• 대한산업공학회지
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• 제34권1호
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• pp.79-89
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• 2008

An end-of-life strategy is concerned with how to disassemble a product and what to do with each of the resultingdisassembled parts. A sound understanding of the end-of-life strategy at the early design stage could improve theease of disassembly and recycling in an efficient and effective manner. Therefore, the end-of-life decisionmaking for environmental conscious design has become a great concern to product manufacturers.We introduce a novel concept ofeco-architecture which represents a scheme by which the physical componentsare allocated to end-of-life modules. An end-of-life module is a physical chunk of connected components or afeasible subassembly which can be simultaneously processed by the same end-of-life option without furtherdisassembly. In this paper, a method for analyzing the eco-architecture of a product at the configuration designstage is proposed. It produces an optimal eco-architecture under the given environmental regulations. To dealwith the case ofa complex product, the method is extended for analyzing hierarchical eco-architecture.

• Journal of Ginseng Research
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• 제44권2호
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• pp.300-307
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• 2020

Background: Emerging evidence suggests that endothelial-to-mesenchymal transition (EndMT) in endothelial dysfunction due to persistent inflammation is a key component and emerging concept in the pathogenesis of vascular diseases. Ginsenoside Rg3 (Rg3), an active compound from red ginseng, has been known to be important for vascular homeostasis. However, the effect of Rg3 on inflammation-induced EndMT has never been reported. Here, we hypothesize that Rg3 might reverse the inflammation-induced EndMT and serve as a novel therapeutic strategy for vascular diseases. Methods: EndMT was examined under an inflammatory condition mediated by the NOD1 agonist, γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP), treatment in human umbilical vein endothelial cells. The expression of EndMT markers was determined by Western blot analysis, real-time polymerase chain reaction, and immunocytochemistry. The underlying mechanisms of Rg3-mediated EndMT regulation were investigated by modulating the microRNA expression. Results: The NOD1 agonist, iE-DAP, led to a fibroblast-like morphology change with a decrease in the expression of endothelial markers and an increase in the expression of the mesenchymal marker, namely EndMT. On the other hand, Rg3 markedly attenuated the iE-DAP-induced EndMT and preserved the endothelial phenotype. Mechanically, miR-139 was downregulated in cells with iE-DAP-induced EndMT and partly reversed in response to Rg3 via the regulation of NF-κB signaling, suggesting that the Rg3-miR-139-5p-NF-κB axis is a key mediator in iE-DAP-induced EndMT. Conclusion: These results suggest, for the first time, that Rg3 can be used to inhibit inflammation-induced EndMT and may be a novel therapeutic option against EndMT-associated vascular diseases.

• 산업경영시스템학회지
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• 제44권2호
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• pp.24-35
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• 2021

Due to increasing awareness on the treatment of end-of-use/life products, disassembly has been a fast-growing research area of interest for many researchers over recent decades. This paper introduces a novel lot-sizing problem that has not been studied in the literature, which is the service-parts lot-sizing with disassembly option. The disassembly option implies that the demands of service parts can be fulfilled by newly manufactured parts, but also by disassembled parts. The disassembled parts are the ones recovered after the disassembly of end-of-use/life products. The objective of the considered problem is to maximize the total profit, i.e., the revenue of selling the service parts minus the total cost of the fixed setup, production, disassembly, inventory holding, and disposal over a planning horizon. This paper proves that the single-period version of the considered problem is NP-hard and suggests a heuristic by combining a simulated annealing algorithm and a linear-programming relaxation. Computational experiment results show that the heuristic generates near-optimal solutions within reasonable computation time, which implies that the heuristic is a viable optimization tool for the service parts inventory management. In addition, sensitivity analyses indicate that deciding an appropriate price of disassembled parts and an appropriate collection amount of EOLs are very important for sustainable service parts systems.

• 기본간호학회지
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• 제17권4호
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• pp.450-459
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• 2010

Purpose: The purposes of this study were to identify awareness and attitudes toward advance directives (ADs) among Korean adults and to examine various opinions in the utilization of ADs among young, middle-aged, and older adults. Methods: Data were collected using a structured questionnaire from 384 adults selected by a quota sampling method on the basis of age. Results: The majority of participants preferred that they themselves would be the primary decision maker. Most of them were unaware of the option of ADs but supported the utilization of ADs. Most of the participants preferred detailed descriptions on end-of-life decisions in ADs but wanted to allow some leeway in following it. Significant differences were found among age groups in terms of the preferences regarding the utilization of ADs. Conclusion: It is suggested that nurses make efforts to educate the general public about ADs and facilitate advance care planning, which focuses on the process of communication on end-of-life preferences within the social network of relationships.

• 의료법학
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• 제23권2호
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• pp.67-96
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• 2022

인간의 존엄성과 환자의 자율성에 터잡아 연명의료의 중단이 제도화된 이래, 최근에는 스스로 존엄하게 죽음에 이르기 위해 환자가 자기 생명을 단축시키고자 의료적 도움을 받을 권리가 있는지, 그러한 행위가 어느 범위에서 정당화될 수 있는지의 문제가 활발하게 논의되고 있다. 우리나라에서는 2016년 연명의료결정법의 제정으로 연명의료중단이 제도화된 이래 여러 차례 개정을 거쳤는데, 최근에는 '조력존엄사'를 합법화하기 위한 내용의 연명의료결정법 개정안이 발의되었다. 이번 개정안에서는 조력존엄사를 '환자의 의사로 담당의사의 조력을 통해 스스로 삶을 종결하는 것'으로 정의하고 있는데, 이는 네덜란드, 벨기에 등의 유럽 국가와 미국 일부 주에서 시행되고 있는 조력사망(Aid in Dying)에 해당하는 내용으로 보인다. 조력사망이란 의사결정능력이 있는 환자가 치료가 불가능한 질병으로 고통을 받고 있을 때 환자가 사망을 앞당길 수 있는 약물을 의사로부터 처방받아 이를 이용하여 사망에 이르는 것을 의미한다. 존엄사에 대한 논의는 연명의료중단에서 조력사망의 순서로 진행되는 것이 세계적 추세인데, 2000년대에 이르러 일부 국가에서는 조력사망, 나아가 적극적 안락사까지 합법화하였다. 미국에서는 오리건 주를 필두로 여러 주에서 조력사망을 인정하는 법률을 두고 있지만 적극적 안락사에 대해서는 금지하고 있다. 이 논문에서는 일찌기 존엄한 죽음에 관한 논의를 시작하여 환자의 자기결정권을 제도화한 미국의 일부 주에서 조력사망의 입법화가 어떤 과정을 거쳐 이루어졌는지를 살펴보고 캘리포니아의 임종선택법의 주요 내용과 법시행 이후의 결과를 분석하였다.

• Nuclear Engineering and Technology
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• 제53권11호
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• pp.3517-3527
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• 2021

New 80-MW (electric) ultra-long-life sodium cooled fast reactor core having inherent safety characteristics is designed with heterogeneous fuel assemblies comprised of driver and blanket fuel rods. Several options using upper sodium plenum and SSFZ (Special Sodium Flowing Zone) for reducing sodium void reactivity are neutronically analyzed in this core concept in order to improve the inherent safety of the core. The SSFZ allowing the coolant flow from the peripheral fuel assemblies increases the neutron leakage under coolant expansion or voiding. The Monte Carlo calculations were used to design the cores and analyze their physics characteristics with heterogeneous models. The results of the design and analyses show that the final core design option has a small burnup reactivity swing of 618 pcm over ~54 EFPYs cycle length and a very small sodium void worth of ~35pcm at EOC (End of Cycle), which leads to the satisfaction of all the conditions for inherent safety with large margin based on the quasi-static reactivity balance analysis under ATWS (Anticipated Transient Without Scram).

• Journal of Chest Surgery
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• 제55권4호
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• pp.293-300
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• 2022

Lung transplantation is the only treatment option for patients with end-stage lung disease. Although more than 4,000 lung transplants are performed every year worldwide, the standardized protocols contain no guidelines for monitoring during lung transplantation. Specific anesthetic concerns are associated with lung transplantation, especially during critical periods, including anesthesia induction, the initiation of positive pressure ventilation, the establishment and maintenance of one-lung ventilation, pulmonary artery clamping, pulmonary artery unclamping, and reperfusion of the transplanted lung. Anesthetic management according to the special risks associated with a patient's existing lung disease and surgical stage is the most important factor. Successful anesthesia in lung transplantation can improve hemodynamic stability, oxygenation, ventilation, and outcomes. Therefore, anesthesiologists must have expertise in transesophageal echocardiography, extracorporeal life support, and cardiopulmonary anesthesia and understand the pathophysiology of end-stage lung disease and the drugs administered. In addition, communication among anesthesiologists, surgeons, and perfusionists during surgery is important to achieve optimal patient results.

• Physical Therapy Rehabilitation Science
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• 제12권3호
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• pp.293-299
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• 2023

Objective: This study aimed to investigate the potential benefits of microcurrent stimulation as a non-invasive therapeutic approach for managing pain and improving the quality of life in women suffering from primary dysmenorrhea. Design: A case study. Methods: This study was conducted, involving a cohort of 6 women diagnosed with primary dysmenorrhea, aged between 20 to 30 years. Participants were received microcurrent stimulation using low-intensity microcurrents for 30 minutes every day for 4 weeks. The intensity of microcurrent stimulation was 25 μA and the frequency was 8 Hz. The intervention was administered between the menstruations, with pain intensity and quality of life being assessed at baseline, and then at the end of menstrual cycle. Pain intensity was evaluated using a visual analog scale (VAS) and menstrual symptom questionnaire (MSQ), while the quality of life was assessed through the stress response inventory (SRI), state trait anxiety inventory (STAI), center for epidemiologic studies depression (CES-D), and menstrual distress questionnaire (MEDI-Q). Results: After the intervention, participants demonstrated a statistically significant reduction in pain intensity, as evidenced by improved VAS scores (p<0.05). However, the changes in MSQ scores did not reach statistical significance. Regarding quality of life measures, no statistically significant differences were found in the SRI, STAI, CES-D, and MEDI-Q scores after the intervention (p>0.05). Conclusions: This study suggest that microcurrent stimulation holds promise as a potential treatment option for alleviating pain associated with primary dysmenorrhea.

• Journal of Chest Surgery
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• 제55권4호
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• pp.338-356
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• 2022

Lung transplantation (LT) is now considered as an effective treatment option for end-stage lung diseases that improves the short and long-term survival rates and quality of life. As increasingly many LT procedures are being performed, the medical complications of LT are also increasing in frequency and emerging as a very important issue for transplant clinicians. Although chronic lung allograft dysfunction and infection are major causes of death after LT, many medical complications, several of which result from immunosuppressive treatment, contribute to increased mortality and morbidity. This article reviews the most frequent and important medical complications of LT, accompanied by a review of the literature and studies from South Korea, including lung allograft rejection, infection, and non-allograft organ systemic complications.

• 대한족부족관절학회지
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• 제25권4호
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• pp.181-184
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• 2021

End-stage ankle arthritis is a debilitating condition that causes functional limitations and consequently a poor quality of life. Total ankle replacement arthroplasty is a good alternative to arthrodesis for preserving the ankle's range of motion. However, many complications can occur in patients with rheumatoid arthritis and with poor soft tissue and bone conditions. A 61-year-old female experienced spacer subluxation after surgery, which was not reduced by medial soft tissue release and spacer change. Buttress plating was found to be a good treatment option to prevent spacer subluxation and can be considered in patients with rheumatoid arthritis with bone erosion and soft tissue damage.