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Systematic Review of the Cause of Drug-Induced Liver Injuries in Korean Literature (약인성 간손상의 원인물질에 관한 국내연구의 체계적 고찰)

  • Yun, Young-Ju;Shin, Byung-Cheul;Lee, Myeong-Soo;Cho, Sung-Il;Park, Jae-Hyeon;Lee, Hye-Jung
    • The Journal of Korean Medicine
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    • v.30 no.2
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    • pp.30-45
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    • 2009
  • Background: The safety of herbal products is an important issue in Korea. It is more complicated because of the concomitant use of conventional western drugs and herbal medicine, including prescribed medicine, folk herbs and food supplements. Although both western and traditional Korean medical doctors have studied on the safety of HMP, their results did not show relevant or consistent conclusions because of the poor quality of studies, including bias. Objectives: The aim of this study was to review the studies in Korea related to drug induced liver injury (DILI) systematically. We tried to estimate the proportion of causative materials of DILI and evaluate the clinical difference of DILIs from different materials. Methods: Systematic searches were performed on MedRIC and MEDLIS in Korea. The extraction of data as well as selective screening of the studies was carried out independently by two of the authors. There were no restrictions on the types of publication, including grey literature. Results: Twenty-one articles were included. Of them only 7 adapted prospective design and only 6 were published in peer-reviewed journals. The proportion of conventional drugs associated with hepatotoxic injuries in all DILI ranged from 15.8% to 83.3% and that of herbal medicine was from 28.9% to 44.7%. However, the criteria for herbal medicine were not clearly defined and concomitant medications were not fully investigated in most studies. There were limited objective data in the clinical differences of liver injuries from different materials and their results were conflicting. Conclusions: The causality assessments regarding DILI of herbal medicine were not performed properly and causative materials were misclassified in most of the studies published in Korea. These make the safety issue still ambiguous because of the limitations and lack of objectivity of the studies. More rigorous studies are required for clearly addressing these conflicting issues with cooperative investigation between traditional Korean and western medicine.

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The Study on the Development of the Korean Elderly's Successful Aging Scale (한국 노인의 성공적 노화 척도 개발을 위한 연구)

  • Kim, Dong-Bae
    • Korean Journal of Social Welfare
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    • v.60 no.1
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    • pp.211-231
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    • 2008
  • In phase 1 of the study, data for the construct and items of KESAS(The Korean Elderly's Successful Aging Scale) were collected by indepth interviews with a purposive sampling group of 25 elderly people and focus group interviews with four groups. Content analysis was applied to the data and from this analysis were emerged six key categories of successful aging. In phase 2 of the study, 78 items were collected from the data of 2 sets of interviews mentioned above. Through pilot test, preliminary 66 items are selected. In phase 3 of the study, 597 cases collected from the survey were divided randomly into 345 developmental samples and 252 validity samples. The items were examined exploratorily with the developmental samples and confirmatorily factor analysis with validity samples. Confirmatory factor analysis supported the hypothesized six-factor structure of KESAS, which finally resulted in consisting of 31 items. Six factors are as follows: 'autonomous life', 'self-completion orientation', 'positive life participation', 'satisfaction with one's offsprings', 'self-acceptance', 'other-acceptance'. Cronbach's alpha estimate and split-half estimates of the scale were .903 and .845, which confirms that the scale has reliability. This six-factor model exhibited a good fit on the basis of the overall fit measure criteria(TLI=.983, RMSEA=.057) aquired by using the confirmatory factor analysis. Moreover, KESAS was significantly related highly(r=.72) to the 'Quality of Life for the Korean Elderly'. This proved concurrent validity of the scale.

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Quantitative Microbial Risk Assessment for Clostridium perfringens in Natural and Processed Cheeses

  • Lee, Heeyoung;Lee, Soomin;Kim, Sejeong;Lee, Jeeyeon;Ha, Jimyeong;Yoon, Yohan
    • Asian-Australasian Journal of Animal Sciences
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    • v.29 no.8
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    • pp.1188-1196
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    • 2016
  • This study evaluated the risk of Clostridium perfringens (C. perfringens) foodborne illness from natural and processed cheeses. Microbial risk assessment in this study was conducted according to four steps: hazard identification, hazard characterization, exposure assessment, and risk characterization. The hazard identification of C. perfringens on cheese was identified through literature, and dose response models were utilized for hazard characterization of the pathogen. For exposure assessment, the prevalence of C. perfringens, storage temperatures, storage time, and annual amounts of cheese consumption were surveyed. Eventually, a simulation model was developed using the collected data and the simulation result was used to estimate the probability of C. perfringens foodborne illness by cheese consumption with @RISK. C. perfringens was determined to be low risk on cheese based on hazard identification, and the exponential model ($r=1.82{\times}10^{-11}$) was deemed appropriate for hazard characterization. Annual amounts of natural and processed cheese consumption were $12.40{\pm}19.43g$ and $19.46{\pm}14.39g$, respectively. Since the contamination levels of C. perfringens on natural (0.30 Log CFU/g) and processed cheeses (0.45 Log CFU/g) were below the detection limit, the initial contamination levels of natural and processed cheeses were estimated by beta distribution (${\alpha}1=1$, ${\alpha}2=91$; ${\alpha}1=1$, ${\alpha}2=309$)${\times}$uniform distribution (a = 0, b = 2; a = 0, b = 2.8) to be -2.35 and -2.73 Log CFU/g, respectively. Moreover, no growth of C. perfringens was observed for exposure assessment to simulated conditions of distribution and storage. These data were used for risk characterization by a simulation model, and the mean values of the probability of C. perfringens foodborne illness by cheese consumption per person per day for natural and processed cheeses were $9.57{\times}10^{-14}$ and $3.58{\times}10^{-14}$, respectively. These results indicate that probability of C. perfringens foodborne illness by consumption cheese is low, and it can be used to establish microbial criteria for C. perfringens on natural and processed cheeses.

Equations for Estimating Volume and Height of Larix leptolepis Growing in the Central Region of Korea (중부지방(中部地方) 낙엽송림분(落葉松林分)의 재적식(材積式) 및 수고식(樹高式)에 관(關)한 연구(硏究))

  • Kim, Kap Duk;Choung, Song Hak
    • Journal of Korean Society of Forest Science
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    • v.77 no.1
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    • pp.23-31
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    • 1988
  • A total of 320 Larix leptocepzs Trees growing in Kyonggi and Kangwon Province were examined to estimate tree volume and height with DBH and age. The criteria of selecting the "best" regression equation were based on coefficient of determination, $R^2$, adjusted standard error, I, and the ease of application. From the results obtained in this study, the method of estimating tree volume and height with DBH and age showed the following advantages ; 1. Since no measurement of tree height is needed, it saves time and labor in forest survey. 2. It has the ease of application because age is determined directly in artificial forests. 3. Volume and height can be estimated more easily and accurately with DBH and age than other methods.

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Determination of Investment Priority for River Improvement Project at Downstream of Dams Using PROMETHEE (PROMETHEE 기법을 이용한 댐 직하류 하천정비사업 투자우선순위 결정)

  • Kim, Gil Ho;Sun, Seung Pyo;Yeo, Kyu Dong;Kim, Hung Soo
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.32 no.1B
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    • pp.41-51
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    • 2012
  • Sometimes, there exist many alternatives for doing a SOC project. However, the limitation of the fund requires the determination of investment priority for the alternatives. This may be performed according to the degree of importance of individual alternatives. Especially, the river improvement project at the downstream of dams has complex and various values and this characteristics make it difficult decision-maker to do reasonable determination. This study aims to determine an investment priority of 33 alternatives in the river improvement project at the downstream of dams using PROMETHEE method which has advantages in determining the priority. In this study, we determined evaluation criteria and attributes by considering the functions and objectives of the river improvement project at the downstream of dams. The eigenvector method in AHP was used to estimate the relative importance of evaluation criterion. Based on the estimation, we determined investment priority of 33 alternatives by PROMETHEE method and the priority of alternatives was derived in the order of Juam regulation dam, Unmun dam, Yongdam dam and so on. The results of this study could provide a reasonable standard to the decision-maker for the determination of investment priority of alternatives.

Prevalence of Metabolic Syndrome and Waist Circumference Estimation in Some Korean Adults (일부 우리나라 성인의 대사성증후군의 유병률과 허리둘레 예측치)

  • Hong, Young-Seoub;Jeong, Baek-Geun;Park, Yong-Woo;Park, Jong-Tae;Jung, Kap-Yeol;Kim, Joon-Youn;Kim, Byoung-Gwon
    • Journal of Preventive Medicine and Public Health
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    • v.37 no.1
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    • pp.51-58
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    • 2004
  • Objectives : The purpose of this study was to estimate the prevalence of metabolic syndrome, as defined by the ATP III report, in some Korean adults and use the Asian-Pacific proposed waist circumference to investigate waist circumference in some Korean adults using ROC curves. Methods : Study subjects were seventy-five thousands and ninety one persons(47,979 men and 27,111 women) who were selected among the patients who visited hospital for health evaluation from January 2000 to December 2001. All subjects were measured by height, weight, waist and hip circumferences, blood pressure and blood chemistry(lipid profile). Results : The mean age was $41.6{\pm}8.5$ years in men, $41.1{\pm}10.4$ years in women(p<0.05). Body mass index was in the normal range in 35.3% of men, and 55.9% of women. In both men and women, blood pressure, blood sugar, total cholesterol and triglyceride were positively correlated with BMI. waist circumference, and Broca's index(p<0.01). However HDL. choloesterol was correlated negatively (p< 0.01). Using ROC curve, the calculated waist circumferences were 84 cm in men(sensitivity 61.4% and specificity 64.1%) and 74 cm in women(sensitivity 65.0% and specificity 73.2%). The age adjusted prevalences of the metabolic syndrome as defined by NCEP ATP III were different for men(6.4%) and women(14.6%). The prevalence increased from 1.2% among participants aged 20 through 29years to 15.0% among participants aged over 60years in men(p<0.05) and from 1.6% to 27.4% respectively, in women. The age adjusted prevalences, as defined by using the waist circumference that was recommended by WHO's regional office for the western Pacific, were 10.6% in men and 18.5% in women. The age adjusted prevalences, as defined by using the waist circumference that was calculated by the ROC curves, were 17.1% in men and 22.4% in women. And All prevalences were increased following increased BMI and Broca's index. Conculsions : The prevalence of metabolic syndrome in some Korean adults was lower than that in western adults. Nevertheless because waist circumference was differed among race and region, application of the same criteria was not proper. Morcover, a higher awareness was required in women, because the prevalence of metabolic syndrome was rapidly increased with increment of age.

Estimation of Disease Code Accuracy of National Medical Insurance Data and the Related Factors (의료보험자료 상병기호의 정확도 추정 및 관련 특성 분석 -법정전염병을 중심으로-)

  • Shin, Eui-Chul;Park, Yong-Mun;Park, Yong-Gyu;Kim, Byung-Sung;Park, Ki-Dong;Meng, Kwang-Ho
    • Journal of Preventive Medicine and Public Health
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    • v.31 no.3 s.62
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    • pp.471-480
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    • 1998
  • This study was undertaken in order to estimate the accuracy of disease code of the Korean National Medical Insurance Data and disease the characteristics related to the accuracy. To accomplish these objectives, 2,431 cases coded as notifiable acute communicable diseases (NACD) were randomly selected from 1994 National Medical Insurance data file and family medicine specialists reviewed the medical records to confirm the diagnostic accuracy and investigate the related factors. Major findings obtained from this study are as follows : 1. The accuracy rate of disease code of NACD in National Medical Insurance data was very low, 10.1% (95% C.I. : 8.8-11.4). 2. The reasons of inaccuracy in disease code were 1) claiming process related administrative error by physician and non-physician personnel in medical institutions (41.0%), 2) input error of claims data by key punchers of National Medical Insurer (31.3%) and 3) diagnostic error by physicians (21.7%). 3. Characteristics significantly related with lowering the accuracy of disease code were location and level of the medical institutions in multiple logistic regression analysis. Medical institutions in Seoul showed lower accuracy than those in Kyonngi, and so did general hospitals, hospitals and clinics than tertiary hospitals. Physician related characteristics significantly lowering disease code accuracy of insurance data were sex, age group and specialty. Male physicians showed significantly lower accuracy than female physicians; thirties and fortieg age group also showed significantly lower accuracy than twenties, and so did general physicians and other specialists than internal medicine/pediatric specialists. This study strongly suggests that a series of policies like 1) establishment of peer review organization of National Medical Insurance data, 2) prompt nation-wide expansion of computerized claiming network of National Medical Insurance and 3) establishment and distribution of objective diagnostic criteria to physicians are necessary to set up a national disease surveillance system utilizing National Medical Insurance claims data.

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Distribution of Organic Matter and $Al_o+1/2Fe_o$ Contents in Soils Using Principal Component and Multiple Regression Analysis in Jeju Island (주성분분석 및 다중회귀분석에 의한 제주도 토양유기물 및 $Al_o+1/2Fe_o$ 함량 분포)

  • Moon, Kyung-Hwan;Lim, Han-Cheol;Hyun, Hae-Nam
    • Korean Journal of Soil Science and Fertilizer
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    • v.43 no.5
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    • pp.748-754
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    • 2010
  • The contents of soil organic matter (SOM) and $Al_o+1/2Fe_o$ in soils are important criteria for the classification of new Andisols in Soil Taxonomy system. There are many soil types in Jeju Island with various soil forming environments. This paper was conducted to estimate the contents of soil organic matter and the content of ammonium oxalate extracted Al and Fe ($Al_o+1/2Fe_o$) using various environmental variables and to make soil property maps using a statistical analyses. The soil samples were collected from 321 locations and analyzed to measure the contents of SOM and $Al_o+1/2Fe_o$. It was analyzed the relationships among them and various environmental variables such as temperature, precipitation, net primary product, radiation, evapotranspiration, altitude, soil forming energy, topographic wetness index, elevation, difference surrounded area, and distances from the shore and the peak. We can exclude multi-collinearity among environmental variables with principal component analysis and reduce all the variables to 3 principal components. The contents of SOM and $Al_o+1/2Fe_o$ were estimated by multiple regression models and maps of them were made using the models.

Estimation of Water Quality Improvement Benefit Using Replacement Cost Approach (대체비용법을 이용한 하천 수질개선편익 산정)

  • Yeo, Kyu-Dong;Yi, Choong-Sung;Kim, Gil-Ho;Shim, Myung-Pil
    • Journal of Korea Water Resources Association
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    • v.42 no.4
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    • pp.343-353
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    • 2009
  • The objective of this study is to evaluate the effect of the water quality improvement by water discharge through dams and to provide a benefit estimation methodology, taking domestic situation into consideration, by the replacement cost approach analyzed with a sewage treatment plant instead of an alternative dam. To this end, facility that alternates a dam must have same functions of the discharged water from the dam and the two facilities must be able to be compared objectively. To estimate the benefit, estimation methodology of alternative facility's cost is established and criteria of cost.benefit analysis that are duration period and ratio of large scale repairing expense was presented. As a case study, the water quality improvement benefit of Song-Li-Won dam was evaluated, which is planned to be built on Nae-Sung stream in Nak-Dong River system. The results of applying this methodology to Song-Li-Won dam are 644,006 million won of the annual average discharge and 1,351,526 million won of maximum discharge. The usage of the framework in this study is expected for estimation of water quality improvement benefit in case water quality improvement project is performed.

The importance of NIR spectroscopy in the estimation of nutritional quality of grains for ruminants

  • Flinn, Peter C.
    • Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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    • 2001.06a
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    • pp.1612-1612
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    • 2001
  • The production of grain for export and domestic use is one of Australia's most important agricultural industries, and the NIR technique has been used extensively over many years for the routine monitoring of grain quality, particularly moisture and protein content. Because most Australian grain is intended for human food production, the determinants of grain quality for livestock feed, apart from protein, have been largely ignored. However the increasing use of grain for feeding to pigs, poultry, beef cattle and dairy cows has led to an important national research project entitled “Premium Grains for Livestock”. Two of the objectives of this project are to determine the compositional and functional characteristics of grains which influence their nutritional quality for the various classes of livestock, and to adopt rapid and objective analytical tests for these quality criteria. NIR has been used in this project firstly to identify a set of grain samples from a large population of breeders' lines which showed a wide spectral variation, and hence a potentially wide variation in nutritional value. The selected samples were not only subjected to an extensive array of chemical, physical and in vitro analyses, but also were grown out to produce sufficient quantities of grain to feed to animals in vivo studies. Additional grains were also strategically selected from farms in order to include the effect of weather damage, such as rain, drought and frost. In this study to date, NIR calibrations have been derived or attempted, on both ground and whole grains, for in vivo dry matter digestibility (DMD), pepsin-cellulase dry matter disappearance, protein, fat, acid detergent fibre, neutral detergent fibre, starch, in sacco DMD and in vitro assays to simulate starch digestion in the lumen and small intestine. Results so far indicate high calibration accuracy for chemical components (SECV 0.3 to 2.6%) and very promising statistics for in vivo DMD (SECV 1.8, $R^2$ 0.93, SD 7.0, range 61.9 to 92.3, n=60). There appears to be some potential for NIR to estimate some in vitro properties, depending upon the accuracy of reference methods and appropriate sample populations. Current work is in progress to extend the range of grains with in vivo DMD values (a very laborious and expensive process) and to increase the robustness of the various NIR calibrations, with the aim of implementing uniform testing procedures for nutritional value of grains throughout Australia.

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