• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.29 no.4
• /
• pp.363-368
• /
• 2016

In this study, we numerically analyze fatigue cracks of curved pipes under cyclic loadings. Numerical models of the curved pipes are developed. The models are verified with the experimental results in terms of fatigue lives and development process of the fatigue cracks. Erosion technique is applied to the solid elements in order to describe shapes of the fatigue cracks and estimate the fatigue lives. Also, development of the fatigue cracks is described by allocating sufficient number of solid elements in the radial direction. Fatigue lives and shapes of the crack resulting from numerical analyses show good agreement with those of the experiment considering ${\pm}100mm$ displacement. In addition, estimation of the fatigue life caused by displacement with different magnitude is conducted. We expect that the model can be applied to understand the relation between fatigue lives and characteristics of pipes or loadings.

• Journal of Korea Water Resources Association
• /
• v.47 no.11
• /
• pp.1027-1037
• /
• 2014

Flow and bed changes due to tributary inflow variation at the confluence of the Namhan River and the Geumdang Stream were analyzed in this study using a two-dimensional numerical model. As a result of the numerical analysis, the velocity downstream of the confluence was greater than the velocity upstream of the confluence in the main channel regardless of the magnitude of tributary inflow. However, as tributary discharge increased, the channel erosion was accelerated and the dry area was produced at the tributary. Due to the bed erosion at the tributary, sediment transport was increased and the eroded sediments were deposited in the confluence area. The deposition in the confluence area changed the flow direction at the main channel to the left side and the localized flow eroded the channel bed at the left side. Therefore, it is expected that bank failure due to continuous bed degradation is possible in this area.

• Archives of Pharmacal Research
• /
• v.18 no.3
• /
• pp.183-188
• /
• 1995

Polymeric reinforcement and coatings of alginate beads were carried out to control the release rate of drug from alginate beads. A poorly water-soluble ibuprofen (IPF) was selected as a model drug. A commercially available $Eudragit^{\circledR}$ RS100 was also used as a polymer. Effects of polymeric contents, the presence of plasticizers and amount of drug loading on the release rate of drug were investigated. The release rate of drug from alginate beads in the simulated gastric fluid did not occur within 2 h but released immediately when dissolution media were switched to the simulated intestinal fluid. No significant difference of release rate from polymer-reinforced alginate bead without plasticizers was observed when compared to plain (simple) beads. However, the release rate of drug from polymer-reinforced alginate beads was further sustained and retarded when aluminium tristearate (AT) as a plasticizer was added to polymer. However, polyethylene glycol 400 (PEG400) did not change the release rate of drug from alginate beads although PEG400 was used to improve dispersion of polymer and sodium alginate, and plasticize $Eudragit^{\circledR}$ RS100 polymer. The presence of plasticizer was crucial to reinforce alginate gel matrices using a polymer. As the amount of drug loading increased, the release rate of drug increased as a result of decreasing effects of polymer contents in matrices. The significantly sustained release of drug from polymer-coated alginate beads occurred as the amount of polymer increased because the thickness of coated membrane increased so that cracks and pores of the outer surface of alginate beads could be reduced. The sustained and retarded action of polymer-reinforced and coated beads may result from the disturbance of swelling and erosion (disintegration) of alginate beads. From these findings, polymeric-reinforcement and coatings of alginate gel beads can provide an advanced delivery system by retarding the release rate of various drugs.

• Korean Journal of Remote Sensing
• /
• v.31 no.1
• /
• pp.29-38
• /
• 2015

The coastline influenced naturally and artificially changes dynamically. While the long-term change is influenced by the rise in the surface of the sea and the changes in water level of the rivers, the short-term change is influenced by the tide, earthquake and storm. Also, man-made thoughtless development such as construction of embankment and reclaimed land not considering erosion and deformation of coast has been causes for breaking functions of coast and damages on natural environment. In order to manage coastal environment and resources effectively, In this study is intended to analyze and predict erosion in coastal environment and changes in sedimentation quantitatively by detecting changes in coastal line from data collection for satellite images and aerial LiDAR data. The coastal line in 2007 and 2012 was extracted by manufacturing Digital Surface Model (DSM) with Aviation LiDAR materials. For the coastal line in 2009 and 2010, Normalized Difference Vegetation Index (NDVI) method was used to extract the KOMPSAT-2 image selected after considering tide level and wave height. The change rate of the coastal line is varied in line with the forms of the observation target but most of topography shows a tendency of being eroded as time goes by. Compared to the relatively monotonous beach of Taean, the gravel and rock has very complex form. Therefore, there are more errors in extraction of coastlines and the combination of transect and shoreline, which affect overall changes. Thus, we think the correction of the anomalies caused by these properties is required in the future research.

• Journal of Ocean Engineering and Technology
• /
• v.28 no.3
• /
• pp.236-244
• /
• 2014

This study considered a seagrass habitat in order to analyze the characteristics of a marine environment of seagrass located in the Seomjin river estuary, through an analysis of the distribution of the water depth, field observation, and three-dimensional numerical experiments using an EFDC model. The seagrass habitat was usually distributed at D.L(-) 0.5~0.0 m, and was hardly seen in the intertidal zone higher than that range. The distribution of the water temperature was within the range of $7.0{\sim}23.2^{\circ}C$, and the seagrass was demonstrated to have a strong tolerance to changes in the water temperature. In addition, the salinity distribution was found to be 27.2~31.0 psu, with suspended solids of 32.1 mg/L, which were higher than the previous research results (Huh et al., 1998), implying that there may be a reduction in the amount of deposits caused by the suspended solids. As for the sedimentary facies, they were comprised of 62.7% sand, 19.1% silt, and 18.2% clay, indicating that the arenaceous was superior and the sedimentary facies were similar to that of Dadae Bay. According to a numerical experiment, the maximum tidal current was 75 cm/s, while the tidal residual current was 10 cm/s, confirming that it sufficiently adapted to strong tidal currents. The erosion and deposition are predicted to be less than 1.0 cm/year. Thus, it is judged that the resuspension of sediments due to tidal currents and the changes in sedimentary facies are insignificant.

• Journal of Acupuncture Research
• /
• v.40 no.1
• /
• pp.35-43
• /
• 2023

Background: This study aimed to examine the effect of Scutellaria baicalensis extract (SBE) on ameliorating pain response and inflammation in an animal model. Methods: The effects of SBE on joint inflammation-induced rats and pain writhing response were measured. In rats with monosodium iodoacetate (MIA)-induced knee osteoarthritis (OA), the weight-bearing distribution of the hind legs was measured, the actual joint condition was visually confirmed, and serum cytokines were extracted from whole blood and measured. In addition, the acetic acid-induced pain was measured by the number of abdominal wall contractions and writhing responses. Results: 1. The weight-bearing distribution of the hind limbs of the SBE group was remarkably improved compared with that of the control group 7 days after MIA treatment, and the SBE 300 group was improved similarly to that of the indomethacin group. 2. Cartilage erosion was significantly recovered in the SBE and indomethacin groups, and the degree of healing of cartilage erosion by SBE was similar to that by indomethacin. 3. The serum levels of cytokines interleukin-1β, tumor necrosis factor-α, and interleukin-6 were significantly decreased in the SBE group compared with that in the control group, and the SBE 300 group had reduced levels of cytokines similar to the indomethacin group. 4. As regards acetic acid-induced writhing response, the number of writhes was significantly reduced in the SBE and ibuprofen groups, and the SBE 600 group had fewer writhes than the ibuprofen group. Conclusion: SBE significantly improves knee OA and pain and is expected to show similar therapeutic effects to indomethacin and ibuprofen.

• Molecules and Cells
• /
• v.46 no.10
• /
• pp.627-636
• /
• 2023

Periodontal disease is a chronic inflammatory disease that leads to the gradual destruction of the supporting structures of the teeth including gums, periodontal ligaments, alveolar bone, and root cementum. Recently, interests in alleviating symptoms of periodontitis (PD) using natural compounds is increasing. Avenanthramide-C (Avn-C) is a polyphenol found only in oats. It is known to exhibit various biological properties. To date, the effect of Avn-C on PD pathogenesis has not been confirmed. Therefore, this study aimed to verify the protective effects of Avn-C on periodontal inflammation and subsequent alveolar bone erosion in vitro and in vivo. Upregulated expression of catabolic factors, such as matrix metalloproteinase 1 (MMP1), MMP3, interleukin (IL)-6, IL-8, and COX2 induced by lipopolysaccharide and proinflammatory cytokines, IL-1β, and tumor necrosis factor α (TNF-α), was dramatically decreased by Avn-C treatment in human gingival fibroblasts and periodontal ligament cells. Moreover, alveolar bone erosion in the ligature-induced PD mouse model was ameliorated by intra-gingival injection of Avn-C. Molecular mechanism studies revealed that the inhibitory effects of Avn-C on the upregulation of catabolic factors were mediated via ERK (extracellular signal-regulated kinase) and NF-κB pathway that was activated by IL-1β or p38 MAPK and JNK signaling that was activated by TNF-α, respectively. Based on this study, we recommend that Avn-C may be a new natural compound that can be applied to PD treatment.

• Journal of Korea Water Resources Association
• /
• v.41 no.2
• /
• pp.149-162
• /
• 2008

The Soil and Water Assessment Tool (SWAT) developed by the USDA-Agricultural Research Service for the prediction of land management impact on water, sediment, and agricultural chemical yields in a large-scale basin was applied to Daecheong Reservoir basin to estimate the amount of soil losses from different land uses. The research outcomes provide important indications for reservoir managers and policy makers to search alternative watershed management practices for the mitigation of reservoir turbidity flow problems. After calibrations of key model parameters, SWAT showed fairly good performance by adequately simulating observed annual runoff components and replicating the monthly flow regimes in the basin. The specific soil losses from agricultural farm field, forest, urban area, and paddy field were 33.1, $2.3{\sim}5.4$ depending on the tree types, 1.0, and 0.1 tons/ha/yr, respectively in 2004. It was noticed that about 55.3% of the total annual soil loss is caused by agricultural activities although agricultural land occupies only 10% in the basin. Although the soil erosion assessment approach adopted in this study has some extent of uncertainties due to the lack of detailed information on crop types and management activities, the results at least imply that soil erosion control practices for the vulnerable agricultural farm lands can be one of the most effective alternatives to reduce the impact of turbidity flow in the river basin system.

• Journal of Korean society of Dental Hygiene
• /
• v.21 no.5
• /
• pp.507-515
• /
• 2021

Objectives: The aim of this study was to evaluate the extent of the potential erosion of enamel induced by three different types of commercial fermented milk using the pH cycle model. Methods: Specimens were treated and soaked up in three types of fermented milk and in mineral water for 10 min, four times a day for 8 days, and all of the specimens were immersed in artificial saliva outside of treatment times. The microhardness of the surface was measured by a microhardness tester, and a scanning electron microscope (SEM) was used to identify the enamel surface morphology. Results: The differences in the surface microhardness (ΔVHN) of enamel were different among the groups (p<0.05). The four groups were in descending order of ΔVHN: the liquid type group, condensed-drink type group, condensed-stirred type group, and control group. The liquid type group had a higher ΔVHN than the other two fermented milk groups (p<0.05). Based on SEM observation, the most severe surface damage was due to the liquid type of fermented milk. Conclusions: Customers' careful discretion is advised when purchasing these types of fermented milk. This information is anticipated to be of much value in the prevention of dental erosion.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.40 no.3
• /
• pp.187-193
• /
• 2022

In the Yeongdong region of Gangwon-do, coastal areas are important resources in terms of cultural, social and economic aspects. However, the coast of Gangwon-do is experiencing severe erosion, and it is concerned that its adverse effects will gradually increase. In this study, coastline changes of Yangyang and Gangneung in Gangwon-do were tracked and analyzed over a long period of time. In order to build time series image data, aerial photos from the 1940s to the present were mainly used, and data from CORONA satellite, which operated from the 1960s to the early 1970s, were collected and used together. Using 51cm resolution ortho image and 2m resolution Digital Elevation Model(DEM) as reference, ground control points were selected to perform geometric correction on the aerial photos and CORONA images. Subsequently, Canny edge detector applied to these images to extract the coastlines. As a result of analyzing the extracted and vectorized coastlines by overlaying them in chronological order, erosion and deposition occurring around the artificial structures and on the nearby beaches were observed. In this study, the effect of seasonal variation, tide, and various coastal management including the beach filling were not considered. Because coastal erosion is greatly affected by geographic factors, each local government must find its own solution. Continuous research and local data accumulation are required.