• Genomics & Informatics
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• v.12 no.4
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• pp.187-194
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• 2014

Metabolic syndrome (METS) is a disorder of energy utilization and storage and increases the risk of developing cardiovascular disease and diabetes. To identify the genetic risk factors of METS, we carried out a genome-wide association study (GWAS) for 2,657 cases and 5,917 controls in Korean populations. As a result, we could identify 2 single nucleotide polymorphisms (SNPs) with genome-wide significance level p-values (< $5{\times}10^{-8}$), 8 SNPs with genome-wide suggestive p-values ($5{\times}10^{-8}{\leq}$ p < $1{\times}10^{-5}$), and 2 SNPs of more functional variants with borderline p-values ($5{\times}10^{-5}{\leq}$ p < $1{\times}10^{-4}$). On the other hand, the multiple correction criteria of conventional GWASs exclude false-positive loci, but simultaneously, they discard many true-positive loci. To reconsider the discarded true-positive loci, we attempted to include the functional variants (nonsynonymous SNPs [nsSNPs] and expression quantitative trait loci [eQTL]) among the top 5,000 SNPs based on the proportion of phenotypic variance explained by genotypic variance. In total, 159 eQTLs and 18 nsSNPs were presented in the top 5,000 SNPs. Although they should be replicated in other independent populations, 6 eQTLs and 2 nsSNP loci were located in the molecular pathways of LPL, APOA5, and CHRM2, which were the significant or suggestive loci in the METS GWAS. Conclusively, our approach using the conventional GWAS, reconsidering functional variants and pathway-based interpretation, suggests a useful method to understand the GWAS results of complex traits and can be expanded in other genomewide association studies.

• Bulletin of the Korean Chemical Society
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• v.24 no.6
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• pp.805-808
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• 2003

Fundamental ideas of the free energy gradient method are briefly reviewed with three applications: the stable structures of glycine and ammonia-water molecule pair in aqueous solution and the transition state (TS) structure of a Menshutkin reaction $NH_3 + CH_3Cl → CH_3NH_3^+ + Cl^-$ in aqueous solution, which is the first example of full TS optimization of all internal degrees of freedom.

• Journal of applied mathematics & informatics
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• v.19 no.1_2
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• pp.385-395
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• 2005

A finite element scheme is considered for the viscous Cahn-Hilliard equation with the nonconstant gradient energy coefficient. The scheme inherits energy decay property and mass conservation as for the classical solution. We obtain the corresponding error estimate using the extended Lax-Richtmyer equivalence theorem.

• Journal of applied mathematics & informatics
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• v.26 no.3_4
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• pp.573-581
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• 2008

In this paper, a finite difference method for a Cauchy problem of RLW-Burgers equation was considered. Although the equation is not energy conservation, we have given its the energy conservative finite difference scheme with condition. Convergence and stability of the difference solution were proved. Numerical results demonstrate that the method is efficient and reliable.

• Journal of applied mathematics & informatics
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• v.8 no.3
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• pp.919-934
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• 2001

The concepts of material frame-indifference and material symmetry group with respect to isotropic scalar functions, as represented by energy functions, are discussed. An energy function for a structured heterogeneous (transversal isotropic) medium in large elastic deformations, which is known to satisfy the Ponyting’s effect [1], is highlighted. It is shown that the constitutive relation due to this energt function is material frame-indifferent.

• Bulletin of the Korean Chemical Society
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• v.30 no.8
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• pp.1835-1838
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• 2009

Inhibition of human phenylethanolamine N-methyltransferase (hPNMT) has been proposed as a method for the treatment of several mental processes which related on adrenaline metabolism. We performed in silico screening to identify flavonoid inhibitors of hPNMT using automated docking method and selected 9 inhibitor candidates based on ligand score (LigScore) and binding free energy (${\Delta}G_{bind}$) estimation. Among 9 flavonoid candidates, 7 flavonoids belong to flavones while the rest of them belong to flavanone. All candidates have common chemical features; two hydrogen bond interactions with side chain of Lys75 and backbone carbonyl oxygen of Asn39, and two hydrophobic interactions. One hydrophobic site is formed by Val53, Leu262, and Met258 and the other is made up of Phe182, Ala186, Tyr222, and Val269. This study can be helpful to understand the structural features for inhibition of PNMT and showed flavonoids as promising inhibitor candidates for hPNMT.

• Proceedings of the IEEK Conference
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• 2002.07b
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• pp.1165-1168
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• 2002

Knowledge acquisition is the process that extracts the required knowledge from available sources, such as experts, textbooks and databases, for incorporation into a knowledge-based system. Knowledge acquisition is described as the first step in building expert systems and a major bottleneck in the efficient development and application of effective knowledge based expert systems. One cause of the problem is that the process of human reasoning we need to understand for knowledge-based system development is not available for direct observation. Moreover, the expertise of interest is typically not reportable due to the compilation of knowledge which results from extensive practice in a domain of problem solving activity. This is also a problem of modeling knowledge, which has been described as not a problem of accessing and translating what is known, but the familiar scientific and engineering problem of formalizing models for the first time. And this formalization process is especially difficult for knowledge engineers who are often faced with the difficult task of creating a knowledge model of a domain unfamiliar to them. In this paper, we propose an automated knowledge acquisition tool which is based on an implementation of the Inferential Modeling Technique. The Inferential Modeling Technique is derived from the Inferential Model which is a domain-independent categorization of knowledge types and inferences ［Chan 1992］. The model can serve as a template of the types of knowledge in a knowledge model of any domain.

• Journal of Mechanical Science and Technology
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• v.15 no.3
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• pp.327-338
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• 2001

This paper presents the results of a structural analysis to determine design variables such as the inner basket array type, and thicknesses of the outer shell, and lid and bottom of a spent nuclear fuel disposal canister. The canister construction type introduced here is a solid structure with a cast iron insert and a corrosion resistant overpack, which is designed for the spent nuclear fuel disposal in a deep repository in the crystalline bedrock, entailing an evenly distributed load of hydrostatic pressure from the groundwater and high swelling pressure from the bentonite buffer. Hence, the canister must be designed to withstand these high pressure loads. Many design variables may affect the structural strength of the canister. In this study, among those variables, the array type of inner baskets and thicknesses of outer shell and lid and bottom are attempted to be determined through a linear structural analysis. Canister types studied hear are one for the pressurized water reactor (PWR) fuel and another for the Canadian deuterium and uranium reactor (CANDU) fuel.

• Korean Journal of Poultry Science
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• v.32 no.4
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• pp.239-244
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• 2005

Uncoupling protein(UCP) is expressed exclusively in brown adipose tissue(BAT). It is blown to uncouple phosphorylation from oxidation and hence to be involved in energy metabolism and heat production, especially under cold exposure. In the present study, we identified single nucleotide polymorphism(SNP) in exon 3 of avUCP gene in Korean native chicken(KNC) population. It was detected a SNP T+1316C in exon 3 of avUCP gene by sequence analysis in KNC population. For PCR-RFLP analysis of the SNP T+1316C, used by AP III restriction enzyme. The result of PCR-RFLP analysis showed that allele T has two fragments of 255 bp and 86 bp, and allele C has only one fragment of 341 bp. The genotype frequencies were TT type, 0.7875; TC type, 0.1875 and CC type, 0.025; and the frequencies of allele T and C were 0.881 and 0.119, respectively in KNC population. Next study was conducted to investigate the effect of the SNP in avUCP gene on economic traits in the KNC population. The TT genotype had a significant higher daily percent lay(84.61) than CC genotype(p<0.05) in KNC population. This study may be useful for genetic studies of avCUP gene and selection on daily percent lay of KNC.

• International Journal of Computer Science & Network Security
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• v.23 no.6
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• pp.49-58
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• 2023

Renewable energy is not a new terminology. One of the fastest growing renewable energies is solar energy. The implementation of solar energy provides several advantages including the reduction of some of the environmental risks of fossil fuel consumption. This research elaborated the importance of the adaption of solar energy by developing a spatial decision support system (SDSS), while the Residential Solar Energy Adoption (RSEA) is an instantiation artifact in the form of an SDSS. As a GIS web-based application, RSEA allows stakeholders (e.g., utility companies, policymakers, service providers homeowners, and researchers) to navigate through locations on a map interactively. The maps highlight locations with high and low solar energy adoption potential that enables decision-makers (e.g., policymakers, solar firms, utility companies, and nonprofit organizations) to make decisions. A combined qualitative and quantitative methodological approach was used to evaluate the application's usability and user experience, and results affirmed the ability of the factors of utility, usefulness, and a positive user experience of the residential solar energy adoption of spatial decision support system (RSEA-SDSS). RSEA-SDSS in improving the decision-making process for potential various stakeholders, in utility, solar installations, policy making, and non-profit renewable energy domains.