• Imaging Science in Dentistry
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• 제52권2호
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• pp.187-195
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• 2022

Purpose: This study developed a convolutional neural network (CNN) model to diagnose maxillary sinusitis on panoramic radiographs(PRs) and cone-beam computed tomographic (CBCT) images and evaluated its performance. Materials and Methods: A CNN model, which is an artificial intelligence method, was utilized. The model was trained and tested by applying 5-fold cross-validation to a dataset of 148 healthy and 148 inflamed sinus images. The CNN model was implemented using the PyTorch library of the Python programming language. A receiver operating characteristic curve was plotted, and the area under the curve, accuracy, sensitivity, specificity, positive predictive value, and negative predictive values for both imaging techniques were calculated to evaluate the model. Results: The average accuracy, sensitivity, and specificity of the model in diagnosing sinusitis from PRs were 75.7%, 75.7%, and 75.7%, respectively. The accuracy, sensitivity, and specificity of the deep-learning system in diagnosing sinusitis from CBCT images were 99.7%, 100%, and 99.3%, respectively. Conclusion: The diagnostic performance of the CNN for maxillary sinusitis from PRs was moderately high, whereas it was clearly higher with CBCT images. Three-dimensional images are accepted as the "gold standard" for diagnosis; therefore, this was not an unexpected result. Based on these results, deep-learning systems could be used as an effective guide in assisting with diagnoses, especially for less experienced practitioners.

• 한국지반신소재학회논문집
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• 제10권3호
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• pp.25-32
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• 2011

본 연구에서는 자동 흙-함수특성곡선 시험장치를 이용하여 새만금지역에서 채취한 준설토의 모관흡수력과 체적함수비를 측정하였다. 측정결과를 토대로 Van Genuchten(1980)의 방법을 이용하여 흙-함수특성곡선(SWCC)을 산정하였다. 동일한 유효포화도에서 건조과정의 모관흡수력은 습윤과정의 모관흡수력보다 크게 나타났다. Lu and Likos(2006)의 방법을 이용하여 모관흡수력에 따른 흡입응력을 산정하고, 흙-함수특성곡선(SWCC)의 불포화 관련계수를 토대로 흡입응력특성곡선(SSCC)을 예측하였다. 건조과정의 흡입응력은 유효포화도가 증가함에 따라 증가하다가 감소하지만 습윤과정의 흡입응력은 유효포화도가 증가함에 따라 지속적으로 감소한다. 또한 동일한 유효포화도에서 건조과정의 흡입응력은 습윤과정의 흡입응력보다 크게 나타났다. 한편 van Genuchten(1980)의 방법을 이용하여 투수계수함수(HCF)를 예측하였다. 체적함수비가 증가함에 따라 불포화 투수계수는 증가하며, 동일한 모관흡수력에서 건조과정의 투수계수가 습윤과정의 투수계수보다 크게 나타났다. 흙-함수특성곡선(SWCC)과 흡입응력특성곡선(SSCC)의 산정결과에 의하면 건조 및 습윤과정에서 흡입응력 혹은 모관흡수력에 대한 이력현상이 발생되었다. 이러한 이력현상은 흙입자 사이의 간극수로 인한 잉크병 효과에 의한 것이다.

• 한국정밀공학회지
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• 제25권1호
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• pp.145-150
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• 2008

One of the unresolved questions in articular cartilage biomechanics is the magnitude of the dynamic modulus and tissue compressive strains under physiological loading conditions. The objective of this study was to characterize the dynamic modulus and compressive strain magnitudes of bovine articular cartilage at physiological compressive stress level and loading frequency. Four bovine calf shoulder joints (ages 2-4 months) were loaded in Instron testing system under load control, with a load amplitude up to 800 N and loading frequency of 1 Hz, resulting in peak engineering stress amplitude of ${\sim}5.8\;MPa$. The corresponding peak deformation of the articular layer reached ${\sim}27%$ of its thickness. The effective dynamic modulus determined from the slope of stress versus strain curve was ${\sim}23\;MPa$, and the phase angle difference between the applied stress and measured strain which is equivalent to the area of the hystresis loop in the stress-strain response was ${\sim}8.3^{\circ}$. These results are representative of the functional properties of articular cartilage in a physiological loading environment. This study provides novel experimental findings on the physiological strain magnitudes and dynamic modulus achieved in intact articular layers under cyclical loading conditions.

• 품질경영학회지
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• 제50권3호
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• pp.305-332
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• 2022

Purpose: As the public interest in entrepreneurship has been highlighted and entrepreneurship policies have been generated, this study is to construct Entrepreneurship Ecosystem (EE) models which have a significant relationship to national entrepreneurship with quantitative analysis. It aims to provide implications to EE policymakers that which national components are effective in cultivating innovative entrepreneurship and validate its EE quality based on quantitative performance goals. Methods: This study utilizes secondary data, categorized under the PESTLE factor from credible international organizations (WB, UNDP, GEM, GEDI, and OECD) to determine significant factors in the quality of the entrepreneurial ecosystem. This paper uses the Multiple Linear Regression (MLR) analysis to select the significant variables contributing to entrepreneurship performance. Using the AUC-ROC performance evaluation method for machine learning MLR results, this paper evaluates the performance of EE models so that it can allow approving EE quality by predicting potential performance. Results: Among nine hypothesis models, MLR analysis examines that the number of the Unicorn company, Unicorn companies' economic value, and entrepreneurship measured as GEI can be reasonable dependent variables to indicate the performance derived from EE quality. Rather than government policies and regulations, the social, finance, technology, and economic variables are significant factors of EE quality determining its performance. By having high Area Under Curve values under AUC-ROC analysis, accepted MLR models are regarded as having high prediction accuracy. Conclusion: Superior EE contributes to the outstanding Unicorn companies, and improvement in macro-environmental components can enhance EE quality.

• 한국임상약학회지
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• 제11권2호
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• pp.57-61
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• 2001

The effect of circadian rhythm on the pharmacokinetics of acebutolol was studied in rabbits administered intravenous 5 mg/kg dose of acebutolol at 09:00 in the morning (a.m) and 22:00 in the evening (p.m). A significant effect of circadian rhythm of pbarmacokinetic parameters as a function of time of day was noted in rabbits, showing lower total body clearance (CLt), higher plasma concentration and the area under the plasma concentration time curve (AUC) when acebutolol was given in the evening. The plasma concentration of acebutolol was increased significantly (p<0.05) at 12-24 hr after dosing in the evening. The AUC was greater in the evening $(111\%)$ than that in the morning and $CL_t$, was higher when acebutolol was given in the morning ($1.12\pm0.24$ ml/hr) versus in the evening ($1.01\pm0.22$ ml/hr), but those were not significant. Therefore, It is reasonable to consider individual circadian rhythm for effective dosage regimen of acebutolol in clinical chronotherapeutics.

• 한국농공학회지
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• 제39권2호
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• pp.134-142
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• 1997

This study was performed to evaluate the drain runoff characteristics from one paddy field, and to provide the basic data required for the determination of flood discharge and unit drainage water for drainage improvement and farmland consolidation. For this purpose, under the assumption that drain discharge from paddy field was similar to outflow of reservoir, runoff model based on storage equation was applied to the experimental field, and simulated results were compared to the measured discharge at weir point. To estimate effective storage volume of paddy field with water depth, 4 regression formula were examined such as linear, exponential, power, and combined. From the observed runoff characteristics, it was shown to be 3.3~16.3${\ell}$/sec in weir discharge, 57.2~98% in runoff ratio, and relative error of simulated result was 3.0~39.4%, 8.5 ~56.0 % for peak flow and runoff ratio, respectively. Curve number by SCS method was calculated as mean value of 96.4 using measured rainfall and runoff data, it was considered relatively high because paddy field has generally flooding depth contrary to the upland watershed area.

• 한국임상약학회지
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• 제9권1호
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• pp.66-70
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• 1999

The effect of circadian rhythm on cyclosporine pharmacokinetics was studied in rabbits after oral administration of 10 mg/kg dose of cyclosporine at 10:00 a.m. and 10:00 p.m. The blood concentration data were subjected to simultaneous computer nonlinear least squares regression analysis using a 1-compartment pharmacokinetic model. The blood concentrations of cyclosporine at 10:00 a. m. were increased significantly during 2-6 hr compared to those at 10:00 p.m. The area under the blood concentration-time curve (AUC) and peak concentration $(C_{max})$ of cyclosporine at 10:00 a.m. were increased significantly compared to those at 10:00 p.m. The mean total body clearance (CL) of cyclosporine at 10:00 a.m. were decreased significantly compared to those at 10:00 p.m. It is reasonable to consider individual circadian rhythm for effective dosage regimen of cyclosporine in therapeutics.

• 한국조경학회지
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• 제14권1호
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• pp.1-13
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• 1986

The purpose of this study is to investigate the effect of temperature control by a shade tree and the lawn area. In this investigation, we find out that artificial-lawn, concerte, and exposed soil are more higher temperature than covered with plant materials. The results of the measurement may to summerized as follows; 1) Low-temperature effects of zoysia japonica is more controlled by condition of growth than leaf length of grass. Surface temperature make 0.7$^{\circ}C$ difference between long grass (15cm), and short grass (5cm), but make 5$^{\circ}C$ difference between good growth grass (230/10$\textrm{cm}^2$) and bad growth grass (80/10$\textrm{cm}^2$). 2) The surface temperature of the lawn area is 40.5$^{\circ}C$ lower on a maxinum than that of the artificial lawn (July 28, 1985). During the day of summer, shade area under the shade tree is 0.9$^{\circ}C$ lower then lawn area surface temperature, 6.9$^{\circ}C$ lower than bad growth lawn, 10.3$^{\circ}C$ lower than exposed soil, and 18$^{\circ}C$ lower than concrete surface temperature. 3) Natural irrigation effect on the surface temperature fluctuation. But this effect is changed by compositions of ground materials and time-lapse. 4) Sunny day is more effective than cloud day. 5) In summer season, surface temperature make a difference compare to temperature of 0.5-1.5m height from ground : Surface temperature is 3.4$^{\circ}C$ lower at the lawn area (11 a.m.), 4.2$^{\circ}C$ lower at the shade area the shade tree, 12.7$^{\circ}C$ higher at the concrete area (3p.m.), 38.8$^{\circ}C$ higher at the artificial lawn (2p.m.) 6) According to compositions of ground materials and season have specific vertical temperature distribution curve. 7) In summer season, temperature distribution of 0.5-1.5m hight at the shade tree is 4.8-5.7$^{\circ}C$ lower than concrete area (noon-3p.m.)

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1447-1452
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• 2012

Aim: To evaluate the differential diagnostic potential of lesion stiffness assessed by the sonoelastographic strain index ratio (SR) and elastographic color scoring system (UE) for breast lesions. Materials and Methods: Three hundred and forty two breast masses (158 benign and 184 malignant) from 325 consecutive patients (mean age 44.2 years; range 16-81)who had been scheduled for a sonographically guided core biopsy were examined proposed by Itoh et al, with scoring 1-3=benign and 4-5=malignant. Strain and area ratios of each lesion were calculated within the same machine. Histological diagnosis was used as the reference standard. The area under the curve (AUC) and cut-off point were obtained by receiver operating curve and the cross table Fischer Test was carried out for assessing diagnostic value. Sensitivity, specificity, PPV, NPV, accuracy and false-discovery rates were compared. Results: The mean strain ratios for benign and malignant lesions were 1.87 and 7.9 respectively. (P<0.0001). When a cutoff point of 3.54 was used, SR had a sensitivity of 94.6%, a specificity 94.3%, a PPV of 95.1%, an NPV of 93.7% and an accuracy of 94.4%. The AUC values were 0.90 for the 5 point scoring system (UE) and 0.96 for the strain index ratio. The overall diagnostic performance was SR method was better (P<0.05). Conclusions: Strain ratio measurement could be another effective predictor in elastography imaging besides 5 the point scoring system for differential diagnosis of breast lesions.

• 대한의용생체공학회:의공학회지
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• 제31권3호
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• pp.177-186
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• 2010

In 3D ultrasound color Doppler imaging (CDI), 8-16 pulse transmissions (ensembles) per each scanline are used for effective clutter rejection and flow estimation, but it yields a low volume acquisition rate. In this paper, we have evaluated three flow estimation methods: autoregression (AR), eigendecomposition (ED), and autocorrelation combined with adaptive clutter rejection (AC-ACR) for a small ensemble size (E=4). The performance of AR, ED and AC-ACR methods was compared using 2D and 3D in vivo data acquired under different clutter conditions (common carotid artery, kidney and liver). To evaluate the effectiveness of three methods, receiver operating characteristic (ROC) curves were generated. For 2D kidney in vivo data, the AC-ACR method outperforms the AR and ED methods in terms of the area under the ROC curve (AUC) (0.852 vs. 0.793 and 0.813, respectively). Similarly, the AC-ACR method shows higher AUC values for 2D liver in vivo data compared to the AR and ED methods (0.855 vs. 0.807 and 0.823, respectively). For the common carotid artery data, the AR provides higher AUC values, but it suffers from biased estimates. For 3D in vivo data acquired from a kidney transplant patient, the AC-ACR with E=4 provides an AUC value of 0.799. These in vivo experiment results indicate that the AC-ACR method can provide more robust flow estimates compared to the AR and ED methods with a small ensemble size.