Journal of Industrial and Engineering Chemistry

  • Volume 67
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  • Pages.284-292
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  • 2018
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  • 1226-086X(pISSN)
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  • 1876-794X(eISSN)
The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent

  • Lee, Dahee (Department of Bioengineering, College of Engineering, Hanyang University) ;
  • Choi, Eunji (Department of Bioengineering, College of Engineering, Hanyang University) ;
  • Lee, Jaewon (Department of Bioengineering, College of Engineering, Hanyang University) ;
  • Oh, Jungju (Department of Bioengineering, College of Engineering, Hanyang University) ;
  • Lee, Seonyeong (Department of Bioengineering, College of Engineering, Hanyang University) ;
  • Lee, Minhyung (Department of Bioengineering, College of Engineering, Hanyang University)
  • Received : 2018.04.21
  • Accepted : 2018.06.28
  • Published : 2018.11.25
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Abstract

Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25 kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an anti-angiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy.

Keywords

Acknowledgement

Supported by : NRF

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