• Environmental Mutagens and Carcinogens
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• v.22 no.2
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• pp.65-69
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• 2002

To elucidate the effect of microsphere coinjection on the administration of oligodeoxynucleotides (ODN), we have investigated biodistribution of ［S-35］-labeled antisense ODN targeted to cAMP-dependent protein kinase (PKA) RI-$\alpha$ subunit in nude mice xenografted with WiDr (human colon cancer, ATCC CCL218). The strategy of using microsphere has been proposed for cancer treatment as a carrier of therapeutic ODN so that it could offer an advantage with respect to maintaining constant ODN levels in blood and obtaining higher therapeutic ODN concentration at tumor sites. Comparative biodistribution studies were performed in nude mice (female, 20 g of body weight, n = 4-6) xenografted with WiDr cancer cells, when 0.1 $\mu$Ci (specific activity, 2.94 mCi/$\mu$mole) of ［S-35］-labeled RI-$\alpha$ antisense ODN was injected alone or with microsphere (PLG-18, polylactic copolymer with cationic surfactant DDAB18). Peak tumor uptake of ［S-35］-labeled ODN was significantly increased from 17.7% (at 6 h) of injected dose per gram of tissue (ID/g) to 42.5% (at 24 h) ID/g when microsphere was coinjected with ODN. The different biodistribution in the kidney accumulation (e.g., 100.2% ID/g for ODN alone and 54.9%/ID/g for microshpere coinjection) may contribute to higher blood concentration (e.g., 21.5%ID/$m\ell$ for ODN alone and 37.5%ID/$m\ell$ for microsphere coinjection) of radiolabeled ODN. Of importance is the fact that the whole body retention of radioactivity increased with microsphere coinjection from 50.8%ID/g to 68.0%ID/g after 24-h of injection. This decreased kidney accumulation and increased whole body retention of ［S-35］-labeled ODN resulted in a significant improvement of ODN targeting to the tumor site. In conclusion, the coinjection of microsphere appears to be an important carrier system in vehiculation of antisense oligonucleotide to the tumor tissue in vivo.

• Journal of Bio-Environment Control
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• v.26 no.4
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• pp.411-417
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• 2017

Environmental and growth factors such as light intensity, vapor pressure deficit, and leaf area index are important variables that can change the transpiration rate of plants. The objective of this study was to compare the transpiration rates estimated by modified Penman-Monteith model and artificial neural network. The transpiration rate of paprika (Capsicum annuum L. cv. Fiesta) was obtained by using the change in substrate weight measured by load cells. Radiation, temperature, relative humidity, and substrate weight were collected every min for 2 months. Since the transpiration rate cannot be accurately estimated with linear equations, a modified Penman-Monteith equation using compensated radiation (Shin et al., 2014) was used. On the other hand, ANN was applied to estimating the transpiration rate. For this purpose, an ANN composed of an input layer using radiation, temperature, relative humidity, leaf area index, and time as input factors and five hidden layers was constructed. The number of perceptons in each hidden layer was 512, which showed the highest accuracy. As a result of validation, $R^2$ values of the modified model and ANN were 0.82 and 0.94, respectively. Therefore, it is concluded that the ANN can estimate the transpiration rate more accurately than the modified model and can be applied to the efficient irrigation strategy in soilless cultures.

• Geophysics and Geophysical Exploration
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• v.4 no.4
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• pp.133-144
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• 2001

An effective seismic reflection technique for mapping the cavities and bedrock surface in carbonate rocks is described. The high resolution seismic reflection images were successfully registered by using the hydrophones employed in the stream-water driven trench, and were effectively focused by applying optimal data processing sequences. The strategy included enhancement of the signal interfered with the large-amplitude scattering noise, through pre- and post stack processing such as time-variant filtering, bad-trace editing, residual statics, velocity analysis, and careful muting after NMO (normal moveout) correction. The major reflections including the bedrock surface were mapped with the desired resolution and were correlated to the seismic crosshole tomographic data. Shallow major reflectors could be identified and analyzed on the AGC (auto gain control)-applied field records. Three subhorizontal layers were identified with their distinct velocities; overburden (<3000 m/s), sediments (3000-4000 m/s), limestone bedrock (>4000 m/s). Taking into account of no diffraction effects in the field records, gravel-rich overburdens and sediments are considered to be well sorted. Based on the images mapped consistently on the whole survey line and seismic velocity increasing with depth, this area probably lacks in sizable cavities (if any, no air-filled cavities).

• Economic and Environmental Geology
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• v.53 no.1
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• pp.111-120
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• 2020

Remarkable scientific and technological achievements are mainly shown in the 'super-convergence' or 'convergence of convergence' among cross- disciplinary fields, and advanced countries are promoting the 'high-risk, high-return research' ecosystem. Google LLC is carrying out numerous new challenges in terms of a non-failure perspective. Innovative research by the US Defense Advanced Research Projects Agency (DARPA) has produced such breakthroughs as the Internet, GPS, semiconductors, the computer mouse, autonomous vehicles, and drones. China is pioneering a 'Moon Village' and planning the world's largest nuclear fusion energy and ultra-large particle accelerator project. Japan has also launched 'the moonshot technology development research system' to promote disruptive innovation. In Korea, the government is preparing a new research program to tackle the global scientific challenges. Therefore, it is necessary to determine the reasonable geoscientific challenges to be addressed and to conduct a preliminary study on these topics. For this purpose, it is necessary to conduct long-term creative research projects centered on young researchers, select outstanding principal investigators, extract innovative topics without prior research or reference, simplify research proposal procedures, innovate the selection solely based on key ideas, and evaluate results by collective intelligence in the form of conferences.

• Journal of Environmental Impact Assessment
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• v.29 no.2
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• pp.122-131
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• 2020

Marine Spatial Planning is an emerging strategy that promoting sustainable development at coastal and marine areas based on the concept of ecosystem services. Regarding its methodology, usage rate of resources and its impact should be considered in the process of spatial planning. Particularly, considering the rapid increase of coastal tourism, visitation pattern is required to be identified across coastal areas. However, actions to quantify visitation pattern have been limited due to its required high cost and labor for conducting extensive field-study. In this regard, this study aimed to pose the usage of social big data in Marine Spatial Planning to identify spatial visitation density and critical management zone throughout coastal areas. We suggested the usage of GPS information from Flickr and Twitter, and evaluated the critical management zone by applying spatial statistics and density analysis. This study's results clearly showed the coastal areas having relatively high visitors in the southern sea of South Korea. Applied Flickr and Twitter information showed high correlation with field data, when proxy excluding over-estimation was applied and appropriate grid-scale was identified in assessment approach. Overall, this study offers insights to use social big data in Marine Spatial Planning for reflecting size and usage rate of coastal tourism, which can be used to designate conservation area and critical zones forintensive management to promote constant supply of cultural services.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.12 no.2
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• pp.19-28
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• 2009

Echinosophora koreensis (Nakai) Nakai (Leguminosae) is one of the threatened plant growing in secondary forest with sparse pine forest. The aim of this research is to investigate current status in a habitat of E. koreensis population, and obtain knowledge for conservation of the population. The flora of vascular plants and vegetation were investigated in the habitat E. koreensis in Mt. Bibong, Gangweon Province. Investigation were carried out in August 2003 and May 2008 at the three different habitats. As a result, a total 40 species 7 varieties of 28 family were recorded in whole area. The vegetation of investigated area was typical northern-temperate Pinus forest, humidity of soil was low and located at a slope area. These investigated area is very important for conservation of rare plant, E. koreensis. Therefore, sustainable conservation strategy such as designation of conservation area should be prepared urgently by the results of long-term monitoring studies.

• Journal of Korea Water Resources Association
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• v.46 no.9
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• pp.897-907
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• 2013

Climate change is expected to worsen the depletion of streamflow in urban watershed. In this study, we therefore considered the treated wastewater (TWW) use as an adaptation strategy and devised a framework to identify prioritized areas for TWW use. An integrated framework that includes hydrological factors as well as social and environmental components were employed to determine the criteria for decision making. Fuzzy theory was employed to consider the uncertainties in the climate change scenarios and the weights of the performance value. All alternatives were evaluated using the fuzzy TOPSIS method. In addition, statistical method and decision making methods under complete uncertainty were used for robust decision making. As a result, ranking the alternatives using the fuzzy TOPSIS method and robust approach such as maximin, maximax, Hurwicz and equal likelihood criterion mitigated the level of uncertainty and ambiguity in each alternative. The finding of this study can be helpful in prioritizing water resource management projects considering various climate change scenarios.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.271-279
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• 2019

In extreme environment regions, unmanned rovers equipped with various sensors and devices are being developed for long-term exploration on behalf of humans. On the other hand, due to the harsh weather conditions and rough terrain, the rover camera has limited visible distance and field of view. Therefore, the rover cameras should be located for safe navigation and efficient terrain mapping. In this regard, to minimize the cost and time to manufacture the camera system on a rover, the simulation method using the rover design is presented to optimize the camera locations on the rover efficiently. In the simulation, a simulated terrain was taken from cameras with different locations and angles. The visible distance and overlapped extent of camera images, and terrain data accuracy calculated from the simulation were compared to determine the optimal locations of the rover's cameras. The simulated results will be used to manufacture a rover and camera system. In addition, self and system calibrations will be conducted to calculate the accurate position of the camera system on the rover.

• Journal of the Korea Organic Resources Recycling Association
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• v.20 no.1
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• pp.61-70
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• 2012

Feasibility of co-digestion was investigated by a series of anaerobic batch experiments using sewage sludge, swine waste, and food waste leachate as substrates. The organic solid wastes were collected from M city, where the daily productions of sewage sludge, swine waste, and food waste leachate were 178 ton/d, 150 ton/d, and 8 ton/d, respectively. Both swine waste and food waste leachate showed superior methane yields, methane productivities, and organic pollutant removal efficiencies compared to sewage sludge. Co-digestion of the total amounts of organic solid wastes would enhance methane production by 5.60 times $(530\;m^{3}\;CH_{4}/d\;{\rightarrow}\;2,968\;m^{3}\;CH_{4}/d)$. However, it also increase the amount of digestate by 1.88 times with 3.79 to 4.92 times higher pollutants (chemical oxygen demands total nitrogen, and total phosphorus) loading rates. Co-digestion of organic solid wastes is a valid strategy to enhance the performance of an anaerobic sludge digester and the energy independence of a wastewater treatment plant. Anyhow,the increment of digestate with higher pollutant loading would need a careful counterplan in the operation of the main stream of the treatment plant.

• Korean Journal of Environmental Biology
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• v.30 no.2
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• pp.107-120
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• 2012

This study was carried out to illiminate the diversity of vascular plants by making list of rheophyte and hydorphyte plants at Yugu stream. This study was conducted from Aug., 2009 to Sept. 2010 at 7 points. Based on the voucher specimens, vascular plants from investigated areas were 88 families 229 genera 290 species 3 subspecies 30 varieties 5 forms, totally 328 taxa. Korean endemic plants were 3 species such as Forsythia koreana (Rehder) Nakai (planted) and Paulownia coreana Uyeki (planted), and Weigela subsessilis (Nakai) L.H. Bailey. The rare and endangered plants were designated by Korea Forest Service were 4 taxa, such as Penthorum chinense Pursh, Acorus calamus L., Lilium callosum Siebold & Zucc. and Iris ensata var. spontanea (Makino) Nakai. Floristic special plants were totally 26 taxa, which were grade V of 2 taxa, grade IV of 2 taxa and grade III of 9 taxa. Naturalized plants were 27 taxa, that was 8.3% of whole discovered vascular plants in this area. Even naturalized plants has not influence on the vegetation of Yugu stream. Since village was composed along the stream and the roads and banks were linked, naturalized plants were flowed continuously into this region. So, strategy of the conservation for this region should be designed. Based on flora, 3 types of group were discriminated such as main stream type (4 points), branch stream type (2 points) and reservior type (1 point). Each group has difference in composition of plants.