• Title/Summary/Keyword: Efficacy research

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Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng

  • Hyun, Sun Hee;Kim, Sung Won;Seo, Hwi Won;Youn, Soo Hyun;Kyung, Jong Soo;Lee, Yong Yook;In, Gyo;Park, Chae-Kyu;Han, Chang-Kyun
    • Journal of Ginseng Research
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    • v.44 no.4
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    • pp.527-537
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    • 2020
  • Panax ginseng, a medicinal plant, has been used as a blood-nourishing tonic for thousands of years in Asia, including Korea and China. P. ginseng exhibits adaptogen activity that maintains homeostasis by restoring general biological functions and non-specifically enhancing the body's resistance to external stress. Several P. ginseng effects have been reported. Korean Red Ginseng, in particular, has been reported in both basic and clinical studies to possess diverse effects such as enhanced immunity, fatigue relief, memory, blood circulation, and anti-oxidation. Moreover, it also protects against menopausal symptoms, cancer, cardiac diseases, and neurological disorders. The active components found in most Korean Red Ginseng varieties are known to include ginsenosides, polysaccharides, peptides, alkaloids, polyacetylene, and phenolic compounds. In this review, the identity and bioactivity of the non-saponin components of Korean Red Ginseng discovered to date are evaluated and the components are classified into polysaccharide and nitrogen compounds (protein, peptide, amino acid, nucleic acid, and alkaloid), as well as fat-soluble components such as polyacetylene, phenols, essential oils, and phytosterols. The distinct bioactivity of Korean Red Ginseng was found to originate from both saponin and non-saponin components rather than from only one or two specific components. Therefore, it is important to consider saponin and non-saponin elements together.

Eating Self-Efficacy: Development of a Korean Version of the Weight Efficacy Life-Style Questionnaire - A Cross-Cultural Translation and Face-Validity Study (식이 자기 효능감: 한국어판 Weight Efficacy Life-Style 설문지 개발 - 횡문화적 번역 및 안면 타당도 검증)

  • Seo, Hee-Yeon;Ok, Ji-Myung;Kim, Seo-Young;Lim, Young-Woo;Park, Young-Bae
    • Journal of Korean Medicine for Obesity Research
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    • v.19 no.1
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    • pp.24-30
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    • 2019
  • Objectives: Eating self-efficacy is an important predictor of successful weight control behaviors during obesity treatment. The Weight Efficacy Life-Style Questionnaire (WEL) is an internationally used measure of eating self-efficacy. The objective of this study was to develop the Korean version of WEL (K-WEL) and verify face validity. Methods: According to previously published guidelines, the cross-cultural translation was conducted through organizing the expert committee, translation, back-translation, synthesis, grammar review, and final synthesis. Following the translation of the WEL into Korean, face validity was performed for 35 subjects. Results: After all the versions of the questionnaire were examined, the translated WEL questionnaires were finally synthesized and licensed by the developer in writing. Regarding the translated WEL questionnaires, seven out of 35 subjects (20%) offered ideas about ambiguous expressions in them. All four points indicated in the face validity verification were additionally modified for greater clarity and understanding. Conclusions: We developed the Korean version of WEL and completed face validity. In future research, it would be necessary to provide further study on the reliability and validity of the Korean version of WEL.

The Effects of Transformational Leadership on Subordinate's Self-Efficacy and Subordinate's Acceptance Degree of Leader as Moderator (변혁적인 리더십이 부하의 자기효능감에 미치는 영향과 부하의 상사 수용도 조절효과)

  • Cho, Yoon-Geun;Hwang, Ho-Young
    • Korea Journal of Hospital Management
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    • v.12 no.3
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    • pp.68-95
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    • 2007
  • This research is designed for studying between transformational leadership and behavior of subordinate. We took a practical analysis with conception of leader acceptance to search function between transformational leadership and self-efficacy. For practical proof of this research, we look hypothetical inspection with collected data after posing a question with medical Staff of 459. The practical analysis of this research is as below. First, We could know that transformational leadership affect partially positive effect to self-efficacy of subordinate. That is, as a result for researching into the influence of subordinate to self-efficacy, setting each element which forms transformational leadership as hypotheses, charismatic behavior and intellectual stimulation of leader's have an positive effect on self-efficacy of subordinate. However, there is no relation between individualized consideration and self-efficacy of subordinate. Second, we analyzed effect of subordinate's acceptance of leader between transformational leadership and acceptance degree of leader, we could know that all of them which is Two subordinate purpose of transformational leadership have a controling effects as there must be existed differences on self-efficacy before and after interaction. It is also another suggestion of this research to provide a clue to next research which is related with the importance of acceptance and it, conception, because we find the fact there could be existed the difference according to acceptance degree of leader.

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Study of connections between efficacy terms and remedy terms by conversion the raw terms into the representative terms (대표 술어로의 변환을 통한 치법 용어의 본초, 처방의 효능 용어 연계에 관한 연구)

  • Oh, Yong-Taek;Jeon, Byoung-Uk;Jang, Hyun-Chul;Kim, Chang-Seok;Kim, Jin-Hyun;Kim, Sang-Kyun;Song, Mi-Young
    • Journal of Korean Medical classics
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    • v.24 no.5
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    • pp.99-105
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    • 2011
  • The medical treatment is process of collecting symptoms, making a diagnosis and treatment for the diagnosis. The remedy and the efficacy are the important hinge that links the diagnosis to the means of medical treatment. Lots of medical data are stored on database or saved as files in these days. The preferential way to find the efficacy related to the remedy is search all efficacy terms match up to the remedy term. To increase the rate of matching remedy terms with efficacy terms, we study the relation between efficacy terms and remedy terms and research the conversion way of the terms into the representative terms. The rate of matching the raw remedy terms with the raw efficacy terms is below 30%. The rate of matching the disaggregate remedy terms with the disaggregate efficacy terms is about 50%. The rate of matching the representative remedy terms with the representative efficacy terms is almost 70%.

Biodistribution and pharmacokinetic evaluation of Korean Red Ginseng components using radioisotopes in a rat model

  • Sung-Won Kim;Byung-Cheol Han;Seung-Ho So;Chang-Kyun Han;Gyo In;Chae-Kyu Park;Sun Hee Hyun
    • Journal of Ginseng Research
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    • v.47 no.1
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    • pp.74-80
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    • 2023
  • Background: Although many studies have evaluated the efficacy and pharmacokinetics of Korean Red Ginseng (KRG) components (Rg1, Rb1, Rg3, Rd, etc.), few have examined the in vivo pharmacokinetics of the radiolabeled components. This study investigated the pharmacokinetics of ginsenosides and their metabolite compound K (CK), 20(s)-protopanaxadiol (PPD), and 20(s)-protopanaxatriol (PPT) using radioisotopes in rat oral administration. Methods: Sprague-Dawley rats were dosed orally once with 10 mg/kg of the tritium(3H) radiolabeled samples, and then the blood was collected from the tail vein after 0.25, 0.5, 1, 1.5, 2, 4, 6, 8, 12, 24, 48, 96, and 168 h. Radioactivity in the organs, feces, urine, and carcass was determined using a liquid scintillation counter (LSC) and a bio-imaging analyzer system (BAS). Results and conclusion: After oral administration, as the 3H-labeled ginsenosides were converted to metabolites, Cmax and half-life increased, and Tmax decreased. Interestingly, Rb1 and CK showed similar values, and after a single oral administration of components, the cumulative excretion ratio of urine and feces was 88.9%-92.4%. Although most KRG components were excreted within 96-168 h of administration, small amounts of components were detected in almost all tissues and mainly distributed to the liver except for the digestive tract when observed through autoradiography. This study demonstrated that KRG components were distributed to various organs in the rats. Further studies could be conducted to prove the bioavailability and transmission of KRG components to confirm the mechanism of KRG efficacy.

High efficacy PDP

  • Oversluizen, G.;Dekker, T.;Gillies, M. F.;Zwart, S.T. de
    • 한국정보디스플레이학회:학술대회논문집
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    • 2003.07a
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    • pp.339-342
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    • 2003
  • Main PDP panel efficacy improvement factors are discussed. A large panel efficacy improvement can be obtained through a combination of discharge efficiency improvement and phosphor improvement. Important design elements are a high Xe-content gas mixture, the application of a $TiO_2-layer$, and a new green phosphor with little saturation at high VUV-load. In a 4-inch color test panel with a conventional stripe-type cell configuration a white efficacy of 4.4 lm/W and a luminance of 5000 $cd/m^2$ is obtained for sustaining at 250V in addressed condition.

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Level of Self-Efficacy of Science Teachers Towards Engaging Students

  • Upadhyaya, Indra Raj
    • Korean Educational Research Journal
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    • v.40 no.2
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    • pp.57-73
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    • 2019
  • The study aimed at investigating the level of self-efficacy of science teachers towards student engagement. Although the general self-efficacy of teachers has been explored a lot but the efficacy of science teacher has not been explored more and student engagement is crucial towards understanding of science concepts. Therefore, the main purpose of the study was to find the self-efficacy of science teachers mainly towards three dimensions of student engagement (Behavioral, Cognitive and Emotional engagement). The study was carried with 150 secondary science teachers as Kathmandu. Secondary science teachers were found to be moderately high efficacious in all aspects of behavioral engagement of students except four aspects in which they showed moderate efficacy. Regarding the self-efficacy on cognitive engagement they were moderately efficacious in two aspects and were found to be moderately high efficacious in other all aspects. However, science teachers' self-efficacy was found to be moderately high. Teachers were found to be efficacious in making clasroom constructive, developing collaborative skill and high order thinking among the students. However in some aspects they were found less efficacious.

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Development of a Comprehensive Self-Management Program Promoting Self Efficacy for Type 2 Diabetic Patients (제 2형 당뇨병 환자를 위한 포괄적 자기효능증진 자가관리 프로그램 개발)

  • Park, Ju-Young;Ko, Il-Sun
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.19 no.1
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    • pp.74-86
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    • 2012
  • Purpose: The purpose of this study was to develop a comprehensive self-management program promoting self efficacy for Type 2 diabetic patients. Methods: The study was a methodological research design in which previous related research was reviewed to develop the comprehensive self-management program promoting self efficacy using self efficacy theory. Results: Comprehensive self-management programs promoting self efficacy included the whole range of eight self-management domains: diet, exercise, medication, self-testing of blood glucose, complication or foot, stress, time, and general health, and consisted of four sources of self efficacy: enactive mastery experience, vicarious experience, verbal persuasion, and physiological and affective states, as strategies to promote self efficacy. Developmental methods included, in addition to large and small group education, individual education or counseling, and telephone counseling. Conclusion: Further studies are needed in community health centers or hospitals to establish the effects on self-management compliance and glycemic control of the comprehensive self-management program promoting self efficacy.

Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial

  • Hyun, Sun Hee;Ahn, Ha-Young;Kim, Hyeong-Jun;Kim, Sung Won;So, Seung-Ho;In, Gyo;Park, Chae-Kyu;Han, Chang-Kyun
    • Journal of Ginseng Research
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    • v.45 no.1
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    • pp.191-198
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    • 2021
  • Background: Most clinical studies of immune responses activated by Korean Red Ginseng (KRG) have been conducted exclusively in patients. However, there is still a lack of clinical research on immune-boosting benefits of KRG for healthy persons. This study aims to confirm how KRG boosts the immune system of healthy subjects. Methods: A total of 100 healthy adult subjects were randomly divided into two groups that took either a 2 g KRG tablet or a placebo per day for 8 weeks. The primary efficacy evaluation variables included changes in T cells, B cells, and white blood cells (WBCs) before and after eight weeks of KRG ingestion. Cytokines (TNF-α, INF-γ, IL-2 and IL-4), WBC differential count, and incidence of colds were measured in the secondary efficacy evaluation variables. Safety evaluation variables were used to identify changes in laboratory test results that incorporated adverse reactions, vital signs, hematological tests, blood chemistry tests, and urinalysis. Results: Compared to the placebo group, the KRG intake group showed a significant increase in the number of T cells (CD3) and its subtypes (CD4 and CD8), B cells, and the WBC count before and after eight weeks of the intake. There were no clinically significant adverse reactions or other notable results in the safety evaluation factors observed. Conclusion: This study has proven through its eight-week intake test and subsequent analysis that KRG boosts the immune system through an increase in T cells, B cells, and WBCs, and that it is safe according to the study's safety evaluation.

Research on the Leadership Types in Italian Restaurants (이태리 레스토랑 종사자들의 리더십 유형에 관한 연구)

  • Yim, Seoung-Bean;Kim, Pan-Jin
    • Journal of Distribution Science
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    • v.10 no.12
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    • pp.35-43
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    • 2012
  • Purpose - This study analyzes the effects of types of leadership on the employees of Italian restaurants, its efficacy, and organizational citizenship behavior, utilizing a causal assessment model. In this study, independent variables such as the type of leadership perceived in the manager or chef by an Italian restaurant's employees, and its efficacy were parameters, and the organizational citizenship behavior and organizational effectiveness were the variables representing the results in the hypothesis. The study aimed to draw implications by verifying the leadership via efficacy and the impact on organizational citizenship behavior of Italian restaurants. Research design, data, methodology - For the purpose of this analysis, specific questionnaire items were configured according to the theory and efficacy of the study. From a questionnaire used in organizational citizenship behavior comprising 22 questions, six were modified to suit the research purpose of this study. The configured questionnaire comprised 5 parts and 40 items. A Likert (Likert) 5-point scale was utilized to measure responses to the questionnaire items from the employees of an Italian restaurant in Seoul who participated in the survey. For data collection, 400 questionnaires were distributed, and 344 collected. Factor analysis and reliability verification were conducted using SPSS18.0 and AMOS18.0. A covariance structure analysis was conducted to test the research hypotheses. Results - Based on the results of the analyses, the summary and suggested implications of the research are as follows: The covariance structure analysis used to analyze the kind of effect transformational and transactional leadership styles in Italian restaurant employees had on self-efficacy, group-efficacy, and organizational citizenship behavior, indicated that among the characteristics of transformational leadership (such as, idealized influence, inspirational motivation, individual consideration, and intellectual stimulation), idealized influence and individual consideration had a positive influence on self-efficacy. Idealized influence, individual consideration, conditional reward, and management by exception also positively influenced self-efficacy and altruistic and conscientious behavior (organizational citizenship behavior). Conclusions - Results suggest that with regard to self-efficacy and group efficacy, managers in different departments and chefs should provide team members with a vision for the future, increase their confidence in their abilities, and build their trust in the organization. By evaluating employee performance and experiences, management can demonstrate leadership and encourage organizational citizenship behavior through enjoyable, voluntary participation. Transformational and transactional leadership is effective in group processes that include social-exchange relationships, self-efficacy and group efficacy, and organizational citizenship behavior. However, as this research study utilizes only self-reported data, it has several limitations, such as a vulnerability of errors caused by the various experiment types. A significant limitation of this study is the lack of potential for the duplication of results. The covariance structure analysis, however, provides complementation to limit the impact of errors from self-reporting studies. A future study can extend this research by utilizing different data collection methods.

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