• 대한통합의학회지
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• 제6권4호
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• pp.183-189
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• 2018

Purpose : As age increases, a low-level systemic inflammatory state develops and the levels of anti-aging hormones decrease. The vagus nerve activates parasympathetic nerves and promotes sulfation and secretion of neurotransmitter in the brain. Therefore, the purpose of this study was to investigate the effects of electrical vagus nerve stimulation on systemic inflammation (CRP) and anti-aging hormone (DHEA-S) levels in elder people. Methods : A total of 30 healthy elder people participated in this study, randomly divided into two groups of 15 subjects. Electrical vagus nerve stimulation was applied to the experimental group for 4 weeks. CRP and DHEA-S levels were compared with those of the control group. Results : The CRP level was significantly lower in the experimental group than in the control group. In the experimental group, there was a significant decrease in CRP before and after the intervention. However, the DHEA-S level was not significantly different between groups. Conclusion : Electrical vagus nerve stimulation may alleviate the low-level systemic inflammatory state found in elderly people. These results suggest that it may have the effect of reducing the degenerative inflammatory diseases of the elderly and delaying aging.

• 국제물리치료학회지
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• 제12권2호
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• pp.2323-2330
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• 2021

Background: Stroke patients have weak trunk muscle strength due to brain injury, so a single type of exercise is advised for restoring functionality. However, even after intervention, the problem still lies and it is suggested that another intervention method should be applied with exercise in order to deal with such problem. Objectives: To Investigate the effect of bridge exercise combined with functional electrical stimulation (FES) on trunk muscle activity and balance in stroke patients. Design: Randomized controlled trial. Methods: From July to August 2020, twenty stroke patients was sampled, ten patients who mediated bridge exercises combined with functional electrical stimulation were assigned to experiment group I, and ten patients who mediated general bridge exercises were assigned to experiment groupII. For the pre-test, using surface EMG were measured paralyzed rectus abdominis, erector spinae, transverse abdominis/internal oblique muscle activity, and using trunk impairment scale were measured balance. In order to find out immediate effect after intervention, post-test was measured immediately same way pre-test. Results: Change in balance didn't show significant difference within and between groups, but muscle activity of trunk was significant difference rectus abdominis and erector spinae within groups I (P<.01), also between groups was significant difference (P<.05). Conclusion: Bridge exercise combined with FES could improve trunk function more effectively than general bridge exercise due to physiological effect of functional electrical stimulation.

• Physical Therapy Rehabilitation Science
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• 제12권2호
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• pp.140-148
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• 2023

Objective: Meniscal injuries are a common and high-risk condition among military personnel, leading to difficulties in performing missions.The objective of this study is to investigate the effects of combining electrical muscle stimulation therapy with exercise therapy during rehabilitation on pain, muscle strength, and function in patients after meniscectomy. Design: A two-group pretest-posttest design Methods: A total of 30 subjects were included in this study. They were randomly assigned to either the experimental group (n=15), which received knee extensor strengthening exercise along with electrical muscle stimulation, or the control group (n=15), which received only knee extensor strengthening exercise. Pre-test was conducted prior to the intervention, which consisted of 30 minutes of treatment five times a week for a total of 20 sessions. Post-test was performed after a 4-week period. Pain, strength, and function were assessed before and after the intervention. Results: The results of the study showed that there was a significant difference in pain reduction and muscle strength improvement in the experimental group, and a significant difference was also found between the experimental group and the control group in terms of functional evaluation. Conclusions: The combination of exercise therapy and electrical muscle stimulation therapy resulted in greater improvements in pain, strength, and function assessment, contributing to improved overall function.

• Physical Therapy Rehabilitation Science
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• 제12권3호
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• pp.300-309
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• 2023

Objective: The purpose of this study was to investigate the effects of gastrocnemius neuromuscular electrical stimulation training on ankle mobility and gait in patients with stroke. Design: A randomized controlled trial. Methods: 31 patients with stroke were selected and classified into an experimental group (n=16) and a control group (n=15). Both groups were assessed for ankle mobility using the Knee to Wall Test and gait parameters using G-walk before and after the intervention. The intervention was applied five times a week for four weeks. The experimental group performed gastrocnemius neuromuscular electrical stimulation followed by ankle control exercises, while the control group only applied NMES to the tibialis anterior muscle of the paretic side for 30 min per session five times a week for 4 weeks. Results: Experimental group showed significant improvements in Knee to wall test. and lumbar flexibility after the intervention. both group showed significant improvements in gait parameters after the intervention. However, when comparing between the two groups, the experimental group showed a more significant effect than the control group. Conclusions: Gastrocnemius neuromuscular electrical stimulation training can be considered an effective approach to improve ankle mobility and gait ability in patients with stroke.

• 한국정밀공학회지
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• 제20권1호
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• pp.26-35
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• 2003

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2008년도 하계종합학술대회
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• pp.1005-1006
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• 2008

A mechanical or electrical stimulation to the muscle always produces special phenomena, as silent period. Generally, a mechanical stimulation is followed by a single silent period, and an electrical stimulation is followed by multiple silent periods. In this paper, we propose a new algorithm for determining the duration of the silent period.

• Journal of Periodontal and Implant Science
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• 제29권4호
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• pp.821-838
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• 1999

On the basis of the evidences that electrical stimulation could enhance proliferation and differentiation of bone cells and promote healing and regeneration of bone, this study was performed to investigate the effects of electrical stimulation on human periodontal ligament cells and gingival fibroblasts in vitro, which also have important roles in regeneration of periodontium, and to evaluate the potential of clinical application of electrical stimulation. Human periodontal ligament cells and gingival fibroblasts were primarily cultured from the root surface of extracted premolar and the adjacent gingiva without periodontal diseases. In control group, the cells ($5{\times}10^4$ cells/ml)were incubated only in Dulbecco's Modified Eagle's Medium contained with 10% fetal bovine serum. In test groups, electrical stimulation was given at the current intensity of $0.25{\mu]A$(test group 1), $1.0{\mu}A$(test group 2), and $2.5{\mu}A$(test group 3) for 12 hours to the same culture media with the control group. After 12 hour exposure of electrical stimulation, the cells were incubated for 2 and a half days(60 hours), and then each group of cells was analyzed for cell proliferation, protein level, and activity of alkaline phosphatase. The results were as follows ; 1. The Rate of cell proliferation of every test group increased significantly in both periodontal ligament cells and gingival fibroblasts, and in periodontal ligament cells, test group 3 showed significantly increased proliferation compared to the other test groups(p<0.05). 2. In the protein levels, neither periodontal ligament cell nor gingival fibroblast showed statistically significant differences between control and test groups. 3. The activity of alkaline phosphatase in periodontal ligament cells increased significantly in all test groups(p<0.05), but there were no significant differences between 3 test groups. In gingival fibroblasts, the activity of alkaline phosphatase increased significantly only in test group 3(p<0.05). From the above results, it is concluded that electrical stimulation may have beneficial effects on the regeneration of destructed periodontal tissue in regard of the stimulation of periodontal ligament cells and gingival fibroblasts as well as electrically stimulated bone formation that has been known, and that electrical stimulation may have the potential of clinical application.

• 한국광학회:학술대회논문집
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• 한국광학회 2009년도 동계학술발표회 논문집
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• pp.427-428
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• 2009

Optical imaging offers excellent spatio-temporal sensitivity that is unparalleled by any other perfusion based imaging techniques. We used in vivo optical recording of intrinsic signals (ORIS) to map neurovascular hemodynamics of perfusion, oximetry and membrane potential during epileptic events in rat and mouse neocortex. Studies of hemodynamic changes with ORIS alone were also performed in human. Laboratory studies in rodent epilepsy models have demonstrated a persistent increase in deoxygenated hemoglobin (Hbr) and a decrease in tissue oxygenation during interictal spikes and ictal events. This "epileptic dip", like the "initial dip" recorded during normal sensory processing, implies that the enormous rise in cerebral blood flow (CBF) is inadequate to meet the increased metabolic demands associated with synchronized epileptic activity. These findings are critically important to the interpretation of the perfusion-based imaging studies, such as fMRI. In addition, we visualized the effect of direct cortical electrical stimulation, an alterative epilepsy treatment. The optical data following direct cortical electrical stimulation showed that hemodynamic signals are sensitive to different electrical stimulation parameters. Furthermore, our recent data demonstrated that the application of unilateral electrical stimulation is able to elicit bilateral hemodynamic responses in rat neocortex.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 D
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• pp.2155-2156
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• 2006

The purpose of this work is to investigate the fundamental properties of the gradual muscle force potentiation for the prediction of muscle force and body movement from the stimulation input with musculo-skeletal model. We investigated the dependence of force potentiation on both the pulse-amplitude and the pulse-duration. The experimental result showed that the force increment ratio during electrical stimulation decreased with pulse-amplitude. The force increment ratio decreased with short pulse-duration and was maintained to be constant with pulse-duration longer than $500{\mu}s$. A new model of the muscle potentiation based on these results is desired in the future.

• 대한물리치료과학회지
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• 제9권1호
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• pp.89-94
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• 2002

Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, constitutively expressed cyclooxygenase(COX)-1 and COX-2, which is induced at sites of inflammation. Inhibition of COX-2 is desirable as this may avoid side effects seen with NSAIDs. We examined the effects of transcutaneous electrical nerve stimulation and cold therapy on the levels of muscle cycloooxygenase-2 mRNA in rats of carrageenan-induced inflammatory. The method of behavioral assessment were paw withdrawal latency(PWL) and tail flick test(TFT). The COX-2 mRNA levels were quantified by reverse transcription-polymerase chain reaction (RT-PCR). Following the transcutaneous electrical nerve stimulation and cold therapy, PWL and TFT were increased and COX-2 mRNA expression in gastrocnemius muscles were decreased. These results suggest that a transcutaneous electrical nerve stimulation and cold therapy were good therapy for a muscle pain.