• BMB Reports
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• v.55 no.12
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• pp.615-620
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• 2022

The murine leukemia virus-based semi-retroviral replicating vectors (MuLV-based sRRV) had been developed to improve safety and transgene capacity for cancer gene therapy. However, despite the apparent advantages of the sRRV, improvements in the in vivo transduction efficiency are still required to deliver therapeutic genes efficiently for clinical use. In this study, we established a gibbon ape leukemia virus (GaLV) envelope-pseudotyped semi-replication-competent retrovirus vector system (spRRV) which is composed of two transcomplementing replication-defective retroviral vectors termed MuLV-Gag-Pol and GaLV-Env. We found that the spRRV shows considerable improvement in efficiencies of gene transfer and spreading in both human glioblastoma cells and pre-established human glioblastoma mouse model compared with an sRRV system. When treated with ganciclovir after intratumoral injection of each vector system into pre-established U-87 MG glioblastomas, the group of mice injected with spRRV expressing the herpes simplex virus type 1-thymidine kinase (HSV1-tk) gene showed a survival rate of 100% for more than 150 days, but all control groups of mice (HSV1-tk/PBS-treated and GFP/GCV-treated groups) died within 45 days after tumor injection. In conclusion, these findings sug-gest that intratumoral delivery of the HSV1-tk gene by the spRRV system is worthy of development in clinical trials for the treatment of malignant solid tumors.

• Journal of the Korean Society for Geothermal and Hydrothermal Energy
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• v.18 no.4
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• pp.45-57
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• 2022

The Ministry of National Defense of the Republic of Korea is showing a lot of interest in net zero-energy buildings (NZEBs) to reduce energy consumption of military facilities and to promote green growth policy in military sector. The application of building passive technologies and renewable energies is essential to achieving NZEBs. This paper analyzed energy performance and energy cost on the conventional heating and cooling system (baseline scenario) and three different alternative scenarios (ALT 1, ALT 2 and ALT 3) applied in a hypothetical military building. A building modeling and simulation software (DesignBuilder V6.1) with EnergyPlus calculation engine was used to calculate the energy consumption for each scenario. Overall, when the GSHPs are applied to both space airconditioning and domestic hot water (DHW) production, Alt-2 and Alt-3, the amount of energy consumption for target building can be greatly reduced. In addition, when the building envelope performance is increased like Alt-3, the energy consumption can be further reduced. The annual energy cost analysis showed that the baseline was approximately 161 million KRW, while Alt-3 was approximately 33 million KRW. Therefore, it was analyzed that the initial construction cost increase could be recovered within about 6.7 years for ALT 3. The results of this study can help decision-makers to determine the optimal strategy for implementing GSHP systems in military buildings through energy performance and initial construction cost assessment.

• Geomechanics and Engineering
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• v.34 no.6
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• pp.683-696
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• 2023

The destruction and fracture of rock masses are crucial components in engineering and there is an increasing demand for the study of the influence of rock mass heterogeneity on the safety of engineering projects. The numerical manifold method (NMM) has a unified solution format for continuous and discontinuous problems. In most NMM studies, material homogeneity has been assumed and despite this simplification, fracture mechanics remain complex and simulations are inefficient because of the complicated topology updating operations that are needed after crack propagation. These operations become computationally expensive especially in the cases of heterogeneous materials. In this study, a heterogeneous model algorithm based on stochastic theory was developed and introduced into the NMM. A new fracture algorithm was developed to simulate the rupture zone. The algorithm was validated for the examples of the four-point shear beam and semi-circular bend. Results show that the algorithm can efficiently simulate the rupture zone of heterogeneous rock masses. Heterogeneity has a powerful effect on the macroscopic failure characteristics and uniaxial compressive strength of rock masses. The peak strength of homogeneous material (with heterogeneity or standard deviation of 0) is 2.4 times that of heterogeneous material (with heterogeneity of 11.0). Moreover, the local distribution of parameter values can affect the configuration of rupture zones in rock masses. The local distribution also influences the peak value on the stress-strain curve and the residual strength. The post-peak stress-strain curve envelope from 60 random calculations can be used as an estimate of the strength of engineering rock masses.

• Journal of Korean Living Environment System
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• v.21 no.6
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• pp.959-964
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• 2014

Energy performance of building envelope components, including external walls, floors, roofs, windows and doors, is crutial for determining how much energy is required for heating and cooling in a building. Among various building technologies, a green roof system can be a good option for reducing heat gain and loss in new buildings as well as existing buildings for green remodeling. This paper evaluates the performance of green roof systems according to soil depth and Leaf Area Index (LAI) for existing buildings. It also attempts to quantify the energy saving effects on new and existing buildings with different insulation levels. Thermal performance of green roofs is mainly dependent on soil thickness and LAI. Installation of green roofs in deteriorated existing buildings can lead to improvements in roof insulation, due to the soil layer. An increase in soil depth leads to a decrease in heating load, regardless of conditions of vegetation on the green roof. Larger LAI values may reduce cooling loads in the cooling season. Installation of green roof in deteriorated existing buildings showed bigger energy saving effect in comparison to a case in new buildings. A simulation study showed that the installation of green roof systems in deteriorated existing buildings with low insulation levels, due to low thermal performance requirements when constructed, could improve the energy performance of the buildings similar or better to the peformance on new buildings with the most updated insulation standard. Thus, when remodeling a deteriorated building, green roofs could be a good option to meet the most recent energy requirements.

• Journal of the Korean Geotechnical Society
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• v.22 no.12
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• pp.77-88
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• 2006

A series of model tests were performed to investigate the ground deformation during trench excavation for diaphragm walls. An apparatus was manufactured to observe the failure pattern of a slurry-supported trench in sandy ground. Ground deformations including settlement and lateral displacement of the surrounding ground adjacent to the trench were carefully monitored during excavation. Experimental observations indicated that the settlement of the adjacent ground increased with closing to the trench. Especially, the considerable settlement occurred at the distance which was equal to 40% of the excavation depth. And, the higher settlement was obtained when the relative density of ground was looser and the ground water table was higher. Also, the lateral wall face of excavated trench was bulged with lowering the slurry level In stages and then the upper part of trench failed finally. The envelope of ground surface settlement could be represented as a hyperbolic line and the measured settlement was smaller than those predicted by Clough and O'Rourke (1990).

• Journal of the Korea Society of Computer and Information
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• v.14 no.5
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• pp.149-156
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• 2009

Korean WiBro becomes international standard to IEEE 802.16e, and We are carrying out a WiBro network business from capital regions. We executed eavesdropping about voices and messenger program and the VoIP which frequently happened in WiBro networks at these papers. We have a lot in common with the Wireshark which is a packet collection and an analyzer, and We execute eavesdropping, and We reproduce eavesdropping data with bases to a SIP, H.263, TCP, UDP protocol through packets. In time of a copy of a packet negative the VoIP which verify time with bases, and was eavesdropped on integrity packet and a X-Lite call record, be matched that a packet is counterfeit forgery did not work, and We demonstrate, and verify integrity. The data which integrity was verified put in a seaming envelope, and we prepare so as it is to a liver of investigator, and execute, and to be able to do use to proof data after seaming in courts in order to utilize as criminal investigation data.

• Geomechanics and Engineering
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• v.28 no.2
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• pp.117-133
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• 2022

Determination of the mechanical behaviour of jointed rock masses has been a challenge for rock engineers for decades. This problem is more pronounced for non-persistent jointed rock masses due to complicated interaction of rock bridges on the overall behaviour. This paper aims to study the effect of a non-persistent joint set configuration on the mechanical behaviour of rock materials under both uniaxial and biaxial compression tests using a discrete element code. The numerical simulation of biaxial compressive strength of rock masses has been challenging in the past due to shortcomings of bonded particle models in reproducing the failure envelope of rock materials. This problem was resolved in this study by employing the flat-joint contact model. The validity of the numerical model was investigated through a comprehensive comparative study against physical uniaxial and biaxial compression experiments. Good agreement was found between numerical and experimental tests in terms of the recorded peak strength and the failure mode in both loading conditions. Studies on the effect of joint orientation on the failure mode showed that four zones of intact, transition to block rotation, block rotation and transition to intact failure occurs when the joint dip angle varies from 0° to 90°. It was found that the applied confining stress can significantly alter the range of these zones. It was observed that the minimum strength occurs at the joint dip angle of around 45 degrees under different confining stresses. It was also found that the joint orientation can alter the post peak behaviour and the lowest brittleness was observed at the block rotation zone.

• Journal of Aerospace System Engineering
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• v.16 no.1
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• pp.70-80
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• 2022

An aerial refueling provides for extension of operational time and range for aircraft and enhances mission effectiveness, hence it application by most military aircrafts. The receiver aircraft should have the aerial refueling clearance that is established by performing technical and operational compatibility assessments to certify it for aerial refueling with a specific tanker model. The compatibility assessment includes aerial refueling handling qualities, functional, fuel, lighting system testing and it is finally verified through flight testing. However, since aerial refueling compatibility assessments have never been performed in Korea, there is no experience to determine the test requirements and the scope and size of the test program for a new development aircraft. This paper therefore introduces the common techniques of aerial refueling and aerial refueling flight test methods to understand the aerial refueling FCS (Flight Control System), OFP (operational flight program) and system validation, and aerial refueling envelope clearance of a fixed wing aircraft for a boom and receptacle refueling system that is being introduced into Korea Air Force.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.66.3-67
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• 2021

Low-mass stars form by the gravitational collapse of dense molecular cores. Observations and theories of low-mass protostars both suggest that accretion bursts happen in timescales of ~100 years with high accretion rates, so called episodic accretion. One mechanism that triggers accretion bursts is infalling fragments from the outer disk. Such fragmentation happens when the disk is massive enough, preferentially activated during the embedded phase of star formation (Class 0 and I). Most observations and models focus on the gas structure of the protostars undergoing episodic accretion. However, the dust and ice composition are poorly understood, but crucial to the chemical evolution through thermal and energetic processing via accretion burst. During the burst phase, the surrounding material is heated up, and the chemical compositions of gas and ice in the disk and envelope are altered by sublimation of icy molecules from grain surfaces. Such alterations leave imprints in the ice composition even when the temperature returns to the pre-burst level. Thus, chemical compositions of gas and ice retain the history of past bursts. Infrared spectral observations of the Spitzer and AKARI revealed a signature caused by substantial heating, toward many embedded protostars at the quiescent phase. We present the AKARI IRC 2.5-5.0 ㎛ spectra for embedded protostars to trace down the characteristics of accretion burst across the evolutionary stages. The ice compositions obtained from the absorption features therein are used as a clock to measure the timescale after the burst event, comparing the analyses of the gas component that traced the burst frequency using the different refreeze-out timescales. We discuss ice abundances, whose chemical change has been carved in the icy mantle, during the different timescales after the burst ends.

• Current Photovoltaic Research
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• v.11 no.2
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• pp.49-53
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• 2023

Expanding the supply of BIPV is crucial to strengthening the competitiveness of the photovoltaic industry and achieving Nationally Determined Contributions through the zero-energy building mandatory policy. BIPV is a technology that integrates into the building envelope to generate electricity and provide functions as a building material. It is suitable for domestic environments with many high-rise buildings due to the narrow land area and urbanization. To expand the supply of BIPV, economics, safety, and aesthetics must be ensured. In this study, a color BIPV module with a color PET film applied as a front material was manufactured for aesthetic and economic feasibility. The relationship between power output and transmittance according to color was analyzed. By analyzing the power output of the module and the transmittance of the film, the wavelength band (transmittance reduction band) that has the greatest effect on efficiency was analyzed regarding the color of the film. The red film showed the narrowest transmittance reduction band and the lowest degree of decrease in transmittance, making it ideal for minimizing the efficiency decrease rate compared to existing ones.