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Static Aortic Pressure Model for a Moving-Actuator type Total Artificial Heart

  • Om, K.S.;Ahn, J.M.;Park, S.K.;Jo, Y.H.;Kim, H.C.;Min, B.G.
    • Proceedings of the KOSOMBE Conference
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    • v.1997 no.11
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    • pp.122-125
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    • 1997

  • It is needless to say that the hemodynamic variables estimation is a very important study or the artificial heart. Even though its importance there have not been satisfactory results which can be applied to the real-world situations. In this paper, we propose a practical afterload model ( AoP, PAP) which can be applied to the real-world situation.

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RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent

  • Lee, Dahee;Choi, Eunji;Lee, Jaewon;Oh, Jungju;Lee, Seonyeong;Lee, Minhyung
    • Journal of Industrial and Engineering Chemistry
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    • v.67
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    • pp.284-292
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    • 2018

  • Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25 kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an anti-angiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy.

  • https://doi.org/10.1016/j.jiec.2018.06.040 인용 KSCI