• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.3
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• pp.337-344
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• 2002

Runx2, a Runt-related osteoblast-specific transcription factor, is essential for osteoblast differentiation and function. Runx2 was identified as a key regulator of osteoblast-specific gene expression through its binding to the OSE2 element present in these genes. However, little is known about the signaling mechanism regulating Runx2 activity. This study examines the role of protein kinase C (PKC) pathway and mitogen-activated protein kinase (MAPK) pathway in regulating Runx2 and bone marker genes (osteopontin; OP, osteocalcin; OC). Luciferase assay and Northern blot analysis suggested that the stimulation of PKC by PMA increased transcription activity of Runx2 and bone marker genes (OP and OC) and also increased expression of Runx2. The stimulation of MAPK by okadaic acid increased transcription activity of Runx2 and bone marker genes (OP and OC). Pretreatment with PD98059 (Erk pathway inhibitor) and SB203580 (P38 pathway inhibitor) prior to PMA treatment decreased PMA stimulated Runx2 activity. Together these results indicate that both PKC and MAPKs are involved in the regulation of Runx2 activity and also the stimulation of Runx2 transcriptional activity by the PKC pathway is through activation of MAPK pathway.

• Journal of the Korean Geotechnical Society
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• v.32 no.11
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• pp.5-19
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• 2016

This paper presents the results from three-dimensional finite element (FE) analysis undertaken to provide insight into the lateral behaviors of piled gravity base foundation (GBF) for offshore wind turbine. The piled GBF was originally developed to support the gravity based foundation in very soft clay soil. A GBF is supported by five piles in a cross arrangement to achieve additional vertical bearing capacity. This study considered four different cases including a) single pile, b) three-by-three group pile (with nine piles), c) cross-arrangement group pile (with five piles), and d) piled GBF. All the cases were installed in homogenous soft clay soil with undrained shear strength of 20 kPa. From the numerical results, p-y curves and thus P-multiplier was back-calculated. For the group pile cases, the group effect decreased with increasing the number of piles. Interestingly, for the piled GBF, the P-multipliers showed a unique trend, compared to the group pile cases. This study concluded that the global lateral behaviour of the piled GBF was influenced strongly by the interaction between GBF and contacted soil surface.

• Journal of the Korean Chemical Society
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• v.53 no.6
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• pp.774-783
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• 2009

The purpose of this study was to survey the secondary science teachers' viewpoints of basic particles conceptions addressed in science course. The first content of this study was to analyze the secondary science teachers conceptions related to basic particles founded on scientific history viewpoints. The second content was to investigate their understanding of relations between atom, element, and molecule concepts. The third content was to search the factors influenced on basic particles conceptions of science teachers. For this study, 96 secondary science teachers were selected. The data of this study were collected through a questionnaire developed for this study and were analysed using the method of constant comparative analysis. The results showed that their viewpoints towards basic particles were similar to each other regardless of their majors and their conceptions belonged to the past viewpoints. The teachers lacked linking understand among basic particles conceptions because they applied different viewpoints on different problems. Most of the teachers were influenced on science textbooks, guidebooks for teachers, and reference books to form confusing viewpoints of basic particles.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.30 no.4
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• pp.329-334
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• 2017

The structures, which are made up with the huge number of degrees-of-freedom and the assembly of substructures, have a great complexity. In order to increase the computational efficiency, the analysis models have to be simplified. Many substructuring techniques have been developed to simplify large-scale engineering problems. The techniques are very powerful for solving nonlinear problems which require many iterative calculations. In this paper, a modal derivatives-based model order reduction method, which is able to capture the stretching-bending coupling behavior in geometrically nonlinear systems, is adopted and investigated for its performance evaluation. The quadratic terms in nonlinear beam theory, such as Green-Lagrange strains, can be explained by the modal derivatives. They can be obtained by taking the modal directional derivatives of eigenmodes and form the second order terms of modal reduction basis. The method proposed is then applied to a co-rotational finite element formulation that is well-suited for geometrically nonlinear problems. Numerical results reveal that the end-shortening effect is very important, in which a conventional modal reduction method does not work unless the full model is used. It is demonstrated that the modal derivative approach yields the best compromised result and is very promising for substructuring large-scale geometrically nonlinear problems.

• Journal of the Earthquake Engineering Society of Korea
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• v.14 no.5
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• pp.13-22
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• 2010

Masonry infill walls are frequently used as interior partitions and exterior walls in low- or middle- rise RC buildings. In the design and assessment of buildings, the infill walls are usually treated as non-structural elements and they are ignored in analytical models because they are assumed to be beneficial to the structural responses. Therefore, their influences on the structural response are ignored. In the case of buildings constructed in the USA in highly seismic regions, infill walls have a lower strength and stiffness than the boundary frames or they are separated from the boundary frames. Thus, the previously mentioned assumptions may be reasonable. However, these systems are not usually employed in most other countries. Therefore, the differences in the seismic behaviors of RC buildings with/without masonry infill walls, which are ignored in structural design, need to be investigated. In this study, structural analyses were performed for a masonry infilled low-rise RC moment-resisting frame. The infill walls were modeled as equivalent diagonal struts. The seismic behaviors of the RC moment-resisting frame with/without masonry infill walls were evaluated. From the analytical results, masonry infill walls can increase the global strength and stiffness of a structure. Consequently, the interstory drift ratio will decrease but seismic forces applied to the structure will increase more than the design seismic load because the natural period of the structure decreases. Partial damage of the infill walls by the floor causes vertical irregularity of the strength and stiffness.

• Journal of the Korean Society of Marine Environment & Safety
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• v.20 no.4
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• pp.451-460
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• 2014

In this paper, we examined the problem of the structural stability according to the patch load of a rectangular plate that reflects the material properties of A6082-T6 is used primarily for marine plant structure. it applied to the four patch loading shapes, the effect of aspect ratio, a boundary condition and calculated the critical elastic buckling load. Calculating the critical elastic buckling load, During the eigenvalue buckling analysis it is applied to the shell181 as 4 node shell element. when the plate subjected to patch loading compare to the plate under a uniform axial compression load, it is possible observed to occur the different elastic buckling behaviour and it could be confirmed that it is affected significantly on a variable position and type of loadings, such as the effect of the aspect ratio. Also, Critical elastic buckling load according to th patch loading type in simply supported rectangular plate a/b=1.0, ${\gamma}b$=200mm are calculated 67%(Loading type I), 119 %(Loading type II), 76 %(Loading type III), 160 %(Loading type IV), respectively. Loading type I and III could be determined with the strong elastic buckling behavior much more than Loading type II and IV.

• Journal of Korean Tunnelling and Underground Space Association
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• v.15 no.5
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• pp.455-468
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• 2013

In recent, various types of steel pipe-roof methods, which is reinforced by mortar after propulsion of steel pipe into the ground, have been used for the construction of trenchless underpass. Integrated steel pipe-roof has flexural stiffness and can resist against overburden load and reduce the stress acting on the concrete underpass structures. Due to arching effect, vertical and horizontal stress distribution around the steel pipe-roof is changing. In this study, therefore, the characteristic of stress distribution around the underpass induced by the construction of integrated steel pipe-roof is investigated by using numerical method. To examine the soil-structure interaction, interface element is introduced. Results show that vertical stress acting on the concrete structure placing inside the steel pipe-roof is significantly reduced due to arching effect and flexural stiffness of integrated steel pipe-roof. Design load can be reduced and effective design of underpass will be available if the earth pressure reduction due to arching effect is considered in the design stage.

• Journal of Korean Tunnelling and Underground Space Association
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• v.19 no.2
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• pp.265-281
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• 2017

For shallow tunnel constructions, settlement of the ground surface is a main issue. Recent technical developments in shield TBM tunneling technique have enabled a decrease in such settlements based on tunneling with ground deformation controls. For this objective, the tail void grouting is a common practice. Generally surface settlements in a soil of low permeability occur during a tunnel construction but also during a long period after completion of the tunnel. The long-term settlements occur mainly due to consolidation around the tunnel. The consolidation process is caused and determined by the tail void grouting which leads to an excess pore water pressure in the vicinity of the tunnel. Because of this, the grouting pressure has a strong effect on the long-term settlements in the shield tunneling. In order to investigate this effect, a series of coupled hydro-mechanical 3D finite element simulations have been performed. The results show that an increase in grouting pressure reduces the short-term settlements, but in many cases, it doesn't lead to a reduction of the final settlements after the completion of consolidation. Thereby, the existence of a critical grouting pressure is identified, at which the minimal settlements are expected.

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.9
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• pp.749-755
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• 2016

A new method for measuring the 3-axis cutting forces of a pick cutter by substituting costly 3-D load cells is proposed in this paper. The proposed cutting force measurement method is capable of estimating the 3-axis cutting forces through mechanical constraints using four single-axis compressive load cells and shoulder bolts. The feasibility of the proposed method was verified by finite element analysis, and the accuracy of the force measurement of the developed force measurement device was investigated by conducting linear rock cutting tests. The tests showed that the new cutting force measurement method is able to measure 3-axis cutting forces with a relative error of approximately 6%. These results imply that the new method could be a suitable alternative to conventional 3-D load cells. In addition, it will allow a significant reduction of approximately 20-30% in the costs required for measuring the cutting force when compared to conventional 3-D load cells.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.3
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• pp.307-313
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• 2010

In this study, alternative designs for the bends used in district heating pipes are investigated. The district heating pipes, which are subjected to temperatures of 10 to $120^{\circ}C$ and a water pressure of $16\;kgf/cm^2$, have to withstand thermomechanical cyclic loads when in use. These pipes comprise three concentric tubes: a steel pipe (internal), polyurethane (PUR) insulator (middle), and a high-density polyethylene (HDPE) case (external). In addition, the bends in the district heating pipe system are covered with foam pads that cause aging. In this study, an alternative bend design that does not involve the use of a foam pad is proposed to overcome the aging problem in the bends. In the proposed design, "shear rings" are added to the surface of a bend, and its dimensions are determined by a combination of the statistical (Taguchi) method and FEM. The geometrical parameters such as thickness, height, and number of the rings significantly affect the design optimization, and hence, they affect the results of the FEM.