• Journal of Korean Society of Environmental Engineers
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• v.36 no.5
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• pp.317-324
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• 2014

Environmental tobacco smoke (ETS) samples were collected separately in mainstream and side-stream smoke using a self-designed smoking machine, and a total 40 of PM2.5 was collected with low volume air sampler at indoor environments with and without ETS in Daejeon, Korea. About 20 trace elements including toxic metals like As, Cr, Mn, Se, V, and Zn were determined in PM2.5 and ETS samples by instrumental neutron activation analysis (INAA). It is found that the emission factors of K, Cl, Na, and Al were much higher than those of toxic elements for both mainstream and side-stream smoke. The average concentration of PM2.5 was enriched by 1.5 times at smoking area ($58.7{\pm}18.1{\mu}g/m^3$) than at smoking free area ($38.6{\pm}12.7{\mu}g/m^3$). The concentration ratio of each element between smoking and smoking free area were ranged from 1.1 to 6.0 except Cu (1.0); especially, Ce (6.0), La (5.2), K (2.3), and Co (2.0) showed higher ratio, which suggests that the ETS is one of the possible increasing factors of PM2.5 and elemental concentration at indoor environment.

• Journal of Preventive Medicine and Public Health
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• v.36 no.2
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• pp.117-124
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• 2003

Objectives : This study was performed to examine the relationship between maternal exposure to environmental tobacco smoke (ETS) and pregnancy outcomes (low birth weight or preform baby) in a prospective cohort study. Methods : We made a pregnant women's cohort, and followed the pregnancy outcomes, between May 1st 2001 and August 31st 2002. We surveyed 2,250 women who visited our hospital during their 35th gestational week, with a self-administered questionnaire. The final total of mother-infant pairs analyzed in this study was 1,712. We used a multiple logistic regression analysis to analyze the effect of maternal ETS on the incidence of preform or low birth weight, and a linear regression analysis for the birth weight and gestational age. Results : Higher exposure to ETS (>=1 hours/day) during pregnancy was more negatively associated with the gestational age and birth weight, than no exposure to ETS (no or less than 1 hour). Maternal exposure to ETS was associated with preform baby(adjusted odds ratio (AOR) 1.7; 95% confidence interval (CI) 0.9, 3.3) and low birth weight (AOR 2.3; 95% CI 0.9, 5.5). In addition, we found that maternal ETS may reduce the birth weight by 70g after adjusting for potential confounding factors. Conclusions : This study suggests that maternal exposure to ETS during pregnancy may increase the frequency of low birth weights and preform births.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.173-173
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• 2002

This study was conducted to compare two biomarkers of environmental tobacco smoke (ETS); urinary cotinine and 1-hydroxypyrene-glucuronide (1-OHPG). Urine samples were collected from 102 junior high school students. Urinary cotinine was determined by GC and urinary 1-OHPG was assayed by synchronous fluorescence spectroscopy (SFS) after immuno-affinity purification using monoclonal antibody 8E11.(omitted)

• Clinical and Experimental Pediatrics
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• v.59 no.8
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• pp.319-327
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• 2016

Allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, and food allergy, are most common chronic, noncommunicable diseases in childhood. In the past few decades, the prevalence has increased abruptly worldwide. There are 2 possible explanations for the rising prevalence of allergic diseases worldwide, that an increased disease-awareness of physician, patient, or caregivers, and an abrupt exposure to unknown hazards. Unfortunately, the underlying mechanisms remain largely unknown. Despite the continuing efforts worldwide, the etiologies and rising prevalence remain unclear. Thus, it is important to identify and control risk factors in the susceptible individual for the best prevention and management. Genetic susceptibility or environments may be a potential background for the development of allergic disease, however they alone cannot explain the rising prevalence worldwide. There is growing evidence that epigenetic change depends on the gene, environment, and their interactions, may induce a long-lasting altered gene expression and the consequent development of allergic diseases. In epigenetic mechanisms, environmental tobacco smoke (ETS) exposure during critical period (i.e., during pregnancy and early life) are considered as a potential cause of the development of childhood allergic diseases. However, the causal relationship is still unclear. This review aimed to highlight the impact of ETS exposure during the perinatal period on the development of childhood allergic diseases and to propose a future research direction.

• Journal of dental hygiene science
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• v.14 no.2
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• pp.123-131
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• 2014

Environmental tobacco smoke (ETS) or second hand smoke or passive smoking has become a well-known risk factor for various health hazards in nonsmoking adults as well as active smokers. In Korea, there have been few studies concerning about the impact of ETS on periodontal health. Therefore, the aim of this study was to investigate the association between exposure to passive smoking and prevalence of periodontitis using Korea National Health and Nutrition Examination Survey (KNHANES) in 2008 and 2009. The Fourth KNHANES data was employed from 2008~2009. The final sample size was 4,669 adults aged over 18 years, who were never-smoker and had the information about ETS both at home and in the workplace, urine analysis and periodontal examination by Community Periodontal Index (CPI). Periodontitis was defined as CPI codes ${\geq}3$. Data were analyzed using PASW Statistics 18.0. The sociodemographic and behavioral factors were adjusted as confounders. Overall, 17.1% (male 16.4%, female 83.6%) of the participants were exposed to ETS. The mean concentration of cotinine in those exposed ETS was significantly higher than that in unexposed people ($46.92{\mu}g/ml$ versus $19.34{\mu}g/ml$, p<0.001). Participants exposed to ETS were more likely to have periodontitis than those unexposed after adjusting for potential confounding variables. ETS is associated with the prevalence of periodontitis in Korean adults. This may suggest that patients with periodontitis or periodontal surgery should be protected from smokers or smoking places.

• Health Policy and Management
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• v.30 no.4
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• pp.505-512
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• 2020

Background: In monitoring exposure to environmental smoke (ETS), biomarkers can overcome the subjectivity and inaccuracy of self-reporting measurements, and have the advantage of reflecting ETS exposure in all places. This study aims to evaluate the effectiveness of ETS exposure measurement using biomarkers such as urine cotinine. Methods: This study used the Korea National Health and Nutrition Survey data from 2009 to 2018. A total of 28,574 non-smokers with urine cotinine data were selected for the study. The cotinine concentration and ETS exposure rate using urine cotinine was estimated and then compared with the self-reporting measurements. The degree of agreement among measurements of ETS exposure was confirmed. Results: As a result of measuring ETS exposure with urine cotinine, 23,594 (83.8%) out of 28,574 subjects were classified as to exposure groups. This estimate differs significantly from measurements made by self-reporting. In addition, the average concentration of cotinine in non-smokers has decreased to a 10th level over the past 10 years. Based on the biomarker, the sensitivity of the self-reporting was 8.5%-29.0%, the specificity was 16.4%-19.5%, and the kappa value was 2.0%-5.8%. Conclusion: The findings of our study show that self-reporting measurement does not well reflect the extent to which non-smoker's exposure to smoking materials. Whereas cotinine concentration has decreased significantly over the past 10 years, the ETS exposure rate has not reduced. It strongly suggests the need for intervention in the group of non-smokers exposed to low concentrations of smoke. Therefore, an assessment using biomarkers such as cotinine-based measurement should be made in the Health Plan 2030.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.3029-3034
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• 2015

Background: While the perinatal outcomes of active maternal smoking are well documented, results of the effects of environmental tobacco smoke (ETS) exposure during pregnancy are inconsistent. We aimed to examine the effect of ETS exposure, assessed by maternal hair nicotine levels at $35^{th}$ week of gestation, on birth weight and the risk of small for gestational age (SGA) and low birth weight (LBW). Materials and Methods: A total of 871 non-smoking healthy pregnant women were recruited by one Korean hospital between 1 October 2006 and 31 July 2007. Hair samples were collected and anthropometric questionnaires administered at $35^{th}$ week of gestation. The primary outcome was birth weight and secondary outcomes were the risk of babies being SGA and LBW. Results: Log-transformed hair nicotine concentrations were inversely related with birth weight after adjusting for confounding variables (${\beta}=-0.077$, p=0.037). After stratifying hair nicotine levels by tertiles (T1, low [0.0-0.28 ng/mg]; T2, medium [0.29-0.62 ng/mg]; and T3, high [0.63-5.99 ng/mg]), the mean birth weight in each groups were 3,342g (T1) 3,296g (T2) and 3,290 g (T3), respectively. However the difference between groups was not statistically significant by analysis of co-variance (ANCOVA) adjusting for covariates (p=0.062). In logistic regression analysis, the risk of SGA was higher in the T3 (OR=1.59, 95%CI 1.05-2.42) than in the reference group (T1), after controlling for confounding variables. The risk of low birth weight (<2,500g, LBW) was not significantly higher (OR=1.44, 95%CI 0.95-2.19), but the risk of babies being below 3,000g birth weight was increased in the T3 group (OR=1.53, 95%CI 1.00-2.36) compared with that in the T1 group. Conclusions: Maternal ETS exposure during pregnancy was inversely related with birth weight. The risk of SGA increased in the highest ETS exposure group compared with in the low exposure group. To prevent ETS exposure during pregnancy, more comprehensive tobacco control policies are needed.

• Analytical Science and Technology
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• v.17 no.5
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• pp.410-415
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• 2004

In order to learn the emission characteristics of hazardous pollutants associated with environmental tobacco smoking (ETS), we measured the concentrations of major aromatic VOC and carbonyl compounds released from ETS. By acquiring the different smoke types of ETS, we were able to determine that the concentrations of those species range from ppb (normal exhaled air of smoker prior to smoking) to ppm levels (direct release of ETS without filter). Using these measurement data, we also evaluated the body-retaining rate of these compounds as the result of ETS. The results of our analysis indicated that predominant portion of them (e.g., > 99%) are retained as the result of cigarette smoking. To learn more about the potential impact of ETS, more extensive study may be required to assess the gross picture of pollutant deposition inside respiratory intake and their health-effects.

• Proceedings of the Korean Society of Tobacco Science Conference
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• 1997.10a
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• pp.30-78
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• 1997

Exposure of nonsmokers to environmental tobacco smoke (ETS) has been claimed to be associated with an increased risk for lung cancer e. g., in the US, Europe, Japan and several Asian countries. The present paper reports on and discusses the scientific evidence available to date that can be used in order to assess this potential risk for Korea. Evidence related to three key steps in risk assessment, i.e., the characterization of a potential risk, data associating a response to a dose, and data characterizing actual exposures of people to ETS will be reviewed. The final assessment of the potential risk will be left to those qualified and commissioned with the task of risk assessment as a basis for public health policy in Korea.

• Environmental Analysis Health and Toxicology
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• v.5 no.3_4
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• pp.47-56
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• 1990

Smoking damages nonsmoker's health who have been exposed to passive smoking as well as smoker's own health. Passive smoking can cause serious health damage to particular groups, such as the old aged, children and pregnant women. The purpose of this study is to investigate the relationship between nicotine concentrations in environmental tobacco smoke (ETS) and urinary cotinine concentrations of nonsmokers exposed to ETS, and to provide basic information related to health risk assessment. The results of this study were summarized as follows: 1. When 180 cigarrette were smoked during S hours (high concentrations exposure) in 132 m$^3$chamber, mean concentrations of nicotine in ETS showed 263.52 $\mu\textrm{g}$/m$^3$${\pm}$51.93. When 45 cigarretts were smoked (low concentrations exposure), it was 69.43${\pm}$8.96 $\mu\textrm{g}$/m$^3$. 2. The urinary cotinine concentrations of each times (0, 2.5, 5, 17 and 24 hours) in nonsmokers ranged from 0.27∼12.52 ng/ml in high concentrations exposure and 0.22∼2.28 ng/ml in low concentrations exposure. Mean while the total urinary cotinine concentrations during 24 hours ranged from 11.62∼31.65 ng/ml in high concentrations exposure and 3.45∼5.64 ng/ml in low concentrations exposure. 3. The correlation equation and coefficient between cotinine concentrations in nonsmokers' urine (y) and nicotine concentrations in ETS (x) was y=0.421+0.0171x and 0:875 (p<0.01) respectively, 4. The quantity of nonsmokers' smoking exposure by passive smoking can be assumed as based on the estimation of nicotine concentrations in ETS by measuring cotinine concentrations of nonsmokers' urine.