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Research on the Development of Microneedle Arrays Based on Micromachining Technology and the Applicability of Parylene-C (미세가공 기술 기반의 마이크로니들 어레이 개발 및 패럴린 적용 가능성에 관한 연구)

  • Dong-Guk Kim;Deok-kyu Yoon;Yongchan Lee;Min-Uk Kim;Jihyoung Roh;Yohan Seo;Kwan-Su Kang;Young Hun Jeong;Kyung-Ah Kim;Tae-Ha Song
    • Journal of Biomedical Engineering Research
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    • v.44 no.6
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    • pp.404-413
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    • 2023
  • In this research, we studied the development of a SUS304 microneedle array based on microfabrication technology and the applicability of Parylene-C thin film, a medical polymer material. First of all, four materials commonly used in the field of medical engineering (SUS304, Ti, PMMA, and PEEK) were selected and a 5 ㎛ Parylene-C thin film was deposited. The applicability of Parylene-C coating to each material was confirmed through SEM analysis, contact angle measurement, surface roughness(Ra) measurement, and adhesion test according to ASTM standards for each specimen. Parylene-C thin film was deposited based on chemical vapor deposition (CVD), and a 5 ㎛ Parylene-C deposition process was established through trial and error. Through characteristic experiments to confirm the applicability of Parylene-C, SUS304 material, which is the easiest to apply Parylene-C coating without pretreatment was selected to develop a microneedle array based on CNC micromachining technology. The CNC micromachining process was divided into a total of 5 steps, and a microneedle array consisting of 19 needles with an inner diameter of 200 ㎛, an outer diameter of 400 ㎛, and a height of 1.4 mm was designed and manufactured. Finally, a 5 ㎛ Parylene-C coated microneedle array was developed, which presented future research directions in the field of microneedle-based drug delivery systems.

Minimum area for circular isolated footings with eccentric column taking into account that the surface in contact with the ground works partially in compression

  • Inocencio Luevanos-Soto;Arnulfo Luevanos-Rojas;Victor Manuel Moreno-Landeros;Griselda Santiago-Hurtado
    • Coupled systems mechanics
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    • v.13 no.3
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    • pp.201-217
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    • 2024
  • This study aims to develop a new model to obtain the minimum area in circular isolated footings with eccentric column taking into account that the surface in contact with the ground works partially in compression, i.e., a part of the contact area of the footing is subject to compression and the other there is no pressure (pressure zero). The new model is formulated from a mathematical approach based on a minimum area, and it is developed by integration to obtain the axial load "P", moment around the X axis "Mx" and moment around the Y axis "My" in function of σmax (available allowable soil pressure) R (radius of the circular footing), α (angle of inclination where the resultant moment appears), y0 (distance from the center of the footing to the neutral axis measured on the axis where the resultant moment appears). The normal practice in structural engineering is to use the trial and error procedure to obtain the radius and area of the circular footing, and other engineers determine the radius and area of circular footing under biaxial bending supported on elastic soils, but considering a concentric column and the contact area with the ground works completely in compression. Three numerical problems are given to determine the lowest area for circular footings under biaxial bending. Example 1: Column concentric. Example 2: Column eccentric in the direction of the X axis to 1.50 m. Example 3: Column eccentric in the direction of the X axis to 1.50 m and in the direction of the Y axis to 1.50 m. The new model shows a great saving compared to the current model of 44.27% in Example 1, 50.90% in Example 2, 65.04% in Example 3. In this way, the new minimum area model for circular footings will be of great help to engineers when the column is located on the center or edge of the footing.

Enhanced Indoor Localization Scheme Based on Pedestrian Dead Reckoning and Kalman Filter Fusion with Smartphone Sensors (스마트폰 센서를 이용한 PDR과 칼만필터 기반 개선된 실내 위치 측위 기법)

  • Harun Jamil;Naeem Iqbal;Murad Ali Khan;Syed Shehryar Ali Naqvi;Do-Hyeun Kim
    • Journal of Internet of Things and Convergence
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    • v.10 no.4
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    • pp.101-108
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    • 2024
  • Indoor localization is a critical component for numerous applications, ranging from navigation in large buildings to emergency response. This paper presents an enhanced Pedestrian Dead Reckoning (PDR) scheme using smartphone sensors, integrating neural network-aided motion recognition, Kalman filter-based error correction, and multi-sensor data fusion. The proposed system leverages data from the accelerometer, magnetometer, gyroscope, and barometer to accurately estimate a user's position and orientation. A neural network processes sensor data to classify motion modes and provide real-time adjustments to stride length and heading calculations. The Kalman filter further refines these estimates, reducing cumulative errors and drift. Experimental results, collected using a smartphone across various floors of University, demonstrate the scheme's ability to accurately track vertical movements and changes in heading direction. Comparative analyses show that the proposed CNN-LSTM model outperforms conventional CNN and Deep CNN models in angle prediction. Additionally, the integration of barometric pressure data enables precise floor level detection, enhancing the system's robustness in multi-story environments. Proposed comprehensive approach significantly improves the accuracy and reliability of indoor localization, making it viable for real-world applications.

Comparison of Treatment Planning System(TPS) and actual Measurement on the surface under the electron beam therapy with bolus (전자선 치료 시 Bolus를 적용한 경우 표면선량의 Treatment Planning System(TPS) 계산 값과 실제 측정값의 비교)

  • Kim, Byeong Soo;Park, Ju Young;Park, Byoung Suk;Song, Yong Min;Park, Byung Soo;Song, Ki Weon
    • The Journal of Korean Society for Radiation Therapy
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    • v.26 no.2
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    • pp.163-170
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    • 2014
  • Purpose : If electron, chosen for superficial oncotherapy, was applied with bolus, it could work as an important factor to a therapy result by showing a drastic change in surface dose. Hence the calculation value and the actual measurement value of surface dose of Treatment Planning System (TPS) according to four variables influencing surface dose when using bolus on an electron therapy were compared and analyzed in this paper. Materials and Methods : Four variables which frequently occur during the actual therapies (A: bolus thickness - 3, 5, 10 mm, B: field size - $6{\time}6$, $10{\time}10$, $15{\time}15cm2$, C: energy - 6, 9, 12 MeV, D: gantry angle - $0^{\circ}$, $15^{\circ}$) were set to compare the actual measurement value with TPS(Pinnacle 9.2, philips, USA). A computed tomography (lightspeed ultra 16, General Electric, USA) was performed using 16 cm-thick solid water phantom without bolus and total 54 beams where A, B, C, and D were combined after creating 3, 5 and 10 mm bolus on TPS were planned for a therapy. At this moment SSD 100 cm, 300 MU was investigated and measured twice repeatedly by placing it on iso-center by using EBT3 film(International Specialty Products, NJ, USA) to compare and analyze the actual measurement value and TPS. Measured film was analyzed with each average value and standard deviation value using digital flat bed scanner (Expression 10000XL, EPSON, USA) and dose density analyzing system (Complete Version 6.1, RIT, USA). Results : For the values according to the thickness of bolus, the actual measured values for 3, 5 and 10 mm were 101.41%, 99.58% and 101.28% higher respectively than the calculation values of TPS and the standard deviations were 0.0219, 0.0115 and 0.0190 respectively. The actual values according to the field size were $6{\time}6$, $10{\time}10$ and $15{\time}15cm2$ which were 99.63%, 101.40% and 101.24% higher respectively than the calculation values and the standard deviations were 0.0138, 0.0176 and 0.0220. The values according to energy were 6, 9, and 12 MeV which were 99.72%, 100.60% and 101.96% higher respectively and the standard deviations were 0.0200, 0.0160 and 0.0164. The actual measurement value according to beam angle were measured 100.45% and 101.07% higher at $0^{\circ}$ and $15^{\circ}$ respectively and standard deviations were 0.0199 and 0.0190 so they were measured 0.62% higher at $15^{\circ}$ than $0^{\circ}$. Conclusion : As a result of analyzing the calculation value of TPS and measurement value according to the used variables in this paper, the values calculated with TPS on 5 mm bolus, $6{\time}6cm2$ field size and low-energy electron at $0^{\circ}$ gantry angle were closer to the measured values, however, it showed a modest difference within the error bound of maximum 2%. If it was beyond the bounds of variables selected in this paper using electron and bolus simultaneously, the actual measurement value could differ from TPS according to each variable, therefore QA for the accurate surface dose would have to be performed.

The Comparative Assessment of the KVA and Dynamic Stereoacuity (동적시력(KVA)과 동적 입체시의 비교 평가)

  • Kim, Young-Cheong;Shim, Hyun-Suk;Kim, Sang-Hyun
    • Journal of Korean Ophthalmic Optics Society
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    • v.19 no.4
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    • pp.519-525
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    • 2014
  • Purpose: On this study, we investigated the relationship between the kinetic visual acuity (KVA) and the dynamic stereoacuity and the effects of anisometropia with measuring KVA and the dynamic stereoacuity. Methods: For 63 adults (male 30, female 33), KVA and the dynamic stereoacuity were measured by using the kinetic visual acuity tester (KOWA AS-4A) and the Howard-Dolman test (H-D test) at distance 2.5 m after conducted full correction of subjects' refractive error respectly. Results: The means of KVA were $0.49{\pm}0.25$ for total subjects, $0.58{\pm}0.26$ for male, $0.40{\pm}0.22$ for female, and LogMAD (Log minimum angle of displacement) dynamic stereoacuities were $1.27{\pm}0.44$($28.44{\pm}25.03sec$ of arc) for total subjects, $1.28{\pm}0.44$($28.23{\pm}23.34sec$ of arc) for male, $1.27{\pm}0.45$($28.63{\pm}26.83sec$ of arc) for female. KVA showed a statistically significant difference between male and female (p=0.00), but dynamic stereoacuity was no significant difference (p=0.97). No significant correlation was present between KVA and dynamic stereoacuity (r=0.03). Also there were no significant differences in the dynamic stereoacuity of the three group which were classified according to the low, middle, high range of KVA (p=0.99). The anisometropia were less than 1 D and over 1 D when divided into two groups, KVA and dynamic stereoacuity showed no significant difference between each (p=0.11, p=0.99). There was no significant correlation between anisometropia and KVA (r=0.33), dynamic stereoacuity (r=0.18) but the correlation between KVA and anisometropia revealed more higer than between dynamic stereoacuity and anisometropia. Conculsions: The KVA for adults showed a significant difference between male and female and male was higher than female for KVA. The dynamic stereoacuity due to the KVA, the KVA and dynamic stereoacuity due to anisometropia were not significant differences between each and also were not great correlations.

A Study on the Variation of Daily Urban Water Demand Based on the Weather Condition (기후조건에 의한 상수도 일일 급수량의 변화에 관한 연구)

  • Lee, Gyeong-Hun;Mun, Byeong-Seok;Eom, Dong-Jo
    • Water for future
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    • v.28 no.6
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    • pp.147-158
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    • 1995
  • The purpose of this study is to establish a method of estimating the daily urban water demand using statistical model. This method will be used for the development of the efficient management and operation of the water supply facilities. The data used were the daily urban water use, the population, the year lapse and the weather conditions such as temperature, precipitation, relative humidity, etc. Kwangju city was selected for the case study area. The raw data used in this study were rearranged either by month or by season for the purpose of analysis, and the statistical analysis was applied to the data to obtain the regression model. As a result, the multiple linear regression model was developed to estimate the daily urban water use based on the seather condition. The regression constant and the model coefficients were determined for each month of a year. The accuracy of the model was within 3% of average error and within 10% of maximum error. The developed model was found to be useful to the practical operation and management of the water supply facilities.

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Matching Points Filtering Applied Panorama Image Processing Using SURF and RANSAC Algorithm (SURF와 RANSAC 알고리즘을 이용한 대응점 필터링 적용 파노라마 이미지 처리)

  • Kim, Jeongho;Kim, Daewon
    • Journal of the Institute of Electronics and Information Engineers
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    • v.51 no.4
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    • pp.144-159
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    • 2014
  • Techniques for making a single panoramic image using multiple pictures are widely studied in many areas such as computer vision, computer graphics, etc. The panorama image can be applied to various fields like virtual reality, robot vision areas which require wide-angled shots as an useful way to overcome the limitations such as picture-angle, resolutions, and internal informations of an image taken from a single camera. It is so much meaningful in a point that a panoramic image usually provides better immersion feeling than a plain image. Although there are many ways to build a panoramic image, most of them are using the way of extracting feature points and matching points of each images for making a single panoramic image. In addition, those methods use the RANSAC(RANdom SAmple Consensus) algorithm with matching points and the Homography matrix to transform the image. The SURF(Speeded Up Robust Features) algorithm which is used in this paper to extract featuring points uses an image's black and white informations and local spatial informations. The SURF is widely being used since it is very much robust at detecting image's size, view-point changes, and additionally, faster than the SIFT(Scale Invariant Features Transform) algorithm. The SURF has a shortcoming of making an error which results in decreasing the RANSAC algorithm's performance speed when extracting image's feature points. As a result, this may increase the CPU usage occupation rate. The error of detecting matching points may role as a critical reason for disqualifying panoramic image's accuracy and lucidity. In this paper, in order to minimize errors of extracting matching points, we used $3{\times}3$ region's RGB pixel values around the matching points' coordinates to perform intermediate filtering process for removing wrong matching points. We have also presented analysis and evaluation results relating to enhanced working speed for producing a panorama image, CPU usage rate, extracted matching points' decreasing rate and accuracy.

Formulation of a reference coordinate system of three-dimensional head & neck images: Part II. Reproducibility of the horizontal reference plane and midsagittal plane (3차원 두부영상의 기준좌표계 설정을 위한 연구: II부 수평기준면과 정중시상면의 재현성)

  • Park, Jae-Woo;Kim, Nam-Kug;Chang, Young-Il
    • The korean journal of orthodontics
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    • v.35 no.6 s.113
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    • pp.475-484
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    • 2005
  • This study was performed to investigate the reproducibility of the horizontal and midsagittal planes, and to suggest a stable coordinate system for three-dimensional (3D) cephalometric analysis. Eighteen CT scans were taken and the coordinate system was established using 7 reference points marked by a volume model, with no more than 4 points on the same plane. The 3D landmarks were selected on V works (Cybermed Inc., Seoul, Korea), then exported to V surgery (Cybermed Inc., Seoul, Korea) to calculate the coordinate values. All the landmarks were taken twice with a lapse of 2 weeks. The horizontal and midsagittal planes were constructed and its reproducibility was evaluated. There was no significant difference in the reproducibility of the horizontal reference planes, But, FH planes were more reproducible than other horizontal planes. FH planes showed no difference between the planes constructed with 3 out of 4 points. The angle of intersection made by 2 FH planes, composed of both Po and one Or showed less than $1^{\circ}$ difference. This was identical when 2 FH planes were composed of both Or and one Po. But, the latter cases showed a significantly smaller error. The reproducibility of the midsagittal plane was reliable with an error range of 0.61 to $1.93^{\circ}$ except for 5 establishments (FMS-Nc, Na-Rh, Na-ANS, Rh-ANS, and FR-PNS). The 3D coordinate system may be constructed with 3 planes; the horizontal plane constructed by both Po and right Or; the midsagittal plane perpendicular to the horizontal plane, including the midpoint of the Foramen Spinosum and Nc; and the coronal plane perpendicular to the horizontal and midsagittal planes, including point clinoidale, or sella, or PNS.

GOCI-II Capability of Improving the Accuracy of Ocean Color Products through Fusion with GK-2A/AMI (GK-2A/AMI와 융합을 통한 GOCI-II 해색 산출물 정확도 개선 가능성)

  • Lee, Kyeong-Sang;Ahn, Jae-Hyun;Park, Myung-Sook
    • Korean Journal of Remote Sensing
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    • v.37 no.5_2
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    • pp.1295-1305
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    • 2021
  • Satellite-derived ocean color products are required to effectively monitor clear open ocean and coastal water regions for various research fields. For this purpose, accurate correction of atmospheric effect is essential. Currently, the Geostationary Ocean Color Imager (GOCI)-II ground segment uses the reanalysis of meteorological fields such as European Centre for Medium-Range Weather Forecasts (ECMWF) or National Centers for Environmental Prediction (NCEP) to correct gas absorption by water vapor and ozone. In this process, uncertainties may occur due to the low spatiotemporal resolution of the meteorological data. In this study, we develop water vapor absorption correction model for the GK-2 combined GOCI-II atmospheric correction using Advanced Meteorological Imager (AMI) total precipitable water (TPW) information through radiative transfer model simulations. Also, we investigate the impact of the developed model on GOCI products. Overall, the errors with and without water vapor absorption correction in the top-of-atmosphere (TOA) reflectance at 620 nm and 680 nm are only 1.3% and 0.27%, indicating that there is no significant effect by the water vapor absorption model. However, the GK-2A combined water vapor absorption model has the large impacts at the 709 nm channel, as revealing error of 6 to 15% depending on the solar zenith angle and the TPW. We also found more significant impacts of the GK-2 combined water vapor absorption model on Rayleigh-corrected reflectance at all GOCI-II spectral bands. The errors generated from the TOA reflectance is greatly amplified, showing a large error of 1.46~4.98, 7.53~19.53, 0.25~0.64, 14.74~40.5, 8.2~18.56, 5.7~11.9% for from 620 nm to 865 nm, repectively, depending on the SZA. This study emphasizes the water vapor correction model can affect the accuracy and stability of ocean color products, and implies that the accuracy of GOCI-II ocean color products can be improved through fusion with GK-2A/AMI.

Evaluation of Sensitivity and Retrieval Possibility of Land Surface Temperature in the Mid-infrared Wavelength through Radiative Transfer Simulation (복사전달모의를 통한 중적외 파장역의 민감도 분석 및 지표면온도 산출 가능성 평가)

  • Choi, Youn-Young;Suh, Myoung-Seok;Cha, DongHwan;Seo, DooChun
    • Korean Journal of Remote Sensing
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    • v.38 no.6_1
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    • pp.1423-1444
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    • 2022
  • In this study, the sensitivity of the mid-infrared radiance to atmospheric and surface factors was analyzed using the radiative transfer model, MODerate resolution atmospheric TRANsmission (MODTRAN6)'s simulation data. The possibility of retrieving the land surface temperature (LST) using only the mid-infrared bands at night was evaluated. Based on the sensitivity results, the LST retrieval algorithm that reflects various factors for night was developed, and the level of the LST retrieval algorithm was evaluated using reference LST and observed LST. Sensitivity experiments were conducted on the atmospheric profiles, carbon dioxide, ozone, diurnal variation of LST, land surface emissivity (LSE), and satellite viewing zenith angle (VZA), which mainly affect satellite remote sensing. To evaluate the possibility of using split-window method, the mid-infrared wavelength was divided into two bands based on the transmissivity. Regardless of the band, the top of atmosphere (TOA) temperature is most affected by atmospheric profile, and is affected in order of LSE, diurnal variation of LST, and satellite VZA. In all experiments, band 1, which corresponds to the atmospheric window, has lower sensitivity, whereas band 2, which includes ozone and water vapor absorption, has higher sensitivity. The evaluation results for the LST retrieval algorithm using prescribed LST showed that the correlation coefficient (CC), the bias and the root mean squared error (RMSE) is 0.999, 0.023K and 0.437K, respectively. Also, the validation with 26 in-situ observation data in 2021 showed that the CC, bias and RMSE is 0.993, 1.875K and 2.079K, respectively. The results of this study suggest that the LST can be retrieved using different characteristics of the two bands of mid-infrared to the atmospheric and surface conditions at night. Therefore, it is necessary to retrieve the LST using satellite data equipped with sensors in the mid-infrared bands.