Conclusion: Tl-201 myocardial perfusion SPECT imaging performed early within 10 days after reperfusion can be used to predict the salvaged myocardium and functional recovery with high sensitivity during the 7 months following primary PTCA in patients with acute MI.