• Radiation Oncology Journal
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• 제10권1호
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• pp.107-113
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• 1992

4-5MeV의 전자선은 피부표면의 흡수선량을 증가시키고 표면하 10mm 내외에서 급속히 감소함으로 Mycosis fungoides, Kaposi's sarcoma등 전신피부암에 대한 가장적당한 치료방사선으로 알려져왔다. 그러나 평면이 아니고 굴곡이 심한 인체표면에 균일한 선량을 계획하기는 많은 어려움이 있었다. 연세암센터에서는 1980년부터 시행하여왔던 6MeV 전자선의 마름모형, 네방향 조사방법을 개량하고 많은 문헌을 참고하여 상하 양방향의 조사면과 환자위치를 각각 여섯가지 자세로 나누어 조사(Six-Dual-Field)하는 방법을 사용하였으며 이에따른 전신피부표면의 선량과 선량분포를 측정하였다. 선형가속기에서 발생되는 6MeV 전자선을 0.5 cm 두께의 아크릴판으로 감약시키고 콜리메터가 완전히 열린 조사면을 상하 $19^{\circ}$씩 옮기므로서 타겟트에서 3m 거리에 약 $2m{\times}1m$의 균일한선량의 조사면(평탄도 $+3\%$)과 10 mm 내외의 실효깊이 ($80\%$, 선량지점) 및 산란선에 의한 피부표면선량을 증가시킬 수 있었다. 환자는 일부피부가 가려지지 않도록 팔과 다리를 적당한 자세로 고정시키고 전자선을 여섯방향에서 각각 2회씩 상하로 조사시키므로서 피부표면에 균일한 선량분포(표준편차 $5\%$)가 가능하였으며 $80\%$,의 심부율이 $8\~10mm$에서 측정되었다. 모든 측정은 인체등가팬텀과 폴리스틸렌팬텀을 사용하였으며 필름, 평형전리측정기 및 표준전리측정기를 이용하였다. 특히 환자피부표면의 흡수선량분포를 확인하기 위하여 열형광측정기와 반도체측정기를 이용하였으며 $6\~20$개의 소형 측정기를 환자 피부표면에 부착시킨후 전자선 치료과정 동안 피폭 시켜 측정하였고 그결과 차폐된 부위를 제외하고 평균 $10\%$, 이 내의 균일한 선량분포를 얻을수 있었다.

• 정보처리학회논문지B
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• 제11B권6호
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• pp.653-660
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• 2004

객체지향 분석-합성 부호화는 일련의 영상들을 여러 개의 동 객체로 분할한 후 각 객체의 움직임을 추정하고 보상한다. 그것은 각 객체에 있는 움직임 정보를 추정하기 위해 변환 파라미터 기법을 적용하는데 이때 변환 파라미터 기법은 그레디언트 연산자를 사용하기 때문에 매우 복잡한 계산이 요구된다. 본 논문의 목적은 객체지향 분석-합성 부호화에서 계층적 구조를 사용한 효율적인 변환파라미터 기법을 개발하는 것이다. 이러한 목표를 달성하기 위해 본 논문은 계층적 구조를 사용한 하이브리드 변환파라미터 추정 방법과 적응형 변환 파라미터 방법의 두 가지 알고리듬을 제안한다. 전자는 파라미터 검증 방법을 사용하는데 원 영상을 1/4로 축소한 저해상도 영상에서 파라미터 검증 처리 방법에 의해 6-파라미터 또는 8-파라미터로 추정한다. 후자는 동일한 계층적 방법을 적용한 다음 변환 파라미터를 적응적으로 추정하기 위해 temporal co-occurrence 행렬에 기반 한 움직임 량을 측정하는 움직임 판단기준을 사용한다. 이러한 방법은 고속이며, 병렬처리 기법을 사용할 경우 쉽게 하드웨어로 구현할 수 있는 이점이 있다. 이론 분석 및 모의시험 결과 제안한 방법이 기존 방법에 비해 약 1/4 정도로 월등한 계산량 감축을 얻을 수 있었으며, 아울러 제안한 방법들에 의해 복원된 신호대 잡음비는 6-파라미터와 8-파라미터 추정 방법에 의해 복원된 결과들 사이에 있음을 보여 준다.

• 농약과학회지
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• 제10권2호
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• pp.149-152
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• 2006

벼도열병균에 선택적 활성을 나타내는 3-알킬-2-페닐이미노-1,3-티아졸린 유도체 1의 분자수정을 통하여 2-벤질이미노-1,3-티아졸린 유도체 7의 집중 라이브러리 구축 및 이들의 대표적인 식물병원균 6종에 대한 살균활성(in vivo)을 기술하였다. 조합화학기법에 의하여 54종의 2-벤질이미노-1,3-티아졸린 유도체 7의 집중 라이브러리를 이에 상응하는 $\gamma$-클로로아세토아세트아닐라이드 유도체 6과 N-벤질 티오우레아 5의 반응으로부터 합성하였다. 대표적인 식물병원균 6종에 대한 살균활성시험 결과, 28종의 화합물 7이 $100{\mu}g$ $mL^{-1}$(in vivo)에서 토마토 역병에 대하여 방제가 50% 이상을 나타냈다.

• Nutrition Research and Practice
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• 제11권1호
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• pp.43-50
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• 2017

BACKGROUND/OBJECTIVES: The present study investigated the hypothesis that a highly pure linear ${\beta}$-1,3-glucan produced by Agrobacterium sp. R259 enhances human natural killer (NK) cell activity and suppresses pro-inflammatory cytokines. SUBJECTS/METHODS: In an eight-week, double-blind, randomized, placebo-controlled clinical trial, 83 healthy adults with white blood cell counts of $4,000-8,000cells/{\mu}L$ were participated and randomly assigned to take two capsules per day containing either 350 mg ${\beta}$-1,3-glucan or placebo. Six participants withdrew their study consent or were excluded due to NK cell activity levels outside the normal range. NK cell activity and serum levels of immunoglobulin G (IgG) and cytokines, such as interferon (IFN)-${\gamma}$, interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12 and tumor necrosis factor (TNF)-${\alpha}$ were measured. RESULTS: NK cell activity and the serum levels of IL-10 were significantly higher from baseline to week 8 in the ${\beta}$-glucan group compared with the placebo group (P = 0.048, P = 0.029). Consumption of ${\beta}$-1,3-glucan also significantly increased NK cell activity compared with placebo after adjusting for smoking and stress status (P = 0.009). In particular, the effect of ${\beta}$-1,3-glucan on NK cell activity was greater in participants with severe stress than in those experiencing mild stress. However, the administration ${\beta}$-1,3-glucan did not significantly modulate the levels of IFN-${\gamma}$, IL-2, IL-4, IL-6, IL-12, TNF-${\alpha}$ and IgG compared with the placebo. CONCLUSION: The results showed that supplementation with bacterial ${\beta}$-1,3-glucan significantly increased NK cell activity without causing any adverse effects. Additionally, the beneficial effect of ${\beta}$-1,3-glucan on NK cell activity was greater in participants experiencing severe stress.

• Ecology and Resilient Infrastructure
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• 제7권3호
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• pp.160-170
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• 2020

철도와 도로는 대표적인 선형사업으로, 전국적으로 철도망과 도로망이 확대되고 있는 추세이며, 환경에 미치는 영향을 최소화하기 위해 철도와 도로의 평행노선에 따른 생태계 단절을 최대한 지양하고 있다. 본 연구에서는 우선적으로 철도와 도로개발 시, 환경에 미치는 영향을 살펴보기 위한 각 사업의 중점평가항목에 대한 비교·분석을 통해 차이점과 특징을 고찰하였다. 그 결과, 도로 개발은 철도사업과는 달리 효율적인 토지이용계획 수립에 대한 사항과 토양 보호를 중점평가항목으로 제시하고 있다. 본 연구에서는 철도 노선이 도로와 인접하게 될 때의 환경적 영향을 살펴보기 위한 구체적인 평가 항목과 기준이 제시되어 있지 않음에 따라, 관련 문헌을 검토하여 총 8개 평가 항목을 제시하였다. 특히, 계획의 적정성과 입지타당성을 살펴보기 위한 전략환경영향평가 단계에서 기존의 도로에 철도가 인접하게 될 때 미치는 환경적 영향을 사전에 검토할 수 있는 이격거리 기준을 제안하고자, 기 운영 중인 철도 노선을 대상으로 도로와의 이격거리를 살펴보았으며, 환경생태적 영향을 최소화하기 위해 검토해야 할 이격거리로 200 m 이내일 것을 제시하였다. 본 연구 결과는 철도와 도로가 인접할 때 환경생태적 영향을 최소화할 수 있는 대안노선을 검토하는 사업계획 단계에서 근거 자료로 활용될 수 있을 것이다.

• 대한수의학회지
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• 제1권1호
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• pp.1-29
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• 1961

A routine hematological observation in the course of starvation was carried out on eight experimentel1y starved rabbits. They were strictly selected and restricted all of food intake with the exception of optional water intake until death. The body weight of each rabbit on the day before starvation was about 2 kilograms. The results are summarized as follows. 1. The average decrememt ratio of body weight on the terminal day before death was $34.3{\pm}7.5$ per cent with the range from 24.5 to 46.3 per cent. The average life duration until death was $10.25{\pm}2.6$ days, the range being from 6 to 14 days. 2. The decrease in number of reticulocytes with a parallel disappearance of polychromatic erythrocytes in peripheral blood in the course of starvation Was the most remarkable change in erythrocytic series, an evidence suggesting marked restriction of the erythropoietic function on 3rd to 4th day and almost complete suspension in about a week of starvation. 3. Erythrocyte count, hemoglobin content and haematocrit value of peripheral blood, were normal or indicative of slight hemoconcentration. 4. Mean Corpuscular Hemogloin Concentration was slightly higher than normal and Mean Corpuscular Volume tended to be low and no appreciable shifts were observed in Mean Corpuscular Diameter and Price-Jones curve of erythrocytes, while fewer macrocytes than normal were seen. These changes were considered to have resulted from a marked decrease in young erythrocytes in peripheral blood in the course of starvation. 5. Neither poikilccytoses or anisosytosis was observed. 6. Leukopenia was observed in all of 8 starved rabbits. The decrement ratio on the terminal day of starvation was between 13 to 64 per cent. The leukopenia was mainly due to fall of lymphocytes in 6 cases and to fall of neutrophilic leukocytes in the other 2 cases. In many cases, irregular fluctuation of neutrophilic leukocytes in its biological curve were seen in contrast to the relatively smooth changes of lymphocytes. Eosinophilic leukocytes tended to decrease in absolute number especially in later stage of starvation. Little significance in regard to monocytes and basophilic leukocytes in this study was discussed. 7. Proplasma cells, rarely plasma cells, appeared with a tendency to increase in number at later stage of starvation. 8. The most characteristic changes on circulating blood cells in complete starvation of rabbits were the leukoponia and failure of regeneration of erythroctes. These changes were considered as adaptive phenomena in response to the catabolic consumption of body constituents.

• 대한수의학회지
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• 제25권2호
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• pp.91-101
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• 1985

This study was conducted in order to observe the changes in cellular associations of seminiferous tubules from 8 to 20 weeks of age and to obtain the cycle and relative duration of the seminiferous epithelia from 24 to 32 weeks of age. Twenty-eight Korean native male goats were used in the experiment and divided into 7 groups, consisting of 4 goats each, with four weeks intervals from 8 to 32 weeks of age. The results were summarized as follows; 1. Gonocytes were seen at 8 weeks of age, however they were not observed as from 12 weeks. Both type A-spermatogonia and type B-spermatogonia occurred from 8 weeks, while primary spermatocytes were found from 12 weeks. Secondary spermatocytes and spermatids appeared from 16 weeks, and increased in numbers sequentially until 32 weeks of age. Spermatozoa were observed at first at 20 weeks of age. 2. Type A-spermatogonia appeared approximately twice as many at stage 2 as compared to stage 1, while the same numbers of cells were seen in both stages 1 and 8, showing the least number among 8 stages of the cycle of the seminiferous epithelia. The type B-spermatogonia were found during the stage 5 to 8, not to be detactable during stage 1 to 4. The number of primary spermatocytes of the leptotene phase increased markedly during stage 1 to 4, and decreased afterwards. The primary spermatocytes of the pachytene phase were shown the least in number at stage 4. The secondary spermatocytes could be seen only at stage 4 and the largest number of spermatids was seen at the stage 4 among 8 stages. 3. The relative frequencies of each stage among stages 1 to 8 of the cycle of the seminiferous epithelia were 27.5, 17.5, 12.8, 5.8, 8.9, 8.3, 12.0 and 7.2% respectively. 4. Some of the nuclei of Sertoli cells transformed from the "parallel" type to the "perpendicular" type. This evolution took place from stage 1 to 6, when the number of "perpendicular" type nuclei reached a peak and the number was decreased in the rest of the stages. Thus, establishment of spermatogenesis in Korean native goats was completed at the age of 20 weeks.

• 식물분류학회지
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• 제38권4호
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• pp.509-522
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• 2008

The achene morphology of ten taxa (eight species and two varieties) of the genus Bidens L. (Asteraceae) in Korea was studied in detail using the stereo-microscopy (SM) and scanning electron microscopy (SEM). The size of achenes excluding the arista part is $3.0-19.5{\times}0.7-2.6 mm$. The pappus is made up of 2-4 aristae, and the length of arista is 2.2-5.6 mm long. The striations of barb are 1-3. The achene polymorphism is confirmed in six studied taxa (B. bipinnata, B. biternata, B. frondosa, B. parviflora, B. pilosa var. pilosa, B. tripartita var. tripartita). Four types of achene were recognized based on the shape and the number of arista per fruit. - Type A: oblong with two aristae (B. parviflora); Type B: oblong with three or more aristae (B. bipinnata, B. biternata, B. pilosa var. pilosa, B. pilosa var. minor); Type C: obovate with two aristae (B. frondosa, B. radiata var. radiata, B. radiata var. pinnatifida, B. tripartita var. tripartita); Type D: obovate with three or more aristae (B. cernua). Three surface patterns (i.e., spiral, smooth, and irregular straight in parallel) of barb are also distinguished. The achene surface can be recognized into three types (ribbed areolate, smooth, subfavulariate). Systematic implications of achene characters are also briefly discussed. On the basis of the achene characters, a key of Bidens taxa in Korea is provided.

• Journal of Nutrition and Health
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• 제52권2호
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• pp.149-156
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• 2019

본 연구에서는 12주간 김치에서 추출한 유산균 Lactobacillus plantarum 섭취가 피부의 산도 및 관련인자인 유리아미노산, 젖산 및 유리지방산의 함량을 변화시키는지 파악하였다. CJLP 군에서 12주차에 피부 산도가 대조군에 비해 개선되었다. 표피의 유리아미노산 함량은 대조군에 비해 변화하지 않았으며, 총 유리지방산 및 Stearic acid (C18:0), Palmitic acid (C16:0)의 함량은 감소하였다. 그러나 CJLP군에서 젖산의 함량은 대조군에 비해 12주차에 유의적으로 증가하였다. 즉 김치유산균 Lactobacillus plantarum 섭취는 CJLP 군에서 젖산 함량 증가와 함께 산도를 개선하였다.

• 한방비만학회지
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• 제20권2호
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• pp.138-148
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• 2020

Objectives: The aim of this study is to evaluate the effects of Bangpungtongseong-san (Fangfengtongsheng-san, BTS) and Daesiho-tang (Dachaihu-tang, DST) on weight loss and improvement in lipid metabolism and glucose metabolism. Furthermore, we intend to develop a prediction model for drug effects through the analysis of the single nucleotide polymorphism (SNP), gut-microbiota, and the expression of immune-related biomarkers. Methods: This study is a single-center, randomized, double-blind, parallel-design clinical trial. One hundred twenty-eight participants will be assigned to the BTS group (n=64) and DST group (n=64). Both groups will be administered 4 g medication three times a day for up to 2 weeks. The primary outcomes is weight loss. The secondary outcomes include bioelectrical impedance analysis, waist circumstance, body mass index, total cholesterol, high-density lipoprotein, triglyceride, insulin resistance. The exploratory outcomes include 3-day dietary recall, food frequency questionnaire, quality of life questionnaire, gut microbiota analysis, immune biomarkers analysis, and SNP analysis. Assessment will be made at baseline and at week 4, 8, and 12. Conclusions: This protocol will be implemented by approval of the Institutional Review Board of Dongguk University. The results of this trial will provide a systematic evidence for the treatment of obesity and enable more precise herbal medicine prescriptions.