• 한국대기환경학회지
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• 제15권5호
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• pp.613-623
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• 1999

A Lagrangian particle dispersion mode l(LPDM) coupled with the prognostic flow model based on nonequilibrium level 2.5 turbulence closure has been dcveloped to simulate the dispersion from an elevated emission source. The proposed model did not require any empirical formula or data for the turbulent statistics such as velocity variances and Lagrangian time scales since the turbulence properties for LPDM were calculated from results of the flow model. The LPDM was validated by comparing the model results against the wind tunnel tracer experiment and ISCST3 model. The calculated wind profile and turbulent velocity variances were in good agreement with those measured in the wind tunnel. The ground level concentrations along the plume centerline as well as the dispersion codfficients also showed good agreement in comparison with the wind tunnel tracer experiment. There were some discrepancies on the horizontal spread of the plume in comparison with the ISCST3 but the maximum ground level concentrations were in a good confidence range. The results of comparisons suggested that the proposed LPDM with the flow model was an effective tool to simulate the dispersion in the flow situation where the turbulent characteristics were not available in advance.

• 대한한의학회지
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• 제37권2호
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• pp.104-109
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• 2016

Objectives: A 74-year-old male patient with unresectable advanced gastric cancer (clinical initial stage T3N+, Borrmann type III) admitted due to gastric bleeding at tumor site. On first admission day, hemoglobin level was 5.7g/dl and performance status was grade 3 according to Eastern Cooperative Oncology Group Performance Status(ECOG-PS). After performing red blood cell transfusion as an emergency treatment, hemoglobin level was increased up to 9.5g/dl. However, bleeding of oozing site was continued. For hemostasis, decoction of notoginseng radix (30g/day) was administered since day 7 after admission. The dose was elevated to 40g/day after hemoglobin level was decreased to 6.5g/dl on day 11. Since then, melena was stopped and hemoglobin level was maintained over 9.1g/dl. This case shows the hemostasis effect of decoction of notoginseng radix on gastric bleeding in unresectable advanced gastric cancer.

• 한국동물학회지
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• 제19권1호
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• pp.7-14
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• 1976

본인은 생후 24일 된 쥐에 PMS와 더불어 estradiol을 처리하면 排卵이 예정보다 24시간 앞당겨 일어남을 보고한 바 있다. 본 실험은 이의 계속 연구로 腦下垂體前葉에서 분비되는 preovulatory LH surge가 PMS 처리 후 51$\\sim$56시간에 일어남을 보았다. 그러나 estradiol을 PMS와 동시에 처리하면 예정보다 24시간 단축된다. 卵巢를 제거한 쥐에 0, 24, 48시간에 $2.5\\sim 40\\mu g$의 estradiol을 처리하면 51$\\sim$56시간에 腦下垂體의 LH가 증가되지 않는다. 그러나 estradiol을 처리하고 이어 48시간에 1mg의 progesterone을 처리하면 卵巢를 제거한 쥐에서도 腦下垂體의 LH level은 증가된다. 본 실험의 결과로 estradiol처리가 PMS로 유도한 排卵을 24시간 앞당기는 사실은 estrogen이 progesterone과 길항작용으로 腦下垂體에서 LH분비를 24시간 앞당겨 일으키고, 따라서 排卵도 24시간 단축되는 것이라고 생각된다.

• 한국동물학회지
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• 제33권2호
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• pp.158-165
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• 1990

Calpain은 $Ca^2$+-의존성 단백질 분해요소로서, 세포 골격단백질이나 근수축성 단백질을 분해하는 것으로 알려져있다. 한편, 배양 근원세포의 분화는 세포융합이라는 뚜렷한 형태적인 변화를 겪는데, 이때 근원세포의 세포막과 세포골격에 많은 변화가 일어난다고 알려져 있다. 본 실험에서는 근원세포 융합과정에서의 calpain의 역할을 알아보기 위하여 배양근원세포의 융합에 따른 calpain의 활성과 양적 변화를 조사하였다. 배양시간이 경과할 수록 calpain의 활성은 증가하여 세포융합이 왕성히 일어나고 있는 배양 60시간에 최대치를 이루었다. 또한, 닭골격근으로 부터 순수분리된 calpain에 대한 항체를 만들어서 배양 근원세포의 분화에 따른 calpain의 양적 변화를 immunoblot으로 조사하여 본 결과, calpain은 배양 24시간에서 48시간 사이에 그 양이 급격히 증가하여, 세포융합이 시작되는 배양 48시간 사이에 최다량으로 존재하는 것으로 나타났다. 이러한 결과는 calpain의 단백질 분해활성이 세포 융합과정에 관련된 있음을 암시해준다.

• 약학회지
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• 제43권2호
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• pp.214-220
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• 1999

Present study was aimed to examine whether indomethacin affected the production of NO in the rat paw exudate by carrageenin. Paw edema and nitrite/nitrate levels in the paw exudate were maximal after 4 h and remained elevated up to 10 h, whereas indomethacin (10 mg/kg, po) significantly inhibited the carrageenin-induced paw edema and levels of nitrate in the paw exudate. However, paw edema and nitrite/nitrite levels were increased thereafter for 10 h. Indomethacin also enhanced the expression of iNOS mRNA and protein 4 h after carrageenin infection. Indomethacin inhibited the level of $PGE_2$ in the paw exudate in a time-dependent manner. These results suggest the possibility that indomethacin may potentiate expression of iNOS and subsequently increase nitrite/nitrate level in the late phase of carrageenin-induced rat paw inflammation possibly by suppressing cycloxygenase activity.

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 2002년도 봄 학술발표대회 발표논문집
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• pp.468-471
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• 2002

The present study was undertaken to Investigate the effects of low temperature and salicylic acid (SA) on chilling tolerance In acclimated and nonacclimated cucumber seedlings. Acclimation significantly affected survival and shoot dry weights. Injuries of acclimated seedlings at the third leaf stage were on the average smaller by half than those of the nonacclimated ones. Chilling caused a large increase in free proline levels, regardless of acclimation status. Exogenous treatment with SA resulted in improvement in growth and survival of acclimated, chilled seedlings, indicating SA and acclimation have common effects. Cycloheximide treatment In the presence of SA restored acclimation-induced chilling tolerance. An elevated proline level was observed in cold-treated and SA- treated plants and the level was more pronounced in the light than in the dark at chilled temperature, indicating that endogenous proline may play a role in chilling tolerance.

• Food Science and Biotechnology
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• 제16권3호
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• pp.489-492
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• 2007

We investigated the antioxidant activity of ethanol extracts obtained from the flowers of Elsholtzia splendens on Chinese hamster ovary CHO-K1 cells. When cells were treated with E. splendens extracts (ESEs), low concentrations (<12.5 ug/mL) of stimulated cell proliferation via radical generation. Relative mRNA expression of Cu/Zn-superoxide dismutase (SOD) and Mn-SOD in cells exposed to ESEs (1-20 ug/mL) was significantly induced in a dose-dependent manner (p<0.05). In the case of catalase, ESEs had opposing effects; that is, a low-level treatment caused a decrease, and a high-level treatment induced elevated levels (p<0.05). The results demonstrated that components of ESEs exhibit potential antioxidant properties. Also, further studies are required to clarify the active components of Elsholtzia splendens extracts responsible for such biological activities.

• 대한의생명과학회지
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• 제11권4호
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• pp.539-543
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• 2005

Elevated level of serum cholesterol in humans is a risk factor correlated with the development of coronary heart disease. We have screened lactic acid bacteria from pig and human feces for the development of probiotics which have an anti-cholesterol effect. We have used special media to isolate only lactic acid bacteria and they were subjected to the experiments such as oxgal test, carbohydrate fermentation test. Results from the acid tolerance test and growth test in the presence of oxgal demonstrated that some strains would likely survive in thuman stomach, where acidity is high, and in small intestine, where bile fluid is present. In conclusion, we were able to screen lactic acid bacteria which were tolerant against bile acid and supposed to be prominent to lower the cholesterol level in human serum.

• Journal of Pharmaceutical Investigation
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• 제10권3호
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• pp.20-26
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• 1980

The purpose of this paper was to study the effect of sulpyrin on the absorption, excretion, metabolism, and protein binding of ampicillin in the small intestine of the rats and rabbits. The results are as follows; The absorption of ampicillin in small intestine of rats was increased by the combination of sulpyrin and ampicillin. The blood level of ampicillin in rabbits was elevated by oral administration of sulpyrin. The bioavailability of ampicillin was increased by simultaneous administration of sulpyrin and ampicillin. The urinary excretion of ampicillin was slightly decreased by combined administration of sulpyrin. The blood level of ampicillin was decreased and the urinary excretion was increased by long term administration of sulpyrin. On the other hand, metabolising enzyme of ampicillin was influenced by long term administration of sulpyrin. Protein binding rate of ampicillin was decreased by combination of sulpyrin as compared with control.

• 한국환경보건학회지
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• 제4권1호
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• pp.23-25
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• 1977

Transaminase has been a popular methods in the clinical laboratory for the diagnosis of particular diseases. The methods we are familiar with should be considered further on the serum states provided on the test to be done. (serum freshness, temperature and duration preserved) I have studied transaminase activities of the serum preserved under frozen (-10$\circ$C), refrigerated (4$\circ$C) and room temperature conditions. At a given interval those activities of serum are measured and then the results are compared with the optical density and calculated for the standard deviation and percent variation (Table 1. & Fig. 1.) G.O.T. activity is maintained decreased at a relatively constant rate from 2nd day to 14th day preservation under frozen and refrigerated but its activity variation at 25$\circ$C are far greater than the above conditions throughout the test periods. Elevated G.P.T. level of serum compared with G.O.T. are remained at any temperature and duration. Unless the determination of amino acid level study can not ruled out clearly.