• Title/Summary/Keyword: Elderly males

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Prevalence and Risk Factors for Lumbar Spondylosis and Its Association with Low Back Pain among Rural Korean Residents

  • Lee, Sung Yeon;Cho, Nam H.;Jung, Young Ok;Seo, Young Il;Kim, Hyun Ah
    • Journal of Korean Neurosurgical Society
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    • v.60 no.1
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    • pp.67-74
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    • 2017
  • Objective : The purpose of this study was to investigate the prevalence of and the relevant risk factors for lumbar spondylosis (LS) among middle-aged and elderly rural Korean residents and to explore the association between radiographic LS and lower back pain (LBP) in relation to age and gender. Methods : This community-based, cross-sectional study evaluated 1512 subjects with available radiograph. The prevalence of LBP was obtained using a questionnaire and disability resulting from LBP was measured using a validated Korean version of the Oswestry disability index (ODI). In lumbar spine radiographs, vertebral levels from L1/2 to L4/5 were evaluated for the presence of osteophytes and joint-space narrowing (JSN), and Kellgren-Lawrence (KL) grading was applied. Results : Of 4261 subjects aged 40-79 years, data from 1512 subjects were included. The prevalence of radiographic LS indicated by grade ${\geq}2$ osteophytes and JSN were 53.9 and 15.8%, respectively. Seventy-three percent of subjects had KL grade ${\geq}2$ spondylosis and LBP was present in 36.5% of subjects. Although LS was more common among males, the prevalence of LBP was higher among females. Age, male gender and history of hand or knee arthritis were risk factors for LS. LS was significantly associated with LBP mostly among females over 60 years old and correlated with the ODI after adjusting for age and gender. Conclusion : Our study among rural Korean residents revealed a high prevalence of LS and LBP. The association between LS and LBP was observed mostly among females and LS was significantly correlated with the severity of back pain.

Estimation of the National Burden of Disease and Vulnerable Population Associated with Natural Disasters in Korea: Heavy Precipitation and Typhoon

  • Han, Hyun-Jin;Kim, Jong-Hun;Chung, Soo-Eun;Park, Jae-Hyun;Cheong, Hae-Kwan
    • Journal of Korean Medical Science
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    • v.33 no.49
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    • pp.314.1-314.15
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    • 2018
  • Background: Despite its growing significance, studies on the burden of disease associated with natural disasters from the perspective of public health were few. This study aimed at estimating the national burden of disease associated with typhoons and torrential rains in Korea. Methods: During the period of 2002-2012, 11 typhoons and five torrential rains were selected. Mortality and morbidities were defined as accentual death, injury and injury-related infection, and mental health. Their incidences were estimated from National Health Insurance Service. Case-crossover design was used to define the disaster-related excess mortality and morbidity. Disability-adjusted life years (DALYs) were directly assessed from excess mortality and morbidity. Results: The burden of disease from typhoons increased with the intensity, with 107.7, 30.6, and 36.6 DALYs per 100,000 per event for strong, moderate, and weak typhoons, respectively. Burden of disease from torrential rains were 56.9, 52.8, and 26.4 DALYs per 100,000 per event for strong, moderate, and weak episodes, respectively. Mental disorders contributed more years lived with disability (YLDs) than did injuries in most cases, but the injury-induced YLDs associated with strong typhoon and torrential rain were higher than those of lower-intensity. The elderly was the most vulnerable to most types of disaster and storm intensities, and males younger than 65 years were more vulnerable to a strong torrential rain event. Conclusion: The intensity of torrential rain or typhoon was the strongest determinant of the burden of disease from natural disasters in Korea. Population vulnerable may vary depending on the nature and strength of the disasters.

6-sialyllactose ameliorates dihydrotestosterone-induced benign prostatic hyperplasia through suppressing VEGF-mediated angiogenesis

  • Kim, Eun-Yeong;Jin, Bo-Ram;Chung, Tae-Wook;Bae, Sung-Jin;Park, Hyerin;Ryu, Dongryeol;Jin, Ling;An, Hyo-Jin;Ha, Ki-Tae
    • BMB Reports
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    • v.52 no.9
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    • pp.560-565
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    • 2019
  • Benign prostatic hyperplasia (BPH), a common disease in elderly males, is accompanied by non-malignant growth of prostate tissues, subsequently causing hypoxia and angiogenesis. Although VEGF-related angiogenesis is one of the therapeutic targets of prostate cancer, there is no previous study targeting angiogenesis for treatment of BPH. Dihydrotestosterone (DHT)-induced expressions of vascular endothelial growth factor (VEGF) in prostate epithelial RWPE-1 cells and human umbilical vascular endothelial cells (HUVECs). Conditioned media (CM) from DHT-treated RWPE-1 cells were transferred to HUVECs. Then, 6SL inhibited proliferation, VEGFR-2 activation, and tube formation of HUVECs transferred with CM from DHT-treated RWPE-1 cells. In the rat BPH model, 6SL reduced prostate weight, size, and thickness of the prostate tissue. Formation of vessels in prostatic tissues were also reduced with 6SL treatment. We found that 6SL has an ameliorative effect on in vitro and in vivo the BPH model via inhibition of VEGFR-2 activation and subsequent angiogenesis. These results suggest that 6SL might be a candidate for development of novel BPH drugs.

Correlation between Telomere Length and Chronic Obstructive Pulmonary Disease-Related Phenotypes: Results from the Chronic Obstructive Pulmonary Disease in Dusty Areas (CODA) Cohort

  • Moon, Da Hye;Kim, Jeeyoung;Lim, Myoung Nam;Bak, So Hyen;Kim, Woo Jin
    • Tuberculosis and Respiratory Diseases
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    • v.84 no.3
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    • pp.188-199
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    • 2021
  • Background: Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease with increased prevalence in the elderly. Telomeres are repetitive DNA sequences found at the end of the chromosome, which progressively shorten as cells divide. Telomere length is known to be a molecular marker of aging. This study aimed to assess the relationship between telomere length and the risk of COPD, lung function, respiratory symptoms, and emphysema index in Chronic Obstructive Pulmonary Disease in Dusty Areas (CODA) cohort. Methods: We extracted DNA from the peripheral blood samples of 446 participants, including 285 COPD patients and 161 control participants. We measured absolute telomere length using quantitative real-time polymerase chain reaction. All participants underwent spirometry and quantitative computed tomography scan. Questionnaires assessing respiratory symptoms and the COPD Assessment Test was filled by all the participants. Results: The mean age of participants at the baseline visit was 72.5±7.1 years. Males accounted for 72% (321 participants) of the all participants. The mean telomere length was lower in the COPD group compared to the non-COPD group (COPD, 16.81±13.90 kb; non-COPD, 21.97±14.43 kb). In COPD patients, 112 (75.7%) were distributed as tertile 1 (shortest), 91 (61.1%) as tertile 2 and 82 (55%) as tertile 3 (longest). We did not find significant associations between telomere length and lung function, exacerbation, airway wall thickness, and emphysema index after adjusting for sex, age, and smoking status. Conclusion: In this study, the relationship between various COPD phenotypes and telomere length was analyzed, but no significant statistical associations were shown.

Enhancing Communication on Medication Side Effects: Insights from a Survey Study (의약품 부작용 정보 전달의 중요성: 설문조사 기반 고찰)

  • Ji Hye Choi;Hye Seong Han;Mi Kyong Shim;Hyun Soon Sohn
    • Korean Journal of Clinical Pharmacy
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    • v.34 no.2
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    • pp.126-133
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    • 2024
  • Background: Medication's benefits and harms require careful management. Laws mandate pharmacists to provide essential medication details since inadequate counseling may pose risks. This study explores public expectations for pharmacist-provided side effect information to enhance safety. Methods: A self-developed questionnaire was created for participant to self-report, refined through pilot surveys with experts and laypersons. Nineteen items were categorized into four sections, using closed-ended questions. Adults over 20, having obtained prescription medications within the past year, were surveyed via convenience sampling. Data analysis employed descriptive statistics and T-tests using IBM SPSS Statistics 21 and Microsoft Excel. Results: The study involved 189 participants, with a slightly higher proportion of females (59.3%) than males (40.7%), predominantly in their 20s (45.0%) and college graduates (57.1%). Health professionals represented 76.2% of respondents. Over half visited pharmacies at least 5 times yearly for prescriptions. Indirect experience with side effects was more common (30.2%) than direct experience (17.5%). Most (82.0%) showed interest in media-reported side effect events. Satisfaction with pharmacist-provided side effect explanations was low (59.7%), but importance was high (98.9%). Preferences favored combined verbal and written explanations (65.1%), with a majority desiring explanations for common but less serious side effects (82.5%). Healthcare professionals found explanations significantly more sufficient than non-professionals did. Older individuals, those living with elderly, and frequent pharmacy visitors attributed greater importance to pharmacist-provided explanations. Conclusion: Koreans view pharmacist-provided medication side effect explanations as vital but find current services lacking. Enhancements in content and delivery methods are needed in pharmacy counseling to meet public expectations.

Prevalence and Risk Factors of Stroke in Korean Older Adults: Focusing on Demographic and Health Behavior Factors (우리나라 노인의 뇌졸중 유병률 및 위험 요인: 인구사회학적 및 건강행태 요인을 중심으로 )

  • Do-Youn Lee
    • Journal of the Korean Society of Physical Medicine
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    • v.19 no.3
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    • pp.103-110
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    • 2024
  • PURPOSE: This study aims to analyze the prevalence and risk factors of stroke in Korean older adults and provide basic data for stroke prevention. METHODS: Based on the data from the 2019-2021 Korea National Health and Nutrition Examination Survey, 5,750 adults aged 65 or older who participated in the health survey were selected. Risk factors for stroke were analyzed through complex sample multiple logistic regression analysis. RESULTS: As a result of this study, the prevalence of stroke among the subjects was 6.20%. Stroke risk factors were elderly, male, low personal income level, and current and past smoking experience. The risk of stroke prevalence was OR 1.076 (95% CI 1.048-1.104) higher with each age increase. According to gender, the risk of stroke prevalence was OR 1.587 (95% CI 1.068-2.358) higher in males compared to females. In the case of individual income level, the risk of stroke prevalence was OR 1.509 (95% CI 1.011-2.253) higher in Q1, the lowest compared to Q4, which has the highest income level, and it was not significant in Q2, and Q3. Compared to non-smokers, current smokers had an OR 1.717 (95% CI 1.087-2.712), and past smokers had an OR 1.546 (95% CI 1.095-2.183). CONCLUSION: The prevalence of stroke in Korean older adults was 6.20%, and the risk factors for stroke were old age, men, low individual income level, and smoking. Therefore, prevention programs and smoking cessation education are needed for subjects with stroke risk factors.

A Study on Nutritional Status of the Long-lived Elderly People in Kyungnam (경남 일부지역 장수노인의 영양섭취상태에 관한 연구)

  • 최희정;김경업;김성희;강동희;정효숙
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.31 no.5
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    • pp.877-884
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    • 2002
  • This study was carried out to examine nutrients intake and food preference in 100 elderly people aged over 85 years residing in Namhae-gun Kyungnam. Mean daily energy intake and Korean recommended dietary allowances (RDA) percent were 1547.6$\pm$452.7 kcal and 91.5%, respectively. Mean daily intakes of protein (63.1$\pm$28.2 g), iron (16.7$\pm$11.2 mg), vitamin Bi (1.0410.4 mg) and vitamin C (97.0$\pm$45.3 mg) were higher than RDA. The intakes of calcium (418.1$\pm$189.7 mg) and vitamin B2 (0.94$\pm$0.5 mg) were shown to be 58.4% and 78.4% of the RDA. Females had higher intakes of energy and most other nutrients than males. Major food source of energy and protein intakes was rice and cereals, and that of lipid intake was meat, fish, egg and beans. Cooked rice, all kind of vegetables, fish, yogurt and sugars were preferred to the subjects. The most preferred taste was sweet.

Nutritional Status and Knowledge of the Elderly over 65 Years in Young-Nam Area (영남 일부지역 65세 이상 노인의 섭취상태와 영양지식에 관한 연구)

  • 김성미
    • Journal of the East Asian Society of Dietary Life
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    • v.13 no.2
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    • pp.98-110
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    • 2003
  • This study investigated the nutritional status and the knowledge of the 204 elderly in Young-nam area. Their weight and height were measured and their dietary intake and nutritional knowledge evaluated. The sutjects were 74.7$\pm$5.9 years old in average. The BMIs were in the moderate range. Weights and BMI decreased significantly with age. The dietary assessment data showed that each energy intake of the males and the females was 90.9% and 97.0% compared with the Korean RDA, respectively. The dietary intake of vitamin A, calcium and iron was lower than that of the Korean RDA. The fiber intake of the subjects was 7.4g~7.8g. The MAR of vitamin $_{B2}$ was the lowest, 0.66 and that of phosphorus was the highest, 0.99. According to the nutritional knowledge level, the intake of protein, vitamin A, vitamin $B_1$and iron in the excellent group was significantly higher than that in the poor group. The correlation analysis revealed that the score of nutritional knowledge was positively associated with BMI, MAR and protein intake, while negatively with age.e.

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The Relationship Between Chewing Ability and Health Status in the Long-lived Elderly of Kyungpook Area (경북지역 장수노인의 저작능력과 건강상태)

  • Lee, Hee-Kyung;Lee, Young-Kwon
    • Journal of Yeungnam Medical Science
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    • v.16 no.2
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    • pp.200-207
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    • 1999
  • Background: The objective of this study is to evaluate the effect of the dental and general health in relation to the state of dentition and chewing ability by surveying oral condition and anthropometric measure in order to provide primary statistics for the development of a program which may lead to an improvement in the long-lived elderly health status in a rural community. Materials and Methods: The subjects of this study were 97 rural long-lived elderly(27 males and 70 females) who were over 85 years-old (average age of subjects are $88.14{\pm}3.20$ year old) in Sungju-Gun, Kyungpook Province. Data were collected by using questionnaires and direct measurement of anthropometrics, and oral examination from all 97 subjects on July, 1999. Results: The following results were obtained: 1. 53.6% of all subjects believe that they are healthy. The average values of height, weight, BMI, body fat, lean body fat and total water were $148.8{\pm}11.2cm$, $46.9{\pm}10.5kg$, $21.2{\pm}3.5kg/m^2$, $26.7{\pm}6.9%$, $73.0{\pm}7.1%$, and $53.4{\pm}5.2%$, respectively. 2. The average number of teeth remaining in the subjects were $3.50{\pm}5.71$; the number of maxillary teeth remaining were $1.08{\pm}2.88$; and the number of mandibular teeth remaining were $2.41{\pm}3.76$. The maximum number of teeth remaining among subjects were 22 teeth, and the fully edentulous(no natural teeth) people were 76.3%. The oral conditions of the subjects were 52.6% using denture, 23.7% using natural teeth, and 23.7% masticating edentulous ridge without denture. 3. In terms of oral condition in self-assessment of health, digestive ability, and chewing ability ; On self-assessment of health, 47.1% of those wearing denture group responded as feeling good, 56.5% of those in the group of edentulous without denture, and 65.2% in group of natural teeth only. On self-assessment of digestive ability, 82.4% of those in group of denture responded as feeling good, 65.2% of those in group of no teeth and no denture, and 73.9% of those in group of natural teeth only. On self-assessment of chewing ability, 90.2% of those in the group wearing a denture, 60. 9% of those in the group of no teeth and no denture, and 65.2% of those in the group of natural teeth only. 4. In terms of oral condition in anthropometric measurements; The height, weight, body fat, lean body mass, and total water according to oral conditions were $150.0{\pm}10.7cm$, $49.0{\pm}10.9kg$, $26.9{\pm}6.6%$, $72.7{\pm}7.0%$, $53.2{\pm}5.1%$, respectively, in group wearing a denture, $142.7{\pm}6.0cm$, $43.2{\pm}5.5kg$, $29.5{\pm}7.2%$, $70.8{\pm}6.9%$, $51.8{\pm}5.0%$, respectively, in the group of no teeth and no denture, and $152.3{\pm}14.1cm$, $45.9{\pm}12.6kg$, $23.4{\pm}6.0%$, $75.9{\pm}6.9%$, $55.6{\pm}5.1%$, respectively, in the group of natural teeth only. Conclusion: The subjective measurements of good health were higher denture user, and natural teeth.

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Molecular Characterization of FLT3 Mutations in Acute Leukemia Patients

  • Ishfaq, Mariam;Malik, Arif;Faiz, Mariam;Sheikh, Ishfaq Ahmad;Asif, Muhammad;Khan, Muhammad Nasrullah;Qureshi, Muhammad Saeed;Zahid, Sara;Manan, Abdul;Arooj, Mahwish;Qazi, Mahmood Husain;Chaudhary, Adeel;Alqahtani, Mohammed Hussain;Rasool, Mahmood
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.9
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    • pp.4581-4585
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    • 2012
  • Fms-like tyrosine kinase 3 (FLT3) performs a vital role in the pathogenesis of hematopoietic malignancies. Therefore in recent times, the focus of several studies was on use of FLT3 as a prognostic marker. The present study investigated the molecular characterization and incidence of FLT3 mutations in acute leukemia patients in Pakistan. A total of 55 patients were studied, of which 25 were suffering from acute lymphoblastic leukemia (ALL) and 30 were suffering from acute myeloid leukemia (AML). The polymerase chain reaction demonstrated FLT3/ITD mutations in 1 (4%) of 25 ALL patients, a male with the L2 subtype. In AML cases the rate was 4 (13.3%) of 30, three males and one female. The AML-M4 subtype was found in three and the AML M2 subtype in the other. In the AML cases, a statistically significant (p=0.009) relationship was found between WBC (109/L) and FLT3/ITD positivity. However, no significant relationship was found with other clinical parameters (p>0.05). In acute myeloid leukemia (AML) $FLT3/ITD^+$ mutation was more prevalent in elderly patients 31-40 age groups, 21-30 and 51-60 age groups respectively. In acute lymphoblastic leukemia (ALL) statistically no significant relationship was found between clinical features and FLT3/ITD positivity (p>0.05). However, in acute lymphoblastic leukemia (ALL) $FLT3/ITD^+$ mutation was more commonly found in age groups of 21-30.