• 한국식품위생안전성학회지
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• 제37권5호
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• pp.306-309
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• 2022

프로바이오틱스가 널리 사용됨에 따라 European Food Safety Authority (EFSA)와 식품의약품안전평가원이 제시하는 프로바이오틱스 안전성 평가 가이드라인에 준수하여 B. breve BB077의 안전성을 평가하였다. 본 실험에 사용한 B. breve BB077 균주는 용혈성이 발생하지 않았으며, 독소를 거의 생성하지 않았음을 확인하였다. 항생제 내성 평가에서는 7종의 항생제에서는 EFSA 권고 cut-off value 보다 낮은 항생제 내성을 보였으며, 2종의 항생제인 streptomycin와 tetracycline에서는 cut-off value 보다 높은 항생제 내성을 보였다. streptomycin, tetracycline에 대한 내성 결정인자는 B. breve 종의 공통 유전적 특징으로 외부로부터 전달 받은 내성이 아닌 자연돌연변이에 의한 획득내성이기에 사용에 안전한 균주임을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4847-4851
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• 2013

Objectives: To evaluate accuracy of FDG-PET CT in prediction of persistent disease in head and neck cancer cases and to determine prognostic value of metabolic tumor response. Materials and Methods: Between 2009 and 2011, 46 patients with squamous cell carcinoma of head and neck receiving PET-CT were treated with definitive radiotherapy, with or without chemotherapy. There were 29 nasopharyngeal, 11 hypopharyngeal, 3 oropharyngeal and 3 laryngeal cancer patients, with a median age of 50.5 years (range 16-84), 32 males and 14 females. All patients were evaluated with PET-CT median 3-5 months (2.4-9.4) after completion of radiotherapy. Results: After a median 20 months of follow up, complete metabolic response was observed in 63% of patients. Suspicious residual uptake was present in 10.9% and residual metabolic uptake in 26.0% of patients. The overall sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET-CT for detection of residual disease was 91% and 81%, 64% and 96% respectively. Two year LRC was 95% in complete responders while it was 34% in non-complete responders. Conclusions: FDG PET CT is a valuable tool for assessment of treatment response, especially in patients at high risk of local recurrence, and also as an indicator of prognosis. Definitely more precise criteria are required for assessment of response, there being no clear cut uptake value indicating residual disease. Futhermore, repair processes of normal tissue may consume glucose which appear as increased uptake in control FDG PET CT.

• 패션비즈니스
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• 제18권6호
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• pp.188-207
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• 2014

The purpose of this research was to examine the extent of deontological (values) and teleological evaluation (considering consequences) used in arriving at an ethical judgment concerning intention to purchase a fashion counterfeit. In addition, the effect of psychographic (attitudes toward counterfeiting, risk taking, self-image, value consciousness, public self-consciousness, and materialism) and product attributes (perceived fashion content, physical appearance, and image) on intention to purchase a counterfeit product were investigated. Two alternatives and possible consequences as well as the scenario were given to the participants. The first alternative is persuading a friend not to buy a counterfeit and the second alternative is purchasing a counterfeit product with a friend. Participants (n = 245) were undergraduate volunteers enrolled in courses at a Midwestern university. Data were analyzed using confirmatory factory analysis and structural equation modeling. The proposed structural models fit the data adequately in both alternatives, and all paths were significant. Participants followed the decision making steps outlined by Hunt and Vitell (1986) in both alternatives. Personal characteristics exerted no influence on behavioral intentions concerning counterfeits. Two product-related characteristics (i.e., physical appearance of a counterfeit and projected image of a counterfeit) had direct effects on the behavioral intentions. The conclusions of this research are helpful in improving our understanding of variables that influence consumers' purchasing counterfeit luxury products.

• 한국방재안전학회논문집
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• 제10권1호
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• pp.35-42
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• 2017

본 연구는 지반함몰 발생 및 피해저감을 위한 지반 안정성 평가 및 굴착 보강 기술개발 과제 중 지반함몰 위험성 예측 및 평가기술 개발을 위한 기초자료로 활용하기 위한 연구로 수도권 6개 굴착지역에 대한 문헌자료에 의한 강도정수 산정, 시추에 의한 지반조사 및 표준관입시험, 시추공을 이용한 하향식탄성파 결과를 이용하여 지반특성을 비교 연구 하였다. 연구결과 표준관입시험 결과인 N치와 문헌자료를 이용하여 지반정수를 산정하였고, 시추된 홀에 하향식탄성파탐사를 실시하여 지반의 동적지반특성을 확인하였다. 각 지역별 지반특성을 확인한 결과 지반물성치가 상이하게 나타나는 것을 볼 수 있다. 이는 각 현장별 N치와 문헌자료 조사자의 경험적 지반정수가 반영된 결과인 것으로 판단된다.

• 보존과학회지
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• 제38권4호
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• pp.277-288
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• 2022

'Eve 58-1', the subject of this study is a statue made of plaster and its structural stability was evaluated by utilizing the CAE program in order to prevent the risk of damage arising from impact and vibration that are generated during the packaging and transportation process given its material characteristics. CAE is an abbreviation for Computer Applied Engineering for realization by predicting changes at the time of application of virtual physical energy. It is applied by reflecting the physical property conditions and each boundary condition of plaster, and the digital images of the internal and external structure of the work were acquired through 3D scanning and CT analysis for interpretation by executing finite element modeling. When acceleration is applied to the work in the direction of its own weight, the left-right side and the front-rear side, it was possible to confirm a maximum displacement value of 15.24 mm in the head section of the front-rear side direction that has been tilted by approximately 27° from the Y-axis and the largest stress value of 12.46 MPa was at the left ankle section. The corresponding results confirmed that the left ankle section is the most vulnerable area and the section for which precautions need to be exercised and supplemented at the time of transporting the work by means of objective values.

• 대한방사선기술학회지:방사선기술과학
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• 제40권1호
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• pp.35-40
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• 2017

본 연구는 임신초기 초음파에 의해 측정된 임산부의 복부 피하지방두께(Abdominal Subcutaneous Fat Thickness; ASFT)와 임신중기 발현되는 임신성당뇨(Gestational Diabetes Mellitus; GDM)와의 연관성을 확인하고 GDM 예측을 위한 ASFT의 기준을 알아보고자 하였다. 286명의 임산부를 대상으로 임신초기 ASFT를 측정한 후 임신중기 GDM 선별검사(50 g OGTT) 140 mg/dL 이상을 고위험군으로 산정하고 산모연령, 임신 전 체질량지수, 임신 중 체중증가량과 함께 비교 분석하였다. ROC 곡선분석을 이용하여 GDM 예측을 위한 ASFT의 cut-off value를 결정하였다. 산모연령, 임신 중 체중증가량은 임신중기 GDM과 관련성이 없었으며, 임신 전 체질량지수와 임신초기 ASFT는 정상군과 GDM 고위험군에서 의미있는 차이를 보였다. GDM 예측을 위한 ASFT의 cut-off value는 2.23 cm(AUC 0.913, Sensitivity 76.19%, Specificity 93.72%)로 결정하였다. 임신초기 초음파로 측정된 ASFT는 임신중기 GDM 예측을 위한 중요한 지표로 유용하게 평가되었다. 따라서 ASFT는 GDM을 조기에 인식하는데 있어서 보조적인 진단지표로 활용할 수 있을 것으로 사료된다.

• 한국축산식품학회지
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• 제38권1호
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• pp.43-51
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• 2018

This study was conducted to analyze the microbiological contamination status of raw beef distributed in Korea, and evaluate the suitability of current aerobic plate count (APC) guidelines. We analyzed five years (2010-2014) of microbiological monitoring data obtained from the Ministry of Food and Drug Safety and investigated the microbiological status of raw beef collected from meat packing centers and meat shops in the Seoul/Gyeonggi, Gangwon, and Chungcheong regions in August 2015. From 2010-2014, most raw beef (>94%) displayed APC levels of < $1.0{\times}10^6CFU/g$. However, raw beef samples collected from all three regions in August 2015 had comparatively higher APC levels than those reported in previous years. To evaluate the relationship between the APC level and quality, changes in beef loin were evaluated during cold storage for 15 days at $4^{\circ}C$. On day 11, the mean APC level ($4.7{\times}10^6CFU/g$) conformed to current guidelines in Korea ($1.0{\times}10^7CFU/g$) and the pH value was 5.82. However, the sensory evaluation score for color and overall acceptability was under 3.0, meaning that the beef loin was not acceptable for eating. These results suggest that current APC guideline for raw beef should be lowered to $1.0{\times}10^6CFU/g$ to improve both the microbiological safety and palatability of raw beef.

• 농업과학연구
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• 제47권4호
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• pp.791-802
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• 2020

Theoredoxin (TRX) transgenic soybeans were developed using the human Theoredoxin gene under the control of the ��-conglycinin promoter with a selection marker, the phosphinothricin acetyltransferase (PAT) gene. This study was done to assess the acute toxicity of a genetically modified (GM) soybean using the fresh water planktonic crustacean Daphnia magna. The acute toxicity effect of the TRX soybean and non-GM soybean (Gwangan) on D. magna was investigated at different concentrations (0, 156, 313, 625, 1,250, 2,500, and 5,000 mg·L-1). The TRX soybean used for the test was confirmed to express the TRX/PAT genes by PCR and enzyme-linked immunosorbent assay (ELISA). D. magna feeding tests showed no significant differences in the cumulative immobility or an abnormal response with either the TRX soybean or non-GM soybean. The feeding study showed a similar abnormal response and cumulative immobility of the D. magna between the TRX soybean and Gwangan treatments. Additionally, the 48 h-EC50 values for the TRX and Gwangan soybeans were 755.6 and 778 mg·L-1, respectively. The soybean NOEC (no observed effect concentration) value for D. magna was suggested to be 156 mg·L-1. These results suggest that there is no significant difference in toxicity to Daphnia magna between the TRX soybean and its non-GM counterpart.

• 대한방사선치료학회지
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• 제33권
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• pp.89-97
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• 2021

목 적: 본 연구에서는 자궁경부암 방사선치료 시 전산화치료계획에 없던 직장 내 가스 용적 변화에 따른 선량변화를 비교 평가하고자 한다. 대상 및 방법: 인체모형 팬텀(Anderson Research Laboratories Inc, RANDO^TM phantom, USA)의 전산화 단층촬영 영상에 전산화치료계획시스템(Eclipse^TM Treatment Planning System, Varian, Palo Alto, version 15.6, USA)으로 9개의 필드를 이용한 정적 세기조절방사선치료계획(Static Intensity Modulated Radiation Therapy, S-IMRT)과 Full arc로 두 방향의 체적변조회전방사선치료계획(Volumetric Modulated Arc Therapy, VMAT)을 수립하였다. 임의의 가스 변수는 0.5 cm 단위로 2.0 cm까지 변화를 주어 계획표적체적(Planning Target Volume, PTV)에 포함될 수 있도록 하였다. 표적에 대한 처방선량지수(Conformity Index, CI), 선량균질지수(Homogeneity Index, HI), PTV D_max를 구하였고, 손상위험장기(Organ At Risk, OAR)에 대한 최소선량(Minimum Dose, D_min)과 평균선량((Mean Dose, D_mean), 최대선량(Maximum Dose, D_max)을 계산하여 비교하였다. T-검정을 실시하여 p-value를 구했으며 유의수준은 0.05로 설정하였다. 결 과: S-IMRT와 VMAT의 HI 결정계수(R²)는 0.9423, 0.8223으로 상관관계가 비교적 명확하였고, PTV D_max 결과 임의의 가스 용적이 커질수록 최대 2.8%까지 증가하는 것으로 나타났다. OAR의 경우 두 전산화치료계획 모두 방광에서 유의한 차이가 없었고, 직장의 경우 +1.0 cm 이상의 가스 용적에서 두 전산화치료계획 모두 D_mean 700 cGy 이상의 유의한 선량 차이가 나타났다. 방광의 D_mean을 제외한 모든 값에서 p-value 0.05 이하로 통계적인 유의한 차이를 확인하였다. 결 론: 기준 전산화치료계획에 없던 가스 발생 시 가스 용적 크기가 커질수록 PTV의 선량 변화와 직장에 전달되는 선량이 증가하였다. 방사선치료 진행 시 직장 가스의 용적이 클 경우 발생 할 수 있는 선량 전달 오류를 최소화하기 위한 노력이 반드시 필요한 것으로 판단되었다. 향후 가스 용적의 다양한 크기와 위치를 변수로 설정하여 추가적인 연구가 진행되어진다면 유익한 평가가 이루어 질 수 있을 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.863-866
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• 2016

Background: Extensive efforts have been made to investigate c-KIT expression in lung cancer specimens and its correlation with clinical outcomes, but the issue remains unresolved. Thus, this study will be conducted to clarify the prognostic value of c-KIT expression in lung cancer patients. Materials and Methods: We will search Pubmed, SCOPUS, and ISI web of sciences with no restriction of language. Studies with any design (except case reports or case series) evaluating correlations of c-KIT expression with survival or outcome in patients with lung cancer will be included. The outcome measures will include all types of survival indexes, including overall survival rate and disease free survival using Kaplan-Meier analysis and hazard ratios. Study selection and data extraction will be performed by two independent researchers. Quality assessment (assessment of risk of bias) and data synthesis will be implemented using Stata software version 11.1. Results: No ethical issues are predicted. These findings will be published in a peer-reviewed journal and presented at national and international conferences. Conclusions: This systematic review protocol is registered in the PROSPERO International Prospective Register of Systematic Reviews, registration number = CRD42015023391.