• Title/Summary/Keyword: Ethylene Glycol

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Binding of Acid Dyes by Crosslinked Poly(4-vinylpyridine) in Ethylene Glycol (에틸렌글리콜중에서 가교폴리(4-비닐피리딘)과 산성염료와의 결합)

  • Lee, Suk Kee;Kim, Woo Sik
    • Textile Coloration and Finishing
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    • v.9 no.3
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    • pp.27-32
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    • 1997
  • Two poly(4-vinylpyridines) having different degree of crosslinking were prepared by radical copolymerization of 4-vinylpyridine with N, N'-tetramethylenebis-acrylamide as a crosslinker. The abilities of these crosslinked polymers to bind acid dyes (methyl orange, ethyl orange, and propyl orange) were investigated at various temperatures in ethylene glycol as the binding medium. From the equilibrium amounts, the first binding constants and thermodynamic parameters for the bindings were evaluated. The first binding constants and thermodynamic parameters were not varied with these dyes. This result indicates that there is no hydrophobic interaction between the crosslinked polymers and the dyes in ethylene glycol. However, the first binding constants showed bell-shaped curves againtst the binding temperatures. This result could be explained in terms of the crosslinked hole size with temperature variation.

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Synthesis and Hydrolysis of Ketoprofen Prodrug Conjugated to Poly(Ethylene Glycol) (케토프로펜-폴리에틸렌글리콜 전구약물의 합성 및 가수분해)

  • Lee, Se-Hee;Kim, Hee-Doo;Oh, Seaung-Youl
    • Journal of Pharmaceutical Investigation
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    • v.33 no.1
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    • pp.37-43
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    • 2003
  • The objective of this study is to prepare ketoprofen (KP) - poly(ethylene glycol) (PEG) conjugates and to investigate their degradation kinetics. KP-PEG conjugates were synthesized from KP and PEG methy1ester by esterification in the presence of DCC. The KP-PEG conjugates (KPEG) were characterized by IR and $^{1}H-NMR$ spectroscopy. The hydrolysis of KPEG with time was studied using HPLC by simultaneous quantification of KP and KPEG. The hydrolysis rate constant was high at low and high pHs, and showed minimum at pH 4 and 5. As the size of KPEG increases, hydrolysis rate increased. The slope of degradation rate profile suggests that catalytic reaction seems to occur by specific acid/base catalysis. These results suggest that KPEG could be used as a prodrug for KP, which releases KP slowly in the body.

CLINICO-HAEMATOLOGICAL AND BIOCHEMICAL ALTERATIONS IN ETHYLENE GLYCOL INDUCED ACUTE NEPHROTOXICITY IN COW CALVES

  • Singh, D.P.;Kumar, M.;Sharma, S.P.
    • Asian-Australasian Journal of Animal Sciences
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    • v.8 no.1
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    • pp.7-11
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    • 1995
  • Ethylene glycol was given orally in 6 crossbred male cow calves @ 12 ml/kg b wt for 2 days continuously to develop acute nephrotoxicity and monitor blood chemicals profile in affected calves. Progressive depression, hypersalivation, ataxia, incoordination, staggering gait, grinding of teeth, recumbency, coma, convulsions and death were prominent symptoms in affected calves. Respiration and pulse rates were increased whereas body temperature and rumen movements were low. Haematological investigations revealed increase in total erythrocyte count, platelets count and packed cell volume till death and total leukocyte count up to day 3 which decreased on day 4 and 5. These calves revealed azotaemia, reduction in calcium, chloride and potassium and rise in sodium and AST, ALT and alkaline phosphatase enzymes activity.

Antithrombogenicity of the Surfacfe of Poly(r-benzyl L-glutamate)/ Poly(ethylene glycol) Block Copolymer (Poly(r-benzyl L-glutamate)/ poly(ethylene glycol) block 공중합체 표면의 항혈전성에 관한 연구)

  • 조종수;송수창
    • Journal of Biomedical Engineering Research
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    • v.8 no.2
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    • pp.199-204
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    • 1987
  • ABA type block copolymers composed of r benzyle L-glutamate as the A component and poly(ethylene glycol) as the B components were obtained. Platelet adhesion on their sunfaces was investigated by a column elusion method to examine the effects of microdomain and secondary structure. The number of platelets adhered from whole blood and plasma rich platelet was smaller for the block copolymer systems than for the homopolymers. In the block copolymer system, the number of platelets adrered on their surfaces increased with increasing the content of PEG, that is, with decreasing of a-helix of block copolymers. A thick thrombus formation on the PBLG homopolymer was observed than block copolymer by scanning electron micrographs. The platelets adhesion increased with increasing the critical surface tension of the block copolymer.

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A preparation of dysprosium monotitanate powder by mixed-oxide ceramics processing employing polymer carrier (Polymer carrier 효과에 의하여 단순화된 새로운 세라믹분말 제조방법)

  • 이상진
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.8 no.2
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    • pp.350-355
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    • 1998
  • Dysprosium monotitanate $(Dy_2TiO_5)$ powder was synthesized by a simple mixed-oxide ceramics process using ethylene glycol (EG). Ethylene glycol, as the organic carrier for the metal cations, was used for polymerization mechanism. The successful used of a non-chelating polymer for the mixed-oxide ceramic process indicated that cation chelation is not the only route for creating stable ceramic precursors. Characterization of the powders by various thermal analysis, microscopy, and diffraction methods has been carried out.

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A study on formation of slurry ice by the reversing flow (역전 유동층에 의한 슬러리아이스 생성에 관한 연구)

  • Oh, C.;Mun, S.B.;Choi, Y.G.
    • Journal of Advanced Marine Engineering and Technology
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    • v.30 no.3
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    • pp.376-381
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    • 2006
  • This study is experimented to observe an influence of experimental conditions on production characteristics of slurry ice by putting ball into test section to disturb ice adhesion. And at this experiment it used ethylene glycol-water solution and the concentration is 20wt%. The experimental apparatus was constructed of ethylene glycol-water solution and slurry ice storage tank. brine tank, pumps for ethylene glycol-water solution and brine circulating, a mass flow-meter data logger for fluid temperature measuring and a vertical circular tube with two copper tubes as test section. The experiments were carried out under various conditions, with mean velocity of fluid at the entry ranging from 0.07 to 0.13m/s and ball diameter is 10mm, 15mm. Also ball filling rate is 33%, 50%.

An experimental study on formation of slurry ice in reversing flow (역전 유동층 내에서의 슬러리아이스 생성에 관한 실험적 연구)

  • Choi, Young-Gyu;Yoon, Seok-Hun;Oh, Cheol
    • Proceedings of the Korean Society of Marine Engineers Conference
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    • 2006.06a
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    • pp.49-50
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    • 2006
  • This study experimented to observe an influence of experimental conditions on production characteristics of slurry ice by putting ball into test section to disturb ice adhesion. And at this experiment it used ethylene glycol-water solution and the concentration is 20wt%. The experimental apparatus was constructed of ethylene glycol-water solution and slurry ice storage tank, brine tank. pumps for ethylene glycol-water solution and brine circulating, a mass flow-meter, data logger for fluid temperature measuring and a vertical circular tube with two copper tubes as test section. The experiments were carried out under various conditions, with mean velocity of fluid at the entry ranging from 0.07 to 0.13m/s and ball diameter is 10mm, 15mm. Also ball filling rate is 33%, 50%.

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Post-thaw Survival of Mouse Embryos of Various Developmental Stages Cryopreserved by Vitrification in Ethylene Glycol-Based Solution (Ethylene Glycol을 이용한 유리화 동결시 배 발달단계별 생쥐배의 생존성)

  • 정기화;공일근;박준규;곽대오;박충생
    • Journal of Embryo Transfer
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    • v.8 no.1
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    • pp.31-36
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    • 1993
  • The post-thaw survival of mouse embryos of the various developmental stages was determined after cryopreservation by vitrification in a solution containing ethylene glycol, Ficoll and sucrose (EFS). All the embryos were equilibrated for 2 minutes just prior to freezing. The number of blastomeres during in vitro development was counted by nuclei higher rates of post-thaw survival were obtained from the embryos of 2-cell(92.2%), 8-cell(77.2%) or morula stage(90.0%) than those of blastocyst stage(62.7%). The number of blastomeres per embryo following in vitro culture for 24 hours was significantly(P<0.05) smaller as 66.0f22.3 in vitrified and thawed morulae than fresh morulae(91.7$\pm$12.2).

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The Studies on Treatment of Liver Disease Using Lasers and Acupuncture in Dogs (고양이에서 Lasers 및 침술을 이용한 신장질환 치료에 관한 연구)

  • 김명철;변흥섭;정종만;남윤이;김무강;정주영
    • Journal of Veterinary Clinics
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    • v.15 no.2
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    • pp.325-330
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    • 1998
  • The purpose of this study is to investigate the effect of acupuncture after the induction of acute kidney disease in dogs by ethylene glycol. Twenty four mixed breed, adult cats were used in the experiment. Ethylene glycol was administered orally at 1 ml/kg in 24 cats, and then 6 cats were treated by acupunchuture 6 cats were treated by electroacupuncture, 6 cats were treated by acupuncture and 6 cats were not treated as a control group. Treatment was done once daily far 4 dsys. The acupoint used were Gan-shu and Tai-xi. The effect of acnpuncture was evaluated by clinical symptom, blood chemical values, electrocardiogram (ECG) and histopathologkal findings. After treatement, acupuncture group revealed relatively fast recovery compared with other groups, in clinical symptoms, blood chemical values, ECG waves and histopathological findings. Laserpuncture group revealed secondly fast recovery compared with control group.

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Viability of Mouse Morula Embryos Frozen Rapidly in Liquid Nitrogen Vapour (급속동결한 마우스 상실배의 체외배양후 생존성에 관하여)

  • 신상태
    • Journal of Embryo Transfer
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    • v.4 no.1
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    • pp.35-40
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    • 1989
  • The effects of cryoprotectants (glycerol, DMSO and ethylene glycol) and the concentrations (0, 0, 25, 0.5and 1.0 M) of sucrose in the diluent on the is vitro survival of mouse morulae froaen rapidly in liquid nitrogenvapour were examined. When the embryos were equilibrated in 1.5 M cryoprotectants +0.25 M sucrose in one-step or in 3.0 M cryoprotectants +0.25 sucrose in two-step and diluted with 0, 0.25, 0.5, or 1.0 M sucrose solution after thawing, high survival rates were obtained in ethylene glycol (48.0% to 88.2 %) or in glycerol (35.0 % to 77.8 %). These results show that 1.5 M ethylene glycol is a highly efficient cryoprotective agent for the rapid freezing of mouse morula embryos and 0.5 M sucrose was optimal concentration in the diluent after thawing.

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