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http://dx.doi.org/10.1016/j.jiec.2018.06.040

RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent  

Lee, Dahee (Department of Bioengineering, College of Engineering, Hanyang University)
Choi, Eunji (Department of Bioengineering, College of Engineering, Hanyang University)
Lee, Jaewon (Department of Bioengineering, College of Engineering, Hanyang University)
Oh, Jungju (Department of Bioengineering, College of Engineering, Hanyang University)
Lee, Seonyeong (Department of Bioengineering, College of Engineering, Hanyang University)
Lee, Minhyung (Department of Bioengineering, College of Engineering, Hanyang University)
Publication Information
Journal of Industrial and Engineering Chemistry / v.67, no., 2018 , pp. 284-292 More about this Journal
Abstract
Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25 kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an anti-angiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy.
Keywords
Anti-angiogenesis; Gene delivery; Glioblastoma; Polyethylenimine; RAGE-binding peptide;
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