• Journal of Gynecologic Oncology
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• v.29 no.6
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• pp.96.1-96.12
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• 2018

The 3-weekly regimen of carboplatin and paclitaxel is the backbone of first line adjuvant chemotherapy for advanced ovarian cancer. The landmark Japanese Gynaecologic Oncology Group (JGOG) 3016 study demonstrated significant improvements in progression-free survival and overall survival with dose dense weekly administration of paclitaxel in combination with 3-weekly carboplatin. However, efforts to replicate these benefits have failed in subsequent phase III trials. Weekly paclitaxel is purported to have enhanced antitumor activity, with stronger anti-angiogenic effects, and yet is better tolerated. In this review, we explore the rationale for dose dense weekly paclitaxel, and compare the relevant trials as well as quality of life considerations. Possible reasons for the difference in outcomes between the JGOG 3016 and other studies are reviewed, with a focus on how the addition of bevacizumab, the variations between histological and molecular subtypes of epithelial ovarian cancers, and ethnic pharmacogenetic differences may potentially affect the efficacy of dose dense paclitaxel.

• Toxicological Research
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• v.32 no.3
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• pp.195-205
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• 2016

This study was performed to select single nucleotide polymorphisms (SNPs) related to the body burden of heavy metals in Koreans, to provide Korean allele frequencies of selected SNPs, and to assess the difference in allele frequencies with other ethnicities. The candidate-gene approach method and genome-wide association screening were used to select SNPs related to the body burden of heavy metals. Genotyping analysis of the final 192 SNPs selected was performed on 1,483 subjects using the VeraCode Goldengate assay. Allele frequencies differences and genetic differentiations between the Korean population and Chinese (CHB), Japanese (JPT), Caucasian (CEU), and African (YIR) populations were tested by Fisher's exact test and fixation index ($F_{ST}$), respectively. The Korean population was genetically similar to the CHB and JPT populations ($F_{ST}$ < 0.05, for all SNPs in both populations). However, a significant difference in the allele frequencies between the Korean and CEU and YIR populations were observed in 99 SNPs (60.7%) and 120 SNPs (73.6%), respectively. Ten (6.1%) and 26 (16.0%) SNPs had genetic differentiation ($F_{ST}$ > 0.05) among the Korean-CEU and Korean-YIR comparisons, respectively. The SNP with the largest $F_{ST}$ value between the Korean and African populations was cystathionine-${\beta}$-synthase rs234709 ($F_{ST}$: KOR-YIR, 0.309; KOR-CEU, 0.064). Our study suggests that interethnic differences exist in SNPs associated with heavy metals of Koreans, and it should be considered in future studies that address ethnic differences in heavy-metal concentrations in the body and genetic susceptibility to the body burden of heavy metals.

• Korea journal of population studies
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• v.31 no.3
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• pp.131-157
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• 2008

The purpose of this study was to examine the difference in depression level of Japanese, Chinese and Vietnamese wives who are residing in Korean society. Special focus was taken to compare the differences in terms of the origin of nationality. Guided by the role theory, we analyzed the effect of parental role and work role on depression of foreign wives. Also we considered the social resources, ethnic characteristic that are well-known to be associated with the role performance, in this study. The data came from the sample of 524 foreign wives case (Japanese 35%, Chinese 31%, Vietnamese 34%). The result show us that depression level is different by origin of nationality of foreign wives: Vietnamese wives were more depressed compare to Japanese or Chinese wives. The effects of two social role on depression were significant even if the social resources and ethnicity are considered in the model. However, the strength of the effect of social roles were different by one another: having a job was especially effective to decrease the Chinese wife's depression level, while for the Vietnamese wives, parental role was essential to lower the depression level. In addition, the social determinants of depression were differ by the nationalities of wives. The results imply that the social adaptation process of foreign wife may be varied by the origin of nationality.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1459-1463
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• 2014

Background: Urological cancers represent a major public problem associated with high mortality and morbidity. The pattern of these cancers varies markedly according to era, region and ethnic groups, but increasing incidence trends overall makes focused epidemiological studies important. The aim of the present study was to assess the incidence of most prevalent urological cancers in Iran from 2003 to 2009. Materials and Methods: The data for this study were obtained from the population-based Cancer Registry Center of the Iran Ministry of Health and Medical Education. Differences of mean age and age distributions of each cancer were compared between 2003 and 2009 in men and women. Results: Bladder cancer was the most common urologic cancer in both genders. The rate difference of age standardized ratio (ASR) of bladder and renal cell carcinoma in women were 1.54 and 2.01 percent per 100,000 population from 2003 to the 2009, respectively. In men, the rate difference of age standardized ratio of prostate, testis, kidney and bladder cancer was also 2.23, 1.2, 1.8 and 1.5 percent per 100,000 population from 2003 to 2009, respectively. The mean ages of patients in all cancers in both genders did not differ significantly through time (p value>0.05) but the distribution of ages of patients with bladder and prostate cancer changed significantly from 2003 to 2009 (p value<0.001). Conclusions: The results of present study suggest the general pattern and incidence of urological cancers in Iran are changing, the observed increase pointing to a need for urological cancer screening programs.

• Journal of the Korean Society of Clothing and Textiles
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• v.33 no.4
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• pp.554-562
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• 2009

As a result of comparison analysis on body types of Korean women in their forties and Korean women residing in Japan, the following results had been found. 1. In terms of factors composing the body type, while women residing in Korea did not show large differences in obesity and horizontal size factors, women living in Japan showed higher contribution of obesity factor compared to horizontal size factor. That is, obesity factor was substantially more important among factors composing the body type for women residing in Japan. 2. Cluster analysis was done to understand the characteristics of body types and comparatively analyze them. Women residing in Korea were classified into tall and normal body, normal height with obese body, and short and chubby body. Women residing in Japan showed different characteristics with tall and obese body, tall and normal body with long lower part, and short and thin body. As a result of this study, identical ethnic group was found to take on different body types resulting from sociocultural differences and difference in eating habits if their place of residence differs for a long time.

• Journal of the Korea Fashion and Costume Design Association
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• v.13 no.2
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• pp.1-11
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• 2011

As a result of comparison analysis on body types of Korean women in their twenties and Korean women residing in Japan, the following results had been found. 1. The comparison of 49 items in physical measurements between the Korean women in their 20's and Korean women residing in Japan resulted in the differences in 33 items. 2. The comparison of the factor analysis results for physical measurements did not reveal big differences. 3. The comparison of the physical shapes according to the grouping resulted in three types each for both groups, with different features for individual types. Women residing in Korea were classified into tall and normal body, normal height with obese body, and short and thin body. Women residing in Japan showed different characteristics with tall and obese body, short and thin body and normal height with obese body. As a result of this study, identical ethnic group was found to take on different body types resulting from sociocultural differences and difference in eating habits if their place of residence differs for a long time.

• Journal of the Korean Society of Costume
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• v.64 no.4
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• pp.131-149
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• 2014

Tibetans are one of the ethnic Chinese minorities, and this research examined the characteristics and features of their traditional costumes by investigating their historical, geographical and cultural background. This research also examined the cultural elements according to their characteristics based on Tibet's nature, religion, arts culture such as the Jang-po, Chin-sam, Kam-kjun and belts, which are used to fix the costumes. Based on such studies the traditional Tibetan costumes were set as a motif and were expressed appropriately into a contemporary style. By studying the composition of its costumes and its costume culture, the characteristics of the Tibetan costumes could be classified into four features. First, the 'variability of form' expresses a new type depending on how it is worn. Second, the 'color contrast' shows a strong visual contrast. Third, the 'difference of materials' combines different materials into one. Fourth, the 'symbolic meaning' grants meaning to the wearer. As a result of this study, by using the characteristics of the Tibetan nature culture, religion culture and art culture as a basis, two suits of clothes for each characteristics and six suits of clothes were produced as a fashion design product.

• The Journal of Korean Medicine
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• v.24 no.4
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• pp.113-119
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• 2003

The association between apolipoprotein E (apo E) gene polymorphism and ischemic cerebrovascular disease (ICVD) has been controversial. These controversies may be due to inaccurate classification of patients and ethnic differences. We investigated the association between apo E genotypes and ICVD patients by case-control study in a Korean population. The association between apo E polymorphism and ICVD was examined in 121 patients with ICVD and 132 controls without ICVD. The E3/E4 phenotype was more frequent in control subjects (23.8％) than in patients (13.0％) (p<0.05). The E2/E3 phenotype was more frequent in patients (14.8％) than in control subjects (10.8％), but the difference was not statistically significant (p>0.05). These results suggest that the E4 allele may be a protective factor against early vascular morbidity, and the E2 allele may be a risk factor for cerebrovascular morbidity.

• Journal of the Korean Society of Costume
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• v.64 no.6
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• pp.161-175
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• 2014

This paper investigates the differences between characteristics of street fashions due to regional and cultural differences in southern and northern region of China. Beijing and Shenzhen were chosen as representative cities for the two areas. Empirical research and literature study were performed for this study. Empirical studies were performed by using a total of 708 images of dresses, which were collected through direct imaging. Through discussion with experts, the collected data were classified into five categories; Modern trendy, Romantic, Easy casual, Ethnic, and Classical/Traditional. The data was analyzed by using cross tabulation and frequency analysis. Content analysis for each category was also conducted. As a consequence of this study, a significant difference between Beijing and Shenzhen were observed. As a city, which puts emphasis on practicality and modernity, Beijing showed a higher frequency of modern and trendy style than the other city. On the other hand, Shenzhen showed a higher frequency of romantic style and was distinguished as a city of femininity and decorative preference of fashion style. This study intends to contribute to the academic community of Chinese fashion and to help Korean clothing companies to be launched in Chinese market in the future.

• Journal of Korean Public Health Nursing
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• v.27 no.3
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• pp.437-449
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• 2013

Purpose: To improve the cultural competency of nurses and physicians in Korea by disclosing their degree of prejudice toward foreigners who were major target of international medical tourists. Method: A descriptive research design was employed. Data were collected from a total of 458 nurses and physicians at general hospitals in Korea. Subjects completed questionnaires on their demographic information and prejudice toward foreigners from a cognitive, emotional, and behavioral perspective. Results: While there was a positive attitude toward Caucasian Americans and Japanese, there was a negative prejudice toward Chinese and African Americans. There was an especially high and negative prejudice from a cognitive and behavioral perspective toward Chinese. There was a significant difference in the level of prejudice according to the education level, workplace, and multi-cultural education of Korean health professionals. Conclusion: It is necessary to investigate the negative prejudice toward foreigners of specific races or countries with cautious consideration. We also recommend the development and application of strategies to improve the multi-cultural competency of Korean nurses and physicians.