• The Journal of Korean Academy of Sensory Integration
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• v.8 no.1
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• pp.41-49
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• 2010

Objective : Multisensory integration (MSI) is the essential process to use diverse sensory information for cognitive task or execution of motor action. Especially, visual and somatosensory integration is critical for motor behavior and coordination. This study was designed to explain spatial and temporal characteristics of visual and somatosensory integration by neurophysiological research method that identifies the time course and brain location of the SI process. Methods : Electroencephalography (EEG) and event-related potential (ERP) is used in this study in order to observe neural activities when integrating visual and tactile input. We calculate the linear summation (SUM) of visual-related potentials (VEPs) and somatosensory-related potentials (SEPs), and compared the SUM with simultaneously presented visual-tactile ERPs(SIM) Results : There were significant differences between the SIM and SUM in later time epochs (about 200-300ms) at contralateral somatosensory areas (C4) and occipital cortices (O1&O2). The amplitude of the SIM was mathematically larger than the summed signals, implying that the integration made some extra neural activities. Conclusion : This study provides some empirical neural evidence of that multisensory integration is more powerful than just combing two unisensory inputs in the brain and ERP data reveals neural signature relating to multisensory integrative process. Since this study is preliminary pilot study, larger population and criteria are needed for level of the significance. Further study is recommended to consider issues including effect of internally-driven attention and laterality of interaction to make the evidence by this study solid.

• Annals of Clinical Neurophysiology
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• v.1 no.1
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• pp.26-30
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• 1999

Background : The origin of P300 was still on debate nbut thought to be in the frontal, temporal or parietal lobe. As the transcranial doppler ultrasonography(TCD) gives us and opportunity to observe hemodynamic chaged dynamically and the middle cerebral artery feeds these ares of the hemisphere, we observed the change of mean flow velocity of MCA during the event related potential test(ERP) to determine the role of these structures in P300 generation. Method : Twenty normal subjects(male : 13, age : 24-29 years) performed ERP. An auditory oddball pardigm was used to elicit the ERPs. TCD examination was performed with 2-MHz probe monitoring the left MCA(Transscan, EME). After signal identification and adjustments to maximize the Doppler signal strength, the probe was mechanically locked during the monitoring. The changes of blood flow velocity of the left middle cerebral artery(MCA) induced by cognitive demands were monitored. The measurement of the meal flow velocities(MFV) of MCA were made while the subjects were prior to, during, and after ERP. We recorded the MFVs during ERP. Statistical analysis was performed using t-tests with SPSS-PC for windows release 6.0. Results : All subjects showed a relative increase in MFV of MCA during the task. The mean rise was about 3.2-4.2%(p <0.05). Although TCD does not measure absolute values of regional cerebral blood flow(rCBF) or absolute rCBF changes, changes of flow velocity can reflect relative rCBF changes. Conclusions : The generation site of P300 still remains unclear but the neocortical, thalamic and limbic region and temporal-parietal cortex have been proposed. The MCA supplies these anatomical structures. The Changes of flow veolocity of MCA during the ERP test suggest that the some part of the brain fed y the MCA activate of the temporal lobe or parietal lobes, we can deduce that some parts of brain fed by the MCA participate in the generation of P300.

• 제어로봇시스템학회:학술대회논문집
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• 1994.10a
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• pp.1.1-5
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• 1994

In the single sweep record of event-related potential (ERP), the peak latency of P300, which is one of the most prominent positive peaks in the ERP record, might fluctuate according to the recording conditions. The fluctuation of the peak latency (measurement fluctuation) is the summation of the fluctuation caused by physiological factor (physiological fluctuation) and one by noise of background EEG (noise fluctuation). We propsed a method for estimating the interval of the physiological fluctuation based on a limited number of single sweep records. The noise fluctuation was estimated by using the relationship between the signal-to-noise (SN) ratio and the noise fluctuation based on the P300 model and the background EEG model. The interval estimate of the physiological fluctuation were obtained by subtracting the interval estimate of the noise fluctuation from that of the measurement fluctuation. The proposed method was tested by using simulation data of ERP and applied to actual ERP and data of normal subjects, and gave satisfactory results.

• Journal of Biomedical Engineering Research
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• v.43 no.1
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• pp.52-60
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• 2022

Purpose: For now, cognitive load is assessed based on survey-based methods, which can be difficult to track the amount of cognitive load in real-time. In this study, we investigated the difference in electrophysiological activation due to different levels of cognitive load not only at sensor-level but also at source-level using electroencephalogram that might be potentially used for quantitative cognitive load evaluation. Materials and Methods: In this study, ten healthy subjects (mean age 24.3 ± 2.1, three female) participated the experiment. All participants performed 4 sessions of n-back task in different difficulties: 0-, 1-, 2-, and 3-back during electroencephalogram recording. For sensor-level analysis, we calculated the event-related potential and event-related spectral perturbation while low resolution brain electromagnetic tomography (LORETA) to estimate the source activation. Each result was compared between different workload conditions using statistical analysis. Results: Statistical results revealed that the accuracy of the task performance was significantly different between different cognitive loads (p = 0.018). The post-hoc analysis confirmed that the accuracy of the 3-back task was significantly decreased compared to 1-back condition (p = 0.018), but not with 2-back condition (p = 0.180). ERP results showed that P300 target amplitude between 1-back and 3-back had a marginal difference in Cz (p = 0.059) and Pz(p = 0.093). A significant inhibition in Cz high-beta activation (p = 0.017) and decrease in source activation of right parahippocampal gyrus was found in 3-back condition compared to 1-back condition (p < 0.05). Conclusion: In this study, we compared the sensor- and source-level differences in electroencephalogram between different levels of cognitive load, that were found to be in line with the previous reports related to cognitive load evaluation. We expect that the outcome of the current study can be used as a feature to establish a quantitative cognitive load assessment system.

• Anxiety and mood
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• v.6 no.1
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• pp.31-36
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• 2010

Objective : Mismatch negativity (MMN) provides an electrophysiological index of an involuntary attention switching process. This study investigated MMN anomalies and their relationship to clinical variables in patients with obsessive-compulsive disorder (OCD). Methods : Study participants were 29 OCD patients and 24 normal controls. We used a 128-channel EEG to measure MMN during a passive oddball paradigm. Then we assessed the correlations between MMN amplitudes and clinical measures. Results : The OCD patients exhibited significantly greater MMN amplitude compared to the controls. Also, the right frontal lobe MMN amplitudes correlated significantly to the OCD patients' Yale-Brown Obsessive Compulsive Scale total scores (r=-0.520, p=0.005). Conclusion : These results suggest that MMN anomalies in OCD patients reflect a monitoring circuit dysfunction, raising the possibility that the OCD's pathophysiology includes glutamatergic dysfunction.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2011.07a
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• pp.490-493
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• 2011

최근 사용자와 컴퓨터간의 상호작용이 가능한 사용자 인터페이스(UI, User Interface)에 대한 연구가 활발히 진행되고 있다. 이중 키보드나 마우스, 리모컨과 같은 별도의 입력장치가 없이 뇌의 활동으로부터 발생하는 생체신호를 이용하여 사용자의 생각만으로 컴퓨터와 커뮤니케이션을 할 수 있는 뇌만으로 컴퓨터와 커(BCI, Brain-Computer Interface) 시스템이 각광을 받고 있다. 본 연구에서는 뇌의 생체신호로는 뇌전도도(EEG, Electroencephalogram)를 사용하였으며, 이를 통하여 P300 speller 실험을 수행하였다. P300 speller 실험을 통하여 발생된 뇌전도도를 취합하여 P300(사건 관련 전위(ERP, Event-related potential)에서 자극 제시 약 300msec 후에 정점에 달하는 정파)을 분석하였다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2023.07a
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• pp.357-358
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• 2023

본 연구는 실제 행동과 운동 심상으로 팔과 다리 동작 인식을 위한 BCI 패러다임을 제안하고 유도성 분석을 한다. 이 페러다임은 각 팔과 양다리의 특정 움직임을 인식하기 위해 ERP를 기반 페러다임을 구성한다. BCI 페러다임은 왼팔, 오른팔, 양다리를 움직이는 영상 자극을 주며 이를 기반으로 왼팔, 오른팔, 양다리 움직임에 대한 인식을 한다. 거울뉴런은 실제 행동과 실제 행동을 보았을때와 운동심상을 통한 자극을 받았을 때 같은 뉴런이 활성화된다는 성질을 가지고 있다. 이러한 성질을 이용하여 운동심상만과 실제 행동을 동시에 학습할 경우를 유도성 분석을 진행한다. 또한 유도성 특징 분석을 통해 나타난 결과를 바탕으로 BCI 패러다임을 제안한다.

• Korean Journal of Biological Psychiatry
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• v.19 no.3
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• pp.115-120
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• 2012

Objectives : Event-related potentials have been suggested as an objective marker for brain functions in psychiatric disorders. This study was aimed to investigate the relationships between P300, the mismatch negativity (MMN), the loudness dependence of the auditory evoked potential (LDAEP), demographic and clinical variables including neurocognitive abilities in patients with schizophrenia. Methods : P300, the MMN, and the LDAEP were measured and the Korean Stroop color-word test (K-stroop test) and the Wisconsin Card Sorting Test (WCST) were performed in 43 patients with schizophrenia. The relationship of the latency and amplitude of P300 and the MMN as well as regression slope of the LDAEP with demographic and clinical variables were analyzed by t-test and correlation analyses for categorical and continuous variables, respectively. Results : After controlling for age, the latency of central (Cz) and parietal (Pz) P300 posivitively correlated with GAF at admission (Cz ; ${\gamma}$ = 0.385, p = 0.047, Pz ; ${\gamma}$ = 0.421, p = 0.029). The amplitude of parietal P300 correlated with the correction rate of the K-stroop test (${\gamma}$ = 0.575, p = 0.002). In addition, the frontal (Fz) P300 latency tended to negatively correlated with the correction rate of the WCST (${\gamma}$ = -0.371, p = 0.057). Conclusions : Our findings suggest that the values of P300 latency and amplitude might be correlated with GAF at admission and working memory measured by the K-Stroop test and the WCST. Meanwhile, the MMN and the LDAEP did not correlate with demographic and clinical variables. These results support the results of previous studies showing associations with P300 and impaired cognitive ability.

• Science of Emotion and Sensibility
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• v.18 no.2
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• pp.85-100
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• 2015

This study aimed at examining if the original memory remains after a misinformation is presented, using Event-Related Potential based Concealed Information Test (ERP-based CIT). In the first stage of the study, the participant was presented with either the original information or a misleading information after experiencing an event (Post-information). The second stage was to measure brain wave and reaction time on the original, misleading, and irrelevant information (CIT-Stimulus). P300 amplitude, P300 area, P300 latency, and reaction time were used as dependant variables. In the result, a significant Post-information ${\times}$ CIT-Stimulus interaction effect was found on the P300 area measured at Cz, Pz, and Oz area. This interaction effect implied the possibility that the original information could be partially impaired in memory by misleading information presented afterward. P300 amplitude at Pz area did not differ between the accurate and the misleading stimuli in the condition in which a misleading information was presented. This result can be explained by source monitoring error. In discussion, the limitations of this study and directions of future studies were discussed.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.10 no.1
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• pp.9-15
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• 2017

In this study we performed the experiment to detect the ERP using SVM with wavelet features. The EEG signal that is generated visual stimulated ERP database in SCCN applied for the experiment. The feature vectors for experiment are categorized frequency and continuous wavelet- based vectors. In experimental results, the detection rate of SVM with wavelet feature vectors improved above 10% comparing with frequency- based feature vector. Based on the experimental results we analyzed the relation between the activity degree of the ERP and the band split characteristics of the ERP by wavelet transform.