• 제목/요약/키워드: Evidence Combination

검색결과 370건 처리시간 0.025초

탄력밴드와 단축발 운동이 중등도 이하 무지외반증환자의 발가락 휨 각도와 족저압, 균형에 미치는 영향 (The Effects of Combined Exercises of Elastic-Band and Short Foot Exercise on Plantar Foot Pressure, Toe Angle and Balance for Patients with Low to Moderate Hallux Valgus)

  • 이형수;김은주;박인서;배민식;신재원;이지운;장요윤;조호진;최근옥;최하림;김장선
    • 대한통합의학회지
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    • 제3권3호
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    • pp.73-88
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    • 2015
  • Objective: The purpose of this study was to further the empirical evidence regarding exercise as an effective alternative to surgery for treating patients with low to moderate hallux valgus. Method: A total of 20 students with low to moderate hallux valgus participated in this study for six weeks. Participants were selected according to foot-print. All participants exercised using a combination of Elastic-band and Short Foot Exercises twice a week for thirty minutes each time. Measurements were taken at week 0 and week 6 for plantar foot pressure, toe angle and balance. The data was processed using a paird t-test. Results: There were significant differences in pretest and posttest measurements for balance. However there were no significants differences in plantar foot pressure and toe angle. Conclusion: Although our study did not support the effect of exercises on plantar foot pressure and toe angle, we did show evidence that exercise was effective for balance. In order to increase the effectiveness of this exercise program, patients need to be more aware of the footwear they use in their daily lives so as to contribute to the contribute to the overall effectiveness of treating low to moderate hallux valgus and offer an alternative to surgery.

입체해석학을 통해 신경과학의 정보를 작업치료학에 어떻게 전달할수 있을까? (How does stereology help to inform translation from neuroscience to OT?)

  • 박지혁;이주현;박진혁
    • 재활치료과학
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    • 제3권2호
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    • pp.5-48
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    • 2014
  • 서론: 작업치료에서는 수행기술을 매우 중요하며, 이런 수행기술에는 감각 인지 기술, 운동실행 기술, 감정 조절기술, 인지기술, 소통 사회 기술 등이 있다. 모든 수행기술은 통합된 신경처리를 통해 이루어진다. 본론: 입체해석학(stereology)란 신경세포, 대뇌 겉질, 기능과 관련되어 뇌의 특정 영역의 형태 변화를 알아 낼 수 있는 과학적 방법이다. 입체해석학은 평면으로 잘려진 생물학적 샘플을 확률이론과 과학적 추출방법을 사용하여 3 차원적으로 분석하는 다학문분야이다. 편견 없는 입체해석학적 방법은 확률이론을 바탕으로하며, 생물학적 영역의 해부학적 형태적 변화를 예측할 수 있다. 부피, 숫자, 길이와 같은 세포구조적변화는 뇌의 기능에 영향을 미치게 된다. 작업치료사들은 신경계환자들의 뇌 기능을 향상시켜 참여를 증진하는 것을 목적으로 한다. 뇌기능 장애 환자들에게 있어 기능적 증진은 뇌의 변화를 의미한다. 그러므로 신경학적 변화와 기능적 증진에 대한 두 가지 증거는 신경계 환자들의 작업치료에 매우 중요한 기초적 치료 근거가 된다. 비록 입체해석학 자체가 실험이나 인체 사후 검사에 많이 쓰일지라도 입체해석학은 신경계 환자들의 작업치료에 근본적 지식들 제공한다. 결론: 그러므로 입체해석학은 신경과학의 지식들을 경험의존가소성과 수행기술에 대한 뇌의 구조-기능관계를 바탕으로 작업치료에 전달해 준다고 볼 수 있다.

생강 건조 분말의 임신 및 멀미에 의한 오심, 구토 개선 기능성에 대한 체계적 고찰 (Systematic review of the effect of dried ginger powder on improvement of nausea and vomiting associated with early pregnancy or motion sickness)

  • 곽진숙;백주은;정세원;김주희;김지연;권오란
    • Journal of Nutrition and Health
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    • 제47권1호
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    • pp.45-50
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    • 2014
  • 생강 건조 분말의 임신 또는 멀미로 인해 발생하는 오심, 구토 개선 기능성을 평가하기 위하여 체계적 고찰을 실시하였다. 2013년 3월 기준으로 DB 검색을 통해 870건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 12건의 연구가 평가되었다. 12건 (2,694명) 중 11건 (2,630명)의 연구에서 통계적으로 유의한 개선 효과 나타났으며 (p < 0.05), 효과를 보이는 일일 섭취량은 0.25~2.5 g이었다. 특히 임신부 대상 연구 9건에서는 모두 유의한 개선 효과를 보였고, 멀미에 대한 효과를 관찰한 3건의 연구 중 1,741명을 대상으로 한 대규모 연구 1건을 포함한 2건에서 구토를 유의하게 개선시키는 것으로 보고되었다. 해당 연구에서 모두 생강섭취로 인한 이상 반응은 없는 것으로 확인되었다.

Protein Intake Recommendation for Korean Older Adults to Prevent Sarcopenia: Expert Consensus by the Korean Geriatric Society and the Korean Nutrition Society

  • Jung, Hee-Won;Kim, Sun-Wook;Kim, Il-Young;Lim, Jae-Young;Park, Hyoung-Su;Song, Wook;Yoo, Hyung Joon;Jang, HakChul;Kim, Kirang;Park, Yongsoon;Park, Yoon Jung;Yang, Soo Jin;Lee, Hae-Jeung;Won, Chang Won
    • Annals of Geriatric Medicine and Research
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    • 제22권4호
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    • pp.167-175
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    • 2018
  • Sarcopenia, a common clinical syndrome in older adults, is defined as decreased muscle mass, strength, and physical performance. Since sarcopenia is associated with the incidence of functional decline, falls, and even mortality in older adults, researchers and health care providers have been keen to accumulate clinical evidence to advocate the screening and prevention of sarcopenia progression in older adults. The factors that may accelerate the loss of muscle mass and function include chronic diseases, inactivity, and deficiency in appropriate nutritional support. Among these, nutritional support is considered an initial step to delay the progression of muscle wasting and improve physical performance in community-dwelling older adults. However, a nationwide study suggested that most Korean older adults do not consume sufficient dietary protein to maintain their muscle mass. Furthermore, considering age-associated anabolic resistance to dietary protein, higher protein intake should be emphasized in older adults than in younger people. To develop a dietary protein recommendation for older adults in Korea, we reviewed the relevant literature, including interventional studies from Korea. From these, we recommend that older adults consume at least 1.2 g of protein per kg of body weight per day (g/kg/day) to delay the progression of muscle wasting. The amount we recommend (1.2 g/kg/day) is 31.4% higher than the previously suggested recommended daily allowance (i.e., 0.91 g/kg/day) for the general population of Korea. Also, evidence to date suggests that the combination of exercise and nutritional support may enhance the beneficial effects of protein intake in older adults in Korea. We found that the current studies are insufficient to build population-based guidelines for older adults, and we call for further researches in Korea.

북중국 우강 지역에 분포하는 호상철광상의 성인에 대한 지구화학적 연구 (Geochemical Studies of BIF in Wugang, North China Craton: Implication for the Genesis)

  • 문인경;이인성
    • 자원환경지질
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    • 제52권3호
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    • pp.213-221
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    • 2019
  • 우강 호상철광상은 북중국 남쪽 끝 부분의 타이후아 복합체에 위치 하고 있다. 본 연구에서는 우강 호상철광상에서 산출되는 철광석 시료의 전암 분석 결과의 해석을 통하여 우강 호상철광상의 유형과 성인을 이해하고자 하였다. 이 광상의 철광석의 조직은 밴딩 구조가 약하게 나타나는 것과, 밴딩 구조가 나타나지 않는 것 두 가지로 분류할 수 있다. 주요 구성 광물들은 조립질의 자철석, 석영, 휘석, 각섬석 등이다. 지구화학적 연구 결과 우강 호상철광상은 해수와 0.1~1 %를 차지하는 열수로부터 철을 공급받아 형성 되었다. 또한 이 과정에서 육지성 물질로부터의 철 공급이 있었음을 확인하였다. 이전 연구 결과와 종합해 보았을 때, 대부분의 철광석에서 Ce 이상치는 뚜렷하게 나타나지 않지만 일부 철광석에서는 음의 Ce 이상치를 보였다. 이러한 결과는 우강 호상철광상은 환원 환경이 우세한 해양 환경에서 형성되었지만, 상대적으로 산화된 해양의 표층 환경의 가능성을 제시해 준다. 이러한 지구 화학적 특징을 바탕으로 우강 호상철광상이 형성된 지구조적인 환경은 대륙붕 연안이나 후열도 분지환경이라 생각된다. 또한 우강 호상철광상은 혼성암, 각섬석 편마암, 규암, 대리암이 함께 산출되는데, 이는 연구 광상이 화산 활동과 밀접한 연관성이 없음을 지시한다. 본 연구에서는 지금까지 보고된 지구화학적 분석 결과와 이번 연구 결과를 종합해 우강 호상철광상이 슈피리어 유형 호상철광상의 특징을 보임을 확인하였다.

Pharmacoacupuncture for the Treatment of Frozen Shoulder: protocol for a systematic review and meta-analysis

  • Ji-Ho Lee;Hyeon-Sun Park;Sang-Hyeon Park;Dong-Ho Keum;Seo-Hyun Park
    • 대한약침학회지
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    • 제27권1호
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    • pp.14-20
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    • 2024
  • Objectives: Frozen shoulder (FS) is one of the most challenging shoulder disorders for patients and clinicians. Its symptoms mainly include any combination of stiffness, nocturnal pain, and limitation of active and passive glenohumeral joint movement. Conventional treatment options for FS are physical therapy, nonsteroidal anti-inflammatory drugs, injection therapy, and arthroscopic capsular release, but adverse and limited effects continue to present problems. As a result, pharmacoacupuncture (PA) is getting attention as an alternative therapy for patients with FS. PA is a new form of acupuncture treatment in traditional Korean medicine (TKM) that is mainly used for musculoskeletal diseases. It has similarity and specificity compared to corticosteroid injection and hydrodilatation, making it a potential alternative injection therapy for FS. However, no systematic reviews investigating the utilization of PA for FS have been published. Therefore, this review aims to standardize the clinical use of PA for FS and validate its therapeutic effect. Methods: The protocol was registered in Prospero (CRD42023445708) on 18 July 2023. Until Aug. 31, 2023, seven electronic databases will be searched for randomized controlled trials of PA for FS. Authors will be contacted, and manual searches will also be performed. Two reviewers will independently screen and collect data from retrieved articles according to predefined criteria. The primary outcome will be pain intensity, and secondary outcomes will be effective rate, Constant-Murley Score, Shoulder Pain and Disability Index, range of motion, quality of life, and adverse events. Bias and quality of the included trials will be assessed using the Cochrane handbook's risk-of-bias tool for randomized trials. Meta analyses will be conducted using Review Manager V.5.3 software. GRADE will be used to evaluate the level of evidence for each outcome. Results: This systematic review and meta-analysis will be conducted following PRISMA statement. The results will be published in a peer-reviewed journal. Conclusion: This review will provide scientific evidence to support health insurance policy as well as the standardization of PA in clinical practice.

Effects of Exogenous Enzymes on Ruminal Fermentation and Degradability of Alfalfa Hay and Rice Straw

  • Yang, H.E.;Son, Y.S.;Beauchemin, K.A.
    • Asian-Australasian Journal of Animal Sciences
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    • 제24권1호
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    • pp.56-64
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    • 2011
  • This study was conducted to evaluate the use of exogenous enzymes as a potential means of improving the ruminal digestion (i.e., degradability) of alfalfa hay and rice straw. Twenty six enzyme-additives were examined in terms of protein concentration and enzymic activities on model substrates. The exogenous enzymes contained ranges of endoglucanase, xylanase, ${\beta}$-glucanase, ${\alpha}$-amylase, and protease activities. Six of the enzyme additives were chosen for further investigation. The enzyme additives and a control without enzyme were applied to mature quality alfalfa hay substrate and subsequently incubated in rumen batch cultures. Five of the enzyme additives (CE2, CE13, CE14, CE19, and CE24) increased total gas production (GP) at 48 h of incubation compared to the control (p<0.05). The two additives (CE14 and CE24) having the greatest positive effects on alfalfa hay dry matter, neutral detergent fibre (NDF) and acid detergent fibre (ADF) degradability were further characterized for their ability to enhance degradation of low quality forages. The treatments CE14, CE24, a 50:50 combination of CE14 and CE24 (CE14+24), and control (no enzyme) were applied to mature alfalfa hay and rice straw. For alfalfa hay, application of the two enzyme additives, alone and in combination, increased GP compared to the control at 48 h fermentation (p<0.05), whereas only CE14 and CE14+24 treatments improved GP from rice straw (p<0.05). Rumen fluid volatile fatty acid concentrations throughout the incubation of rice straw were analyzed. Acetate concentration was slightly lower (p<0.05) for CE14${\times}$CE24 compared to the control, although individually, CE14 and CE24 acetate concentrations were not different from the control. Increases (p<0.05) in alfalfa hay NDF degradability measured at 12 and 48 h of incubation occurred only for CE14 (at 12 h) and for CE14+24 (at 12 and 48 h). Similarly, ADF degradability increased (p<0.05) with CE14 and CE14+24. As for rice straw, increased DM degradability was observed at 12 and 48 h of incubation for all enzyme treatments with an exception for CE14 at 12 h. The degradability of NDF was improved by all the enzyme treatments at either incubation time, while ADF degradability was only enhanced at 48 h. Overall, the enzymes led to enhanced digestion of mature alfalfa and there was evidence of improved digestibility of rice straw, an even lower quality forage.

Catalpol and Mannitol, Two Components of Rehmannia glutinosa, Exhibit Anticonvulsant Effects Probably via GABAA Receptor Regulation

  • Kim, Mikyung;Acharya, Srijan;Botanas, Chrislean Jun;Custodio, Raly James;Lee, Hyun Jun;Sayson, Leandro Val;Abiero, Arvie;Lee, Yong Soo;Cheong, Jae Hoon;Kim, Kyeong-man;Kim, Hee Jin
    • Biomolecules & Therapeutics
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    • 제28권2호
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    • pp.137-144
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    • 2020
  • Epilepsy is a brain disorder that affects millions of people worldwide and is usually managed using currently available antiepileptic drugs, which result in adverse effects and are ineffective in approximately 20-25% of patients. Thus, there is growing interest in the development of new antiepileptic drugs with fewer side effects. In a previous study, we showed that a Rehmannia glutinosa (RG) water extract has protective effects against electroshock- and pentylenetetrazol (PTZ)-induced seizures, with fewer side effects. In this study, the objective was to identify the RG components that are responsible for its anticonvulsant effects. Initially, a number of RG components (aucubin, acteoside, catalpol, and mannitol) were screened, and the anticonvulsant effects of different doses of catalpol, mannitol, and their combination on electroshock- and chemically (PTZ or strychnine)-induced seizures in mice, were further assessed. Gamma-aminobutyric acid (GABA) receptor binding assay and electroencephalography (EEG) analysis were conducted to identify the potential underlying drug mechanism. Additionally, treated mice were tested using open-field and rotarod tests. Catalpol, mannitol, and their combination increased threshold against electroshock-induced seizures, and decreased the percentage of seizure responses induced by PTZ, a GABA antagonist. GABA receptor binding assay results revealed that catalpol and mannitol are associated with GABA receptor activity, and EEG analysis provided evidence that catalpol and mannitol have anticonvulsant effects against PTZ-induced seizures. In summary, our results indicate that catalpol and mannitol have anticonvulsant properties, and may mediate the protective effects of RG against seizures.

기관지 선종의 외과적 치료[17례 보고] (Surgical Treatment of Bronchial Adenoma - Reports of 17 Cases -)

  • 문석환
    • Journal of Chest Surgery
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    • 제25권3호
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    • pp.247-257
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    • 1992
  • Bronchial adenoma, firstly described by Muller[1882] had been reported on the subject stressed their benign nature prior to 1940`s, but these tumors including carcinoid tumor, mucoepidermoid carcinoma, adenoid cystic carcinoma, pleomorphic adenoma are now known to possess the various degree of malignant natures from benign course, low grade malignant potential to distant lymphatic or hematogenous metastasis or combination. Although histologically diffeerent, four varieties except carcinoid tumor which is a spectrum of neu-roendocrine tumor originating Kulchitsky cell of the bronchial epithelium and form the part of the APUD tumor spectrum, are morphologically and in many respects clinically similar to the corresponding tumor of the salivary gland is a specific varient of adenocarcinoma that occurs most commonly in the major and minor salivary gland and less frequently tra-cheobronchial tree, esophagus etc. To better understand the clinical characteristics and assess more precisely the malignat nature of bronchial adenoma, we studied 17 cases of bronchial adenoma, which had been experienced at the Department of Thoracic and Cardiovascular surgery of Catholic University Medical College from April 1977 to september 1991. Seventeen cases of bronchial adenoma consist of 2 carcinoid tumors, 6 adenoid cystic carcinomas, 8 mucoepidermoid carcinomas and one pleomorphic adenoma. There is a slight predominace of male patients[10/17] and the age of pt studied varied with a higher incidence occurring between the ages of 40 years and 60 years[mean age, 46.5 years]; the youngest being 15 years and oldest 69 years. Their leading complaints were hemoptysis[4], exertional dyspnea[8], fever & chilness [4], and symptoms mimicking the bronchial asthma[4]. Diagnosis was aided by the radiologic studies such as chest X-ray, polytomography, CT scan, brochography and bronchoscopy. The preferred locations of fumor were in the trachea[4], main stem bronchus[3], bronchus intermedius[3], bronchus of RUL[2], LUL[1], RLL[1], LLL[3] with no peripheral location. Modalities of treatments were single or combination of surgical resection, radiation therapy, chemotherapy. Complete resections were permitted in 12 cases with late recurrences of 4 cases ranging from 6 months to 10 years: pneumonectomy[4], lobectomy[4], bil-obectomy[2], sleeve resection[2]. Gross findings of resected specimens in 14 cases showed that 4 cases were polyp-like pedunculated mass[entirely intraluminal mass] with intact mucosa, 8 cases were broad-bas-ed sessile mass[predominatly intraluminal] and the main portions were located below the mucosa similar to tip of iceburg[predominantly extraluminal] in 2 cases. Follow-up information was availble in all 17 cases ; eight were alive without evidence of disese ranging from 1 month to 13 years. But seven cases died of the causes related to tumor[6 cases within 12 months, one case 10 years after pneumonectomy]. We concluded that 8 cases[47%] of 17 cases were metastasizing bronchial adenoma and precise survival rate cannot be answered by the scanty materials available for study.

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합성 Calcium Sulfoaluminate계 시멘트 수화물의 Trichloroethylene (TCE) 제거능 (Trichloroethylene (TCE) Removal Capacity of Synthesized Calcium Sulfoaluminate Minerals in Hydrated Cement-based Materials)

  • 하민규;고르파데 프라빈;김정주;박주양
    • 대한토목학회논문집
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    • 제33권4호
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    • pp.1463-1469
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    • 2013
  • 고화제로 사용되는 포틀랜드 시멘트와 2가철을 이용하여 염소계 유기화합물을 탈염소화 시키는 기술은 많은 연구로부터 알려져 왔다. 하지만 TCE (trichloroethylene)의 탈염소화에 관계하는 명확한 유효물질 및 기작 규명은 요원한 상태이다. 많은 연구에서 ettringite와 monosulfate와 같은 시멘트 수화물질이 TCE의 탈염소화 반응에 관여할 가능성을 보고한 바 있다. 따라서 본 연구에서는 TCE의 탈염소화 반응에 유효물질로 예상 되어왔던 ettringite와 monosulfate를 별도로 합성하여, TCE 제거 실험을 수행함으로서 기존 시멘트/2가철을 사용한 TCE 분해제거에 관계하는 명확한 유효물질 및 기작을 규명 하고자 하였다. 실험결과, $Fe^{3+}$$Al^{3+}$로 구성된 ettringite, monosulfate 합성에 성공하였고, 이후 2가철을 첨가하여 TCE 분해실험에서 합성물의 분해능을 확인하였지만 뚜렷한 제거가 나타나지 않았다. 이는 기존문헌의 예상과는 상반된 결과를 나타냈으며, 실험결과를 통해 시멘트/2가철을 사용한 TCE 제거 실험의 분해기작을 예상할 수 있었다. 예상 되는 분해기작으로는 ettringite 및 monosulfate 외의 시멘트 수화물에 의한 것과 C3A외의 시멘트 클링커 화합물 그리고 시멘트 내 trace metal에 의한 영향일 것으로 추측하였다.