• Title/Summary/Keyword: Event mean concentration

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Influences of Histamine on Permeability across Blood-brain Barrier (혈액-뇌장벽 투과성에 대한 히스타민의 영향)

  • Kim, Kee-Jin;Shin, Dong-Hoon
    • The Korean Journal of Physiology
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    • v.2 no.2
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    • pp.33-43
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    • 1968
  • Histamine, 0.5 mg as histamine base in 4 ml of normal saline solution, was injected into rabbits anesthetized with nembutal and the mean blood pressure was kept in the range of $52{\sim}80\;mmHg$ for over one hour by supplemental additions. Following the injection of the test substances, 300 mg of urea and 200 mg of antipyrine intravenously, serial blood samples were obtained from the femoral artery and the internal jugular vein at $0.5{\sim}3$ minutes interval. The decreasing patterns in the concentrations of arterial and venous blood plasma samples were compared with each other. The ratio of the concentration of brain tissue to that of the final arterial plasma was also studied. By these measures the degrees of penetration of the test substances in the brain in the control and in the histamine treated rabbits were observed. The concentrations of antipyrine and urea in the arterial blood plasma were decreasing exponentially with respect to the time elapsed. The venous concentrations were anticipated to increase initially and to cross the arterial concentration curve in the point of equlibrium between the plasma and the tissue. On the contrary to the expectation venous concentration also revealed the decreasing tendency similar to that of arterial plasma. The similarity between these two curves, arterial and venous, would be atributable to the fact that the cerebral blood flow rate was large enough and the rising phase in the venous concentration curve was instantly over before serial blood samples were taken. Inspite of some similarity in the decreasing tedency in both concentration curves there were appreciable discrepancies between the arterial and venous plasma which would reflect the situation far from the equlibria among several compartments in the brain. Changes in plasma potassium levels caused by the injection of histamine or bleeding were observed, too. Using 8 rabbits as the control and 12 rabbits for the histamine treated group following results were obtained: 1. Both of the concentration curves, arterial and venous, declined rapidly at_first and slowly later on and approached same equilibrium concentration with the passage of time after a single injection. The time at which attained the same concentration was $2.0{\pm}0.54\;min.$ in the control and $4.3{\pm}1.92\;min.$ in the histamine treated group with respect to antipyrine. On the other hand in the case of urea they were $2.4{\pm}0.59\;min.$ in the control and $4.4{\pm}1.31\;min.$ in the histamine group, respectively. In the histamine treated group enlarged spaces for distribution of test substances were postulated. 2. The concentration of antipyrine in the brain tissue water revealed no significant differences between the control and experimental groups, showing $212{\pm}40.2\;mg/l$ in the control and $206{\pm}64.1\;mg/l$ in the histamine treated group. On the other hand urea revealed higher value in the histamine treated group than in the control, showing an enhanced penetration of urea into the tissue after injection of histamine. Urea concentration in the brain water was $32.3{\pm}3.36\;mg%$ in the control and $39.2{\pm}4.25\;mg%$ in the histamine treated group. 3. The distribution ratio of antipyrine in the brain tissue was very close to unity in the histamine treated animals as well as in the control. 4. The average of the distribution ratio of urea in the control animals was 0.77 and it showed the presence of blood-brain barrier with regard to urea. However in the histamine treated animals the distribution ratios climbed up to 0.86 and they were closer to unity than in the control animals. Out of 12 cases 5 were greater than 0.9 and 8 exceeded 0.85. It appeared that histamine enhanced the penetration of urea through the barrier. 5. Histamine injection and or hemorrhage caused an elevation of the concentration of potassium in plasma. In the event that histamine and hemorrhage were applied together the elevation of potassium exceed the elevation seen at the histamine alone. There was no evidence that the leakage of potassium from the brain tissue was dominant in comparison with the general leakage from the whole body.

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Characteristics of heavy metal concentrations in urban stormwater runoff, Daejeon, Korea (도시 유역 강우유출수 내 중금속 농도의 변화 특성에 관한 연구)

  • Yu, Eunjin;Seo, Dongil
    • Journal of Korea Water Resources Association
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    • v.51 no.10
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    • pp.917-927
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    • 2018
  • Seven heavy metal concentrations (As, Cd, Cr, Cu, Ni, Pb, Zn) were continuously analyzed for twenty rainfall events in 2017~2018 in an urban basin. The overall and dynamic correlations between runoff characteristics and heavy metal concentrations were examined. The peak metal concentration generally appeared in the initial runoff but found to be delayed when the rainfall intensity was low. The rainfall duration had no relationship with either heavy metal concentrations or their total mass. Dynamics of heavy metal mass (load), with the exception of Cu and Zn, showed strong correlation with the 30 minute rainfall intensity (0.60~0.88) and runoff volume (0.74~0.89). While event mean concentration (EMC) showed positive correlation (0.54~0.73) with antecedent dry days (ADD), no significant relationship was found between runoff volume and pollutant concentration. This implies that the pollutants built up on the surface during dry days are washed off even with low rainfall energy. The dynamics of heavy metal and TSS concentrations showed good correlation (0.68~0.87). This result shows that the metals are transported along with solid particles as adsorbate in surface runoff. Regular street sweeping will reduce significant amount of heavy metal loads in urban surface runoff.

Runoff Characteristics of Non-Point Source Pollutants in Storm Event -Case Study on the Upstream and Downstream of Kokseong River, Korea- (강우시 비점오염물질의 유출특성에 관한 연구 -곡성천 상.하류를 대상으로-)

  • Yang Hea-Kun
    • Journal of the Korean Geographical Society
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    • v.41 no.4 s.115
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    • pp.418-434
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    • 2006
  • The study was investigated to runoff characteristics of non-point pollutants according to rainfall in Kokseong river watershed. The result of which is as follows : First of all, major reason which affect the formation of water quality of Kokseong River is judged to be caused by non-point pollution source which flows out from farmland and residential area. Flow of rainfall effluent in the downstream in which direct flow components of urban district and combined sewer overflows of farmland was intervened faster than that in the upstream reacted more promptly. Generation of pollutants by non-point source shows increasing trend in general in accordance with the increase in the intensity of rainfall but it was affected by SS, BOD, COD and T-P in the upstream part whereas BOD, COD and T-N were significantly affected by beginning period of rainfall in the downstream. EMC in the downstream increased approximately 3-315 times as compared to upstream, particularly the discharge of SS5 and T-P were extremely increased. While surface flow out of rainfall effluent in the upstream was only 4.7%, the surface flow in the downstream took up as much as 29%, which was major reason for the increase of EMC. From the above contents, we can see that the change in water quality according to the increase and decrease of effluent at the time of rainfall showed very complex pattern depending on the type of land use, and it is judged that the most important thing for the administration of non-point pollution source is to come up with the solution for the reduction of effluent at the beginning.

L-THIA Modification and SCE-UA Application for Spatial Analysis of Nonpoit Source Pollution at Gumho River Basin (환경부 토지피복 중분류 적용을 위한 L-THIA 모델 수정과 SCE-UA연계적용에 의한 금호강유역 비점오염 분포파악)

  • Kim, Jung-Jin;Kim, Tae Dong;Choi, Dong Hyuk;Lim, Kyoung Jae;Engel, Bernard;Jeon, Ji-Hong
    • Journal of Korean Society on Water Environment
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    • v.25 no.2
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    • pp.311-321
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    • 2009
  • Long-Term Hydrologic Impact Assessment (L-THIA) was modified to improve runoff and pollutant load prediction for Korean watersheds with changes in land use classification and event mean concentration produced from observed data in Korea. The L-THIA model was linked with SCE-UA, which is one of the global optimization techniques, to automatically calibrate direct runoff. Modified L-THIA model was applied to Gumho River Basins to analyze spatial distribution of nonpoint source pollution. The results of model calibration during 1991~2000 and validation during 1981~1990 for direct runoff represented high model efficiency of 0.76 for calibration and 0.86 for validation. As a results of spatial analysis of nonpoint source pollution, the BOD was mainly loaded from urban area but SS, TN, and TP from agricultural area which is mainly located along the stream. Modified L-THIA model improve its accuracy with minimum imput data and application efforts. From this study, we can find out the L-THIA model is very useful tool to predict direct runoff and pollutant loads from the watershed and spatial analysis of nonpoint source pollution.

An Analysis of Long-term Trends in Precipitation Acidity of Seoul, Korea (서울지역 강수 산성도의 장기적인 경향분석)

  • 강공언;임재현;김희강
    • Journal of Korean Society for Atmospheric Environment
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    • v.13 no.1
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    • pp.9-18
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    • 1997
  • Precipitation samples were collected by the wet- only event sampling method from Seoul during September 1991 to April 1995. These samples were analyzed for the concentrations of the major ionic components (N $O_3$$^{[-10]}$ , N $O_2$$^{[-10]}$ , S $O_4$$^{2-}$, C $l^{[-10]}$ , $F^{[-10]}$ , N $a^{+}$, $K^{+}$, $Ca^{2+}$, $Mg^{2+}$, and N $H_4$$^{+}$), pH, and electric conductivity. During the study period, a total of 182 samples were collected, but only 163 samples were used for the data analysis via quality assurance of precipitation chemistry data. The volume-weighted pH was found to be 4.7. The major acidifying species from our precipitation studies were identified to be non-seasalt sulfate (84$\pm$9 $\mu$eq/L) and nitrate (24$\pm$2 $\mu$eq/L) except for chloride. Because the Cl/Na ratio in the precipitation was close to the ratio in seawater. If all of the non-seasalt sulfate and nitrate were in the form of sulfuric and nitric acids, the mean pH in the precipitation could have been as low as 3.7 lower than the computed value. Consequently, the difference between two pH values indicate that the acidity of precipitation was neutralized by alkaline species. The equivalent concentration ratio of sulfate to nitrate was 3.5, indicating that sulfuric and nitric acids can comprise 78% and 22% of the precipitation acidity, respectively. Analysis of temporal trend in the measured acidity and ionic components were also performed using the linear regression method. The precipitation acidity generally showed a significantly decreasing trend, which was compatible with the pattern of the ratio (N $H_4$$^{+}$+C $a^{2+}$)/ (nss-S $O_4$$^{2-}$+N $O_3$$^{[-10]}$ ).).

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Characteristics of Storm Runoff and Analysis of Its Correlation with Forest Properties (산림특성에 따른 강우유출수 유출특성 및 상관관계 분석)

  • Chung, WooJin;Chang, SoonWoong
    • Journal of Environmental Science International
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    • v.25 no.7
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    • pp.1007-1016
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    • 2016
  • Environmental policy implementation has been strengthened to protect the source waters in Korea and to improve their water quality. Increasing of non-point source caused water quality problem continuously. Research on runoff from forests, which occupy over 65% of the land in korea, is insufficient, and studies on the characteristics and influences of storm runoff are necessary. In this study, we chose to compare the effects of land use in the form of two types of forest distribution and then gathered data on storm characteristics and runoff properties during rainfall events in these areas. Furthermore, the significance and influences of the discharges were analyzed through correlation analysis, and multilateral runoff characteristics were examined by deducing a formula through $COD_{Mn}$ and TOC regression analysis. At two forest points, for which the basin areas differed from each other, flow changed according to storm quantity and intensity. The peak discharge at point A, where the basin area was big, was high, whereas water-quality fundamental items (BOD, $COD_{Mn}$, and SS) and TOC density were high at point B where the slope and storm intensity were high. Effects of dissolved organic matter were determined through correlation analysis, and the regression formulas for $COD_{Mn}$ and TOC were deduced by regression analysis. It is expected that the data from this study could be useful as basic information in establishing forest management measures.

Spatial Analysis of Nonpoint Source Pollutant Loading from the Imha dam Watershed using L-THIA (L-THIA를 이용한 낙동강수계 임하댐유역 비점오염원의 공간적 분포해석)

  • Jeon, Ji-Hong;Cha, Daniel K.;Choi, Donghyuk;Kim, Tae-Dong
    • Journal of The Korean Society of Agricultural Engineers
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    • v.55 no.1
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    • pp.17-29
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    • 2013
  • Long-Term Hydrologic Impact Assessment (L-THIA) model which is a distributed watershed model was applied to analyze the spatial distribution of surface runoff and nonpoint source pollutant loading from Imha watershed during 2001~2010. L-THIA CN Calibration Tool linked with SCE-UA was developed to calibrate surface runoff automatically. Calibration (2001~2005) and validation (2006~2010) of monthly surface runoff were represented as 'very good' model performance showing 0.91 for calibration and 0.89 for validation as Nash-Sutcliffe (NS) values. Average annual surface runoff from Imha watershed was 218.4 mm and Banbyun subwatershed was much more than other watersheds due to poor hydrologic condition. Average annual nonpoint source pollutant loading from Imha wateshed were 2,295 ton/year for $BOD_5$, 14,752 ton/year for SS, 358 ton/year for T-N, and 79 ton/year for T-P. Amount of pollutant loading and pollutant loading rates from Banbyun watershed were much higher than other watersheds. As results of analysis of loading rate from grid size ($30m{\times}30m$), most of high 10 % of loading rate were generated from upland. Therefore, major hot spot area to manage nonpoint source pollution in Imha watershed is the combination of upland and Banbyun subwatershed. L-THIA model is easy to use and prepare input file and useful tool to manage nonpoint source pollution at screening level.

Determination of Pollutant EMCs and Loadings of Runoff in Paved Areas (포장지역내 강우유출수의 EMCs 및 부하량 산정)

  • Gil, Kyung-Ik;Wee, Seung-Kyung;Park, Moo-Jong
    • Journal of the Korean Society of Hazard Mitigation
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    • v.8 no.4
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    • pp.119-122
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    • 2008
  • The paved area like a road or bridge where having high impermeable rates were accumulated various non-point sources(NPS) by passing vehicles during dry season periods. They are flowed in the river continuous when it rains and could negative impact on environment. Therefore, this study monitoring NPS for two years and determinating for each pollutant EMCs and mass loading. The result shows that the EMC ranges are 11.60$\sim$230.90 mg/L for TSS, 4.58$\sim$31.90 mg/L for BOD, 1.86$\sim$9.20 mg/L for TN and 0.14$\sim$1.55 mg/L for TP. Also, the ranges of washed-off mass loading are determined to 0.78$\sim$18.01 kg/day for TSS, 0.47$\sim$1.17 kg/day for BOD, 0.00$\sim$0.01 kg/day for Pb and 0.01$\sim$0.06 kg/day for Zn.

Determination of EMC and Unit Loading of Rainfall Runoff from Forestry-Crops Field (산림과 밭 지역 강우 유출수의 EMC 및 원단위 산정)

  • Won, Chul-hee;Choi, Yong-hun;Seo, Ji-yeon;Kim, Ki-cheol;Shin, Min-hwan;Choi, Joong-dae
    • Journal of Korean Society on Water Environment
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    • v.25 no.4
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    • pp.615-623
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    • 2009
  • The research of the determination of event mean concentration (EMC) was focussed combined sewer overflows and highway runoff in korea. But those of non-urban areas are few. In this study, EMC and unit loading on land use types in Nogok watershed were estimated by runoff loading of non-point source (NPS) on non-urban area. Two monitoring sites were equipped with an automatic velocity meter, flow meter, and water sampler. Monitoring was conducted at two monitering site during the rainy season. The results show that the EMC ranges in forest land use are 1.3~2.6 mg/L for BOD, 2.0~16.1 mg/L for SS, 0.1~2.1 mg/L for TN, and 0.12~0.49 mg/L for TP. The unit loading of NPS in this study was difficult to compare directly with that used conventionally because of the difference of field investigation. In near future, it needs to conduct more systematic and long-term research about NPS within the watershed. The results of this research can be used to estimate the total pollution load management system (TPLMS) program in korea.

Washoff Characteristics of Non-point Source pollutants and Estimation of Unit Loads in Suburban Industrial Complex Areas Runoff (교외 산업단지지역 강우유출수내 비점오염물질의 유출특성 및 원단위 산정)

  • Kim, Sung-Joon;Shin, Seon-Mi;Jeon, Yong-Tae;Won, Chan-Hee
    • Journal of Environmental Impact Assessment
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    • v.21 no.2
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    • pp.315-325
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    • 2012
  • The characteristics of stormwater runoff and estimation of unit loads were examined in suburban industrial complex areas. During rainfall event, the peak concentrations occurred within the first 100 minutes after rainfall and then the highest concentration of NPS pollutants sharply decreased, showing strong first flush effect in suburban industrial complex. The cumulative load curves for NPS pollutants showed above the straight line, indicating that first flush effect occurred in suburban industrial complex. While the mean TSS, BOD, COD, TN and TP EMCs values were shown the highest values as 120.6 mg/L, 20.8 mg/L, 44.0 mg/L, 5.58 mg/L and 1.46 mg/L respectively. Unit loads estimated from the EMCs were TSS $43.86kg/km^2/day$, COD $52.45kg/km^2/day$, BOD $24.79kg/km^2/day$, T-N $6.65kg/km^2/day$, T-P $1.75kg/km^2/day$, and Pb $0.10kg/km^2/day$. Results of unit loads were compared with the unit pollutant loads from land-use in Korea and USA. The unit load of TSS was lower than that of USA. Estimated BOD and T-N and T-P unit loads were lower than that of Korea.