• Journal of the Society of Disaster Information
• /
• v.14 no.1
• /
• pp.59-64
• /
• 2018

In the trend of increasing awareness of chemical accidents, hazardous chemical transport vehicle accidents are occurring every year. In this study, we analyzed improvement of accident prevention and countermeasures through statistical analysis of hazardous chemical transport vehicle accidents. A total of 383 chemical accidents between January 2014 and December 2017 were analyzed. During this period, number of transportation accidents was 83 cases, accounting for 21.67% of total chemical accidents. In the current system, despite the direct handling of hazardous chemical, it is out of regulation of damage prediction unlike the workplace. In order to effectively respond to actual accident, information on damage prediction is required and should be shared with related ministry. And it should be developed to real-time monitoring of hazardous chemical transport vehicle through integrated control tower.

• Journal of Wetlands Research
• /
• v.18 no.4
• /
• pp.413-423
• /
• 2016

Effects of the design flood share of the Kyeongpo retarding basin, which has a function for flood control of the Kyeongpo river assigned to the Kyeongpo prickly water lily wetland, on the Kyeongpo lake and the downstream of Kyeongpo river were analyzed on the bassis of the hydraulic experiments and the numerical simulations using RMA-2 model. Reproducing a complex water flow system of the area of Kyeongpo lake, the unsteady flow simulations were performed. The data obtained in hydraulic experiments were used to determine parameters of the numerical model which simulated the flows for various flood scenarios in the downstream area of Kyeongpo river. With increasing the design flood share rates in the retarding basin, the water level was increased in the lake and is decreased in the river. The characteristics of flood flow interaction between Kyeongpo river and Kyeongpo lake were understood. These results may be used to management the Kyeongpo lake during flood season.

• Journal of Microbiology and Biotechnology
• /
• v.27 no.10
• /
• pp.1877-1884
• /
• 2017

Mesenchymal stem cells (MSCs) have been suggested as a primary candidate for cell therapy applications because they have self-renewal and differentiation capabilities. Although they can be expanded in ex vivo system, clinical application of these cells is still limited because they survive poorly and undergo senescence or apoptosis when transplanted and exposed to environmental factors such as oxidative stress. Thus, reducing oxidative stress is expected to improve the efficacy of MSC therapy. The milk protein lactoferrin is a multifunctional iron-binding glycoprotein that plays various roles, including reduction of oxidative stress. Thus, we explored the effect of lactoferrin on oxidative stress-induced senescence and apoptosis of human MSCs (hMSCs). Measurement of reactive oxygen species (ROS) revealed that lactoferrin inhibited the production of hydrogen peroxide-induced intracellular ROS, suggesting lactoferrin as a good candidate as an antioxidant in hMSCs. Pretreatment of lactoferrin suppressed hydrogen peroxide-induced senescence of hMSCs. In addition, lactoferrin reduced hydrogen peroxide-induced apoptosis via inhibition of caspase-3 and Akt activation. These results demonstrate that lactoferrin can be a promising factor to protect hMSCs from oxidative stress-induced senescence and apoptosis, thus increasing the efficacy of MSC therapy.

• Proceedings of the Korean Society for Agricultural Machinery Conference
• /
• 2017.04a
• /
• pp.27-27
• /
• 2017

Biocompatible capsules have recently been highlighted as novel delivery platforms of any "materials" (e.g., drug, food, agriculture pesticide) to address current problems of living systems such as humans, animals, and plats in academia and industry for agriculture, biological, biomedical, environmental, food applications. For example, biocompatible alginate capsules were proposed as a delivery platform of biocontrol agents (e.g., bacterial antagonists) for an alternative to antibiotics, which will be a potential strategy in future agriculture. Here, we proposed a new platform based on biocompatible alginate capsules that can control the movements as an active target delivery strategy for various applications including agriculture and biological engineering. We designed and fabricated large scale biocompatible capsules using alginates and custom-made nozzles as well as gelling solutions. To develop the active target delivery platforms, we incorporated the iron oxide nanoparticles in the large scale alginate capsules. It was found that the sizes of large scale alginate capsules could be controlled via various working conditions such as concentrations of alginate solutions and iron oxide nanoparticles. As a proof of concept work, we showed that the iron oxide particles-incorporated large scale alginate capsules could be moved actively by the magnetic fields, which would be a strategy as active target delivery platforms for agriculture and biological engineering (e.g., controlled delivery of agriculture pesticides and biocontrol agents).

• Biomolecules & Therapeutics
• /
• v.12 no.4
• /
• pp.209-214
• /
• 2004

Lead has long been considered as a toxic environmental pollutant that severely damages the central nervous system. In various neurogenerative diseases, actrocytes become activated by proinflammatory cytokines. In the present study, we investigated whether lead (Pb$^{2+}$) affects inducible nitric oxide synthase (iNOS) expression in activated glial cells. Rat primary glial cells were stimulated with lipopolysaccharide (LPS, 1 ${\mu}$g/ml) plus IFN$_{\gamma}$(100 U/ml). Pre-treatment of Pb$^{2+}$ increased nitric oxide (NO) production in LPS/IFN$_{\gamma}$-stimulated glial cells. Lead itself, however, suppressed the basal production of NO in control glial cells. Addition of the iNOS inhibitors L-NAME (1 mM) and L-NNA (800 ${\mu}$M) prevented the Pb$^{2+}$-induced increase in NO production. Western blot analysis showed that pre-treatment of Pb$^{2+}$ augmented LPS/IFN$_{\gamma}$-induced increase in iNOS immunoreactivity, which was well correlated with the increased NO production. In addition, pre-treatment of Pb$^{2+}$ synergistically increased the iNOS mRNA expression induced by LPS and IFN${\gamma}$. The present results indicate that lead intoxication adversely affect brain function by potentiating iNOS expression and NO production in activated glial cells observed in various neurodegenerative diseases.

• CELLMED
• /
• v.4 no.1
• /
• pp.2.1-2.17
• /
• 2014

The plant kingdom is considered to be a repository of modern medicine, attributable to their rich source of bio-active molecules and secondary metabolites. It is indeed the Nutraceuticals that enhance immunity and ensure a healthier life because of their prophylactic and therapeutic values. Over centuries, papaya [Caricaceae; (Carica papaya Linn.)] is a renowned nutritious and medicinal plant. Each part of the papaya like root, stem, leaf, flower, fruit, seed, rinds, and latex has its own nutraceutical properties. It serves as food, cooking aid, and Ethnomedicine to prevent and treat wide-range of diseases and disorders. It has also been traditionally used as appetite enhancer, meat tenderizer, purgative, medicinal acne, abortifacient and vermifuge. Over decades, a series of scientific attempts were made to authenticate the nutraceutical properties of papaya. These studies validated that the papaya has antiplasmodial, antitrichochramal, antitrichomonal, antidengue, and anti-cancer activities. They have also exhibited that papaya possesses antiseptic, antiparasitic, anti-inflammatory, antidiabetic, and contraceptive features, and it helps in the management of sickle-cell anaemia, HIV, heart diseases and digestional disorders too. Nevertheless, the responsible bio-active molecules and their mode of actions remain indistinct and imprecise, and this calls for further pharmacological and clinical research on them. Conclusively, papaya is one of the naturally gifted plants; though its nutraceutical properties as a food or as a quasi-drug are poorly understood or undervalued by people. Accordingly, this scrutiny, demand for instigation of public health awareness campaigns to promote papaya consumption, so that the society shall acquire optimal benefits of papaya and in turn prevent and alleviate various diseases and illness.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.34 no.1
• /
• pp.341-353
• /
• 2014

In order to deliver a centimeter-level kinematic positioning solution with GPS carrier-phase measurements, it is prerequisite to use correctly resolved integer ambiguities. Based on the mathematical modeling of GPS network with application of its geometrical constraints, this research has investigated an instantaneous ambiguity resolution procedure for the so-called 'integer constrained least-squares' technique which can be effectively implemented in real-time structure monitoring. In this process, algorithms of quality control for the float solutions and hypothesis tests using the constrained baseline for the ambiguity validation are included to enhance reliability of the solutions. The proposed procedure has been implemented by MATLAB, the language of technical computing, and processed field trial data obtained at a cable-stayed bridge to access its real-world applicability. The results are summarized in terms of ambiguity successful rates, impact of the stochastical models, and computation time to demonstrate performance of the instantaneous ambiguity resolution proposed.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.18 no.5
• /
• pp.85-90
• /
• 2010

As the environmental regulation of vehicle emission is strengthened, investigations for $NO_x$ and PM reduction strategies are popularly conducted. Two current available technologies for continuous $NO_x$ reduction onboard diesel vehicles are Selective Catalytic Reduction (SCR) using aqueous urea and lean $NO_x$ trap (LNT) catalysts. The experiments were conducted to investigate the $NO_x$ reduction performance of SCR system which can control the ratio of $NO/NO_2$, temperature and SV(space velocity), and the model gas was used which is similar to a diesel exhaust gas. The maximum reduction efficiency is indicated when the $NO:NO_2$ ratio is 1:1 and the SV is 30,000 $h^{-1}$ in $300^{\circ}C$. Generally, ammonia slip from SCR reactors are rooted to incomplete conversion of $NH_3$ over the SCR. In this research, slip was occurred in 6cases (except low SV and $NO:NO_2$ ratio is 1:1) after SCR. Among 6 case of slip occurrence, the maximum conversion efficiency is observed when SV is 60,000 $h^{-1}$ in $400^{\circ}C$.

• ALGAE
• /
• v.20 no.2
• /
• pp.121-125
• /
• 2005

The modern integrated fish-seaweed mariculture has been tested to reduce the environmental impacts of an intensive fed culture. To obtain the best seaweed bioremediation performance, the effects of therapeutants used for fish disease control on the selected seaweed species should be considered. As a selected seaweed, Porphyra yezoensis was tested with six commercial antibiotics including erythromycin thiocyanate_A, erythromycin thiocyanate_B, oxytetracycline, doxycycline, pefloxacin, and amoxicillin trihydrate under the batch incubation at a photon flux density of 10 $\mu$mol ${\cdot}m^{-2}\;{\cdot}\;s^{-1}$ at 15$^{\circ}C$. Among the tested commercial antibiotics, erythromycin thiocyanate_A, erythromycin thiocyanate_B, oxytetracycline, and doxycycline showed decreases in Fv/Fm, the photochemical efficiency of photosystem II, with a dose-dependant and time-dependant manner. From the quenching analysis of chlorophyll fluorescence, three differential patterns were observed in the antibiotics-treated Porphyra: (1) high nonphotochemical quenching (NPQ) and low photochemical quenching (qP) in the cases of Erythromycin thiocyanate_B and amoxicillin trihydrate, (2) high NPQ and high qP in the case of pefloxacin and (3) low NPQ and low qP in the case of oxytetracycline. These results indicated that antibiotics affected in various ways on the photosynthetic apparatus, reflecting differential lesion sites of antibiotics. In addition, the rates of ammonium uptake also decreased with a decrease of Fv/Fm in P. yezoensis thalli treated with erythromycin thiocyanate_B and oxytetracycline. Therefore, the four antibiotics mentioned could affect the bioremediation capacity of the selected seaweed species in the integrated fish-seaweed mariculture system due to the decrease of photosynthetic activity and the simultaneous decrease of ammonium uptake.

• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.20 no.2
• /
• pp.119-130
• /
• 2010

Pulmonary toxicity of talc containing tremolite asbestos (TCT) has been studied in term sequential in Sprague-Dawely rats. UICC chrysotile(average diameter 0.03${\mu}m$, average length 2.93${\mu}m$) was applied as the positive control. TCT was analyzed for its physicochemical properties by transmission electron microscope equipped with energy dispersive X-ray spectrometer(TEM-EDS). The effects of 2mg TCT(talc average diameter 9.7${\pm}$8.4${\mu}m$; tremolite average diameter 1.6${\pm}$1.6${\mu}m$, average length 10.8${\pm}$7.0${\mu}m$) on pathological changes were evaluated after 1, 8 weeks instilled into rat lungs. 2mg Chrysotile continuously affected lung pathological changes. Inflammation and granuloma response broke out from 1 week after instilled with chrysotile and the pathological examination further showed increased legions of lung after 8 weeks. But TCT did not showed lung pathological changes. The biopersistence of TCT and chrysotile was evaluated by TEM- EDS. Whereas chrysotile continuously have retained to 8 weeks instilled into rat lungs, talc of TCT showed statistically significant decrease of diameter from 1 weeks and statistically significant change in Si atomic % compositions at 8 weeks instilled into rat lungs. Physicochemical properties of tremolite of TCT were not affected until 8 weeks instilled into rat lungs. This study showed that the durability of TCT in the lungs is much weaker than chrysotile.