• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.3
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• pp.63-70
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• 2007

Objectives : Atopic dermatitis is a recurrent or chronic eczematous skin disease with severe pruritus. Although the pathogenic mechanisms of atopic dermatitis are yet unknown, recently hyperresponsive Th2 cells in the acute phase are reported as the important mechanisms. Cheonggisan(CGS) is used in oriental clinics for curing acute skin lesions of eczema, atopic dermatitis or urticaria. There have been no studies on the therapeutic mechanism of CGS for curing atopic dermatitis. We aimed to find out the therapeutic mechanism of CGS on atopic dermatitis, so we observed Th2 cell differentiation in EL 4 cells and $NF-kB$ p65 activation in RAW 264.7 cells. Materials and Methods : EL 4 cells were induced the increase of IL-4 mRNA expression by phorbol-12-myristate-13-acetate(PMA) and 4-tert-Octylphenol(OP) and treated with CGS extract. RAW 264.7 cells were induced the increase of cyclooxygenase(COX)-2 mRNA expression by lipopolysaccharide(LPS) and treated with CGS extract. Results : The PMA and OP induced IL-4 mRNA expression was dose-dependantly decreased in CGS treated EL 4 cells. The LPS-induced COX-2 mRNA expression was dose-dependantly decreased in CGS treated RAW 264.7 cells. Conclusion : The results may suggest that the CGS inhibits Th2 cell differentiation in EL 4 cells and inhibits $NF-kB$ p65 activation in RAW 264.7 cells.

• ETRI Journal
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• v.35 no.6
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• pp.990-1000
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• 2013

This paper describes the scalable extension of High Efficiency Video Coding (HEVC) to provide flexible high-quality digital video content services. The proposed scalable codec is designed on multi-loop decoding architecture to support inter-layer sample prediction and inter-layer motion parameter prediction. Inter-layer sample prediction is enabled by inserting the reconstructed picture of the reference layer (RL) into the decoded picture buffer of the enhancement layer (EL). To reduce the motion parameter redundancies between layers, the motion parameter of the RL is used as one of the candidates in merge mode and motion vector prediction in the EL. The proposed scalable extension can support scalabilities with minimum changes to the HEVC and provide average Bj${\o}$ntegaard delta bitrate gains of about 24% for spatial scalability and of about 21% for SNR scalability compared to simulcast coding with HEVC.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2010.06a
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• pp.168-168
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• 2010

DCM derivatives were newly synthesized. The OLEDs with a DCM-A as an emitting layer was fabricated and analyzed their opto-electrical properties. The structures of OLEDs were I) ITO/DCM-A/Al, II) ITO/-NPD/DCM-A/LiF/Al, and III) ITO/-NPD/DCM-A/Alq3/LiF/Al. The EL peak of the DCM-A shows the red emission in the range of 700 nm. The structure I) shows that 1050 nW/cm2 at 510 mA/cm2. The structure II) shows that takes the most excellent luminance about 39,000 nW/cm2 at 290 mA/cm2. The EL structure ill shows luminance about 13,000 nW/cm2 at 6 mA/cm2.

• Molecular & Cellular Toxicology
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• v.2 no.4
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• pp.223-228
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• 2006

Several plant-derived cannabinoids and endogenous ligands for cannabinoid receptors such as 2-arachidonyl-glycerol have been known to inhibit interleukin-2 (IL-2) expression. In the present study, we utilized arachidonylethanolamide (AEA), a putative endogenous ligand for cannabinoid receptors, to determine whether AEA modulated the expression of IL-2. AEA inhibited phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io)-induced IL-2 protein secretion and mRNA expression in EL-4 mouse T-cells as determined by ELISA and RT-PCR, respectively. To further characterize the inhibitory mechanism of AEA at the transcriptional level, we performed promoter study for IL-2 gene in PMA/Io-stimulated EL-4 cells. AEA decreased the transcriptional activity of the nuclear factor of activated T-cells (NF-AT) as well as the IL-2 promoter activity. These results suggest that AEA suppresses IL-2 expression and that the inhibition is mediated, at least in part, through the down-regulation of NF-AT.

• The Journal of the Korean Society for Microbiology
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• v.16 no.1
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• pp.13-18
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• 1981

Total 984 specimens were collected from sweages(130 specimens) and human rectal swabs(854 specimens) during period from October 1979 to November 1980 in Korea. Sixteen strains of salmonella were isolated from the human rectal swabs at the St. Mary's Hospital in Dae Jeon. They were confirmed into fifteen strains of S. typhi, one strain of S. paratyphi A. In other hand, fourty three strains of Shigella had been isolated from the stool specimens. They were typed as thirty four strains of Shigella flexneri, five strains of Shigella sonnei and one strain of Shigella dysenteriae. However, 16 strains of Vibrio eltor had been isolated from patients and carriers in the first epidemic areas in Chunla Namdo in September 1980. The serotype of isolated strains was determined as a Inaba which was resistant to the Mukerjee phage group IV but was susceptible to El Tor phage groupe I and II. Authors had been concluded that the strains were certain to be identified with Vibrio cholerae biotype El Tor.

• Proceedings of the KIEE Conference
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• 2000.07c
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• pp.1742-1744
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• 2000

Organic materials have been considered for the fabrication of practical electroluminescent(EL) devices because a large number of organic materials are known to have extremely high fluorescence quantum efficiencies in the visible spectrum. In this study, electroluminescent devices are constructed using novel organic materials PRL-401, PRL-403 as the emitting elements. The devices have a triple-layer structure of organic thin films, prepared by vacuum vapor deposition. Greenish yellow electroluminescent emission is observed. The maximum luminances are over 1000 $cd/m^2$ and the turn-on voltages are about 13 V.

• IE interfaces
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• v.13 no.2
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• pp.178-187
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• 2000

In this paper, we investigate the system performance when the voice traffic is constructed as the ATM Adaptation Layer type 2(AAL-2) and then it is transmitted to the Base Station Controller(BSC) from the Base Station Transceiver Subsystem(BTS) through El link in International Mobile Telecommunication-2000 (IMT-2000) network. For this purpose, we first briefly describe the architecture of the BTS and the BSC, and then model it as a queueing network. By simulation study, we present the required processing time at traffic control blocks and the timeout time which should be set for multiplexing the user packets in the LIU(Line Interface Unit). Further, we evaluate the performance of physical links and the timeout probability that user packets can not be multiplexed within the established timeout time, and the multiplexing gain. Finally, we present the number of voice users who can be simultaneously admitted on one El link and 99.9% value of the transmission delay from the Radio Channel Element(RCE) to the Selector & Transcoder Subsystem(STS).

• Archives of Pharmacal Research
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• v.13 no.4
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• pp.379-381
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• 1990

The effect of calcium gluconate on estrogen (estradiol) serum level as well as follicle stimulating hormone level was studied. Our results revealed that oral administration of calcium gluconate (100 mg/kg body wight) to adult non-pregnant female rabbits caused a significant increase of serum levels of estradiol and follicle stimulating hormone. On the other hand, oral contraceptive (Norminest tablets) decreased significantly follicle stimulating hormone serum level, while combined administration of calcium gluconate and oral contraceptive caused significant increase of serum level of follicle stimulating hormone compared with control values. Also, concurrent administration of calcium gluconate and Norminest tablet increased significantly the rate of conception compared with group recieved Norminest tablets only. These results indicated that combined administration of calcium and oral contraceptives must be cautiously.

• Archives of Pharmacal Research
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• v.27 no.12
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• pp.1194-1201
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• 2004

Michael addition of certain nucleophiles on ${\alpha}$ , ${\beta}$-unsaturated ketones 1 led to the formation of adducts 2-7 as well as the reaction of arylidene derivatives with secondary amines afforded the amino compounds 9 and 11. Also, dialkylmalonates were treated with ${\alpha}$-cyano cinnamide to afford 13. On the other hand, double Michael cycloaddition of ethylcyanoacetate or tetrachlorophthalic anhydride to the suitable divinylketone were synthesized to produce 15-17. Selected compounds (13 and 6) were screened for muscle relaxant, anticonvulsant, and sedative activities using established pharmacological models. Their activities were compared with that of phenobarbital sodium taken as standard. Compound 6 was the most potent muscle relaxant while compounds 13a and 13c offered the highest anticonvulsant activity. Meanwhile compound 13c showed the highest potentiation of phenobarbital induced sleep in mice.

• Journal of Korean Society of Disaster and Security
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• v.13 no.2
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• pp.39-51
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• 2020

Recently, flood damage has been increasing in Korea due to frequent local torrential rains caused by abnormal weather conditions. According to the calculation of the recurrence period of torrential rain that occurred in North Chungcheong Province on July 16, 2017, it was estimated that the rainfall frequency in the upper are of Goessan Dam was around 1,524 years, and the highest level of Goesan Dam rose to EL.137.60 meters, leaving only 5 cm of margin until the height of the dam floor (EL.137.65 meters). The Goesan Dam, which operated for 62 years since 1957, needs to be prepared to cope with the increase of floodgate volume in the basin, the development of a single purpose dam for power generation only, and there are no measurement facilities for flood control, so efficient operation methods are needed to secure the safety of residents in upper and lower regions. In this study, a method of dam operation was proposed by constructing a rain matrix for quick decision making in flood prediction, calculating the highest level of dam for each condition in advance, and preparing a survey table, and quickly finding the level corresponding to the conditions in case of a situation.