• Clinical and Experimental Pediatrics
• /
• 제59권4호
• /
• pp.190-195
• /
• 2016

Purpose: Severe aplastic anemia (SAA), a fatal disease, requires multiple transfusion, immunosuppressive therapy, and finally, hematopoietic stem cell transplantation (HSCT) as the definitive treatment. We hypothesized that iron overloading associated with multiple transfusions and HSCT-related complications may adversely affect cardiac function. Left ventricular (LV) function was assessed in children after HSCT for SAA. Methods: Forty-six consecutive patients with a median age of 9.8 years (range, 1.5-18 years), who received HSCT for SAA and who underwent comprehensive echocardiography before and after HSCT, were included in this study. The data of LV functional parameters obtained using conventional echocardiography, tissue Doppler imaging (TDI), and speckle-tracking echocardiography (STE) were collected from pre- and post-HSCT echocardiography. These data were compared to those of 40 age-matched normal controls. Results: In patients, the LV ejection fraction, shortening fraction, end-diastolic dimension, mitral early diastolic E velocity, TDI mitral septal E' velocity, and STE LV longitudinal systolic strain rate (SSR) decreased significantly after HSCT. Compared to normal controls, patients had significantly lower post-HSCT early diastolic E velocity and E/A ratio. On STE, patients had significantly decreased LV deformational parameters including LV longitudinal systolic strain (SS), SSR, and diastolic SR (DSR), and circumferential SS and DSR. Serum ferritin levels showed weak but significant correlations (P<0.05) with LV longitudinal SS and SSR and circumferential SS and DSR. Conclusion: Subclinical LV dysfunction is evident in patients after HSCT for SAA, and was associated with increased iron load. Serial monitoring of cardiac function is mandatory in this population.

• Journal of Cardiovascular Imaging
• /
• 제31권2호
• /
• pp.85-95
• /
• 2023

BACKGROUND: The prognostic utility of follow-up transthoracic echocardiography (FU-TTE) in patients with hypertrophic cardiomyopathy (HCM) is unclear, specifically in terms of whether changes in echocardiographic parameters in routine FU-TTE parameters are associated with cardiovascular outcomes. METHODS: From 2010 to 2017, 162 patients with HCM were retrospectively enrolled in this study. Using echocardiography, HCM was diagnosed based on morphological criteria. Patients with other diseases that cause cardiac hypertrophy were excluded. TTE parameters at baseline and FU were analyzed. FU-TTE was designated as the last recorded value in patients who did not develop any cardiovascular event or the latest exam before event development. Clinical outcomes were acute heart failure, cardiac death, arrhythmia, ischemic stroke, and cardiogenic syncope. RESULTS: Median interval between the baseline TTE and FU-TTE was 3.3 years. Median clinical FU duration was 4.7 years. Septal trans-mitral velocity/mitral annular tissue Doppler velocity (E/e'), tricuspid regurgitation velocity, left ventricular ejection fraction (LVEF), and left atrial volume index (LAVI) at baseline were recorded. LVEF, LAVI, and E/e' values were associated with poor outcomes. However, no delta values predicted HCM-related cardiovascular outcomes. Logistic regression models incorporating changes in TTE parameters had no significant findings. Baseline LAVI was the best predictor of a poor prognosis. In survival analysis, an already enlarged or increased size LAVI was associated with poorer clinical outcomes. CONCLUSIONS: Changes in echocardiographic parameters extracted from TTE did not assist in predicting clinical outcomes. Cross-sectionally evaluated TTE parameters were superior to changes in TTE parameters between baseline and FU at predicting cardiovascular events.

• 천문학회지
• /
• 제36권spc1호
• /
• pp.37-44
• /
• 2003

In this paper, we review recent studies on the magnetic helicity changes of solar active regions by photospheric horizontal motions. Recently, Chae(200l) developed a methodology to determine the magnetic helicity change rate via photospheric horizontal motions. We have applied this methodology to four cases: (1) NOAA AR 8100 which has a series of homologous X-ray flares, (2) three active regions which have four eruptive major X-ray flares, (3) NOAA AR 9236 which has three eruptive X-class flares, and (4) NOAA AR 8668 in which a large filament was under formation. As a result, we have found several interesting results. First, the rate of magnetic helicity injection strongly depends on an active region and its evolution. Its mean rate ranges from 4 to $17 {\times} 10^{40}\;Mx^2\;h^{-1}$. Especially when the homologous flares occurred and when the filament was formed, significant rates of magnetic helicity were continuously deposited in the corona via photospheric shear flows. Second, there is a strong positive correlation between the magnetic helicity accumulated during the flaring time interval of the homologous flares in AR 8100 and the GOES X-ray flux integrated over the flaring time. This indicates that the occurrence of a series of homologous flares is physically related to the accumulation of magnetic helicity in the corona by photospheric shearing motions. Third, impulsive helicity variations took place near the flaring times of some strong flares. These impulsive variations whose time scales are less than one hour are attributed to localized velocity kernels around the polarity inversion line. Fourth, considering the filament eruption associated with an X1.8 flare started about 10 minutes before the impulsive variation of the helicity change rate, we suggest that the impulsive helicity variation is not a cause of the eruptive solar flare but its result. Finally, we discuss the physical implications on these results and our future plans.

• 한국의학물리학회:학술대회논문집
• /
• 한국의학물리학회 2003년도 제27회 추계학술대회
• /
• pp.49-49
• /
• 2003

목적 : 심초음파는 비침습적이므로 반복적으로 정확히 심질환의 경과를 관찰하여 치료효과 및 수술시기를 정할 수 있는 검사로서 임상적으로 매우 유용하다. 실시간 심근조영심초음파에 의한 time intensity 평가는 부위별로 수행됨으로 연속적으로 위치하는 관심영역이 intensity에 있어 심장의 움직임 변화에 영향을 받는다. Time intensity 곡선의 최적의 곡선맞춤을 위해 주기적인 심장 운동 매개변수를 조합해 기존의 모델을 보정한 안정적인 측정방법을 제시한다. 방법 : 심장의 운동에 의한 특징적인 정보를 설명하기 위해 기존의 문헌에 제시된 지수 함수에 주어진 심박수로 만들어진 시간에 관한 일반적인 정형파 함수를 추가한다. C(t) = A[1 - exp($\beta$t)] + Dsine(2$\pi$ft + $\theta$) C(t): videointensity A: plateau videointensity (blood volume) $\beta$: capillary blood velocity (rate constant of rise in videointensity) t: pulsing interval (ms) D: displacement from the periodic variance of the curve (estimated motion field from the ejection point for the ratio between systole and diastole) f: heart rate $\theta$: transit time issue A $\times$ $\beta$ : myocardial blood flow 관상동맥의 관류 데이터에 대한 실험이 펄스간격에 대한 비디오 세기로 수행되었다. 그리고 이러한 결과들이 the sum of squares due to error, R square, root mean squared error로 평가되었다. 결과 : 실험결과, 주기적인 심장의 움직임과 심박출 시점으로부터의 변위를 잘 기술하고 곡선에서의 측정 점들이 예측된 심장 움직임에 따라 성공적으로 표시되었다. 뿐만 아니라 보정된 모델이 현저한 적합도의 향상을 보여주었다. 결론 : 제시된 접근방법은 각각의 측정에서 심장 운동 영역의 변화에 독립적이며 측정 시점에 의해 영향받지 않고 심근 관류의 안정적인 측정이 가능하다. 심장의 움직임에 관한 매개변수를 조합한 모델로 곡선접합을 수행함으로써 관류의 정량적 정보를 좀더 정확하게 얻을 수 있으며 임상적 이용을 가능하게 할 것으로 기대된다.

• 대기
• /
• 제24권3호
• /
• pp.317-329
• /
• 2014

Eddy covariance data have been analyzed to investigate the influence of surface heterogeneity on turbulent transfer over farmland and industrial sites near Nakdong river, Korea, where both large and small scale heterogeneities co-exist. For this purpose, basic turbulent statistics, quadrant analysis and multi-resolution decomposition have been analyzed during the daytime. Basic turbulent statistics were compared with typical turbulent statistics in the surface layer. Such comparisons were in close agreement for momentum and heat at both sites but not for water vapor at industrial site. The correlation coefficient between water vapor and vertical velocity ($r_{wq}$) is relatively low and skewness of water vapor ($sk_q$) is very low at industrial site, possibly due to limited water source. For heat at both sites and water vapor at farmland, the quadrant analysis show similar behavior to that over homogeneous site but for water vapor at industrial site, the presence of river and limited water source at industrial site seems to influence on water vapor transfer by coherent eddy motion by increasing sweep contribution and decreasing ejection contribution. Multi-resolution decomposition analysis shows that large scale heterogeneity leads to low $r_{Tq}$ at large averaging time regardless of season at both sites and there are seasonal changes of $r_{Tq}$ in mid-averaging times at industrial site, possibly due to seasonal change of trees and grasses near the site.

• 천문학회보
• /
• 제35권1호
• /
• pp.29.2-29.2
• /
• 2010

The Extreme ultraviolet Imaging Spectrometer (EIS) on board Hinode provide us with excellent imaging spectroscopic data with very good spatial and spectral resolutions, which can be used for detecting Doppler flows in transition region and coronal lines as well as diagnosing plasma properties such as temperature, density, and non-thermal velocity. In this study we have made an EUV-imaging spectroscopic study of the source region of a partial halo coronal mass ejection (CME) that occurred on 2007 July 9 in NOAA 10961. Dopplergrams are obtained before and after the CME eruption using 12 EIS spectral lines (Log T= 4.9~7.2). Major results are summarized as follows. First, it is noted that either red shifts disappeared or blue shifts newly appeared for all spectral lines lower than Log T =6.0. Second, there were significant intensity increases for all wavelengths. Third, there were no significant variations in non-thermal motions for all wavelengths. We found one interesting bright point that newly appeared after the CME eruption. We discuss the implication on the results in terms of the CME eruption.

• 천문학회보
• /
• 제43권1호
• /
• pp.43.1-43.1
• /
• 2018

Star formation in galaxies predominantly takes place in giant molecular clouds (GMCs). While it is widely believed that UV radiation feedback from young massive stars can destroy natal GMCs by exciting HII regions and driving their expansion, our understanding on how this actually occurs remains incomplete. To quantitatively assess the effect of UV radiation feedback on cloud disruption, we conduct a series of theoretical studies on the dynamics of HII regions and its role in controlling the star formation efficiency (SFE) and lifetime of GMCs in a wide range of star-forming environments. We first develop a semi-analytic model for the expansion of spherical dusty HII regions driven by the combination of gas and radiation pressures, finding that GMCs in normal disk galaxies are destroyed by gas-pressure driven expansion with SFE < 10%, while more dense and massive clouds with higher SFE are disrupted primarily by radiation pressure. Next, we turn to radiation hydrodynamic simulations of GMC dispersal to allow for self-consistent star formation as well as inhomogeneous density and velocity structures arising from supersonic turbulence. For this, we develop an efficient parallel algorithm for ray tracing method, which enables us to probe a range of cloud masses and sizes. Our parameter study shows that the net SFE, lifetime (measured in units of free-fall time), and the importance of radiation pressure (relative to photoionization) increase primarily with the initial surface density of the cloud. Unlike in the idealized spherical model, we find that the dominant mass loss mechanism is photoevaporation rather than dynamical ejection and that a significant fraction of radiation escapes through low optical-depth channels. We will discuss the astronomical.

• 천문학회보
• /
• 제41권1호
• /
• pp.49.1-49.1
• /
• 2016

Solar System has evolved with numerous collisions among asteroids. Ancient catastrophic collisions of large parent bodies led the formation of asteroid families and relevant dustband structures up to the present day, and it would be interesting to address a question - "what happens if an asteroid collides with another asteroid?" Recent discoveries of "active asteroids" in the main-belt have attracted interest for their potential to witness a catastrophic collision in the current Solar System. So far, however, there is no direct evidence for catastrophic collision on active asteroids while several objects have been confirmed for other mechanisms (e.g., 596 Scheila for impact cratering, P/2013 R3 and P/2013 P5 for rotational breakup). The most potential candidate for catastrophic collision could be a sub-km active asteroid P/2010 A2, which is still controversial on its driving mechanism, but if confirmed, would have made P/2010 A2 the unique example of catastrophic collision on the current main asteroid belt. In this presentation, we revisit all of archival data of P/2010 A2 in a combination with our own observation using Subaru/Suprime-Cam on 2011 June, where we have a great benefit of a large orbital coverage. We found a grain size dependence of dust ejection velocity from P/2010 A2 (a power-law size distribution with an index of k~ -1/10), which is favorable to a catastrophic disruption scenario in agreement with laboratory impact experiments. At this conference, we plan to provide our understanding of the morphology of P/2010 A2 through a perspective of catastrophic collision.

• 한국항공우주학회지
• /
• 제40권6호
• /
• pp.467-474
• /
• 2012

무인항공기의 정찰 및 정보 수집 능력을 효율적으로 수행하기 위해 장기 체공 능력이 요구된다. 분산 추진 장치는 대형 추진 장치를 복수의 소형 추진 장치들로 대체하여 추력을 얻는 장치이다. 날개의 스팬 길이를 따라 넓게 분포하여 효율이 증가하며, 유동의 흡입을 통해 경계층을 제어하고 출구에서 분사되는 흐름이 항공기에 부착되어 흐르기 때문에 양항비가 증가한다. 본 연구에서는 전익기 융합익기와 분산 추진 장치가 장기 체공 성능을 향상시키는 점에 착안하여 연구를 수행하였다. Eppler 337 에어포일 유닛에 추진 장치의 위치 및 입 출구 가로세로비 변화에 따라 나타나는 공력특성을 분석했다. CFD를 사용하여 공력해석을 수행하였고, 빠른 해석 결과를 얻을 수 있도록 팬 영역에 작동판 이론을 적용하였다. 양항비와 모멘트 비교를 통해 추진 장치의 위치 및 형상을 결정하고자 한다.

• 천문학회보
• /
• 제43권2호
• /
• pp.38.3-38.3
• /
• 2018

We present the results of high-resolution near-IR spectral mapping toward the Orion KL outflow. In this study, we used the Immersion Grating Infrared Spectrometer (IGRINS) on the 2.7 m Harlan J. Smith Telescope at McDonald Observatory. IGRINS's large wavelength coverage over the H & K bands and high spectral resolving power (R ~ 45,000) allowed us to detect over 35 shock-excited ro-vibrational H2 transitions and to measure directly the gas temperature and velocity of the dense outflows. In our previous study toward the H2 peak 1 region in the Orion KL outflow, we identified 31 outflow fingers from a datacube of the H2 1-0 S(1) $2.122{\mu}m$ line and constructed a three-dimensional map of the fingers. The internal extinction (${\Delta}AV$ > 10 mag) and overall angular spread of the flow argue for an ambient medium with a high density (105 cm-3). In this presentation, we show preliminary results of additional mapping toward a remarkable chain of bows (HH 205 - HH 207) farther from the ejection center, and obtain a more clear view of the shock physics of a single isolated bullet that improves on the knowledge gained from observations of the more complex peak 1 region in our earlier study.