• Title/Summary/Keyword: Essentiality

Search Result 34, Processing Time 0.025 seconds

An Empirical Study on Interior Landscape Design Trends of High-rise Office Building (생태학적 개념을 도입한 실내조경 디자인에 관한 사례조사 연구 -고층 오피스 건물의 로비공간을 중심으로-)

  • Han, Hae-Ryon;Lee, Eun Jung;Park, young ki
    • KIEAE Journal
    • /
    • v.5 no.4
    • /
    • pp.41-50
    • /
    • 2005
  • The phenomenon due to the abundance of material civilization, and the destruct of environment provokes the damage to the order of nature in the earth. To prevent the fact, the necessity of the ecology start to become influential an important issue. In an outlook on the world of the ecological concept, human evolves with an environment as the mutual interdependence eventually. The approaching of the ecological method to reform of the present environment is an essentiality. In a viewpoint, the interior landscape starts to distinguish as an ecological concept in interior environment. To recognize the necessity of an interior landscape, comparison and analysis have been carried out in the worldwide examples of the lobby space in high-rise office buildings. In the results, the interior landscape is an essential fact to create an ecological interior environment. As the perceiving of the importance in the composition of the ecological environment, it needs to recognize the imminence the introduction of the ecological concept in the human life.

Controversies on governing the rates of protein evolution

  • Choi, Sun-Shim
    • Interdisciplinary Bio Central
    • /
    • v.1 no.3
    • /
    • pp.11.1-11.5
    • /
    • 2009
  • One of the main issues of molecular evolution is to reveal the principles dictating protein evolutionary rates. A traditional hypothesis posits that protein evolutionary rates are mostly determined by the average functional importance of amino acids in a given protein. Thus the correlations of evolutionary rates with different variables such as PPI, gene essentiality and expression abundance have been studied to test the traditional hypothesis. Recently, mRNA expression abundance among the variables has drawn much attention, not only because it shows relatively strong correlation with protein evolutionary rates, but also because of the controversies surrounding an alternative hypothesis against the traditional one. Here, I will give an overview over the traditional hypothesis, and summarize the different variables that have been found to correlate with protein evolutionary rates. Then I will introduce pros and cons on the two different hypotheses.

Reevaluation of the Metabolic Essentiality of the Minerals - Review -

  • Spears, J.W.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.12 no.6
    • /
    • pp.1002-1008
    • /
    • 1999
  • Essential metabolic functions have been identified for seven macrominerals (calcirum, phosprorus, magnesium, sodium, potassium, chloride, and sulfur), and eight microminerals (cobalt, copper, iodine, iron, manganese, molybdenum, selenium, and zinc). Major functions for each of these minerals are summarized. Considerable research suggests that chromium is also essential and that it functions by facilitating insulin activity. Studies are reviewed which indicate that chromium supplementation of animal diets may: 1) increase glucose removal from blood, 2) reduce carcass fat and increase lean in nonruminants, 3) alter egg cholesterol content, and 4) enhance immunity and disease resistance in ruminants. A number of other minerals including nickel, boron, vanadium, arsenic, silicon, lithum, and lead have been reported to be essential, but specific metabolic functions have not been defined for any of these elements. Limited research in poultry suggests that boron may be of practical significance in some instances.

Railway carbody analysis technology development for application Europe crashworthiness standard. (유럽 충돌안전도 규격 적용 철도차량 차체 해석 기술 개발)

  • Jeong, Ji-Ho;Park, Hyung-Soon;Park, Guen-Soo;Lee, Jang-Wook
    • Proceedings of the KSR Conference
    • /
    • 2006.11b
    • /
    • pp.231-237
    • /
    • 2006
  • Recently railroad industry pulls a new interest with stability, fixed time characteristic, low environment pollution characteristic and mass transportation characteristic. With industrial development railroad it joins in, The many research and regulation production are coming to do. Specially like this activities are coming to be advanced actively from North America and Europe. From viewpoint of railway car production company, The vehicle production that a suitable Europe standard is essentiality for find a Europe market that The whole vehicle consuming hold it does a most big specific gravity. From this study, developed finite element model for analysis technology about crashworthiness of inside GM/RT 2100 standard and analyzed crash results.

  • PDF

Novel zinc sources as antimicrobial growth promoters for monogastric animals: a review

  • Lei, Xin Jian;Liu, Zhang Zhuang;Park, Jae Hong;Kim, In Ho
    • Journal of Animal Science and Technology
    • /
    • v.64 no.2
    • /
    • pp.187-196
    • /
    • 2022
  • The essentiality of zinc for animals has been recognized over 80 years. Zinc is an essential trace element that is a component of many enzymes and is associated with the various hormones. Apart from the nutritional function, zinc has antimicrobial property and often be supplemented in diets in the quantities greater than which is required to meet the nutritional requirement, especially for weaning pigs. This review will focus on the application of pharmacological zinc and its mechanisms which may be responsible for the effects of zinc on performance and health of monogastric animals. Various novel sources of zinc in non-ruminant animal production will also be discussed. These should assist in more precisely formulating feed to maximize the production performance and to maintain the health condition of monogastric animals.

Identifying Bridging Nodes and Their Essentiality in the Protein-Protein Interaction Networks (단백질 상호작용 네트워크에서 연결노드 추출과 그 중요도 측정)

  • Ahn, Myoung-Sang;Ko, Jeong-Hwan;Yoo, Jae-Soo;Cho, Wan-Sup
    • Journal of Korea Society of Industrial Information Systems
    • /
    • v.12 no.5
    • /
    • pp.1-13
    • /
    • 2007
  • In this research, we found out that bridging nodes have great effect on the robustness of protein-protein interaction networks. Until now, many researchers have focused on node's degree as node's essentiality. Hub nodes in the scale-free network are very essential in the network robustness. Some researchers have tried to relate node's essentiality with node's betweenness centrality. These approaches with betweenness centrality are reasonable but there is a positive relation between node's degree and betweenness centrality value. So, there are no differences between two approaches. We first define a bridging node as the node with low connectivity and high betweenness value, we then verify that such a bridging node is a primary factor in the network robustness. For a biological network database from Internet, we demonstrate that the removal of bridging nodes defragment an entire network severally and the importance of the bridging nodes in the network robustness.

  • PDF

Analysis on the Sociomathematical norms in math gifted classroom according to the Teacher's belief (교사의 신념에 따른 수학영재교실의 사회수학적 규범 비교 분석)

  • Cho, Yoomi;Song, Sang Hun
    • Journal of Educational Research in Mathematics
    • /
    • v.23 no.3
    • /
    • pp.373-388
    • /
    • 2013
  • This paper is to investigate how two elementary school teacher's belief mathematics as educational content, and teaching and learning mathematics as a part of educational methodology, and what the two teachers believe towards gifted children and their education, and what the classes demonstrate and its effects on the sociomathematical norms. To investigate this matter, the study has been conducted with two teachers who have long years of experience in teaching gifted children, but fall into different belief categories. The results of the study show that teacher A falls into the following category: the essentiality of mathematics as 'traditional', teaching mathematics as 'blended', and learning mathematics as 'traditional'. In addition, teacher A views mathematically gifted children as autonomous researchers with low achievement and believes that the teacher is a learning assistant. On the other hand, teacher B falls into the following category: the essentiality of mathematics as 'non-traditional', teaching mathematics as 'non-traditional, and learning mathematics as 'non-traditional.' Also, teacher B views mathematically gifted children as autonomous researchers with high achievement and believes that the teacher is a learning guide. In the teacher A's class for gifted elementary school students, problem solving rule and the answers were considered as important factors and sociomathematical norms that valued difficult arithmetic operation were demonstrated However, in the teacher B's class for gifted elementary school students, sociomathematical norms that valued the process of problem solving, mathematical explanations and justification more than the answers were demonstrated. Based on the results, the implications regarding the education of mathematically gifted students were investigated.

  • PDF

Site-directed Mutagenesis of Cysteine Residues in Phi-class Glutathione S-transferase F3 from Oryza sativa

  • Jo, Hyun-Joo;Lee, Ju-Won;Noh, Jin-Seok;Kong, Kwang-Hoon
    • Bulletin of the Korean Chemical Society
    • /
    • v.33 no.12
    • /
    • pp.4169-4172
    • /
    • 2012
  • To elucidate the roles of cysteine residues in rice Phi-class GST F3, in this study, all three cysteine residues were replaced with alanine by site-directed mutagenesis in order to obtain mutants C22A, C73A and C77A. Three mutant enzymes were expressed in Escherichia coli and purified to electrophoretic homogeneity by affinity chromatography on immobilized GSH. The substitutions of Cys73 and Cys77 residues in OsGSTF3 with alanine did not affect the glutathione conjugation activities, showing non-essentiality of these residues. On the other hand, the substitution of Cys22 residue with alanine resulted in approximately a 60% loss of specific activity toward ethacrynic acid. Moreover, the ${K_m}^{CDNB}$ value of the mutant C22A was approximately 2.2 fold larger than that of the wild type. From these results, the evolutionally conserved cysteine 22 residue seems to participate rather in the structural stability of the active site in OsGSTF3 by stabilizing the electrophilic substrates-binding site's conformation than in the substrate binding directly.

Zinc and Selenium Requirements for Glutathione Peroxidase Activity and Cell Survival in Chinese Hamster Ovary Cells Overexpressing Metallothionein

  • Kwun, In-Sook;John R. Arthur;John H. Beattie
    • Preventive Nutrition and Food Science
    • /
    • v.8 no.1
    • /
    • pp.36-39
    • /
    • 2003
  • Many defined cell culture media were formulated over 3() years ago and may be deficient in certain micronutrients whose essentiality has only subsequently been recognised. The objective of this study was to evaluate whether alpha-minimal essential medium (MEM) supplemented with 10% foetal bovine serum contained sufficient selenium for optimal activity of the selenium containing enzymes cytosolic glutathione peroxidase (cGPx) and phospholipid hydroperoxide glutathione peroxidase (PHGPx) in cultured Chinese hamster ovary (CHO) cells. Additionally, the effect of zinc deficiency and metallothionein (MT) overexpression on cGPx and PHGPx activity was studied. The addition of 100 nM of selenous acid to the culture medium increased cGPx expression by 10-fold and PHGPx by about 2-fold in both wild-type CHO-K1 cells and CHO-K1 cells overexpressing mouse MT-1. Zinc deficiency had no significant effect on enzyme activity, but cells overexpressing mouse MT-1 had higher levels of cGPx activity. Zinc deficiency decreased cell survival but overexpression of MT-1 was partially protective, probably because its presence in quantity favoured the uptake, sequestration and cellular retention of any remaining zinc. This study demonstrates that selenium in complete alpha-MEM is insufficient for optimal cGPx and PHGPx activity and may compromise the cellular response to oxidative stress.

A Study of Personified Character in Cartoon (카툰에서의 의인화 캐릭터 연구)

  • Choi, Hae-Sol;Yoon, Ki-Heon
    • The Journal of the Korea Contents Association
    • /
    • v.15 no.8
    • /
    • pp.141-148
    • /
    • 2015
  • This study based on hypothesis essentiality of character developing is necessary in origin role of cartoons and concern the characteristic of modern society is great many products and consumptions. On contrary to this hypothesis, characters are not importantly utilized in work and planning. As a fundamental research for developing character in cartoon, this research study for personification. Comparative study personification in fable and cartoon. The common feature underlying personification in fable and cartoon are purified expression for object of satire, putting symbolical meaning to target of satire, presenting a diversity of view, reducing descriptions, supporting to understand context easily and playing a role as make interesting and laugh with irony and fantasy.