Browse > Article

Abnormal Mismatch Negativity in Patients with Obsessive-Compulsive Disorder  

Jang, Joon-Hwan (Department of Psychiatry, Seoul National University College of Medicine)
Shin, Kyung-Soon (Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC)
Son, June-Hee (Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University)
Kwon, Jun-Soo (Department of Psychiatry, Seoul National University College of Medicine)
Publication Information
Anxiety and mood / v.6, no.1, 2010 , pp. 31-36 More about this Journal
Abstract
Objective : Mismatch negativity (MMN) provides an electrophysiological index of an involuntary attention switching process. This study investigated MMN anomalies and their relationship to clinical variables in patients with obsessive-compulsive disorder (OCD). Methods : Study participants were 29 OCD patients and 24 normal controls. We used a 128-channel EEG to measure MMN during a passive oddball paradigm. Then we assessed the correlations between MMN amplitudes and clinical measures. Results : The OCD patients exhibited significantly greater MMN amplitude compared to the controls. Also, the right frontal lobe MMN amplitudes correlated significantly to the OCD patients' Yale-Brown Obsessive Compulsive Scale total scores (r=-0.520, p=0.005). Conclusion : These results suggest that MMN anomalies in OCD patients reflect a monitoring circuit dysfunction, raising the possibility that the OCD's pathophysiology includes glutamatergic dysfunction.
Keywords
Obsessive-compulsive disorder; Mismatch negativity; Event-related brain potential;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Karno M, Golding JM, Sorenson SB, Burnam MA. The epidemiology of obsessive-compulsive disorder in five US communities. Arch Gen Psychiatry 1988;45:1094-1099.   DOI   ScienceOn
2 Opitz B, Rinne T, Mecklinger A, von Cramon DY, Schroger E. Differential contribution of frontal and temporal cortices to auditory change detection: fMRI and ERP results. Neuroimage 2002;15:167-174.   DOI   ScienceOn
3 Rosenberg DR, MacMaster FP, Keshavan MS, Fitzgerald KD, Stewart CM, Moore GJ. Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psychiatry 2000;39:1096-1103.   DOI   ScienceOn
4 Whiteside SP, Port JD, Deacon BJ, Abramowitz JS. A magnetic resonance spectroscopy investigation of obsessive-compulsive disorder and anxiety. Psychiatry Res 2006;146:137-147.   DOI   ScienceOn
5 Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, et al. Riluzole augmentation in treatment-resistant obsessivecompulsive disorder: an open-label trial. Biol Psychiatry 2005;58:424-428.   DOI   ScienceOn
6 Baxter LR Jr, Phelps ME, Mazziotta JC, Guze BH, Schwartz JM, Selin CE. Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Arch Gen Psychiatry 1987;44:211-218.   DOI   ScienceOn
7 van Zuijen TL, Sussman E, Winkler I, Naatanen R, Tervaniemi M. Grouping of sequential sounds--an event-related potential study comparing musicians and nonmusicians. J Cogn Neurosci 2004;16:331-338.   DOI   ScienceOn
8 Escera C, Alho K, Winkler I, Naatanen R. Neural mechanisms of involuntary attention to acoustic novelty and change. J Cogn Neurosci 1998;10:590-604.   DOI   ScienceOn
9 Swedo SE, Schapiro MB, Grady CL, Cheslow DL, Leonard HL, Kumar A, et al. Cerebral glucose metabolism in childhood-onset obsessive- compulsive disorder. Arch Gen Psychiatry 1989;46:518-523.   DOI   ScienceOn
10 Gehring WJ, Himle J, Nisenson LG. Action-monitoring dysfunction in obsessive-compulsive disorder. Psychol Sci 2000;11:1-6.   DOI   ScienceOn
11 Hajcak G, Franklin ME, Foa EB, Simons RF. Increased error-related brain activity in pediatric obsessive-compulsive disorder before and after treatment. Am J Psychiatry 2008;165:116-123.   DOI
12 Oades RD, Dittmann-Balcar A, Zerbin D, Grzella I. Impaired attention- dependent augmentation of MMN in nonparanoid vs paranoid schizophrenic patients: a comparison with obsessive-compulsive disorder and healthy subjects. Biol Psychiatry 1997;41:1196-1210.   DOI   ScienceOn
13 Kerns JG, Cohen JD, MacDonald AW 3rd, Cho RY, Stenger VA, Carter CS. Anterior cingulate conflict monitoring and adjustments in control. Science 2004;303:1023-1026.   DOI   ScienceOn
14 Kreitschmann-Andermahr I, Rosburg T, Demme U, Gaser E, Nowak H, Sauer H. Effect of ketamine on the neuromagnetic mismatch field in healthy humans. Brain Res Cogn Brain Res 2001;12:109-116.   DOI   ScienceOn
15 Hwang SS, Kim CH. Obsessive-compulsive disorder and glutamatergic dysfunction. Anxiety Mood 2007;3:20-25.
16 First MB, Spitzer RL, Gibbon M, Williams JB. Structured clinical interview for DSM-IV Axis I disorder. New York: New York State Psychiatric Institute;1996.
17 Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989;46: 1006-1011.   DOI   ScienceOn
18 Kim JS, Lee YS. Validity of short forms of the korean-wechsler adult intelligence scale. Korean J Clin Psychol 1995;14:111-116.
19 Naatanen R, Paavilainen P, Rinne T, Alho K. The mismatch negativity (MMN) in basic research of central auditory processing: a review. Clin Neurophysiol 2007;118:2544-2590.   DOI   ScienceOn
20 Vuust P, Pallesen KJ, Bailey C, van Zuijen TL, Gjedde A, Roepstorff A, et al. To musicians, the message is in the meter pre-attentive neuronal responses to incongruent rhythm are left-lateralized in musicians. Neuroimage 2005;24:560-564.   DOI   ScienceOn
21 Javitt DC. Intracortical mechanisms of mismatch negativity dysfunction in schizophrenia. Audiol Neurootol 2000;5:207-215.   DOI   ScienceOn
22 Youn T, Park HJ, Kim JJ, Kim MS, Kwon JS. Altered hemispheric asymmetry and positive symptoms in schizophrenia: equivalent current dipole of auditory mismatch negativity. Schizophr Res 2003;59:253-260.   DOI   ScienceOn
23 Sams M, Paavilainen P, Alho K, Naatanen R. Auditory frequency discrimination and event-related potentials. Electroencephalogr Clin Neurophysiol 1985;62:437-448.   DOI   ScienceOn
24 Doeller CF, Opitz B, Mecklinger A, Krick C, Reith W, Schroger E. Prefrontal cortex involvement in preattentive auditory deviance detection: neuroimaging and electrophysiological evidence. Neuroimage 2003;20:1270-1282.   DOI   ScienceOn
25 Kang DH, Kwon JS, Kim JJ, Youn T, Park HJ, Kim MS, et al. Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessivecompulsive disorder. Acta Psychiatr Scand 2003;107:291-297.   DOI   ScienceOn
26 Gu BM, Park JY, Kang DH, Lee SJ, Yoo SY, Jo HJ, et al. Neural correlates of cognitive inflexibility during task-switching in obsessive- compulsive disorder. Brain 2008;131:155-164.
27 Naatanen R, Kahkonen S. Central auditory dysfunction in schizophrenia as revealed by the mismatch negativity (MMN) and its magnetic equivalent MMNm: a review. Int J Neuropsychopharmacol 2009;12:125-135.   DOI   ScienceOn
28 Lee CK, Kwak YS, Yamamoto J, Rhee H, Kim YS, Han JH, et al. Psychiatric epidemiology in Korea. Part I: Gender and age differences in Seoul. J Nerv Ment Dis 1990;178:242-246.   DOI
29 Jang JH, Kwon JS, Jang DP, Moon WJ, Lee JM, Ha TH, et al. A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder. Am J Psychiatry 2006;163:1202-1207.   DOI   ScienceOn
30 Kwon JS, Jang JH, Choi JS, Kang DH. Neuroimaging in obsessivecompulsive disorder. Expert Rev Neurother 2009;9:255-269.   DOI   ScienceOn
31 Garrido MI, Kilner JM, Stephan KE, Friston KJ. The mismatch negativity: a review of underlying mechanisms. Clin Neurophysiol 2009; 120:453-463.   DOI   ScienceOn