• Molecules and Cells
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• v.38 no.10
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• pp.843-850
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• 2015

The1hepatic cell death induced by acetaminophen (APAP) is closely related to cellular adenosine triphosphate (ATP) depletion, which is mainly caused by mitochondrial dysfunction. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of low energy status. AMPK regulates metabolic homeostasis by stimulating catabolic metabolism and suppressing anabolic pathways to increase cellular energy levels. We found that the decrease in active phosphorylation of AMPK in response to APAP correlates with decreased ATP levels, in vivo. Therefore, we hypothesized that the enhanced production of ATP via AMPK stimulation can lead to amelioration of APAP-induced liver failure. A769662, an allosteric activator of AMPK, produced a strong synergistic effect on AMPK Thr172 phosphorylation with APAP in primary hepatocytes and liver tissue. Interestingly, activation of AMPK by A769662 ameliorated the APAP-induced hepatotoxicity in C57BL/6N mice treated with APAP at a dose of 400 mg/kg intraperitoneally. However, mice treated with APAP alone developed massive centrilobular necrosis, and APAP increased their serum alanine aminotransferase and aspartate aminotransferase levels. Furthermore, A769662 administration prevented the loss of intracellular ATP without interfering with the APAP-mediated reduction of mitochondrial dysfunction. In contrast, inhibition of glycolysis by 2-deoxy-glucose eliminated the beneficial effects of A769662 on APAP-mediated liver injury. In conclusion, A769662 can effectively protect mice against APAP-induced liver injury through ATP synthesis by anaerobic glycolysis. Furthermore, stimulation of AMPK may have potential therapeutic application for APAP overdose.

• Composites Research
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• v.31 no.2
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• pp.51-56
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• 2018

A new study was carried out to utilize a pencil drawing paper sensor (PDPS), which drew a line using a pencil on the paper, as a sensor. The sensing effect on 3 different papers based on the properties of PDPS was compared. The specimens were prepared by drawing 4B pencils on plain (A4), Hwasun, and Han papers. The silver paste was used to give good electrical contacts of the copper wires and the pencil drawn line. The chemical structures of 3 papers for PDPS by FT-IR spectrum analysis were similar and the comparative compact states of each paper were observed by optical microscope. From statistical evaluation of tensile strength using 3 papers, plain paper was chosen to be best for the PDPD. The optimum drawing number of PDPD was determined by changing the thickness of the paper with the drawing number. Electrical resistance (ER) with graphite on 3 different papers were compared. The changes in compression was observed through cyclic compressive test of composite materials, it was possible to predict the degree of strain sensing under compressive test. It leads to expectation of properties.

• Journal of the Mineralogical Society of Korea
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• v.26 no.1
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• pp.9-18
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• 2013

In order to optimize the gold leaching process from refractory sulfide concentrate, a chlorine-hypochlorite solution with varying concentrations and temperatures were applied to salt-roasted concentrate. The concentrate consisted of pyrite, chalcopyrite, and galena, which were turned into hematite through air-roasting at $750^{\circ}C$. Also these concentrates were changed into hematite and nantokite (CuCl)) through salt (NaCl)-roasting at $750^{\circ}C$. The results of the gold leaching experiments showed that the best gold leaching parameters were obtained when the hydrochloric acid-sodium hypochlorite mix was at a ratio of 1 : 2, the added concentration was 1.0 M concentration, the pulp density was 1.0%, and the leaching was done at a $60^{\circ}C$ leaching temperature. The leaching rate for gold was much greater in the roasted concentrate than in the raw concentrate. The leaching rate was greater in the salt-roasted concentrate than in the plain roasted concentrate too. From XRD analysis, quartz was found in the salt-roasted concentrate and in the solid residue from the chlorine-hypochlorite leaching solution at $60^{\circ}C$.

• Environmental Engineering Research
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• v.23 no.2
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• pp.181-188
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• 2018

Photocatalytic oxidation in the presence of Fe-doped, Zn-doped or Fe-Zn co-doped $TiO_2$ was used to effectively decompose humic acids (HAs) in water. The highest HAs removal efficiency (65.7%) was achieved in the presence of $500^{\circ}C$ calcined 0.0010% Fe-Zn co-doped $TiO_2$ with the Fe:Zn ratio of 3:2. The initial solution pH value, inorganic cations and anions also affected the catalyst photocatalytic ability. The HAs removal for the initial pH of 2 was the highest, and for the pH of 6 was the lowest. The photocatalytic oxidation of HAs was enhanced with the increase of the $Ca^{2+}$ or $Mg^{2+}$ concentration, and reduced when concentrations of some anions increased. The inhibition order of the anions on $TiO_2$ photocatalytic activities was $CO{_3}^{2-}$ > $HCO_3{^-}$ > $Cl^-$, but a slightly promotion was achieved when $SO{_4}^{2-}$ was added. Total organic carbon (TOC) removal was used to evaluate the actual HAs mineralization degree caused by the $500^{\circ}C$ calcined 0.0010% Fe-Zn (3:2) co-doped $TiO_2$. For tap water added with HAs, the $UV_{254}$ and TOC removal rates were 57.2% and 49.9%, respectively. The $UV_{254}$ removal efficiency was higher than that of TOC because of the generation of intermediates that could significantly reduce the $UV_{254}$, but not the TOC.

• Journal of the Mineralogical Society of Korea
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• v.30 no.3
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• pp.103-112
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• 2017

In order to transform arsenopyrite into pyrrhotite and to decrease As content by less than 2,000 mg/kg, pulp sample and non-magnetic pulp sample were heated in a microwave oven at different heating times and were separated through wet-magnetic separation. As the microwave heating time increased, the phase of pyrrhotite was extended to become arsenopyrite entirely. The melting pores and micro-cracks occurred on the pyrrhotite due to hot spot phenomenon with microwave heating. The heated raw pulp sample (As content : 19,970.13 mg/kg) and non-magnetic pulp sample (As content : 19,970.13 mg/kg) which were heated in a microwave oven for 10 minutes were separated through wet-magnetic separation and magnetic fraction containing less than 2,000 mg/kg of As content was recovered only from the heated sample of magnetic separation. It was discovered that for the sulfide complex ore with As penalty imposed on, if microwave heating and wet-magnetic separation are effectively utilized, magnetic fraction. We expect to be able to obtain ore minerals with an arsenic content below the penalty charge.

• Economic and Environmental Geology
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• v.23 no.3
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• pp.323-328
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• 1990

This study explores that learning model that has been employed for many years in the description of and projection of system or process performance promises to be very useful in long-term forecasting, especially of technology or related productivity measures, in mineral and energy industries. This study also provides some empirical results on the measurement of the learning curve in U. S. petroleum resource assessment and demonstrates how the learning system can be used as an economic forecasting tool.

• New & Renewable Energy
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• v.6 no.2
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• pp.5-11
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• 2010

This paper reviews three commercial softwares for wind climate data analysis in wind resource assessment; WAsP/Observed Wind Climate, WindRose and Windographer. Windographer is evaluated as the best software because of its variety of input data format, analysis functions, easiness of user interface, etc. For a quantitative understanding of uncertainty depending on software selection, a benchmark is carried out with the met-mast observation dataset at the Gimnyeong Wind Turbine Performance Test Site. It is found that Weibull parameter calculation and air density correction have a dependency on the software so that such uncertainty should be considered when an analysis software is selected. It is confirmed that annual energy production calculated by WAsP using a statistical table of frequency of occurrence may have some error compared to a time-series calculation method used by the other softwares.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.3
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• pp.284-299
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• 2014

Coarse-grained reconfigurable architecture (CGRA)-based multi-core architecture aims at achieving high performance by kernel level parallelism (KLP). However, the existing CGRA-based multi-core architectures suffer from much energy and performance bottleneck when trying to exploit the KLP because of poor resource utilization caused by insufficient flexibility. In this work, we propose a new ring-based sharing fabric (RSF) to boost their flexibility level for the efficient resource utilization focusing on the kernel-stream type of the KLP. In addition, based on the RSF, we introduce a novel inter-CGRA reconfiguration technique for the efficient pipelining of kernel-stream on CGRA-based multi-core architectures. Experimental results show that the proposed approaches improve performance by up to 50.62 times and reduce energy by up to 50.16% when compared with the conventional CGRA-based multi-core architectures.

• Environmental and Resource Economics Review
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• v.11 no.1
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• pp.145-184
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• 2002

This paper analyzes the impact of imposing carbon tax on the Seoul economy to reduce Greenhouse Gas(GHG) emission. We construct the social accounting matrix of Seoul, specifying energy and transport sectors which is closely related to air pollution. Then, we formulated the computable general equilibrium (CGE) model of seoul and performed scenario analysis. The main result shows that the economic cost of GHG reduction is quite large but the health benefit is also considerable. It also suggests the importance of cost effective measures such as the development of new energy technology and the improvement of energy efficiency.

• Environmental and Resource Economics Review
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• v.11 no.4
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• pp.633-657
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• 2002

This study presents a demand modelling for landfill gas, which is used as alternative energy source for district cooling business. By analyzing the cost minimizing behavior of producer facing with three alternative energy sources such as electricity, cooling heat water, and gas, a demand function for landfill gas is derived from the optimal operating time of gas fired production facility, and estimated using unpublished data, which are associated with Seoul city's development plan for Sang-am area. The estimation results repeals that Seoul City could supply the land-fill gas of 13.76 million cubic meters each year at the price of about 16 won per cubic meters. However, if the investment costs associated with installation of gas collecting facilities are treated as sunk costs, annual amount of gas supplied is expected to increase to 14.22 million cubic meters at a lower unit price of 14.76 won.