Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Research on the Development of Microneedle Arrays Based on Micromachining Technology and the Applicability of Parylene-C

미세가공 기술 기반의 마이크로니들 어레이 개발 및 패럴린 적용 가능성에 관한 연구

  • Dong-Guk Kim (Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub)) ;
  • Deok-kyu Yoon (Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub)) ;
  • Yongchan Lee (Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub)) ;
  • Min-Uk Kim (Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub)) ;
  • Jihyoung Roh (Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub)) ;
  • Yohan Seo (Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub)) ;
  • Kwan-Su Kang (Department of Biomedical Engineering, School of Medicine, Chungbuk National University) ;
  • Young Hun Jeong (Department of Mechanical Engineering, Kyungpook National University) ;
  • Kyung-Ah Kim (Department of Biomedical Engineering, School of Medicine, Chungbuk National University) ;
  • Tae-Ha Song (Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub))
  • 김동국 ((재)대구경북첨단의료산업진흥재단) ;
  • 윤덕규 ((재)대구경북첨단의료산업진흥재단) ;
  • 이용찬 ((재)대구경북첨단의료산업진흥재단) ;
  • 김민욱 ((재)대구경북첨단의료산업진흥재단) ;
  • 노지형 ((재)대구경북첨단의료산업진흥재단) ;
  • 서요한 ((재)대구경북첨단의료산업진흥재단) ;
  • 강관수 (충북대학교 의과대학 의용생체공학과) ;
  • 정영훈 (경북대학교 기계공학부) ;
  • 김경아 (충북대학교 의과대학 의용생체공학과) ;
  • 송태하 ((재)대구경북첨단의료산업진흥재단)
  • Received : 2023.11.13
  • Accepted : 2023.11.29
  • Published : 2023.12.31
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Abstract

In this research, we studied the development of a SUS304 microneedle array based on microfabrication technology and the applicability of Parylene-C thin film, a medical polymer material. First of all, four materials commonly used in the field of medical engineering (SUS304, Ti, PMMA, and PEEK) were selected and a 5 ㎛ Parylene-C thin film was deposited. The applicability of Parylene-C coating to each material was confirmed through SEM analysis, contact angle measurement, surface roughness(Ra) measurement, and adhesion test according to ASTM standards for each specimen. Parylene-C thin film was deposited based on chemical vapor deposition (CVD), and a 5 ㎛ Parylene-C deposition process was established through trial and error. Through characteristic experiments to confirm the applicability of Parylene-C, SUS304 material, which is the easiest to apply Parylene-C coating without pretreatment was selected to develop a microneedle array based on CNC micromachining technology. The CNC micromachining process was divided into a total of 5 steps, and a microneedle array consisting of 19 needles with an inner diameter of 200 ㎛, an outer diameter of 400 ㎛, and a height of 1.4 mm was designed and manufactured. Finally, a 5 ㎛ Parylene-C coated microneedle array was developed, which presented future research directions in the field of microneedle-based drug delivery systems.

Keywords

Acknowledgement

본 연구는 2023년 산업통상자원부의 재원으로 한국산업기술진흥원(KIAT)의 지원을 받아 수행된 연구임(P0025996, 융합혁신지원단 기술지원사업).

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