Catalpol and Mannitol, Two Components of Rehmannia glutinosa, Exhibit Anticonvulsant Effects Probably via GABAA Receptor Regulation |
Kim, Mikyung
(Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University)
Acharya, Srijan (Department of Pharmacology, College of Pharmacy, Chonnam National University) Botanas, Chrislean Jun (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University) Custodio, Raly James (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University) Lee, Hyun Jun (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University) Sayson, Leandro Val (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University) Abiero, Arvie (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University) Lee, Yong Soo (Department of Pharmacology, College of Pharmacy, Duksung Women's University) Cheong, Jae Hoon (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University) Kim, Kyeong-man (Department of Pharmacology, College of Pharmacy, Chonnam National University) Kim, Hee Jin (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University) |
1 | Gao, J., An, L., Xu, Y. and Huang, Y. (2018) Catalpol exerts an antiepilepticus effect, possibly by regulating the Nrf2-Keap1-ARE signaling pathway. Med. Sci. Monit. 24, 9436-9441. DOI |
2 | Grauncke, A. C., Souza, T. L., Ribeiro, L. R., Brant, F., Machado, F. S. and Oliveira, M. S. (2016) Increased susceptibility to pentylenetetrazol following survival of cerebral malaria in mice. Epilepsia 57, e140-e145. DOI |
3 | Haglund, M. M. and Hochman, D. W. (2005) Furosemide and mannitol suppression of epileptic activity in the human brain. J. Neurophysiol. 94, 907-918. DOI |
4 | Hamoy, M., dos Santos Batista, L., de Mello, V. J., Gomes-Leal, W., Farias, R. A. F., dos Santos Batista, P., do Nascimento, J. L. M., Marcondes, H. C., Taylor, J. G., Hutchison, W. D., Torres, M. F. and Barbas, L. A. L. (2018) Cunaniol-elicited seizures: behavior characterization and electroencephalographic analyses. Toxicol. Appl. Pharmacol. 360, 193-200. DOI |
5 | Hansen, S. L., Sperling, B. B. and Sanchez, C. (2004) Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole- kindled mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 28, 105-113. DOI |
6 | Hauser, W. A. (1992) Seizure disorders: the changes with age. Epilepsia 33, 6-14. DOI |
7 | Heaulme, M., Chambon, J. P., Leyris, R., Wermuth, C. G. and Biziere, K. (1987) Characterization of the binding of [3H] SR 95531, a GA-BAA antagonist, to rat brain membranes. J. Neurochem. 48, 1677-1686. DOI |
8 |
Huang, R. Q., Bell-Horner, C. L., Dibas, M. I., Covey, D. F., Drewe, J. A. and Dillon, G. H. (2001) Pentylenetetrazole-induced inhibition of recombinant |
9 | Kim, M., Kim, H. J., Kim, S. M., De La Pena, J. B., Botanas, C. J., Woo, T., Lee, Y. S., Ryu, J. H. and Cheong, J. H. (2017) Protection against electroshock-and pentylenetetrazol-induced seizures by the water extract of rehmannia glutinous can be mediated through GABA receptor-chloride channel complexes. Nat. Prod. Sci. 23, 40-45. DOI |
10 |
Kim, H., An, C. S., Jung, K. Y., Choo, Y. K., Park, J. K. and Nam, S. Y. (1999) Rehmannia glutinosa inhibits tumour necrosis factor- |
11 | Kim, S. S., Son, Y. O., Chun, J. C.,Kim, S. E., Chung, G. H., Hwang, K. J. and Lee, J. C. (2005) Antioxidant property of an active component purified from the leaves of paraquat-tolerant Rehmannia glutinosa. Redox Rep. 10, 311-318. DOI |
12 | Larson, A. A. and Beitz, A. (1988) Glycine potentiates strychnine-induced convulsions: role of NMDA receptors. J. Neurosci. 8, 3822-3826. DOI |
13 | Lee, S., Yean, M., Kim, J., Lee, J. and Kang, S. (2011) Phytochemical studies on rehmanniae radix preparata. Korean J. Pharmacogn. 42, 127-137. |
14 | Loscher, W., Fassbender, C. P. and Nolting, B. (1991) The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models. Epilepsy Res. 8, 79-94. DOI |
15 | Pontes, J. C., Lima, T. Z., Queiroz, C. M., Cinini, S. M., Blanco, M. M. and Mello, L. E. (2016) Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. Epilepsy Res. 126, 16-25. DOI |
16 | Luttjohann, A., Fabene, P. F. and van Luijtelaar, G. (2009) A revised Racine's scale for PTZ-induced seizures in rats. Physiol. Behav. 98, 579-586. DOI |
17 | Lynch, J. W. (2004) Molecular structure and function of the glycine receptor chloride channel. Physiol. Rev. 84, 1051-1095. DOI |
18 | Pellmar, T. and Wilson, W. (1977) Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance. Science 197, 912-914. DOI |
19 | Quintans Junior, L. J., Almeida, J. R., Lima, J. T., Nunes, X. P., Siqueira, J. S., Oliveira, L. E. G. D., Almeida, R. N., Athayde-Filho, P. F. D. and Barbosa-Filho, J. M. (2008) Plants with anticonvulsant properties: a review. Rev. Bras. Farmacogn. 18, 798-819. DOI |
20 | Rogawski, M. A. and Porter, R. J. (1990) Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev. 42, 223-286. |
21 | Schmidt, D. and Schachter, S. C. (2014) Drug treatment of epilepsy in adults. BMJ 348, 130-136. DOI |
22 | Serafini, R. (2017) A comparison of anticonvulsant efficacy and action mechanism of Mannitol vs Phenytoin in adult rat neocortical slices. IBRO Rep. 3, 55-64. DOI |
23 | Berezhnoy, D., Nyfeler, Y., Gonthier, A., Schwob, H., Goeldner, M. and Sigel, E. (2004) On the benzodiazepine binding pocket in GABAA receptors. J. Biol. Chem. 279, 3160-3168. DOI |
24 | Tan, K. R., Baur, R., Charon, S., Goeldner, M. and Sigel, E. (2009) Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors. J. Neurochem. 111, 1264-1273. DOI |
25 | Tomoda, M., Kato, S. and Mie, O. (1971) Water-soluble constituents of rehmanniae radix. I. Carbohydrates and acids of Rehmannia glutinosa f. hueichingensis. Chem. Pharm. Bull. 19, 1455-1460. DOI |
26 | Woo, T. S., Yoon, S. Y., dela Pena, I. C., Choi, J. Y., Lee, H. L., Choi, Y. J. and Cheong, J. H. (2011) Anticonvulsant effect of Artemisia capillaris Herba in mice. Biomol. Ther. (Seoul) 19, 342-347. DOI |
27 | Yoon, S. Y., dela Pena, I. C., Shin, C. Y., Son, K. H., Lee, Y. S., Ryu, J. H., Cheong, J. H. and Ko, K. H. (2011) Convulsion-related activities of Scutellaria flavones are related to the 5, 7-dihydroxyl structures. Eur. J. Pharmacol. 659, 155-160. DOI |
28 | Zhang, R. X., Li, M. X. and Jia, Z. P. (2008) Rehmannia glutinosa: review of botany, chemistry and pharmacology. J. Ethnopharmacol. 117, 199-214. DOI |
29 | Baek, G. H., Jang, Y. S., Jeong, S. I., Cha, J., Joo, M., Shin, S. W., Ha, K. T. and Jeong, H. S. (2012) Rehmannia glutinosa suppresses inflammatory responses elicited by advanced glycation end products. Inflammation 35, 1232-1241. DOI |
30 | Begley, C. E., Famulari, M., Annegers, J. F., Lairson, D. R., Reynolds, T. F., Coan, S., Dubinsky, S., Newmark, M. E., Leibson, C., So, E. L. and Rocca, W. A. (2000) The cost of epilepsy in the United States: an estimate from population-based clinical and survey data. Epilepsia 41, 342-351. DOI |
31 | Cheng, Y. C. and Prusoff, W. H. (1973) Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem. Pharmacol. 22, 3099-3108. DOI |
32 | Chou, T. C. and Talalay, P. (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Enzym. Regul. 22, 27-55. DOI |
33 | Deyn, P. P. D., Marescau, B. and MacDonald, R. (1989) Epilepsy and the GABA-hypothesis a brief review and some examples. Acta Neurol. Belg. 90, 65-81. |
34 | Fisher, R. S., Vickrey, B. G., Gibson, P., Hermann, B., Penovich, P., Scherer, A. and Walker, S. (2000) The impact of epilepsy from the patient's perspective II: views about therapy and health care. Epilepsy Res. 41, 53-62. DOI |
35 | Fisher, R. S., van Emde Boas, W., Blume, W., Elger, C., Genton, P., Lee, P. and Engel, J., Jr. (2005) Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 46, 470-472. DOI |
![]() |