• BMB Reports
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• 제42권10호
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• pp.655-660
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• 2009

The potential anti-metastasis and anti-invasion activities of early growth response gene-1 (Egr-1) and claudin-3, a tight junction (TJ)-related protein, were evaluated using histone deacetylase (HDAC) inhibitors in human hepatocarcinoma cells. The results of wound healing and Transwell assays showed that HDAC inhibitors such as trichostatin A and sodium butyrate inhibited cell migration and invasion. HDAC inhibitors markedly induced Egr-1 expression during the early period, after which expression levels decreased. In addition, the down-regulation of snail and type 1 insulin-like growth factor receptor (IGF-1R) in HDAC inhibitor- treated cells induced the upregulation of thrombospondin-1 (TSP-1), E-cadherin and claudin-3. Cells transfected with Egr-1 and claudin-3 siRNA displayed significant blockage of HDAC inhibitor-induced anti-invasive activity. Collectively, these findings indicate that the up-regulation of Egr-1 and claudin-3 are crucial steps in HDAC inhibitor-induced anti-metastasis and anti-invasion.

• 한국자동차공학회논문집
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• 제22권4호
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• pp.121-130
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• 2014

This paper is the second investigation on the effects of intake flow control methods on the part load performance in a spark ignition engine. In the previous work, two control methods, port throttling and masking, were compared with respect to lean misfire limit, fuel consumption and emissions. In this work, the effects of these two methods on EGR characteristics were studied and simultaneously the differences between EGR and lean combustion as a dilution method were investigated. The results show that EGR limit is expanded up to 23% and 3 ~ 5% improvement in the fuel consumption are achieved around 8 ~ 13% rates by the flow controls comparing with 10% limit and 1.5% reduction around 3% rate of non-control case. The masking method is more effective on the limit expansion than throttling as like as lean misfire limit; however there is no substantial difference in fuel consumptions improvement regardless the control methods except high load condition. Also it is observed that there exist critical EGR rates around which the combustion performance and NOx formation change remarkably and these rates generally coincide with optimum rates for the fuel consumption. In addition, dilution with fresh air is much more advantageous than that of the exhaust gas from the view point of dilution limit and fuel consumption, while utilization of the exhaust gas is more effective on NOx reduction in spite of considerably small dilution compared with the use of fresh air. Finally, the improvement of fuel consumption by massive EGR is highly dependent on the EGR limit at which the engine runs stably, therefore the stratified combustion technique might be a best solution for this purpose.

• 대한기계학회논문집B
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• 제36권7호
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• pp.759-765
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• 2012

1.7L 커먼레일 직접분사 디젤 엔진을 이용하여 1500rpm 3.9bar BMEP 조건에서 세가지 연소 전략에 따른 배기가스 배출 특성 및 탄화수소 종 분석을 수행하였다. 첫째 전략은 EGR 을 사용하지 않고 연료 분할 분사를 이용하는 방법(split injection), 둘째는 적절한 EGR 적용 및 단일 연료분사 방법(single-1)이며 셋째는 다량의 EGR 및 레일 압력 증대 등을 통한 저온디젤연소(single-2)이다. 본 실험 조건으로부터 split injection 방법과 single-1 방법은 PM-NOx 상반 관계를 보였고, single-2 방법은 PM-NOx 상관관계에서 벗어나 PM 및 NOx 동시 저감이 가능하였다. 탄화수소 종 분석 결과, THC 배출 경향과 동일하게 탄소번호에 관계없이 split injection 이 가장 적은 배출을 보였고, single-1 그리고 single-2 의 순서로 많이 배출하였다. 메탄, 아세틸렌 및 CO 의 THC 에 대한 비율은 공연비가 농후해 짐에 따라서 증가하였고 이는 공연비가 농후에 따른 연소 영역에서 산소 농도 감소로 열해리가 증가하였기 때문이다.

• 한국공작기계학회논문집
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• 제15권1호
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• pp.76-81
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• 2006

Modem after-treatment technology has been developed variously in order to decrease exhausted emission in diesel engine. However, it seems very difficult to comply with updated stringent emission standards. Specially, it has been many years that exhaust gas from gasoline automobile rather than from diesel is the major object concerned by Korea and other countries, and it is strongly required on the reduction techniques on harmful NOx and PM among those compositions. Thus, this research focused on the electronic control EGR and the target for this research is heavy-duty turbo-diesel engine with EGR technology(High pressure route and low pressure route system).

• 한국자동차공학회논문집
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• 제9권5호
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• pp.1-8
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• 2001

It is a present situation that the control on automobile emission is getting more restrictive and also the regulations for emission are changing greatly up to level of those advanced foreign countries. Specially, it has been many years that exhaust gases from gasoline automobile rather than from diesel is the major object concerned by Korea and other countries, and it is strongly required on the reduction techniques on harmful NOx and PM among those compositions. Thus, this research focused on the Exhaust Gas Recirculation (EGR) and the target for this research is heavy-duty turbo-diesel engine with Cooled EGR. Furthermore, this research has been made efforts to accomplish the regulation on emission for heavy duty diesel engine.

• Journal of Nutrition and Health
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• 제29권9호
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• pp.1003-1012
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• 1996

We examined the relationship among riboflavin intake, work activity, erythrocyte glutathione reductase activity coefficient(EGR AC)and urinary riboflavin excretion. We also attempted to determine factors affecting seasonal riboflavin status of rural women. All information about nutrient intake, work activity and riboflavin biochemical status was repeatly collected in three seasons ; farming season(June), harvest season(October), nonfarming season(February). EGR AC was negatively correlated with riboflavin intake(P<0.005) and positively correlated with the duration(min) of farming activity(P<0.005) and the percentage of lean body mass(LBM) (%) representing long term physical activity(P<0.05) in harvestseason. Urinary riboflavin excretion was positively correlated with the ratio of riboflavin intake to 1,000kcal of energy expenditure (P<0.05) in farming season and negatively correlated with the duration(min) of farming activity (P<0.05) and crude nitrogen balance(P<0.005) in harvest season. It appeared that EGR AC seems to increase and urinary riboflavin excretion seems to decrease as work activity increase. Therefore work activity would be expected to deteriorate riboflavin status. Multiple regression analysis of variables showed that in general EGR AC was affected by riboflavin and energy intakes, energy expenditure, energy balance, the duration(min) of farming activity, LBM (%). Urinary riboflavin excretion was affected by riboflavin and protein intakes, LBM(kg) and crude nitrogen balance. Crude nitrogen balance affected urinary riboflavin excretion in all seasons. The result indicated that work activity as well as nutrient intake seemed to affect riboflavin status, especially EGR AC was affected preferentially be work activity in all seasons.

• Journal of Mechanical Science and Technology
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• 제15권11호
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• pp.1524-1532
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• 2001

The effects of recirculated exhaust gas on the wear of cylinder liner and piston were experimentally investigated by a two-cylinder, four cycle, indirect injection diesel engine operating at 75% lo ad and 1600 rpm. For the purpose of comparison between the wear rates of the two cylinders with and without EGR, the recirculated exhaust gas was sucked into one of two cylinders after the soot in exhaust emissions was removed by an intentionally designed cylinder-type scrubber equipped with 6 water injectors(A water injector has 144 nozzles of 1.0 mm diameter), while only the fresh air was inhaled into the other cylinder. These experiments were carried out with the fuel injection timing fixed at 15.3$^{\circ}$ BTDC. It was found that the mean wear rate of cylinder liner with EGR was greater in the measurement positions of the second half than those of the first half, that the mean wear rate without EGR was almost uniform regardless of measurement positions, and that the wear rate of piston skirt with EGR increased a little bit, but the piston head diameter increased, rather than decreased, owing to soot adhesion and erosion wear, and especially larger with EGR.

• 한국산학기술학회논문지
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• 제3권1호
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• pp.58-62
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• 2002

본 연구는 기관의 성능과 배출가스의 ECR 효과을 대한 것으로 기관은 6실린더 11리터의 대형터보디젤기관이며 ECR 방식은 저압루트시스템을 적용하였다. EGR 작동방식은 기계시이며 터빈 출구로부터 압축기 입구로 재순환시키는 방식이다. 또한 실험은 기관회전수와 부하별로 변경시켰으며 ECR율은 4%와 8%로 고정하여 실험하였고 그 결과를 기존 기관의 성능 및 배출가스결과와 비교 분석하였다. 따라서 본 연구의 목적은 대형터보디젤기관에 폭넓은 작동범위에서 ECR에 의한 기관 및 배출가스 성능에 미치는 영향을 고찰하고자 한다.

• 한국산학기술학회논문지
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• 제11권1호
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• pp.55-60
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• 2010

고압의 가스를 이용하여 고온 가스와 저온 가스를 분리하거나 입자상 물질의 분리에 사용 할 수 있는 장치인 볼텍스 튜브의 에너지 분리 특성을 적용하여 자동차의 EGR Cooler 대체장치의 기본 설계 자료를 구축하기 위하여 실험을 수행하였다. 설계를 위한 기초 자료를 확보하기 위하여, 볼텍스 튜브의 입구 압력, 저온출구 및 고온출구압력 변화에 따른 에너지 분리 특성을 분석하였다. 공급압력이 상승할수록 에너지 분리 효과가 상승하였으며, 최고온도는 저온유량비가 약 0.85 에서, 최저온도는 저온유량비가 약 0.35 에서 발생하였다. 볼텍스 튜브의 고온측 출구온도는 고온측 및 저온측 출구압력에 영향을 받으며, 저온측 출구온도는 출구압력 변화에 독립적인 온도변화 특성을 나타내었다. 본 연구의 결과는 자동차의 EGR Cooler 대체장치의 기본 설계 자료로 응용될 수 있을 것이다.

• 대한기계학회논문집B
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• 제24권9호
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• pp.1247-1254
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• 2000

The effects of recirculated exhaust gas on the characteristics of $NO_x$ and soot emissions under a wide range of engine load have been experimentally investigated by a water-cooled, four-cylinder, indirect injection, four cycle and marine diesel engine operating at two kinds of engine speeds. The simultaneous control of $NO_x$ and soot emissions in diesel engines is targeted in this study. The EGR system is used to reduce $NO_x$ emissions, and a novel diesel soot removal device with a cylinder-type scrubber for the experiment system which has 6 water injectors(A water injector has 144 nozzles in 1.0 mm diameter) is specially designed and manufactured to reduce the soot contents in the recirculated exhaust gas to intake system of the engines. The intake oxygen concentration and the mean equivalence ratio calculated by the intake air flow and fuel consumption rate, and the exhaust oxygen concentration measured are used to analyse and discuss the influences of EGR rate on $NO_x$ and soot emissions. The experiments are performed at the fixed fuel injection timing of $15.3^{\circ}$ BTDC regardless of experimental conditions. It is found that $NO_x$ emissions are decreased and soot emissions are increased owing to the drop of intake oxygen concentration and exhaust oxygen concentration, and the rise of equivalence ratio as the EGR rate rises.