• Korean Journal of Oriental Medicine
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• v.16 no.3
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• pp.45-52
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• 2010

This study aims to discuss the establishment and development of the Qiantang Medical School(錢塘醫派) represented by Zhang Zhicong(張志聰) via focusing on an academy of Chinese medicine named L$\"{u}$shantang(侶山堂). The teaching method in L$\"{u}$shantang(侶山堂) displays a representative feature of the Qiantang Medical School(錢塘醫派), but the foundation of the method consisting of lectures and discussions had already been laid by Lu Zhiyi(盧之頤) during the Ming-Qing transition period. The tradition was succeeded by Zhong Xuelu(仲學輅) in the Hangyuan Medical Board(杭垣醫局) even after L$\"{u}$shantang(侶山堂) was burnt down during a war taken place under the Qianlong(乾隆) period. That the function and the role of the local Confucian academies, which had been focused on the discussion of Confucian classics and local issues, were changed to adopt the education of medicine which had been treated as a lesser subject may be interpreted as a gradual change in the social perception of medicine. The change in the function of the Confucian academies combined with the tendency in which the literati elites of the period left the Confucian philosophy for medicine presents one of many examples showing the changes occurred during the Ming-Qing transition period. The education of medicine provided by the Confucian academies is regarded historically significant in that it was offered by ordinary civilians rather than the government before the formal school education system was established in the modern period. This educational tradition played an important role in bridging the Chinese medicine in the medieval times with that in the modern period.

• Geomechanics and Engineering
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• v.7 no.3
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• pp.233-246
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• 2014

Estimation of fracture initiation pressure is one of the most difficult technical challenges in hydraulic fracturing treatment of vertical or horizontal oil wells. In this study, the influence of in-situ stresses and pore pressure values on fracture initiation pressure and its profile in vertical and horizontal oil wells in a normal stress regime have been investigated. Cohesive elements with traction-separation law (XFEM-based cohesive law) are used for simulating the fracturing process in a fluid-solid coupling finite element model. The maximum nominal stress criterion is selected for initiation of damage in the cohesive elements. The stress intensity factors are verified for both XFEM-based cohesive law and analytical solution to show the validation of the cohesive law in fracture modeling where the compared results are in a very good agreement with less than 1% error. The results showed that, generally by increasing the difference between the maximum and minimum horizontal stress, the fracture pressure and its profile has been strongly changed in the vertical wells. Also, it's been clearly observed that in a horizontal well drilled in the direction of minimum horizontal stress, the values of fracture pressure have been significantly affected by the difference between overburden pressure and maximum horizontal stress. Additionally, increasing pore pressure from under-pressure regime to over-pressure state has made a considerable fall on fracture pressure in both vertical and horizontal oil wells.

• Journal of Korea Technology Innovation Society
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• v.16 no.1
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• pp.367-389
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• 2013

The Industry-Academia Technology Holding Company has been established and operated in universities for supporting technology transfer and promoting commercialization since 2008. In the meantime, necessity for operating and methods for vitalizing of the Industry-Academia Technology Holding Company, reviews for legal and institutional requirements and case studies have been performed in various ways. However, a comprehensive actual survey for overall operation of the Industry-Academia Technology Holding Company was insufficient for researchers of universities who were participating in National R&D programs and the projects for the S&T policy. In particular, this is the very time for an interim and overall review now that it has been 5 years since the Industry-Academia Technology Holding Company was introduced. Accordingly, the comprehensive surveys and interviews were conducted on the status of driving the project by the Industry-Academia Technology Holding Company in this study. Based on this analysis result, we have suggested the improvement of Industry-Academia Technology Holding Company in three different ways - (1) expanding the basement of technological business development in universities (2) improving legal and institutional support system, and (3) expanding elites of organizations and securing responsibilities.

• Journal of Pharmacopuncture
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• v.18 no.4
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• pp.7-11
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• 2015

Objectives: Bee venom (BV) is a complex mixture of proteins and contains proteins such as phospholipase and melittin, which have an effect on blood clotting and blood clots. The mechanism of action of honey bee venom (HBV, Apis mellifera) on human plasma proteins and its anti-thrombotic effect were studied. The purpose of this study was to investigate the anti-coagulation effect of BV and its effects on blood coagulation and purification. Methods: Crude venom obtained from Apis mellifera was selected. The anti-coagulation factor of the crude venom from this species was purified by using gel filtration chromatography (sephadex G-50), and the molecular weights of the anti-coagulants in this venom estimated by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Blood samples were obtained from 10 rabbits, and the prothrombin time (PT) and the partial thromboplastin time (PTT) tests were conducted. The approximate lethal dose (LD) values of BV were determined. Results: Crude BV increased the blood clotting time. For BV concentrations from 1 to 4 mg/mL, clotting was not observed even at more than 300 seconds, standard deviations $(SDs)={\pm}0.71$; however, clotting was observed in the control group 13.8 s, $SDs={\pm}0.52$. Thus, BV can be considered as containing anti-coagulation factors. Crude BV is composed 4 protein bands with molecular weights of 3, 15, 20 and 41 kilodalton (kDa), respectively. The $LD_{50}$ of the crude BV was found to be $177.8{\mu}g/mouse$. Conclusion: BV contains anti-coagulation factors. The fraction extracted from the Iranian bees contains proteins that are similar to anti-coagulation proteins, such as phospholipase $A_2(PLA_2)$ and melittin, and that can increase the blood clotting times in vitro.

• Asian Journal for Public Opinion Research
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• v.5 no.1
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• pp.41-62
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• 2017

The political reformation in Indonesia is a determinant factor of the change in political communications and the roles of media. Currently, the political elites need media support, since it contextually has a significant role. Whoever has a good relationship with the media, will be loved by the public. On the other hand, the media also have a vested interest in the elite in running businesses and building the power of industry. Policies and capital pose a challenge to maintaining the continuity of the media. Independence and control of media are at stake, when the interests of the media and the elite collaborate with each other and then build a benefit on both sides. Meanwhile, the role of social media also cannot be neglected. The Indonesian political communication system is characterized by the presence of social media in a pseudo-relationship between the elite and the public. This paper tries to explain the growing trends of research in the academic environment and the research trends in political practice in Indonesia after the occurrence of post-reformation era in legislative and executive elections. The method used is the meta-analysis of research outcomes of university (dissertations) and secondary data sources. Data processing is done by meta-analysis of secondary data. The results of meta-analysis research indicate that, the objective conditions, in Indonesia, especially the political conditions, stimulate new spaces in communication research. The study of political communication becomes dominant in the academic environment. In addition, communication research is also characterized by a shift from the linear perspective (positivistic paradigm) to the interactive perspective (naturalistic paradigm). On the other hand, the development of politic and governance situations in Indonesia has prompted the establishment of polling agencies that help citizens understand the maps of political power and candidates in general elections and regional head elections.

• Land and Housing Review
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• v.7 no.4
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• pp.177-189
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• 2016

Overseas Urban Development is even risky although it is desirable for market-seeking developed countries and developing countries facing urbanization problems. Both sides do not know each other well so that they cannot trust each other to work on this risky projects. This study constructs a frame, which is enhancing trust between developed and developing countries. The first step is to start from small collaborations than a huge project. At the charismatic position, a enterprise from developed country proceeds its first work with its most advanced skills, cooperating with developing countries. By localization with executing projects smaller and easier than urban development project, like constructing facility or buildings, this enterprise can get closer to native elites and get to be supported from native people. And then, they can start huge urban development project. The study begins with trust theory, adding case studies contributing to constructing Cooperative Overseas Urban Development Frame. Five cases were studied and applied by the international urban development framework.

• Korean Institute of Interior Design Journal
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• v.25 no.4
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• pp.90-97
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• 2016

As the paradigm which emphasizes nurturing creative elites is introduced, more attention has been paid to children playing and their creativity. This change means that the importance of creativity is emphasized in the education of children, and furthermore, playgrounds which focus on creativity and imagination are needed. Therefore, this study examines the spatial characteristics of playgrounds for children and suggested strategies to improve them. There are five spatial characteristics of a creative playground: aesthetics, being eco-friendly, exploration, challenging and variable. Through the five characteristics, playgrounds were analysed based on ten expressive elements and the results are summarized: Creative playgrounds for children should have an attractive design with sculptural elements which stimulate children to be excited through associable shapes and abstract colors. Second, shelter type structures and a flexible flow design are needed so that children can feel free and be encouraged to explore in diverse ways. Third, as playgrounds for children provide spaces for rest in addition to play, organic facilities and eco-friendly materials for the rest space should to be used. Fourth, as childhood is a period when emotional, cognitive and physical development are achieved, organic geographical features and atypical facilities should be provided so that children can acquire extensive skills and join in physical activities. Finally, creative playgrounds for children should have mobile or variable facilities which consider the characteristics of children who want to do diverse activities and play different games. This study analysed playgrounds for children and suggested strategies to improve them. For successful design and use of creative playgrounds, it is suggested that intensive research on them and consultation with experts should be considered.

• Journal of Electrochemical Science and Technology
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• v.8 no.1
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• pp.43-52
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• 2017

In this paper, for the first time, the electroanalytical study of Triethylenediamine, TEDA was done on a typically graphene modified carbon paste electrode (Gr/CPE) in pH=10.5 of phosphate buffer solutions (PBS). The surface morphology of the bare and modified electrodes was characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The electro-oxidation of TEDA was investigated at the surface of modified electrode. The results revealed that the oxidation peak current of TEDA at the surface of Gr/CPE is 2.70 times than that shown at bare-CPE. A linear calibration plot was observed in the range of 1.0 to 202.0 ppm. In this way, the detection limit was found to be 0.18 ppm. The method was then successfully applied to determination of TEDA in aqueous samples obtained from two kinds of activated carbon from the masks of war. On the other hand, density functional theory (DFT) method at B3LYP/6-311++G** level of theory and a conductor-like Polarizable Continuum Model (CPCM) was used to calculate the $pK_a$ values of TEDA. The energies of lowest unoccupied molecular orbital ($E_{LUMO}$) and highest occupied molecular orbital ($E_{HOMO}$), gap energy (${\Delta}E$) and some thermodynamic parameters such as Gibbs free energy of TEDA and its conjugate acid ($HT^+$) were calculated. The results of calculated $pK_a$ were found to be in good agreement with the experimental values.

• Journal of the Korean Geographical Society
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• v.38 no.1
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• pp.32-47
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• 2003

The Joseon had made maps of Japan with information that gained during the exchanges with Japan on the basis of the polio of maintaining amicable relations. The elaborate map of Japan similar to Haenggido was in Honilgangniyokdaekukdojido(Map of integrated lands and regions of historical countries and capitals, made in 1402, and more accurate map of Japan was found in Haedongjegukgi(Chronicle of the countries of the Eastern Sea, compiled by Sinsukju in 1471. These products were due to openness of foreign exchanges in 15th century. After 16th century, understanding of Japan based on China-centric view was intensified, as the confucianism of Chu-tzu planted its roots deeply in Joseon society as the social doctrine. These tendency were reflected in the map-making, accordingly many kinds of maps of Japan in the atlas were meager in contents and distorted in shorelines. Apart these currents, as comings and goings of official envoy became brisk, elaborated maps of Japan were imported and copied in the Joseon dynasty. Consequently these maps helped the elites of Joseon to raise understanding of Japan.

• Journal of Pharmacopuncture
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• v.19 no.3
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• pp.225-230
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• 2016

Objectives: Mellitine, a major component of bee venom (BV, Apis mellifera), is more active against gram positive than gram negative bacteria. Moreover, BV has been reported to have multiple effects, including antibacterial, antivirus, and anti-inflammation effects, in various types of cells. In addition, wasp venom has been reported to have antibacterial properties. The aim of this study was to evaluate the antibacterial activity of BV against selected gram positive and gram negative bacterial strains of medical importance. Methods: This investigation was set up to evaluate the antibacterial activity of BV against six grams positive and gram negative bacteria, including Staphylococcus aureus (S. aureus), Salmonella typhimurium, Escherichia coli (E. coli) O157:H7, Pseudomonas aeruginosa, Burkholderia mallei and Burkholderia pseudomallei. Three concentrations of crude BV and standard antibiotic (gentamicin) disks as positive controls were tested by using the disc diffusion method. Results: BV was found to have a significant antibacterial effect against E. coli, S. aureus, and Salmonella typhyimurium in all three concentrations tested. However, BV had no noticeable effect on other tested bacteria for any of the three doses tested. Conclusion: The results of the current study indicate that BV inhibits the growth and survival of bacterial strains and that BV can be used as a complementary antimicrobial agent against pathogenic bacteria. BV lacked the effective proteins necessary for it to exhibit antibacterial activity for some specific strains while being very effective against other specific strains. Thus, one may conclude, that Apis mellifera venom may have a specific mechanism that allows it to have an antibacterial effect on certain susceptible bacteria, but that mechanism is not well understood.