• 디지털융복합연구
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• 제15권8호
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• pp.501-509
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• 2017

본 연구는 과훈련에 따른 선수의 인지정보처리와 정서변화에 관련된 국내 외 문헌들을 고찰하여 과훈련 시 유발되는 신체적 피로감이 어떻게 선수들의 인지정보처리와 정서변화에 미치는 영향을 신경생리학적으로 연구할 필요성을 제시하고, 스포츠 현장에서 활동하고 있는 선수와 코치들에게 뇌 생리적 관점에서 과훈련 증상에 대한 이해를 높일 수 있는 기초자료를 제공하는데 있다. 전자데이터베이스를 이용하여 최근 20년간 발행된 국내외 학술자료 및 연구보고서 등을 검토하였으며, 검색된 학술 문헌 중 본 연구의 목적에 부합되는 문헌들을 중심으로 검토하였다. 검토한 문헌을 바탕으로 과훈련에 따른 선수의 인지정보처리와 정서변화에 대하여 검토한 결과, 신체의 피로감이 과훈련을 통해 누적되어 운동수행 저하뿐만 아니라 선수들의 인지 및 정서적 능력 측면에서도 문제가 발생될 수 있다는 것을 알 수 있었다. 그리고 ERP를 이용한 P300의 진폭과 잠재기 및 EEG를 이용한 대뇌반구비대칭 차이지표를 이용한 접근은 과훈련이 인지정보처리과정과 정서적 변화에 미치는 효과를 뇌생리심리적으로 이해시킬 수 있는 새로운 연구방법의 가능성도 확인하였다.

• 무역상무연구
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• 제18권
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• pp.27-62
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• 2002

The international sale contract is the central contracts in export-import transactions. A good sale contract or set of general conditions of sale will cover all the principal elements of the transaction, so that uncertainties are avoided. The parties' respective duties as concern the payment mechanism, transport contract and insurance responsibilities, inter alia, will all be clearly detailed in the contract. The following key clauses should be included in international contracts of sale and general conditions of sale: ${\bullet}$ preamble ${\bullet}$ identification of parties ${\bullet}$ description of goods ${\bullet}$ price and payment conditions ${\bullet}$ delivery periods and conditions ${\bullet}$ inspection of the goods - obligations and limitations ${\bullet}$ quantity or quality variations in the products delivered ${\bullet}$ reservation of title and passing of property rights ${\bullet}$ transfer of risk - how accomplished ${\bullet}$ seller's warranties and buyer's complaints ${\bullet}$ assignment of rights ${\bullet}$ force majeure clause and hardship clause ${\bullet}$ requirement that amendments and modifications be in writing ${\bullet}$ choice of law ${\bullet}$ choice of dispute resolution mechanism Under most systems of law, a party can be excused from a failure to perform a contract obligation which is caused by the intervention of a totally unforeseeable event, such as the outbreak of war, or an act of God such as an earthquake or hurricane. Under the American commercial code (UCC) the standard for this relief is one of commercial impracticability. In contrast, many civil law jurisdictions apply the term force majeure to this problem. Under CISG, the standard is based on the concept of impediments to performance. Because of the differences between these standards, parties might be well advised to draft their own force majeure, hardship, or excusable delays clause. The ICC publication, "Force Majeure and Hardship" provides a sample force majeure clause which can be incorporated by reference, as well as a hardship clause which must be expressly integrated in the contract. In addition, the ICC Model provides a similar, somewhat more concise formulation of a force majeure clause. When the seller wishes to devise his own excusable delays clause, he will seek to anticipate in its provision such potential difficulties as those related to obtaining government authorisations, changes in customs duties or regulations, drastic fluctuations in labour, materials, energy, or transportation prices, etc.

• 감성과학
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• 제17권2호
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• pp.3-12
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• 2014

기부 광고가 기부의향을 효과적으로 촉진시키기 위해서는 목표 청중이 동정심, 공감이나 심리적 불편감 등의 정서를 느끼도록 하는 전략이 필요한 것으로 알려졌다. 선행연구들은 기부 광고에 의해서 유발되는 정서적 경험에 영향을 미칠 수 있는 요인으로 광고의 언어적 요소인 메시지의 속성(구체성과 정서가)과 그에 따른 심리적 반응(심상 유발과 주의 집중)을 제안한다. 기부 광고를 처리하는 심리적 기제를 이해하기 위해서, 본 연구는 선행 연구들을 근거로 '기부 광고의 메시지 속성 (메시지의 구체성과 정서가) ${\rightarrow}$ 심상 유발과 주의 집중 ${\rightarrow}$ 정서적 경험 ${\rightarrow}$ 기부의향'의 개념적 모형을 제안하였다. 이와 같은 개념적 모형 중 본 연구는 메시지의 구체성과 정서가가 (1) 심상 유발과 주의 집중에 미치는 영향을 ERP로 측정하고, (2) 기부의향에 미치는 영향을 기부의향금액을 측정하여 실증적으로 검증하고자 했다. 그 결과, 구체적인 메시지는 추상적인 메시지에 비해서 심상을 더 유발시키며, 부정적인 메시지는 긍정적인 메시지에 비해서 더 많은 주의를 불러일으키는 것으로 밝혀졌다. 또한 메시지가 구체적이면서 부정적일 경우, 기부희망금액이 가장 높은 것으로 나타났다.

• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 2000년도 Proceedings of 2000 KSAM International Symposium and Spring Meeting
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• pp.3-6
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• 2000

Antimicrobial resistance has been a well-recognized problem ever since the introduction of penicillin into clinical use. History of antimicrobial development can be categorized based on the major antibiotics that had been developed against emerging resistant $pathogens^1$. In the first period from 1940 to 1960, penicillin was a dominating antibiotic called as a "magic bullet", although S.aureus armed with penicillinase led antimicrobial era to the second period in 1960s and 1970s. The second stage was characterized by broad-spectrum penicillins and early generation cephalosporins. During this period, nosocomial infections due to gram-negative bacilli became more prevalent, while those caused by S.aureus declined. A variety of new antimicrobial agents with distinct mechanism of action including new generation cephalosporins, monobactams, carbapenems, ${\beta}$-lactamase inhibitors, and quinolones characterized the third period from 1980s to 1990s. However, extensive use of wide variety of antibiotics in the community and hospitals has fueled the crisis in emerging antimicrobial resistance. Newly appeared drug-resistant Streptococcus pneumoniae (DRSP), vancomycin-resistant enterococci (VRE), extended-spectrum ${\beta}$-lactamase-producing Klebsiella, and VRSA have posed a serious threat in many parts of the world. Given the recent epidemiology of antimicrobial resistance and its clinical impact, there is no greater challenge related to emerging infections than the emergence of antibiotic resistance. Problems of antimicrobial resistance can be amplified by the fact that resistant clones or genes can spread within or between the species as well as to geographically distant areas which leads to a global concern$^2$. Antimicrobial resistance is primarily generated and promoted by increased use of antimicrobial agents. Unfortunately, as many as 50 % of prescriptions for antibiotics are reported to be inappropriate$^3$. Injudicious use of antibiotics even for viral upper respiratory infections is a universal phenomenon in every part of the world. The use of large quantities of antibiotics in the animal health industry and farming is another major factor contributing to selection of antibiotic resistance. In addition to these background factors, the tremendous increase in the immunocompromised hosts, popular use of invasive medical interventions, and increase in travel and mixing of human populations are contributing to the resurgence and spread of antimicrobial resistance$^4$. Antimicrobial resistance has critical impact on modem medicine both in clinical and economic aspect. Patients with previously treatable infections may have fatal outcome due to therapeutic failure that is unusual event no more. The potential economic impact of antimicrobial resistance is actually uncountable. With the increase in the problems of resistant organisms in the 21st century, however, additional health care costs for this problem must be enormously increasing.

• 감성과학
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• 제15권1호
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• pp.17-28
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• 2012

최근의 디스플레이 기술은 2차원 디스플레이에 제시된 영상으로부터 3차원 깊이감을 지각하는 것을 가능하게 하였다. 이런은 디스플레이와 콘텐츠 기술의 발전에도 불구하고, 사용자는 실생활에서 경험하지 않는 시각피로의 문제를 경험하는데, 이 문제를 해결하기 위해서는 시각피로를 안정적이고 타당하게 측정하는 것이 필요하다. 본 연구의 목적은 EEG(Electroencephalography)신호에 기반한 시각피로 측정의 프로토콜을 개발하고 타당성을 검증하는 것이었다. ERP(Event related potential) 성분 중에서 시각피로를 반영하는 성분을 찾아내기 위해 2D 조건과 3D 조건에서 탐색적 실험을 수행하였고, 탐색적 실험에서 발견된 ERP 성분이 양안시차의 차이에 따라 상이한 특성을 보이는지 검증하기 위하여 확인적 실험을 수행하였다. 실험결과, Cz와 Pz 영역에서 P3 성분의 정점 강도가 2D 조건보다는 3D 조건에서 감소하였으며, 양안시차가 증가할수록 일관되게 P3 성분의 강도가 통계적으로 유의하게 감소하는 것을 확인하였다. 양안시차가 증가함에 따라서 주관적인 시각피로가 통계적으로 유의하게 증가함을 검증하였는데, 이 실험결과는 Cz와 Pz 영역에서의 P3 성분의 정점 강도가 3D 시각피로에 대한 인덱스로 사용할 수 있음을 시사한다.

• 시큐리티연구
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• 제61호
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• pp.9-38
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• 2019

한국의 국가기반시설은 시설규모가 증가하고 밀집되어 강화된 북한의 국지도발, 테러공격을 위한 풍부하고 매력적인 잠재적 표적으로 식별될 것이다. 또한 드론위협, 주 52시간 근무제도에 따른 경비병력 부족 등의 보안환경 변화에 따라 현 물리적 방호체계에 대한 유효성과 적절성을 재평가하고 전환을 고려할 시점으로 사료된다. 본 연구에서는 국가기반시설 중 원자력발전소의 외곽 물리적 방호체계에 집중하여 국가 기반시설 외곽 물리적 방호체계의 전환 방향과 개선방안을 운영개념 및 설계 방법론 측면에서 연구하였다. 원자력발전소에 집중하는 이유는 원자력발전소는 피해 시 전기발전 중단의 단기적인 피해와 함께, 방사능 물질 유출과 오염에 따르는 광범위하고 장기적인 피해가 발생하므로 가장 높은 보안수준을 필요로 하기 때문이다. 개선방향 도출 목표로 국내 연구동향과 국내·해외 관련법을 종합 검토하고 한국의 특수성을 고려하여, 과학화, 기동화, 유연성으로 운영개념을 재설정하고 체계전환의 기준을 수립하였다. 새로운 외곽 물리적 방호체계의 기술적 성능개선을 위하여 개별설계에서 탈피, 고신뢰성·다방법론 기반의 통합설계 방법론 적용방안을 연구하고 구매제도 개선 및 해외 수출, 타(他)국가기반시설로의 확대적용을 제언한다.

• Journal of Microbiology and Biotechnology
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• 제33권9호
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• pp.1206-1212
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• 2023

The Wnt/β-catenin pathway plays essential roles in regulating various cellular behaviors, including proliferation, survival, and differentiation [1-3]. The intracellular β-catenin level, which is regulated by a proteasomal degradation pathway, is critical to Wnt/β-catenin pathway control [4]. Normally, casein kinase 1 (CK1) and glycogen synthase kinase-3β (GSK-3β), which form a complex with the scaffolding protein Axin and the tumor suppressor protein adenomatous polyposis coli (APC), phosphorylate β-catenin at Ser45, Thr41, Ser37, and Ser33 [5, 6]. Phosphorylated β-catenin is ubiquitinated by the β-transducin repeat-containing protein (β-TrCP), an F-box E3 ubiquitin ligase complex, and ubiquitinated β-catenin is degraded via a proteasome pathway [7, 8]. Colorectal cancer is a significant cause of cancer-related deaths worldwide. Abnormal up-regulation of the Wnt/β-catenin pathway is a major pathological event in intestinal epithelial cells during human colorectal cancer oncogenesis [9]. Genetic mutations in the APC gene are observed in familial adenomatous polyposis coli (FAP) and sporadic colorectal cancers [10]. In addition, mutations in the N-terminal phosphorylation motif of the β-catenin gene were found in patients with colorectal cancer [11]. These mutations cause β-catenin to accumulate in the nucleus, where it forms complexes with transcription factors of the T-cell factor/lymphocyte enhancer factor (TCF/LEF) family to stimulate the expression of β-catenin responsive genes, such as c-Myc and cyclin D1, which leads to colorectal tumorigenesis [12-14]. Therefore, downregulating β-catenin response transcription (CRT) is a potential strategy for preventing and treating colorectal cancer. Plant cytokinins are N⁶-substituted purine derivatives; they promote cell division in plants and regulate developmental pathways. Natural cytokinins are classified as isoprenoid (isopentenyladenine, zeatin, and dihydrozeatin), aromatic (benzyladenine, topolin, and methoxytopolin), or furfural (kinetin and kinetin riboside), depending on their structure [15, 16]. Kinetin riboside was identified in coconut water and is a naturally produced cytokinin that induces apoptosis and exhibits antiproliferative activity in several human cancer cell lines [17]. However, little attention has been paid to kinetin riboside's mode of action. In this study, we show that kinetin riboside exerts its cytotoxic activity against colon cancer cells by suppressing the Wnt/β-catenin pathway and promoting intracellular β-catenin degradation.

• 경영정보학연구
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• 제15권3호
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• pp.1-37
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• 2013

본 연구는 모바일 러닝의 활성화를 위한 서비스 융합의 가능성을 보고자 하였다. 이를 위해 모바일 러닝의 유형 및 특성을 분석 하였다. 먼저 현재 모바일 러닝 서비스는 어떤 서비스를 중심으로 활성화되고 있으며, 이러한 서비스를 중심으로 사용자의 활용도가 높은 서비스는 무엇인지 알아 보았다. 두 번째로는 모바일에서 주로 이뤄지고 있는 서비스와 이러닝에서 주로 이뤄지고 있는 서비스의 복합적 융합가능성을 살펴 보았다. 세 번째로는 모바일에서의 서비스와 이러닝에서의 공통된 서비스를 중심으로 앞으로 융합이 활성화 될 가능성을 살펴보았다. 분석을 위하여 포털 사이트에서 관련 웹페이지를 통하여 변수를 추출하였으며, 사회 네트워크 분석과 연관성 분석을 사용하였다. 이는 웹페이지마다 변수의 종류와 수가 다르기 때문에 전체적인 웹 상에서 각각의 변수들의 위치와 네트워크상에서의 복잡한 연결 정도를 살펴보기 힘들다. 이러한 문제점을 해결하기 위해 사회 네트워크 분석을 하였으며, 변수들 간의 연관규칙을 발견하고자 연관성 분석을 하였다. 규칙의 해석을 위해서는 사회 네트워크 분석 결과와 연관규칙을 함께 고려하여 살펴보았다. 분석 결과, 모바일에서 제공되는 서비스와 이러닝에서 제공되고 있는 공통된 서비스 중에서 빈도수가 높은 서비스로는 게임과 SNS로 나타났으며, 이외 결제, 광고, 메일, 이벤트, 동영상, 클라우드, 전자책, 증강현실, 취업 등으로 발견되었다. 이러한 서비스를 중심으로 이러닝의 다양한 서비스와 융합하여 이뤄지고 있음을 알 수 있었다. 공통된 서비스와 함께 모바일에서는 검색, 뉴스, GPS 등의 서비스가 활성화 되고 있으며, 이러닝에서는 시뮬레이션, 교양, 공교육 등의 서비스가 활성화 되고 있음을 알 수 있었다. 모바일과 이러닝의 공통된 변수를 기반으로 각각의 서비스의 융합이 높게 나타난 변수로는 모바일에서는 게임과 SNS, 게임과 스포츠, SNS와 광고, 게임과 이벤트, SNS와 전자책, 게임과 커뮤니티가 융합이 높게 나타났으며, 이러닝에서는 게임, 동영상, 상담, 전자책을 전항으로 하여 시뮬레이션, 말하기, 공교육, 출결관리 등의 서비스의 융합정도가 높게 나타난 것을 알 수 있었다. 다음으로 모바일서비스와 이러닝서비스의 공통된 서비스중에서, 모바일 러닝 서비스에서 활성화가 높은 서비스와 사용자를 기반한 모바일 러닝 서비스의 활성화가 높은 서비스인 게임, SNS, 전자책을 기준으로 서비스 융합 활성화 가능성을 예측했다. 본 연구결과를 통해 모바일을 활용한 이러닝 서비스의 관련 서비스 융합으로, 모바일 러닝의 활성화에 대한 전략적 방향성을 제안할 수 있을 것이다.

• Asia pacific journal of information systems
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• 제19권2호
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• pp.117-137
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• 2009

Recently, intelligent traffic information systems have enabled people to forecast traffic conditions before hitting the road. These convenient systems operate on the basis of data reflecting current road and traffic conditions as well as distance-based data between locations. Thanks to the rapid development of ubiquitous computing, tremendous context data have become readily available making vehicle route planning easier than ever. Previous research in relation to optimization of vehicle route planning merely focused on finding the optimal distance between locations. Contexts reflecting the road and traffic conditions were then not seriously treated as a way to resolve the optimal routing problems based on distance-based route planning, because this kind of information does not have much significant impact on traffic routing until a a complex traffic situation arises. Further, it was also not easy to take into full account the traffic contexts for resolving optimal routing problems because predicting the dynamic traffic situations was regarded a daunting task. However, with rapid increase in traffic complexity the importance of developing contexts reflecting data related to moving costs has emerged. Hence, this research proposes a framework designed to resolve an optimal route planning problem by taking full account of additional moving cost such as road traffic cost and weather cost, among others. Recent technological development particularly in the ubiquitous computing environment has facilitated the collection of such data. This framework is based on the contexts of time, traffic, and environment, which addresses the following issues. First, we clarify and classify the diverse contexts that affect a vehicle's velocity and estimates the optimization of moving cost based on dynamic programming that accounts for the context cost according to the variance of contexts. Second, the velocity reduction rate is applied to find the optimal route (shortest path) using the context data on the current traffic condition. The velocity reduction rate infers to the degree of possible velocity including moving vehicles' considerable road and traffic contexts, indicating the statistical or experimental data. Knowledge generated in this papercan be referenced by several organizations which deal with road and traffic data. Third, in experimentation, we evaluate the effectiveness of the proposed context-based optimal route (shortest path) between locations by comparing it to the previously used distance-based shortest path. A vehicles' optimal route might change due to its diverse velocity caused by unexpected but potential dynamic situations depending on the road condition. This study includes such context variables as 'road congestion', 'work', 'accident', and 'weather' which can alter the traffic condition. The contexts can affect moving vehicle's velocity on the road. Since these context variables except for 'weather' are related to road conditions, relevant data were provided by the Korea Expressway Corporation. The 'weather'-related data were attained from the Korea Meteorological Administration. The aware contexts are classified contexts causing reduction of vehicles' velocity which determines the velocity reduction rate. To find the optimal route (shortest path), we introduced the velocity reduction rate in the context for calculating a vehicle's velocity reflecting composite contexts when one event synchronizes with another. We then proposed a context-based optimal route (shortest path) algorithm based on the dynamic programming. The algorithm is composed of three steps. In the first initialization step, departure and destination locations are given, and the path step is initialized as 0. In the second step, moving costs including composite contexts into account between locations on path are estimated using the velocity reduction rate by context as increasing path steps. In the third step, the optimal route (shortest path) is retrieved through back-tracking. In the provided research model, we designed a framework to account for context awareness, moving cost estimation (taking both composite and single contexts into account), and optimal route (shortest path) algorithm (based on dynamic programming). Through illustrative experimentation using the Wilcoxon signed rank test, we proved that context-based route planning is much more effective than distance-based route planning., In addition, we found that the optimal solution (shortest paths) through the distance-based route planning might not be optimized in real situation because road condition is very dynamic and unpredictable while affecting most vehicles' moving costs. For further study, while more information is needed for a more accurate estimation of moving vehicles' costs, this study still stands viable in the applications to reduce moving costs by effective route planning. For instance, it could be applied to deliverers' decision making to enhance their decision satisfaction when they meet unpredictable dynamic situations in moving vehicles on the road. Overall, we conclude that taking into account the contexts as a part of costs is a meaningful and sensible approach to in resolving the optimal route problem.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2014년도 춘계학술대회 및 임시총회
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• pp.27-28
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• 2014

Beauveria bassiana (Cordycipitaceae, Hypocreales, Ascomycota) is an anamorphic fungus having a potential to be used as a biological control agent because it parasitizes a wide range of arthropod hosts including termites, aphids, beetles and many other insects. A number of bioactive secondary metabolites (SMs) have been isolated from B. bassiana and functionally verified. Among them, beauvericin and bassianolide are cyclic depsipeptides with antibiotic and insecticidal effects belonging to the enniatin family. Non-ribosomal peptide synthetases (NRPSs) play a crucial role in the synthesis of these secondary metabolites. NRPSs are modularly organized multienzyme complexes in which each module is responsible for the elongation of proteinogenic and non-protein amino acids, as well as carboxyl and hydroxyacids. A minimum of three domains are necessary for one NRPS elongation module: an adenylation (A) domain for substrate recognition and activation; a tholation (T) domain that tethers the growing peptide chain and the incoming aminoacyl unit; and a condensation (C) domain to catalyze peptide bond formation. Some of the optional domains include epimerization (E), heterocyclization (Cy) and oxidation (Ox) domains, which may modify the enzyme-bound precursors or intermediates. In the present study, we analyzed genomes of B. bassiana and its allied species in Hypocreales to verify the distribution of NRPS-encoding genes involving biosynthesis of beauvericin and bassianolide, and to unveil the evolutionary processes of the gene clusters. Initially, we retrieved completely or partially assembled genomic sequences of fungal species belonging to Hypocreales from public databases. SM biosynthesizing genes were predicted from the selected genomes using antiSMASH program. Adenylation (A) domains were extracted from the predicted NRPS, NRPS-like and NRPS-PKS hybrid genes, and used them to construct a phylogenetic tree. Based on the preliminary results of SM biosynthetic gene prediction in B. bassiana, we analyzed the conserved gene orders of beauvericin and bassianolide biosynthetic gene clusters among the hypocrealean fungi. Reciprocal best blast hit (RBH) approach was performed to identify the regions orthologous to the biosynthetic gene cluster in the selected fungal genomes. A clear recombination pattern was recognized in the inferred A-domain tree in which A-domains in the 1st and 2nd modules of beauvericin and bassianolide synthetases were grouped in CYCLO and EAS clades, respectively, suggesting that two modules of each synthetase have evolved independently. In addition, inferred topologies were congruent with the species phylogeny of Cordycipitaceae, indicating that the gene fusion event have occurred before the species divergence. Beauvericin and bassianolide synthetases turned out to possess identical domain organization as C-A-T-C-A-NM-T-T-C. We also predicted precursors of beauvericin and bassianolide synthetases based on the extracted signature residues in A-domain core motifs. The result showed that the A-domains in the 1st module of both synthetases select D-2-hydroxyisovalerate (D-Hiv), while A-domains in the 2nd modules specifically activate L-phenylalanine (Phe) in beauvericin synthetase and leucine (Leu) in bassianolide synthetase. antiSMASH ver. 2.0 predicted 15 genes in the beauvericin biosynthetic gene cluster of the B. bassiana genome dispersed across a total length of approximately 50kb. The beauvericin biosynthetic gene cluster contains beauvericin synthetase as well as kivr gene encoding NADPH-dependent ketoisovalerate reductase which is necessary to convert 2-ketoisovalarate to D-Hiv and a gene encoding a putative Gal4-like transcriptional regulator. Our syntenic comparison showed that species in Cordycipitaceae have almost conserved beauvericin biosynthetic gene cluster although the gene order and direction were sometimes variable. It is intriguing that there is no region orthologous to beauvericin synthetase gene in Cordyceps militaris genome. It is likely that beauvericin synthetase was present in common ancestor of Cordycipitaceae but selective gene loss has occurred in several species including C. militaris. Putative bassianolide biosynthetic gene cluster consisted of 16 genes including bassianolide synthetase, cytochrome P450 monooxygenase, and putative Gal4-like transcriptional regulator genes. Our synteny analysis found that only B. bassiana possessed a bassianolide synthetase gene among the studied fungi. This result is consistent with the groupings in A-domain tree in which bassianolide synthetase gene found in B. bassiana was not grouped with NRPS genes predicted in other species. We hypothesized that bassianolide biosynthesizing cluster genes in B. bassiana are possibly acquired by horizontal gene transfer (HGT) from distantly related fungi. The present study showed that B. bassiana is the only species capable of producing both beauvericin and bassianolide. This property led to B. bassiana infect multiple hosts and to be a potential biological control agent against agricultural pests.