• 지역사회간호학회지
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• 제29권2호
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• pp.244-256
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• 2018

Purpose: This study tried to understand discourses of life-sustaining treatments in general daily and healthcare newspapers. Methods: A text-network analysis was conducted using the NetMiner program. Firstly, 572 articles from 11 daily newspapers and 258 articles from 8 healthcare newspapers were collected, which were published from August 2013 to October 2016. Secondly, keywords (semantic morphemes) were extracted from the articles and rearranged by removing stop-words, refining similar words, excluding non-relevant words, and defining meaningful phrases. Finally, co-occurrence matrices of the keywords with a frequency of 30 times or higher were developed and statistical measures-indices of degree and betweenness centrality, ego-networks, and clustering-were obtained. Results: In the general daily and healthcare newspapers, the top eight core keywords were common: "patients," "death," "LST (life-sustaining treatments)," "hospice palliative care," "hospitals," "family," "opinion," and "withdrawal." There were also common subtopics shared by the general daily and healthcare newspapers: withdrawal of LST, hospice palliative care, National Bioethics Review Committee, and self-determination and proxy decision of patients and family. Additionally, the general daily newspapers included diverse social interest or events like well-dying, euthanasia, and the death of farmer Baek Nam-ki, whereas the healthcare newspapers discussed problems of the relevant laws, and insufficient infrastructure and low reimbursement for hospice-palliative care. Conclusion: The discourse that withdrawal of futile LST should be allowed according to the patient's will was consistent in the newspapers. Given that newspaper articles influence knowledge and attitudes of the public, RNs are recommended to participate actively in public communication on LST.

• Preventive Nutrition and Food Science
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• 제19권4호
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• pp.321-326
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• 2014

In this study, we developed a method to quantify esculetin (6,7-dihydroxycoumarin) in plasma and tissues using HPLC coupled with ultraviolet detection and measured the level of esculetin in rat plasma after oral administration. The calibration curve for esculetin was linear in the range of 4.8 ng/mL to 476.2 ng/mL, with a correlation coefficient ($r^2$) of 0.996, a limit of detection value of 33.2 ng/mL, and a limit of quantification value of 100.6 ng/mL. Recovery rates for the 95.2 ng/mL and 190.5 ng/mL samples were 95.2% and 100.3%, within-runs and 104.8% and 101.0% between-runs, respectively. The relative standard deviation was less than 7% for both runs. In the pharmacokinetic analysis, the peak plasma esculetin level was reached 5 min after administration ($C_{max}=173.3ng/mL$; $T_{1/2}=45min$; $AUC_{0{\sim}180min}=5,167.5ng{\cdot}min/mL$). At 180 min post-administration (i.e., after euthanasia), esculetin was only detectable in the liver ($30.87{\pm}11.33ng/g$) and the kidney ($20.29{\pm}7.02ng/g$).

• 한국임상수의학회지
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• 제36권6호
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• pp.340-344
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• 2019

A 14-month-old Thoroughbred colt with hind limbs lameness was referred to Equine Hospital of Jeju National University. During physical examination, the patient could not walk in a straight line but wobbled especially with hind limbs. He hesitated when backing and crossed hind limbs while circling tightly by protracting the outer hind limb keeping the inner hind limb stationed. Stenosis was observed between the 2nd (C2) and 3rd (C3), and the C3 and 4th (C4) cervical vertebrae on radiographs. The colt diagnosed as cervical stenotic myelopathy (CSM) based on the clinical signs and radiological findings. To confirm the diagnosis, postmortem computed tomography (CT) and histopathologic examination were performed after the euthanasia. The CT images revealed severe compression of the spinal cavity and cord between C3 and C4 cervical vertebrae. Grossly, there was compression of the spinal cord between the C3 and C4 cervical vertebrae. Histopathologically, severe axonal swelling and demyelination characterized by vacuolation and cavity formation were observed in the white matter of the spinal cord, especially in C3 and C4. CSM is problematic in the horse racing industry because of abnormal walking. This case report of CSM may offer information for diagnosis of the disease in the equine veterinary fields in the Republic of Korea.

• 철학연구
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• 제130권
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• pp.161-186
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• 2014

웰빙'(well being)과 함께 최근 '웰다잉'(well dying)에 대한 사회적 관심이 '안락사'(安樂死) 문제를 계기로 촉발되어 인간 죽음의 존엄성에 대한 중요한 담론으로 대두되고 있다. '웰다잉'(well dying)은 그 어의대로 '좋은 죽음'을 의미하며, 이런 의미적 맥락의 연장선상에서 통상적으로 '준비된 죽음', '품위 있는 죽음', '아름다운 죽음'을 지칭한다. 본고에서 논자는 '죽음'을 교학의 출발점으로, 그리고 '죽음의 극복'을 교학의 종착점으로 삼고 있는 불교의 죽음관이 웰다잉에 대한 담론에 어떠한 기여를 할 수 있는지 면밀히 고찰하였다. 불교의 죽음에 대한 태도와 해석, 그리고 그 극복의 과정은 웰다잉에 대한 보다 풍부한 담론을 형성하는 단초가 되며, 특히 죽음의 극복을 육체적 생리적 영생으로서가 아닌 정신적 심리적 현상으로 해석하고 이러한 정신적 심리적 변화를 통한 사물의 진실상(眞實相)에 대한 깨달음[정각(正覺)]을 통해서 죽음을 극복하는 불교의 견해는 죽음불안의 극복 및 죽음교육에 많은 기여를 할 수 있다.

• Journal of Preventive Medicine and Public Health
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• 제52권3호
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• pp.170-178
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• 2019

Objectives: To determine the epidemiological features of patients and animals after bites/scratches from rabies-suspected animals in Zenica-Doboj Canton, Bosnia and Herzegovina. Methods: Data from all patients (and the causative animals) admitted to the Antirabies Service of the Institute for Health and Food Safety Zenica in the 2009-2017 period were analyzed, including age, sex, anatomical site of the bite/scratch, animal type (stray/owned/wildlife), veterinary observations of the animal, and whether antirabies post-exposure prophylaxis (PEP) was indicated and/or administered. Results: In total, 1716 patients were admitted. Bites/scratches were most frequently recorded during April and May (n=181, 10.5% and n=163, 9.5%, respectively). The persons admitted were mostly from the Zenica municipality (n=1278, 74.5%; incidence: 11.55/1000), which is 66.6% urbanized. Males were more frequently represented (n=1089, 63.6%). The patients were mostly 50-64 and 25-49 years of age (n=425, 24.7% and n=390, 22.7%, respectively). Dog bites were the most common cause (n=1634, 95.1%, of which n=1258, 77.0% were caused by stray dogs). PEP was indicated for 997 (58.1%) patients. Only 340 (19.9%) animals underwent veterinary observations (3.1% of stray and 76.1% of owned animals). The largest number of injuries were presented at lower extremities, 1044 (60.8%) cases. Conclusions: Zenica-Doboj Canton is a rabies-free region. Due to the high rate of stray animals not undergoing veterinary observations, the non-existence of a unique dog registry, and the consequent lack of information about stray animals in terms of number, vaccination, neutering, and euthanasia, there is an urgent need for improving the prevention and control of rabies within the One Health framework.

• 디지털융복합연구
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• 제19권4호
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• pp.435-441
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• 2021

본 연구는 간호대학생의 간호전문직관, 생명의료윤리의식 및 자기성찰지능 간의 상관관계를 확인하여 간호전문직관의 긍정적인 정립을 위한 효과적인 교육전략의 기초자료를 얻기 위해 시도되었다. 대상자는 G시에 재학 중인 간호대학생 159명이며, 자료수집 기간은 2018년 12월 3일부터 12월 7일(5일간)이었다. 자료 분석은 SPSS 22.0 프로그램으로 분석하였다. 연구결과 간호대학생의 간호전문직관은 3.97로 사회적 인식이 낮았으며 생명의료윤리의식은 2.95로 신생아 생명권이 가장 높고 인공임신중절과 안락사가 낮았다. 자기성찰지능은 3.79로 자기반성과 자기이해는 높으나 자기설계가 낮았다. 간호전문직관은 생명의료윤리의식과 자기성찰지능과 정적 상관관계를 나타냈다. 결과적으로 간호대학생의 간호전문직관의 긍정적인 정립을 위한 간호교육 전략은 자기계발을 향상시킬 수 있는 자기성찰지능 증진 교육과 간호전문직관의 토대를 다루는 교육이 제공되어야 할 필요가 있겠다.

• 문화기술의 융합
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• 제8권1호
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• pp.75-83
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• 2022

본 연구는 간호대학생의 생명의료윤리의식, 간호전문직관이 장기이식 태도에 미치는 영향을 파악하기 위해 시도되었다. 연구 대상자는 G, P시에 소재하고 있는 4년제 간호대학에 재학중인 간호대학생 202명으로 자료수집기간은 2021년 10월 12일부터 10월 22일까지였다. 자료는 SPSS 20.0 통계프로그램의 빈도분석, 평균과 표준편차, t-test와 One way ANOVA, Pearson's correlation coefficient, Stepwise multiple regression으로 분석하였다. 본 연구대상자의 생명의료윤리의식은 3.39±0.44, 간호전문직관은 3.84±0.56, 장기이식 태도는 3.67±0.25였다. 장기이식 태도에 영향을 미치는 요인으로 생명의료윤리의식의 신생아의 권리, 안락사영역, 간호전문직관의 사회적 인식, 간호의 전문성, 간호계의 역할영역이 장기이식 태도를 52.4% 설명하는 것으로 나타나 본 연구결과를 토대로 간호대학생의 장기이식 활성화를 위한 간호교육 자료로 활용 할 수 있을 것이다.

• 문화기술의 융합
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• 제7권4호
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• pp.105-112
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• 2021

본 연구는 간호대학생의 생명의료윤리의식이 간호전문직관에 미치는 영향을 파악하기 위해 시도되었다. 연구대상자는 G시에 소재하고 있는 4년제 간호대학에 재학중인 간호대학생 192명으로 자료수집기간은 2021년 5월 20일부터 5월 27일까지였다. 자료는 SPSS 20.0 통계프로그램의 빈도분석, 평균과 표준편차, t-test와 One way ANOVA, Pearson's correation coeffcient, Stepwise multiple regression으로 분석하였다. 본 연구대상자의 생명의료윤리의식은 3.28±0.41, 간호전문직관은 3.32±0.85였다. 간호대학생의 생명의료윤리의식과 간호전문직관의 상관관계는 r=.55(p=.000)으로 나타났으며, 간호전문직관에 영향을 미치는 영향요인은 생명의료윤리의식 중 장기이식이 37%, 안락사가 16.5%의 설명력을 나타내었다. 본 연구결과를 토대로 간호대학생의 간호전문직관 향상을 위한 교욱프로그램 개발에 활용할 수 있을 것이다.

• Journal of Acupuncture Research
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• 제40권4호
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• pp.344-350
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• 2023

Background: 4-carvomenthenol[4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol] is a main component of Origanum vulgare L., Zanthoxylum piperitum (L.) DC., and other plants. It has been reported to exhibit anti-inflammatory, antibacterial, and anti-tumor effects. Furthermore, it is necessary to conduct a toxicity test on 4-carvomenthenol to ensure its safety. Methods: This study included 5-week-old Institute of Cancer Research mice that were categorized into 3 treatment groups (12, 25, and 50 mg/kg 4-carvomenthenol dose levels) and a control group (10% dimethyl sulfoxide, 40% polyethylene glycol 300, 5% Tween 80, and 45% normal saline injection of the final volume), with 5 male mice and 5 female mice per group. All groups were observed for clinical symptoms and body weight in a period of 14 days and were subjected to gross necropsy after euthanasia. Results: No deaths were recorded. No test substance-related clinical signs in the female mice of the 12 mg/kg dose group were observed. Abnormal gait was observed in 1 male from day 1 to day 3 in the 12 mg/kg dose group; 1-3 males from day 1 to day 7 and 1-5 females from day 1 to day 15 in the 25 mg/kg dose group; and 2-5 males and 2-5 females from day 1 to day 15 in the 50 mg/kg dose group. No test substance-related effect on the body weight and necropsy findings was observed. Conclusion: The results of this study suggested that the lethal dose of 4-carvomenthenol could be greater than 50 mg/kg. However, further research is needed, especially repeated-dose toxicity studies, to confirm the efficacy and safety of 4-carvomenthenol.

• Journal of Veterinary Science
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• 제24권5호
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• pp.49.1-49.15
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• 2023

Background: Hystricomorpha rodents display a similar placentation model to humans. The present study was carried out considering the scarcity of information concerning the placental development in agouti. Objective: Describe the microscopy of the placenta, subplacenta and yolk sac of agoutis in early pregnancy and report on the inversion of the yolk sac. Methods: Fifteen females between the 14^th-32^nd day of gestation were used following euthanasia. Gestational buttons were collected, fixed, processed, stained to optical microscopy or immunohistochemistry. Results: Chorioallantoic placenta (CP) ranged from conical to a half-sphere, as follows: from the 14^th to 17^th day, the CP displays an inverted "V" shape, predominantly formed by cytotrophoblasts; from 20 to 22 days, formed almost entirely by cytotrophoblasts; at 28 days, a half sphere, with distinct lobes and interlobular area, numerous maternal gaps delimited by syncytiotrophoblasts and trophoblast giant cells; at 32 days, globose and undergoing the maturation process. Subplacenta, located between decidua and CP, initially presents septa consisting of simple columnar epithelium and after 17 days, comprising stratified epithelium. Visceral yolk sac (VYS) is attached to two CP projections between 14 and 17 days, formed by a simple cubic epithelium and inverted. Between 20 and 22 days, the epithelium displays apical villous projections with cytoplasmic vacuoles and a vascularized mesoderm. After the 24^th day, the VYS near the placenta is pleated, very vascularized and villous, with decreased villi sizes further away from the placenta. Conclusion: The agouti CP displays similar characteristics to other hystricomorpha, including placenta lobulation, a subplacenta and an inverted vitelline placenta.