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Toxicity of Talc Containing Tremolite asbestos on Respiratory System in Sprague-Dawely Rats  

Chung, Yong-Hyun (Chemical Safety and Health Research Center, Occupational Safety & Health)
Han, Jeong-Hee (Chemical Safety and Health Research Center, Occupational Safety & Health)
Kang, Min-Gu (Chemical Safety and Health Research Center, Occupational Safety & Health)
Lee, Sung-Bae (Chemical Safety and Health Research Center, Occupational Safety & Health)
Kim, Jong-Kyu (Chemical Safety and Health Research Center, Occupational Safety & Health)
Kim, Hyeon-Yeong (Chemical Safety and Health Research Center, Occupational Safety & Health)
Yang, Jung-Sun (Chemical Safety and Health Research Center, Occupational Safety & Health)
Publication Information
Journal of Korean Society of Occupational and Environmental Hygiene / v.20, no.2, 2010 , pp. 119-130 More about this Journal
Abstract
Pulmonary toxicity of talc containing tremolite asbestos (TCT) has been studied in term sequential in Sprague-Dawely rats. UICC chrysotile(average diameter 0.03${\mu}m$, average length 2.93${\mu}m$) was applied as the positive control. TCT was analyzed for its physicochemical properties by transmission electron microscope equipped with energy dispersive X-ray spectrometer(TEM-EDS). The effects of 2mg TCT(talc average diameter 9.7${\pm}$8.4${\mu}m$; tremolite average diameter 1.6${\pm}$1.6${\mu}m$, average length 10.8${\pm}$7.0${\mu}m$) on pathological changes were evaluated after 1, 8 weeks instilled into rat lungs. 2mg Chrysotile continuously affected lung pathological changes. Inflammation and granuloma response broke out from 1 week after instilled with chrysotile and the pathological examination further showed increased legions of lung after 8 weeks. But TCT did not showed lung pathological changes. The biopersistence of TCT and chrysotile was evaluated by TEM- EDS. Whereas chrysotile continuously have retained to 8 weeks instilled into rat lungs, talc of TCT showed statistically significant decrease of diameter from 1 weeks and statistically significant change in Si atomic % compositions at 8 weeks instilled into rat lungs. Physicochemical properties of tremolite of TCT were not affected until 8 weeks instilled into rat lungs. This study showed that the durability of TCT in the lungs is much weaker than chrysotile.
Keywords
Talc containing tremolite; rat; biopersistence; intratracheal instillation; TEM-EDS;
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