• Asian-Australasian Journal of Animal Sciences
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• v.26 no.8
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• pp.1080-1088
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• 2013

Our previous results showed that kisspeptin-10 (Kp-10) injections via intraperitoneal (i.p.) once daily for three weeks notably promoted the egg laying rate in quails. In order to investigate the mechanism behind the effects of Kp-10 on enhancing the egg laying rate in birds, this study focused on the alternations of lipids synthesis in liver after Kp-10 injections. 75 female quails (22 d of age) were allocated to three groups randomly, and subjected to 0 (control, Con), 10 nmol (low dosage, L) and 100 nmol (high dosage, H) Kp-10 injections via i.p. once daily for three weeks, respectively. At d 52, quails were sacrificed and sampled for further analyses. Serum $E_2$ concentration was increased by Kp-10 injections, and reached statistical significance in H group. Serum triglyceride (TG) concentrations were increased by 46.7% in L group and 36.8% in H group, respectively, but did not reach statistical significance, and TG contents in liver were significantly elevated by Kp-10 injections in a dose-dependent manner. Serum total cholesterol (Tch) concentrations significantly decreased in H group, while in H group the hepatic Tch content was markedly increased. The level of non-esterified fatty acid (NEFA), apolipoprotein A1 and B (apoA1 and apoB) were not altered by Kp-10 injections. The genes expression of sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthetase (FAS), apolipoprotein VLDL-II (apoVLDL-II), cholesterol $7{\alpha}$-hydroxylase (CYP7A1) and vitellogenin II (VTG-II) were significantly up-regulated by high but not low dosage of Kp-10 injection compared to the control group. However, the expression of SREBP-2, acetyl-CoA carboxylase ($ACC_{\alpha}$), malic enzyme (ME), stearoyl-CoA (${\Delta}9$) desaturase 1 (SCD1), apolipoprotein A1 (apoA1), fatty acid binding protein 2 (FABP2), 3-hydroxyl-3-methyl glutaryl-coenzyme A reductases (HMGCR), estrogen receptor ${\alpha}$, ${\beta}$($ER{\alpha}$ and ${\beta}$) mRNA were not affected by Kp-10 treatment. In line with hepatic mRNA abundance, hepatic SREBP1 protein content was significantly higher in H group. Although the mRNA expression was not altered, the content of $ER{\alpha}$ protein in liver was also significantly increased in H group. However, SREBP-2 protein content in liver was not changed by Kp-10 treatment. In conclusion, exogenous Kp-10 consecutive injections during juvenile stage significantly advanced the tempo of egg laying in quails, which was associated with the significant elevation in hepatic lipids synthesis and transport.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.1
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• pp.363-375
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• 2013

Today, a shortage of the skilled operator has been intensified gradually and the necessity of an earthwork in extreme environment operators are difficult to access is increasing for the purpose of resource development and new living space creation. For this reason, an effort to develop an unmanned excavation robot for fully automated earthwork system is continuing globally. In Korea, a research consortium called 'Intelligent Excavation System' has been formed since 2006 as a part of Construction Technology Innovation Program of Ministry of Land, Transport and Maritime Affairs of Korea. Among detailed technologies of the Task Planning System is one of the core technologies of IES, this paper explains research and development process of the Local Area Design Module, which provides informatization unit to create automated excavators' work command information at operation level such as location, range, target, and sequence for excavation work. Designing of Local Area should be considered various influential factors such as excavator's specification, working mechanism, heuristics, and structural stability to create work plan guaranteed safety and effectiveness. For this research, conceptual and detail design of the Local Area is performed for analyzing design element and variable, and quantization method of design specification corresponding with heuristics and structural safety is generated. Finally, module is developed through constructed algorithm and developed module is verified.

• Journal of Navigation and Port Research
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• v.31 no.8
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• pp.629-635
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• 2007

Reduced crew performance is frequently cited as a major causal factor in maritime accident causation. Although considerable research has been conducted on the hours of work undertaken by seafarers through interviews and the analysis of records, experimental studies to observe the effects of factors such as high workload, shift patterns, stress, sleep deprivation and disturbance on the cognitive performance of mariners have been limited. Other safety-critical transport industries, such as aviation and rail, have developed fatigue management tools to help manage the work patterns of their operators. Such a tool for mariners would assist shipboard crew, marine pilots and shore management in planning and improving work schedules. The overall aim of this paper is to determine a fatigue factor, which can be applied to human performance data, as part of a software program that calculates total cognitive performance. This program enables us to establish the levels of cognitive performance of a group of marine pilots to test a decision-making task based on radar information. This paper addresses one of the factors that may contribute to the determination of various fatigue factors: the effect of different work patterns on the cognitive performance of a marine pilot.

• Tunnel and Underground Space
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• v.18 no.1
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• pp.44-57
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• 2008

In this study, a 2D finite-element analysis, using the SEEP/W program, was carried out to estimate the amount of groundwater flawing into a tunnel, as well as the groundwater tables around wetland areas during and after a tunnel excavation through rock mass. Four sites along the Wonhyo-tunnel in Cheonseong Mountain (Gyeongnam, Korea) were analysed, where the model damain of the tunnel included both wetland and fault zone. The anisotropy of the hydraulic conductivities of the rock mass was calculated using the DFN model, and then used as an input parameter for the cantinuum model. Parametric study on the influencing factors was perofrmed to minimize uncertainties in the hydraulic properties. Moreover, the volumetric water content and hydraulic conductivity functions were applied ta the model to reflect the ability of a medium ta store and transport water under both saturated and unsaturated conditions. The conductivity of fault zone was assumed ta be $10^{-5}m/sec\;or\;10^{-6}m/sec$ and the conductivity of grouting zone was assumed as 1/10, 1/50 or 1/100 of the conductivity of rock mass. Totally $6{\sim}8$ cases of transient flow simulation were peformed at each site. The hydraulic conductivities of fault zone showed a significant influence on groundwater inflow when the fault zone crossed the tunnel. Also, groundwater table around wetland maintained in case that the hydraulic conductivity of grouting zone was reduced ta be less than 1/50 of the hydraulic conductivity of rock mass.

• Journal of Nutrition and Health
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• v.42 no.5
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• pp.434-441
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• 2009

Ferroportin-1 (FPN) is a transporter protein that is known to mediate iron export from macrophages. The purpose of this study was to investigate the effect of copper on the regulation of FPN gene expression in J774 mouse macrophage cells. J774 cells were treated with various concentrations of $CuSO_4$ and RT-PCR analyses were performed to measure the steady-state levels of mRNAs for FPN and divalent metal transporter 1 (DMT1, an iron importer). Copper treatment significantly increased FPN mRNAs in a dose-dependent manner, but didn't change the levels of DMT1 mRNA. Experiments with transcriptional inhibitor actinomycin D (0.5 ${\mu}g$/mL) revealed that copper treatment did not affect the half-life of FPN mRNAs in J774 cells. On the other hand, results from luciferase reporter assays showed that copper directly stimulated the promoter activity of FPN. In summary, our data showed copper induced FPN mRNA of macrophages via a transcriptional rather than post-transcriptional mechanisms.

• Journal of the Korean earth science society
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• v.31 no.3
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• pp.234-245
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• 2010

Twenty-four hour integrated $PM_{10}$ and $PM_{2.5}$ samples were measured during springtime (March, April, and May) in Busan for three years from 2006 to 2008, and mass concentrations and metallic elements of measurement were analyzed to investigate temporal, spatial, chemical characteristics of the mass concentration and metallic elements in association with meteorological conditions including Asian Dust (AD) vs. non Asian Dust (NAD) seasons, and other air mass transport patterns. The result showed that $PM_{10}$, $PM_{2.5}$ and $PM_{10-2.5}$ concentrations were on average of $126.2{\pm}89.8$, $85.5{\pm}41.6$, and $40.7{\pm}54.9{\mu}g/m^3$, respectively, and the $PM_{2.5}/PM_{10}$ and $PM_{10-2.5}/PM_{2.5}$ ratios were 0.70 and 0.48, respectively. The highest concentrations of PM were observed when air parcels were originated from both northwest sector covering Beijing and west sector including Shanghai areas.

• International Journal of Highway Engineering
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• v.14 no.3
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• pp.151-162
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• 2012

It is not surprising to hear news about irresistible natural disasters all over the world due to climate change. Korean Government has focused on developing a variety of green technologies to reduce green house gasses, in particular, carbon dioxide. This study suggested 18 technology divisions for achieving green highway technology development in six different sub-sectors considering life-cycle of roadway and surveyed 29 highway and/or transportation professionals of three institutes using AHP(Analytical Hierarchy Process) analysis to construct "Green Highway"and realize carbon emission reductions and energy use efficiency in a road sector in Korea. Expert Choice Software was used to rank 18 technology divisions weighted by two-level choices. Transport Operating Infrastructure Improvement, Roadway Policy Implementation, Green Transportation(such as Pedestrian and Bicycle) were highly ranked by respondents according to results of the AHP modeling. Among the 18 divisions, technology policy for supporting R&D investments from development to commercialization was ranked as the most significant one to be focused. Green Transportation Facility Design/Construction/Operation and Eco-Friendly Roadway Plan were followed as expected since professionals have thought that the planning/design step of the life-cycle is a starting point to reduce carbon dioxide from roads more and more. Additionally, comparing the results with the Government investment trend 2006-2011 for the roads, it can be interpreted that the Government should invest to the R&D area more widely than before to promote element and core technology development for Green Highway Construction. Above all, small and mid-sized businesses have to be invested as well as encouraged to undertake green highwayrelated objects to accomplish the divisions which ranked high.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.52 no.4
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• pp.364-371
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• 2016

The analysis on the international safety management code (ISM Code) and case of foreign national safety management for fishing vessel was conducted to serve as a basic data on the introduction of safety management system (SMS) for a deep-sea fishing vessel in Korea. As a result, Maritime New Zealand (MNZ) has managed operations of SMS in the maritime rules according to the Maritime Transport Act since 1994. MNZ underwent a safe ship management (SSM), which includes elements applied to shipping companies, ship and verification of the ISM Code for ships, except ISM Code application since 1998. In 2014 the introduction of the advanced maritime operator safety system (MOSS) superior to the SSM by MNZ was promoted actively switch and enforcement. Meanwhile, the safe operation manual of Japanese fishing vessel includes large part of the contents of the ISM Code, and voluntary implementation to fit the realities of the fishing vessel. The law application of SMS for a deep-sea fishing vessel after the newly establishment of the Ocean Industry Development Act to SMS would be advantageous to the schematic management, supervision, maintenance and application and, in 2016 from the implementation of maritime safety supervisor for a deep-sea fishing vessel that the management and supervision through the fishing vessel will be the efficient operation. The configuration of the safety management system in a deep-sea fishing vessel should be included as an element of ISM Code. The introduction of such a system is gradually applicable, such as nationality overseas vessel case study of the ISM Code, and vessels that are excluded from the application will be implemented as autonomous as Japan. The results are expected to contribute to sustainable development in the ocean industry safety culture spread throughout the ocean industry through the enhancement of safety fishing competency and safety management responsibility of fisher.

• Spatial Information Research
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• v.20 no.3
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• pp.83-93
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• 2012

Recent environmental concerns have made interest in environment-friendly transportation means such as walking, biking, and public transportation. However, since it is difficult to move long distance by walking or biking, their scope of application is rather limited. On the other hand, public transportation can solve traffic congestion, a recent social issue, though its usability may depend on its time schedule. Currently available information services on public transportation in the Web do not reflect well such traits of the public transportation; thus, in some cases, they may provide wrong information to end users. To solve such problems and provide information based on timetable of public transportations, this paper proposes a STP(Space Time Point) data model. Unlike existing space-time data models, this model recognizes the bottommost element of an object as a point and structures these points in hierarchical way to define an object. In particular, It can make it possible to implement a variety of dynamic spatial objects changing object information according to time. An objective of this study is to design a STP model for bus and subway based on timetables of public transportation in Daejeon area and builds a system to provide path navigation. With the designed navigation function, a path from the Daejeon National Cemetery to Hannam University was searched by time slot. The result showed that the system provided different paths by time, as the system guided different paths when bus operation was limited in midnight. As existing data model could not provide such results, it is confirmed that the system can provide path navigation based on real-time traffic information. It is expected that based on such functionality, it is possible to provide additional functionalities by applying diverse data models such as real-time transport information or traffic history information.

• Journal of the Korean Association of Geographic Information Studies
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• v.19 no.2
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• pp.63-72
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• 2016

Closed-circuit television(CCTV) is a facility that forms the backbone of the ubiquitous services provided by the Integrated Management Center of the Ministry of Land, Infrastructure and Transport and the Integrated Control Center of the Ministry of the Interior. However, it is installed and managed according to different laws, as it is operated and managed by each department. Moreover, because there are no regulatory grounds for unified management of CCTV, each municipality responsible for the actual management manages it based on the individual standards of each department. Thus, the purpose of this study is to develop a standardized management form to establish an integrated management plan. The author inspected the existing situation by examining the legal system and public data and through hands-on worker interviews, and discovered the managed element by reviewing the specifications of the bidding system. The management form for integrated management comprises the above requirements along with the management histories and linkage of intelligent facilities. A uniform management form for integrated management containing specifications of the CCTVs installed by various departments is created, and is easily searched for facilities to check requirements for joint use. The result of this study can contribute to building the database of facility management system for integrated management of facilities at the integrated management center as well as for a detailed simulation of the selection of location of CCTV depending on the CCTV's specifications.